Q97VJ9 - SULSO - GREMLIN Contacts

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Q97VJ9 - Acetyl-CoA c-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-7)

UniProt:	Q97VJ9	Sequences: MTRRVAVIGVGNSKFGRRDDVSIQELAWESIKEALNDSGVSQSDIGLVVIGSTAYRGIELYPAPIVAEYSGLTGKVPLRVEAMCATGLAAALSAYTAVASGLVDIAMAVGVDKMTEVDTSTSLAIGGRGGNYQWEYHFYGTTFPTYYALYATRHMAVFGTTEEQMALVSVKAHKYGSMNPKAHFQKPVTVEEVLKSRVISWPIKLLDSCPISDGSATAVFASEEKVKELKIDSPVWITGIGYANDYAYVARRGEWVGFKATQLAARQAYEMAKVTPNDIEVATVHDAFTIAEIMGYEDLGFTEKGKGGKFIEEGQSEKGGKVGVNLFGGLKAKGHPLGATGLSMIYEITKQLRDEADKLQQPLKKYIGLVHNVGGTGHFAYVMILRR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	387 (346)
Sequences:	15376 (8414)
Seq/√Len:	452.4

ECOLI - ATOB PAAJ YQEF FADA FADI
BACSU - THL YHFS FADA
HALSA - Q9HRI8 Q9HQZ8 Q9HNK4
SULSO - Q97VJ9 Q97UW8 Q97WQ6 Q97VU9 Q97VD4 Q97UA5 Q97WQ7 Q97W61 Q97VV9 Q7LXW2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
171_K	175_Y	3.529	1.00
225_K	229_L	3.481	1.00
4_R	223_E	3.401	1.00
164_Q	297_E	3.321	1.00
103_V	106_A	3.098	1.00
170_V	190_V	3.010	1.00
91_A	345_I	2.933	1.00
33_E	36_N	2.838	1.00
3_R	224_E	2.834	1.00
225_K	228_E	2.775	1.00
178_M	182_A	2.751	1.00
171_K	174_K	2.727	1.00
223_E	227_K	2.709	1.00
156_A	201_W	2.684	1.00
348_I	360_Q	2.669	1.00
268_A	272_A	2.552	1.00
31_I	107_M	2.468	1.00
10_V	346_Y	2.427	1.00
6_A	226_V	2.412	1.00
11_G	37_D	2.408	1.00
98_V	220_F	2.394	1.00
34_A	219_V	2.256	1.00
105_I	221_A	2.241	1.00
235_V	349_T	2.178	1.00
352_L	357_D	2.162	1.00
161_T	164_Q	2.154	1.00
4_R	236_W	2.153	1.00
94_A	106_A	2.145	1.00
239_G	272_A	2.097	1.00
41_S	44_D	2.067	1.00
27_A	50_I	2.061	1.00
98_V	222_S	2.030	1.00
8_I	221_A	2.023	1.00
234_P	353_R	1.997	1.00
281_V	326_L	1.965	1.00
274_V	359_L	1.943	1.00
163_E	167_L	1.894	1.00
44_D	229_L	1.875	1.00
239_G	268_A	1.863	1.00
296_Y	303_E	1.856	1.00
216_A	342_L	1.841	1.00
280_E	357_D	1.808	1.00
246_Y	254_E	1.807	1.00
193_V	206_L	1.804	1.00
177_S	181_K	1.780	1.00
154_H	160_T	1.755	1.00
104_D	225_K	1.755	1.00
221_A	225_K	1.749	1.00
104_D	222_S	1.745	1.00
276_P	282_A	1.724	1.00
274_V	279_I	1.717	1.00
266_R	270_E	1.709	1.00
170_V	174_K	1.703	1.00
296_Y	324_V	1.701	1.00
279_I	282_A	1.700	1.00
192_E	195_K	1.687	1.00
