GREMLIN Database
Q97VJ9 - Acetyl-CoA c-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-7)
UniProt: Q97VJ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 387 (346)
Sequences: 15376 (8414)
Seq/√Len: 452.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_K175_Y3.5291.00
225_K229_L3.4811.00
4_R223_E3.4011.00
164_Q297_E3.3211.00
103_V106_A3.0981.00
170_V190_V3.0101.00
91_A345_I2.9331.00
33_E36_N2.8381.00
3_R224_E2.8341.00
225_K228_E2.7751.00
178_M182_A2.7511.00
171_K174_K2.7271.00
223_E227_K2.7091.00
156_A201_W2.6841.00
348_I360_Q2.6691.00
268_A272_A2.5521.00
31_I107_M2.4681.00
10_V346_Y2.4271.00
6_A226_V2.4121.00
11_G37_D2.4081.00
98_V220_F2.3941.00
34_A219_V2.2561.00
105_I221_A2.2411.00
235_V349_T2.1781.00
352_L357_D2.1621.00
161_T164_Q2.1541.00
4_R236_W2.1531.00
94_A106_A2.1451.00
239_G272_A2.0971.00
41_S44_D2.0671.00
27_A50_I2.0611.00
98_V222_S2.0301.00
8_I221_A2.0231.00
234_P353_R1.9971.00
281_V326_L1.9651.00
274_V359_L1.9431.00
163_E167_L1.8941.00
44_D229_L1.8751.00
239_G268_A1.8631.00
296_Y303_E1.8561.00
216_A342_L1.8411.00
280_E357_D1.8081.00
246_Y254_E1.8071.00
193_V206_L1.8041.00
177_S181_K1.7801.00
154_H160_T1.7551.00
104_D225_K1.7551.00
221_A225_K1.7491.00
104_D222_S1.7451.00
276_P282_A1.7241.00
274_V279_I1.7171.00
266_R270_E1.7091.00
170_V174_K1.7031.00
296_Y324_V1.7011.00
279_I282_A1.7001.00
192_E195_K1.6871.00
34_A38_S1.6641.00
157_V255_W1.6641.00
222_S225_K1.6541.00
78_L93_S1.6541.00
183_H327_F1.6491.00
221_A226_V1.6451.00
351_Q355_E1.6431.00
50_I109_V1.6431.00
97_A103_V1.6381.00
96_T102_L1.6311.00
9_G38_S1.6311.00
25_E69_Y1.6281.00
148_A200_S1.6151.00
327_F351_Q1.6121.00
167_L171_K1.6011.00
167_L190_V1.6011.00
218_A342_L1.5801.00
263_L266_R1.5791.00
171_K303_E1.5561.00
180_P188_V1.5491.00
6_A236_W1.5341.00
105_I225_K1.5331.00
113_K116_E1.5321.00
32_K36_N1.5201.00
281_V351_Q1.5201.00
31_I66_V1.5201.00
94_A220_F1.4971.00
30_S217_T1.4691.00
3_R222_S1.4661.00
27_A66_V1.4441.00
351_Q354_D1.4431.00
30_S215_S1.4381.00
33_E37_D1.4251.00
174_K178_M1.4251.00
267_Q270_E1.4161.00
282_A361_Q1.4141.00
241_G267_Q1.4121.00
186_K353_R1.4101.00
21_V29_E1.3871.00
241_G268_A1.3851.00
269_Y276_P1.3731.00
183_H351_Q1.3571.00
92_L240_I1.3311.00
28_W69_Y1.3281.00
9_G34_A1.3261.00
224_E228_E1.3051.00
302_T323_G1.3041.00
62_P111_V1.3011.00
265_A361_Q1.2991.00
15_F339_A1.2851.00
74_G246_Y1.2731.00
46_G103_V1.2611.00
91_A218_A1.2551.00
85_A377_G1.2511.00
266_R298_D1.2501.00
160_T165_M1.2481.00
107_M219_V1.2371.00
349_T353_R1.2371.00
50_I217_T1.2361.00
152_T201_W1.2351.00
29_E33_E1.2331.00
326_L351_Q1.2331.00
45_I105_I1.2231.00
346_Y350_K1.2191.00
275_T278_D1.2181.00
164_Q167_L1.2181.00
88_L345_I1.2101.00
5_V220_F1.2061.00
279_I359_L1.2021.00
162_E204_K1.1991.00
