GREMLIN Database
Q97VJ8 - Uncharacterized protein
UniProt: Q97VJ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 128 (106)
Sequences: 2034 (1267)
Seq/√Len: 123.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_E60_K3.2351.00
37_C51_C2.7371.00
67_I113_V2.7331.00
33_K59_I2.7211.00
36_N55_E2.5871.00
35_K57_E2.4801.00
37_C48_C2.4631.00
94_K112_K2.4251.00
48_C51_C2.3841.00
64_E94_K2.3771.00
23_A30_V2.3231.00
18_D22_E2.2561.00
65_G113_V2.2371.00
92_K98_N2.1191.00
34_C37_C2.0961.00
34_C51_C2.0201.00
34_C48_C2.0021.00
27_G119_G1.9081.00
41_Y49_Y1.8811.00
67_I89_G1.8411.00
35_K55_E1.8041.00
39_S50_N1.8021.00
32_T41_Y1.7981.00
64_E114_R1.7091.00
19_E58_W1.6741.00
31_A61_V1.6681.00
30_V60_K1.5281.00
66_E92_K1.5201.00
91_V101_A1.5071.00
41_Y56_M1.4921.00
89_G103_I1.4781.00
70_Y109_V1.3911.00
63_N95_D1.3841.00
66_E112_K1.3811.00
33_K40_V1.3371.00
40_V59_I1.3281.00
27_G117_T1.3171.00
68_M92_K1.2981.00
32_T56_M1.2791.00
64_E112_K1.2340.99
72_V87_V1.1790.99
24_V117_T1.1680.99
66_E110_G1.1590.99
62_S94_K1.1300.99
22_E26_R1.1300.99
106_Q111_N1.1080.99
69_T90_I1.1020.99
31_A97_I1.0790.99
17_P21_I1.0670.98
65_G91_V0.9950.97
53_K56_M0.9940.97
15_K18_D0.9760.97
71_S88_I0.9760.97
89_G101_A0.9750.97
19_E23_A0.9620.97
16_Y46_K0.9300.96
33_K38_G0.9300.96
108_K111_N0.9140.96
23_A26_R0.8860.95
23_A28_E0.8700.95
41_Y45_Q0.8670.94
105_G116_T0.8560.94
36_N53_K0.8440.94
47_D52_G0.8440.94
47_D54_N0.8400.93
40_V61_V0.8380.93
73_V76_K0.8180.93
26_R30_V0.8130.92
73_V86_Y0.8120.92
68_M98_N0.8110.92
24_V115_L0.8090.92
90_I100_M0.8030.92
67_I111_N0.7970.92
20_F24_V0.7910.91
103_I106_Q0.7810.91
32_T42_F0.7740.90
74_S85_D0.7700.90
86_Y102_W0.7680.90
33_K57_E0.7640.90
63_N115_L0.7640.90
19_E22_E0.7520.89
70_Y87_V0.7440.89
31_A59_I0.7230.87
90_I98_N0.7140.86
70_Y103_I0.7140.86
67_I109_V0.7000.85
31_A40_V0.6790.84
20_F23_A0.6760.83
39_S49_Y0.6740.83
77_P84_E0.6710.83
104_K118_D0.6600.82
39_S99_I0.6590.82
81_E84_E0.6570.82
104_K116_T0.6460.80
105_G114_R0.6410.80
61_V93_T0.6400.80
29_I61_V0.6350.79
16_Y40_V0.6330.79
87_V107_P0.6190.78
45_Q49_Y0.6160.77
105_G118_D0.6160.77
44_P58_W0.6060.76
61_V95_D0.6040.76
65_G99_I0.5980.75
22_E25_K0.5950.75
87_V103_I0.5900.74
34_C53_K0.5850.74
16_Y90_I0.5850.74
20_F83_Y0.5790.73
69_T109_V0.5770.73
21_I42_F0.5750.72
62_S95_D0.5740.72
25_K107_P0.5700.72
71_S74_S0.5670.71
38_G59_I0.5660.71
48_C53_K0.5630.71
37_C50_N0.5600.70
21_I85_D0.5590.70
64_E111_N0.5580.70
47_D56_M0.5560.70
42_F99_I0.5530.69
65_G101_A0.5520.69
103_I113_V0.5480.69
31_A93_T0.5480.69
67_I70_Y0.5450.68
24_V99_I0.5450.68
83_Y121_R0.5440.68
70_Y111_N0.5440.68
61_V96_G0.5440.68
52_G73_V0.5440.68
52_G84_E0.5420.68
62_S115_L0.5390.67
52_G76_K0.5390.67
23_A69_T0.5350.67
77_P80_F0.5350.67
32_T58_W0.5340.67
83_Y102_W0.5330.67
92_K97_I0.5320.66
20_F99_I0.5300.66
65_G94_K0.5280.66
73_V80_F0.5260.66
72_V89_G0.5200.65
17_P42_F0.5170.64
20_F115_L0.5140.64
17_P115_L0.5130.64
29_I42_F0.5130.64
74_S107_P0.5120.64
63_N101_A0.5120.64
21_I102_W0.5110.63
29_I85_D0.5110.63
30_V58_W0.5090.63
71_S120_M0.5090.63
45_Q58_W0.5080.63
67_I91_V0.5060.63
56_M90_I0.5050.62
20_F90_I0.5040.62
52_G100_M0.5040.62
26_R60_K0.5010.62
71_S102_W0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3irbA 3 0.9609 100 0.257 Contact Map
2kdxA 1 0.5781 69.2 0.903 Contact Map
2lcqA 1 0.4766 63.6 0.906 Contact Map
5aunA 1 0.5781 59 0.909 Contact Map
4d02A 2 0.0547 58 0.91 Contact Map
3pwfA 4 0.4297 53 0.912 Contact Map
2conA 1 0.5547 48.4 0.914 Contact Map
4aybP 1 0.2969 47.3 0.915 Contact Map
1lkoA 3 0.5078 44.6 0.916 Contact Map
1s24A 1 0.2891 43.5 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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