34_A	38_S	1.664	1.00
157_V	255_W	1.664	1.00
222_S	225_K	1.654	1.00
78_L	93_S	1.654	1.00
183_H	327_F	1.649	1.00
221_A	226_V	1.645	1.00
351_Q	355_E	1.643	1.00
50_I	109_V	1.643	1.00
97_A	103_V	1.638	1.00
96_T	102_L	1.631	1.00
9_G	38_S	1.631	1.00
25_E	69_Y	1.628	1.00
148_A	200_S	1.615	1.00
327_F	351_Q	1.612	1.00
167_L	171_K	1.601	1.00
167_L	190_V	1.601	1.00
218_A	342_L	1.580	1.00
263_L	266_R	1.579	1.00
171_K	303_E	1.556	1.00
180_P	188_V	1.549	1.00
6_A	236_W	1.534	1.00
105_I	225_K	1.533	1.00
113_K	116_E	1.532	1.00
32_K	36_N	1.520	1.00
281_V	351_Q	1.520	1.00
31_I	66_V	1.520	1.00
94_A	220_F	1.497	1.00
30_S	217_T	1.469	1.00
3_R	222_S	1.466	1.00
27_A	66_V	1.444	1.00
351_Q	354_D	1.443	1.00
30_S	215_S	1.438	1.00
33_E	37_D	1.425	1.00
174_K	178_M	1.425	1.00
267_Q	270_E	1.416	1.00
282_A	361_Q	1.414	1.00
241_G	267_Q	1.412	1.00
186_K	353_R	1.410	1.00
21_V	29_E	1.387	1.00
241_G	268_A	1.385	1.00
269_Y	276_P	1.373	1.00
183_H	351_Q	1.357	1.00
92_L	240_I	1.331	1.00
28_W	69_Y	1.328	1.00
9_G	34_A	1.326	1.00
224_E	228_E	1.305	1.00
302_T	323_G	1.304	1.00
62_P	111_V	1.301	1.00
265_A	361_Q	1.299	1.00
15_F	339_A	1.285	1.00
74_G	246_Y	1.273	1.00
46_G	103_V	1.261	1.00
91_A	218_A	1.255	1.00
85_A	377_G	1.251	1.00
266_R	298_D	1.250	1.00
160_T	165_M	1.248	1.00
107_M	219_V	1.237	1.00
349_T	353_R	1.237	1.00
50_I	217_T	1.236	1.00
152_T	201_W	1.235	1.00
29_E	33_E	1.233	1.00
326_L	351_Q	1.233	1.00
45_I	105_I	1.223	1.00
346_Y	350_K	1.219	1.00
275_T	278_D	1.218	1.00
164_Q	167_L	1.218	1.00
88_L	345_I	1.210	1.00
5_V	220_F	1.206	1.00
279_I	359_L	1.202	1.00
162_E	204_K	1.199	1.00
44_D	225_K	1.198	1.00
6_A	223_E	1.194	1.00
157_V	254_E	1.189	1.00
149_L	201_W	1.188	1.00
243_A	263_L	1.186	1.00
46_G	104_D	1.160	1.00
168_V	292_E	1.156	1.00
183_H	354_D	1.149	1.00
189_T	192_E	1.138	1.00
281_V	355_E	1.132	1.00
15_F	333_K	1.132	1.00
120_S	132_Y	1.129	1.00
10_V	349_T	1.124	1.00
102_L	271_M	1.124	1.00
174_K	177_S	1.124	1.00
10_V	350_K	1.123	1.00
255_W	258_F	1.120	1.00
3_R	104_D	1.115	1.00
153_R	157_V	1.108	1.00
99_A	102_L	1.106	1.00
190_V	194_L	1.105	1.00
91_A	220_F	1.102	1.00
11_G	33_E	1.101	1.00
94_A	108_A	1.098	1.00
49_V	106_A	1.089	1.00
148_A	199_I	1.087	1.00
186_K	354_D	1.082	1.00