44_D225_K1.1981.00
6_A223_E1.1941.00
157_V254_E1.1891.00
149_L201_W1.1881.00
243_A263_L1.1861.00
46_G104_D1.1601.00
168_V292_E1.1561.00
183_H354_D1.1491.00
189_T192_E1.1381.00
281_V355_E1.1321.00
15_F333_K1.1321.00
120_S132_Y1.1291.00
10_V349_T1.1241.00
102_L271_M1.1241.00
174_K177_S1.1241.00
10_V350_K1.1231.00
255_W258_F1.1201.00
3_R104_D1.1151.00
153_R157_V1.1081.00
99_A102_L1.1061.00
190_V194_L1.1051.00
91_A220_F1.1021.00
11_G33_E1.1011.00
94_A108_A1.0981.00
49_V106_A1.0891.00
148_A199_I1.0871.00
186_K354_D1.0821.00
31_I72_L1.0811.00
168_V293_I1.0781.00
276_P279_I1.0781.00
160_T293_I1.0721.00
6_A221_A1.0701.00
89_A93_S1.0671.00
96_T100_S1.0671.00
180_P185_Q1.0651.00
170_V193_V1.0631.00
28_W32_K1.0621.00
258_F261_T1.0581.00
52_S55_Y1.0571.00
245_D258_F1.0311.00
44_D228_E1.0311.00
51_G86_T1.0301.00
280_E323_G1.0291.00
280_E352_L1.0261.00
239_G271_M1.0231.00
243_A267_Q1.0201.00
8_I231_I1.0171.00
152_T156_A1.0161.00
196_S206_L1.0091.00
22_S25_E1.0081.00
85_A371_H1.0071.00
92_L379_F1.0021.00
261_T298_D0.9991.00
265_A299_L0.9991.00
158_F258_F0.9951.00
9_G37_D0.9921.00
343_S347_E0.9901.00
48_V67_A0.9851.00
326_L355_E0.9841.00
238_T359_L0.9811.00
132_Y135_E0.9741.00
15_F212_S0.9701.00
327_F354_D0.9671.00
223_E236_W0.9651.00
155_M290_I0.9561.00
267_Q271_M0.9551.00
158_F298_D0.9511.00
35_L72_L0.9471.00
72_L75_K0.9451.00
282_A301_F0.9401.00
4_R99_A0.9401.00
216_A339_A0.9371.00
301_F324_V0.9341.00
186_K350_K0.9341.00
30_S33_E0.9341.00
234_P349_T0.9331.00
371_H377_G0.9321.00
221_A231_I0.9261.00
187_P347_E0.9261.00
163_E194_L0.9231.00
281_V348_I0.9211.00
130_G133_Q0.9201.00
95_Y99_A0.9191.00
258_F298_D0.9191.00
35_L40_V0.9161.00
13_S29_E0.9161.00
153_R156_A0.9161.00
68_E74_G0.9131.00
95_Y237_I0.8951.00
264_A378_H0.8941.00
196_S204_K0.8931.00
49_V78_L0.8801.00
10_V218_A0.8791.00
49_V90_A0.8791.00
279_I361_Q0.8761.00
216_A346_Y0.8741.00
13_S26_L0.8721.00
5_V222_S0.8721.00
166_A207_D0.8691.00
154_H294_M0.8671.00
154_H258_F0.8661.00
13_S30_S0.8641.00
15_F343_S0.8631.00
108_A218_A0.8621.00
197_R205_L0.8551.00
258_F294_M0.8531.00
296_Y301_F0.8531.00
44_D105_I0.8511.00
97_A102_L0.8491.00
292_E296_Y0.8471.00
21_V25_E0.8421.00
237_I240_I0.8421.00
14_K29_E0.8421.00
265_A284_V0.8391.00
171_K304_K0.8371.00
47_L97_A0.8371.00
82_A89_A0.8321.00
268_A361_Q0.8281.00
224_E227_K0.8281.00
289_T331_K0.8261.00
344_M362_P0.8261.00
163_E190_V0.8251.00
182_A354_D0.8241.00
49_V94_A0.8231.00
5_V95_Y0.8191.00
178_M181_K0.8191.00
266_R299_L0.8181.00
34_A107_M0.8171.00
330_L340_T0.8141.00
35_L45_I0.8131.00
134_W139_Y0.8121.00
198_V201_W0.8121.00
327_F355_E0.8121.00
245_D263_L0.8111.00
223_E226_V0.8091.00
139_Y144_P0.8061.00
170_V189_T0.8061.00
93_S96_T0.8051.00
348_I362_P0.8021.00
23_I111_V0.8011.00