31_I	72_L	1.081	1.00
168_V	293_I	1.078	1.00
276_P	279_I	1.078	1.00
160_T	293_I	1.072	1.00
6_A	221_A	1.070	1.00
89_A	93_S	1.067	1.00
96_T	100_S	1.067	1.00
180_P	185_Q	1.065	1.00
170_V	193_V	1.063	1.00
28_W	32_K	1.062	1.00
258_F	261_T	1.058	1.00
52_S	55_Y	1.057	1.00
245_D	258_F	1.031	1.00
44_D	228_E	1.031	1.00
51_G	86_T	1.030	1.00
280_E	323_G	1.029	1.00
280_E	352_L	1.026	1.00
239_G	271_M	1.023	1.00
243_A	267_Q	1.020	1.00
8_I	231_I	1.017	1.00
152_T	156_A	1.016	1.00
196_S	206_L	1.009	1.00
22_S	25_E	1.008	1.00
85_A	371_H	1.007	1.00
92_L	379_F	1.002	1.00
261_T	298_D	0.999	1.00
265_A	299_L	0.999	1.00
158_F	258_F	0.995	1.00
9_G	37_D	0.992	1.00
343_S	347_E	0.990	1.00
48_V	67_A	0.985	1.00
326_L	355_E	0.984	1.00
238_T	359_L	0.981	1.00
132_Y	135_E	0.974	1.00
15_F	212_S	0.970	1.00
327_F	354_D	0.967	1.00
223_E	236_W	0.965	1.00
155_M	290_I	0.956	1.00
267_Q	271_M	0.955	1.00
158_F	298_D	0.951	1.00
35_L	72_L	0.947	1.00
72_L	75_K	0.945	1.00
282_A	301_F	0.940	1.00
4_R	99_A	0.940	1.00
216_A	339_A	0.937	1.00
301_F	324_V	0.934	1.00
186_K	350_K	0.934	1.00
30_S	33_E	0.934	1.00
234_P	349_T	0.933	1.00
371_H	377_G	0.932	1.00
221_A	231_I	0.926	1.00
187_P	347_E	0.926	1.00
163_E	194_L	0.923	1.00
281_V	348_I	0.921	1.00
130_G	133_Q	0.920	1.00
95_Y	99_A	0.919	1.00
258_F	298_D	0.919	1.00
35_L	40_V	0.916	1.00
13_S	29_E	0.916	1.00
153_R	156_A	0.916	1.00
68_E	74_G	0.913	1.00
95_Y	237_I	0.895	1.00
264_A	378_H	0.894	1.00
196_S	204_K	0.893	1.00
49_V	78_L	0.880	1.00
10_V	218_A	0.879	1.00
49_V	90_A	0.879	1.00
279_I	361_Q	0.876	1.00
216_A	346_Y	0.874	1.00
13_S	26_L	0.872	1.00
5_V	222_S	0.872	1.00
166_A	207_D	0.869	1.00
154_H	294_M	0.867	1.00
154_H	258_F	0.866	1.00
13_S	30_S	0.864	1.00
15_F	343_S	0.863	1.00
108_A	218_A	0.862	1.00
197_R	205_L	0.855	1.00
258_F	294_M	0.853	1.00
296_Y	301_F	0.853	1.00
44_D	105_I	0.851	1.00
97_A	102_L	0.849	1.00
292_E	296_Y	0.847	1.00
21_V	25_E	0.842	1.00
237_I	240_I	0.842	1.00
14_K	29_E	0.842	1.00
265_A	284_V	0.839	1.00
171_K	304_K	0.837	1.00
47_L	97_A	0.837	1.00
82_A	89_A	0.832	1.00
268_A	361_Q	0.828	1.00
224_E	227_K	0.828	1.00
289_T	331_K	0.826	1.00
344_M	362_P	0.826	1.00
163_E	190_V	0.825	1.00
182_A	354_D	0.824	1.00
49_V	94_A	0.823	1.00
5_V	95_Y	0.819	1.00
178_M	181_K	0.819	1.00
266_R	299_L	0.818	1.00
34_A	107_M	0.817	1.00
330_L	340_T	0.814	1.00
35_L	45_I	0.813	1.00
134_W	139_Y	0.812	1.00
198_V	201_W	0.812	1.00
327_F	355_E	0.812	1.00
245_D	263_L	0.811	1.00
223_E	226_V	0.809	1.00
139_Y	144_P	0.806	1.00
170_V	189_T	0.806	1.00
93_S	96_T	0.805	1.00
348_I	362_P	0.802	1.00
23_I	111_V	0.801	1.00
56_R	59_E	0.797	1.00
30_S	34_A	0.797	1.00
11_G	30_S	0.795	1.00
29_E	32_K	0.791	1.00
164_Q	293_I	0.788	1.00
130_G	135_E	0.788	1.00
48_V	75_K	0.786	1.00
34_A	217_T	0.786	1.00
27_A	109_V	0.783	1.00
46_G	267_Q	0.782	1.00
232_D	353_R	0.782	1.00
58_I	116_E	0.780	1.00
191_E	195_K	0.778	1.00
371_H	375_G	0.775	1.00
132_Y	136_Y	0.775	1.00
107_M	217_T	0.775	1.00
32_K	42_Q	0.774	1.00
102_L	240_I	0.773	1.00
115_T	213_D	0.772	1.00
176_G	180_P	0.771	1.00
175_Y	178_M	0.769	1.00
5_V	99_A	0.766	1.00
370_V	375_G	0.765	1.00
170_V	192_E	0.764	1.00
151_A	290_I	0.760	1.00
178_M	183_H	0.760	1.00
35_L	42_Q	0.760	1.00
237_I	379_F	0.759	1.00
133_Q	136_Y	0.758	1.00
24_Q	58_I	0.757	1.00
90_A	342_L	0.756	1.00
45_I	107_M	0.755	1.00
93_S	97_A	0.755	1.00
7_V	349_T	0.753	1.00
50_I	63_A	0.751	1.00
274_V	278_D	0.748	1.00
284_V	295_G	0.747	1.00
234_P	350_K	0.745	1.00
348_I	370_V	0.744	1.00
207_D	289_T	0.731	1.00
238_T	272_A	0.726	1.00
52_S	58_I	0.718	1.00
96_T	99_A	0.717	1.00
245_D	259_K	0.717	1.00
134_W	146_Y	0.714	1.00
356_A	359_L	0.713	1.00
52_S	62_P	0.711	1.00
46_G	106_A	0.711	1.00
104_D	228_E	0.710	1.00
277_N	300_G	0.710	1.00
150_Y	256_V	0.710	1.00
38_S	219_V	0.709	1.00
47_L	242_Y	0.704	1.00
145_T	149_L	0.702	1.00
72_L	107_M	0.702	1.00
269_Y	274_V	0.702	1.00
49_V	93_S	0.701	1.00
276_P	301_F	0.696	1.00
277_N	323_G	0.695	1.00
203_I	208_S	0.695	1.00
5_V	98_V	0.693	1.00
176_G	332_A	0.692	1.00
294_M	298_D	0.692	1.00
53_T	337_L	0.690	1.00
131_N	136_Y	0.690	1.00
131_N	135_E	0.689	1.00
190_V	193_V	0.688	1.00
22_S	116_E	0.687	1.00
234_P	238_T	0.687	1.00
119_T	124_A	0.686	1.00
128_R	131_N	0.684	1.00
149_L	153_R	0.684	1.00
32_K	71_G	0.682	1.00
199_I	205_L	0.676	1.00
261_T	266_R	0.672	1.00
105_I	229_L	0.669	1.00
177_S	180_P	0.666	1.00
280_E	359_L	0.666	1.00
31_I	70_S	0.665	1.00
151_A	155_M	0.665	1.00
218_A	346_Y	0.663	1.00