56_R59_E0.7971.00
30_S34_A0.7971.00
11_G30_S0.7951.00
29_E32_K0.7911.00
164_Q293_I0.7881.00
130_G135_E0.7881.00
48_V75_K0.7861.00
34_A217_T0.7861.00
27_A109_V0.7831.00
46_G267_Q0.7821.00
232_D353_R0.7821.00
58_I116_E0.7801.00
191_E195_K0.7781.00
371_H375_G0.7751.00
132_Y136_Y0.7751.00
107_M217_T0.7751.00
32_K42_Q0.7741.00
102_L240_I0.7731.00
115_T213_D0.7721.00
176_G180_P0.7711.00
175_Y178_M0.7691.00
5_V99_A0.7661.00
370_V375_G0.7651.00
170_V192_E0.7641.00
151_A290_I0.7601.00
178_M183_H0.7601.00
35_L42_Q0.7601.00
237_I379_F0.7591.00
133_Q136_Y0.7581.00
24_Q58_I0.7571.00
90_A342_L0.7561.00
45_I107_M0.7551.00
93_S97_A0.7551.00
7_V349_T0.7531.00
50_I63_A0.7511.00
274_V278_D0.7481.00
284_V295_G0.7471.00
234_P350_K0.7451.00
348_I370_V0.7441.00
207_D289_T0.7311.00
238_T272_A0.7261.00
52_S58_I0.7181.00
96_T99_A0.7171.00
245_D259_K0.7171.00
134_W146_Y0.7141.00
356_A359_L0.7131.00
52_S62_P0.7111.00
46_G106_A0.7111.00
104_D228_E0.7101.00
277_N300_G0.7101.00
150_Y256_V0.7101.00
38_S219_V0.7091.00
47_L242_Y0.7041.00
145_T149_L0.7021.00
72_L107_M0.7021.00
269_Y274_V0.7021.00
49_V93_S0.7011.00
276_P301_F0.6961.00
277_N323_G0.6951.00
203_I208_S0.6951.00
5_V98_V0.6931.00
176_G332_A0.6921.00
294_M298_D0.6921.00
53_T337_L0.6901.00
131_N136_Y0.6901.00
131_N135_E0.6891.00
190_V193_V0.6881.00
22_S116_E0.6871.00
234_P238_T0.6871.00
119_T124_A0.6861.00
128_R131_N0.6841.00
149_L153_R0.6841.00
32_K71_G0.6821.00
199_I205_L0.6761.00
261_T266_R0.6721.00
105_I229_L0.6691.00
177_S180_P0.6661.00
280_E359_L0.6661.00
31_I70_S0.6651.00
151_A155_M0.6651.00
218_A346_Y0.6631.00
265_A295_G0.6621.00
131_N134_W0.6611.00
27_A111_V0.6601.00
82_A242_Y0.6591.00
154_H158_F0.6581.00
292_E324_V0.6571.00
97_A106_A0.6561.00
352_L360_Q0.6541.00
104_D271_M0.6521.00
3_R99_A0.6511.00
160_T164_Q0.6501.00
28_W70_S0.6451.00
189_T193_V0.6441.00
11_G34_A0.6441.00
91_A108_A0.6431.00
35_L39_G0.6431.00
25_E28_W0.6420.99
21_V116_E0.6410.99
166_A194_L0.6410.99
64_P68_E0.6410.99
8_I226_V0.6400.99
76_V242_Y0.6400.99
265_A378_H0.6380.99
24_Q69_Y0.6380.99
166_A190_V0.6360.99
173_H177_S0.6360.99
160_T297_E0.6330.99
265_A276_P0.6300.99
31_I217_T0.6300.99
9_G234_P0.6300.99
88_L362_P0.6290.99
21_V113_K0.6290.99
92_L377_G0.6260.99
19_D126_G0.6250.99
270_E275_T0.6220.99
238_T274_V0.6220.99
173_H331_K0.6220.99
266_R300_G0.6210.99
340_T344_M0.6200.99
134_W137_H0.6200.99
32_K70_S0.6170.99
47_L82_A0.6170.99
280_E358_K0.6160.99
55_Y79_R0.6160.99
175_Y303_E0.6150.99
31_I35_L0.6140.99
246_Y255_W0.6130.99
78_L89_A0.6110.99
220_F237_I0.6100.99
345_I362_P0.6090.99
7_V220_F0.6070.99
67_A77_P0.6060.99
20_D116_E0.6060.99
129_G132_Y0.6060.99
148_A202_P0.6050.99
151_A203_I0.6040.99
146_Y149_L0.6030.99
221_A229_L0.6010.99
256_V259_K0.6000.99