265_A	295_G	0.662	1.00
131_N	134_W	0.661	1.00
27_A	111_V	0.660	1.00
82_A	242_Y	0.659	1.00
154_H	158_F	0.658	1.00
292_E	324_V	0.657	1.00
97_A	106_A	0.656	1.00
352_L	360_Q	0.654	1.00
104_D	271_M	0.652	1.00
3_R	99_A	0.651	1.00
160_T	164_Q	0.650	1.00
28_W	70_S	0.645	1.00
189_T	193_V	0.644	1.00
11_G	34_A	0.644	1.00
91_A	108_A	0.643	1.00
35_L	39_G	0.643	1.00
25_E	28_W	0.642	0.99
21_V	116_E	0.641	0.99
166_A	194_L	0.641	0.99
64_P	68_E	0.641	0.99
8_I	226_V	0.640	0.99
76_V	242_Y	0.640	0.99
265_A	378_H	0.638	0.99
24_Q	69_Y	0.638	0.99
166_A	190_V	0.636	0.99
173_H	177_S	0.636	0.99
160_T	297_E	0.633	0.99
265_A	276_P	0.630	0.99
31_I	217_T	0.630	0.99
9_G	234_P	0.630	0.99
88_L	362_P	0.629	0.99
21_V	113_K	0.629	0.99
92_L	377_G	0.626	0.99
19_D	126_G	0.625	0.99
270_E	275_T	0.622	0.99
238_T	274_V	0.622	0.99
173_H	331_K	0.622	0.99
266_R	300_G	0.621	0.99
340_T	344_M	0.620	0.99
134_W	137_H	0.620	0.99
32_K	70_S	0.617	0.99
47_L	82_A	0.617	0.99
280_E	358_K	0.616	0.99
55_Y	79_R	0.616	0.99
175_Y	303_E	0.615	0.99
31_I	35_L	0.614	0.99
246_Y	255_W	0.613	0.99
78_L	89_A	0.611	0.99
220_F	237_I	0.610	0.99
345_I	362_P	0.609	0.99
7_V	220_F	0.607	0.99
67_A	77_P	0.606	0.99
20_D	116_E	0.606	0.99
129_G	132_Y	0.606	0.99
148_A	202_P	0.605	0.99
151_A	203_I	0.604	0.99
146_Y	149_L	0.603	0.99
221_A	229_L	0.601	0.99
256_V	259_K	0.600	0.99
55_Y	59_E	0.599	0.99
50_I	66_V	0.596	0.99
6_A	222_S	0.596	0.99
371_H	376_T	0.596	0.99
40_V	219_V	0.596	0.99
45_I	72_L	0.595	0.99
80_V	93_S	0.594	0.99
94_A	103_V	0.593	0.99
263_L	267_Q	0.593	0.99
158_F	294_M	0.593	0.99
241_G	271_M	0.592	0.99
265_A	269_Y	0.591	0.99
333_K	343_S	0.591	0.99
176_G	333_K	0.590	0.99
114_M	337_L	0.590	0.99
370_V	378_H	0.589	0.99
66_V	70_S	0.589	0.99
90_A	108_A	0.588	0.99
169_S	289_T	0.588	0.99
46_G	75_K	0.588	0.99
89_A	92_L	0.587	0.99
145_T	254_E	0.587	0.99
109_V	217_T	0.587	0.99
124_A	127_G	0.585	0.99
35_L	38_S	0.584	0.99
42_Q	73_T	0.581	0.99
242_Y	377_G	0.580	0.99
47_L	103_V	0.580	0.99
99_A	240_I	0.579	0.99
48_V	107_M	0.579	0.99
291_A	295_G	0.578	0.99
167_L	303_E	0.577	0.99
8_I	225_K	0.577	0.99
6_A	225_K	0.575	0.99
145_T	153_R	0.575	0.99
11_G	38_S	0.574	0.99
158_F	297_E	0.572	0.99
297_E	300_G	0.572	0.99
269_Y	272_A	0.568	0.99
369_L	372_N	0.565	0.99
287_A	335_H	0.565	0.99
104_D	224_E	0.565	0.99
372_N	377_G	0.564	0.99
235_V	352_L	0.564	0.99
108_A	342_L	0.563	0.99
31_I	48_V	0.563	0.99
91_A	342_L	0.561	0.99
290_I	294_M	0.561	0.99
293_I	297_E	0.560	0.99
339_A	342_L	0.560	0.99
174_K	187_P	0.559	0.99
89_A	97_A	0.559	0.99
191_E	194_L	0.558	0.99
67_A	72_L	0.556	0.99
54_A	117_V	0.553	0.99
140_G	143_F	0.553	0.99
119_T	123_L	0.551	0.98
353_R	356_A	0.549	0.98
369_L	377_G	0.549	0.98
49_V	97_A	0.548	0.98
268_A	279_I	0.548	0.98
372_N	375_G	0.546	0.98
183_H	355_E	0.544	0.98
121_T	129_G	0.544	0.98
173_H	210_P	0.544	0.98
169_S	173_H	0.542	0.98
284_V	292_E	0.540	0.98
178_M	358_K	0.537	0.98
188_V	206_L	0.537	0.98
296_Y	302_T	0.535	0.98
169_S	193_V	0.535	0.98
6_A	229_L	0.534	0.98
174_K	190_V	0.533	0.98
159_G	297_E	0.533	0.98
62_P	65_I	0.531	0.98
128_R	133_Q	0.530	0.98
18_R	21_V	0.529	0.98
89_A	242_Y	0.528	0.98
152_T	203_I	0.527	0.98
155_M	160_T	0.527	0.98
278_D	359_L	0.526	0.98
97_A	100_S	0.525	0.98
269_Y	279_I	0.525	0.98
287_A	291_A	0.525	0.98
129_G	134_W	0.524	0.98
61_Y	375_G	0.524	0.98
339_A	343_S	0.523	0.98
123_L	126_G	0.522	0.98
129_G	133_Q	0.521	0.98
92_L	96_T	0.521	0.98
61_Y	83_M	0.520	0.98
167_L	170_V	0.520	0.98
47_L	106_A	0.518	0.98
130_G	136_Y	0.517	0.98
196_S	205_L	0.517	0.98
66_V	111_V	0.516	0.98
165_M	203_I	0.516	0.98
241_G	272_A	0.515	0.98
9_G	219_V	0.513	0.98
171_K	292_E	0.513	0.98
53_T	83_M	0.512	0.98
342_L	346_Y	0.511	0.98
226_V	229_L	0.509	0.97
154_H	290_I	0.509	0.97
60_L	83_M	0.508	0.97
264_A	268_A	0.508	0.97
357_D	360_Q	0.506	0.97
158_F	255_W	0.505	0.97
282_A	323_G	0.505	0.97
121_T	124_A	0.504	0.97
86_T	338_G	0.504	0.97
24_Q	28_W	0.502	0.97
177_S	185_Q	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zbgA	2	0.9871	100	0.223	Contact Map
4u4eA	1	0.9121	100	0.281	Contact Map
1ulqA	4	0.9147	100	0.337	Contact Map
1wdkC	2	0.8992	100	0.338	Contact Map
2wu9A	2	0.907	100	0.342	Contact Map
3goaA	2	0.8837	100	0.352	Contact Map
4e1lA	4	0.8966	100	0.354	Contact Map
3svkA	2	0.8191	100	0.354	Contact Map
2vu1A	4	0.907	100	0.354	Contact Map
4n46A	4	0.9121	100	0.354	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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