55_Y59_E0.5990.99
50_I66_V0.5960.99
6_A222_S0.5960.99
371_H376_T0.5960.99
40_V219_V0.5960.99
45_I72_L0.5950.99
80_V93_S0.5940.99
94_A103_V0.5930.99
263_L267_Q0.5930.99
158_F294_M0.5930.99
241_G271_M0.5920.99
265_A269_Y0.5910.99
333_K343_S0.5910.99
176_G333_K0.5900.99
114_M337_L0.5900.99
370_V378_H0.5890.99
66_V70_S0.5890.99
90_A108_A0.5880.99
169_S289_T0.5880.99
46_G75_K0.5880.99
89_A92_L0.5870.99
145_T254_E0.5870.99
109_V217_T0.5870.99
124_A127_G0.5850.99
35_L38_S0.5840.99
42_Q73_T0.5810.99
242_Y377_G0.5800.99
47_L103_V0.5800.99
99_A240_I0.5790.99
48_V107_M0.5790.99
291_A295_G0.5780.99
167_L303_E0.5770.99
8_I225_K0.5770.99
6_A225_K0.5750.99
145_T153_R0.5750.99
11_G38_S0.5740.99
158_F297_E0.5720.99
297_E300_G0.5720.99
269_Y272_A0.5680.99
369_L372_N0.5650.99
287_A335_H0.5650.99
104_D224_E0.5650.99
372_N377_G0.5640.99
235_V352_L0.5640.99
108_A342_L0.5630.99
31_I48_V0.5630.99
91_A342_L0.5610.99
290_I294_M0.5610.99
293_I297_E0.5600.99
339_A342_L0.5600.99
174_K187_P0.5590.99
89_A97_A0.5590.99
191_E194_L0.5580.99
67_A72_L0.5560.99
54_A117_V0.5530.99
140_G143_F0.5530.99
119_T123_L0.5510.98
353_R356_A0.5490.98
369_L377_G0.5490.98
49_V97_A0.5480.98
268_A279_I0.5480.98
372_N375_G0.5460.98
183_H355_E0.5440.98
121_T129_G0.5440.98
173_H210_P0.5440.98
169_S173_H0.5420.98
284_V292_E0.5400.98
178_M358_K0.5370.98
188_V206_L0.5370.98
296_Y302_T0.5350.98
169_S193_V0.5350.98
6_A229_L0.5340.98
174_K190_V0.5330.98
159_G297_E0.5330.98
62_P65_I0.5310.98
128_R133_Q0.5300.98
18_R21_V0.5290.98
89_A242_Y0.5280.98
152_T203_I0.5270.98
155_M160_T0.5270.98
278_D359_L0.5260.98
97_A100_S0.5250.98
269_Y279_I0.5250.98
287_A291_A0.5250.98
129_G134_W0.5240.98
61_Y375_G0.5240.98
339_A343_S0.5230.98
123_L126_G0.5220.98
129_G133_Q0.5210.98
92_L96_T0.5210.98
61_Y83_M0.5200.98
167_L170_V0.5200.98
47_L106_A0.5180.98
130_G136_Y0.5170.98
196_S205_L0.5170.98
66_V111_V0.5160.98
165_M203_I0.5160.98
241_G272_A0.5150.98
9_G219_V0.5130.98
171_K292_E0.5130.98
53_T83_M0.5120.98
342_L346_Y0.5110.98
226_V229_L0.5090.97
154_H290_I0.5090.97
60_L83_M0.5080.97
264_A268_A0.5080.97
357_D360_Q0.5060.97
158_F255_W0.5050.97
282_A323_G0.5050.97
121_T124_A0.5040.97
86_T338_G0.5040.97
24_Q28_W0.5020.97
177_S185_Q0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbgA 2 0.9871 100 0.223 Contact Map
4u4eA 1 0.9121 100 0.281 Contact Map
1ulqA 4 0.9147 100 0.337 Contact Map
1wdkC 2 0.8992 100 0.338 Contact Map
2wu9A 2 0.907 100 0.342 Contact Map
3goaA 2 0.8837 100 0.352 Contact Map
4e1lA 4 0.8966 100 0.354 Contact Map
3svkA 2 0.8191 100 0.354 Contact Map
2vu1A 4 0.907 100 0.354 Contact Map
4n46A 4 0.9121 100 0.354 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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