GREMLIN Database
Q97VJ2 - Uncharacterized protein
UniProt: Q97VJ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 126 (117)
Sequences: 748 (370)
Seq/√Len: 34.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_I110_I3.8241.00
15_L43_G3.7801.00
7_V34_V3.7401.00
82_K106_E3.5561.00
87_S107_I3.5301.00
58_K62_E2.9181.00
9_S14_R2.4911.00
31_E82_K2.4511.00
26_S81_V2.2440.99
66_E70_S2.2320.99
23_V78_S2.2230.99
30_D118_E2.0890.99
84_Y108_A2.0540.98
4_G113_F1.9970.98
113_F122_I1.9560.98
19_A36_L1.8590.97
4_G120_G1.8160.96
113_F117_V1.8040.96
75_A81_V1.7770.96
33_Y84_Y1.7550.96
16_T56_S1.7340.95
90_S100_Y1.7000.95
95_Y100_Y1.6300.94
19_A72_F1.6210.93
117_V122_I1.6170.93
73_R77_K1.6160.93
19_A34_V1.5820.93
7_V18_A1.5770.92
65_E88_Y1.5680.92
23_V75_A1.5410.92
104_V107_I1.5320.91
36_L44_F1.5180.91
82_K116_D1.4930.90
21_T110_I1.4920.90
8_G13_S1.4640.89
5_I21_T1.4250.88
76_K103_I1.3570.85
41_V85_A1.3050.83
97_K106_E1.2910.82
23_V71_L1.2680.81
34_V83_I1.2610.81
54_D57_S1.2560.80
13_S39_D1.2560.80
67_D70_S1.1940.77
53_E57_S1.1390.73
53_E56_S1.1340.73
20_M71_L1.1030.71
8_G17_Y1.0990.71
33_Y113_F1.0950.70
33_Y116_D1.0720.69
7_V36_L1.0640.68
46_K62_E1.0610.68
89_A92_L1.0210.65
8_G37_T0.9630.60
56_S92_L0.9530.60
33_Y82_K0.9490.59
70_S117_V0.9470.59
12_R57_S0.9410.59
66_E74_K0.9390.58
46_K102_D0.9080.56
87_S109_G0.9030.55
109_G112_T0.8780.53
17_Y52_S0.8730.53
6_I21_T0.8630.52
26_S111_T0.8630.52
6_I37_T0.8430.50
21_T114_S0.8410.50
64_K88_Y0.8400.50
16_T38_M0.8310.49
8_G14_R0.8070.47
14_R17_Y0.8070.47
70_S74_K0.8060.47
43_G104_V0.7950.46
14_R39_D0.7750.45
23_V74_K0.7710.44
11_E52_S0.7700.44
26_S75_A0.7650.44
11_E39_D0.7650.44
17_Y110_I0.7640.44
30_D121_Q0.7630.44
47_N77_K0.7590.43
44_F101_N0.7580.43
84_Y114_S0.7520.43
79_G93_F0.7500.42
30_D122_I0.7380.41
24_I111_T0.7300.41
83_I91_K0.7280.41
58_K61_V0.7230.40
85_A104_V0.7120.39
90_S108_A0.7070.39
19_A44_F0.7050.39
73_R76_K0.7000.38
73_R78_S0.6960.38
27_S61_V0.6900.38
10_N20_M0.6900.38
63_K91_K0.6870.37
73_R98_D0.6870.37
59_I92_L0.6830.37
50_V61_V0.6810.37
59_I62_E0.6750.36
8_G16_T0.6680.36
65_E92_L0.6570.35
43_G76_K0.6560.35
89_A99_D0.6520.35
27_S109_G0.6470.34
84_Y116_D0.6460.34
21_T30_D0.6450.34
68_Y99_D0.6440.34
76_K106_E0.6340.33
97_K103_I0.6340.33
22_S84_Y0.6260.33
5_I77_K0.6230.32
92_L107_I0.6230.32
84_Y117_V0.6210.32
10_N13_S0.6210.32
61_V64_K0.6180.32
45_T95_Y0.6180.32
74_K77_K0.6170.32
38_M68_Y0.6170.32
90_S107_I0.6160.32
41_V91_K0.6150.32
57_S98_D0.6070.31
24_I39_D0.6010.31
52_S93_F0.5990.31
51_K62_E0.5990.31
37_T89_A0.5980.31
6_I46_K0.5920.30
41_V93_F0.5910.30
70_S121_Q0.5890.30
38_M89_A0.5880.30
57_S82_K0.5830.30
8_G39_D0.5820.29
18_A34_V0.5750.29
22_S103_I0.5750.29
85_A107_I0.5750.29
108_A112_T0.5740.29
72_F83_I0.5680.28
45_T99_D0.5660.28
55_I60_M0.5650.28
115_M119_G0.5640.28
39_D93_F0.5590.28
11_E17_Y0.5580.28
47_N51_K0.5580.28
68_Y78_S0.5570.28
88_Y91_K0.5540.28
63_K92_L0.5530.27
16_T71_L0.5520.27
74_K118_E0.5510.27
87_S91_K0.5510.27
23_V62_E0.5510.27
23_V26_S0.5500.27
15_L68_Y0.5490.27
119_G122_I0.5480.27
51_K82_K0.5470.27
23_V27_S0.5460.27
51_K61_V0.5450.27
32_V118_E0.5430.27
41_V90_S0.5390.27
31_E119_G0.5360.26
60_M110_I0.5340.26
56_S121_Q0.5300.26
25_I111_T0.5270.26
71_L89_A0.5270.26
54_D58_K0.5250.26
6_I58_K0.5250.26
28_M73_R0.5240.26
98_D107_I0.5230.25
30_D66_E0.5180.25
26_S78_S0.5180.25
44_F88_Y0.5140.25
27_S111_T0.5130.25
12_R16_T0.5130.25
84_Y106_E0.5120.25
78_S83_I0.5080.25
96_A99_D0.5040.24
57_S69_M0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pnxA 4 0.9762 100 0.34 Contact Map
2qs7A 3 0.9921 100 0.353 Contact Map
3mc3A 3 0.8333 99.8 0.615 Contact Map
1jx7A 5 0.8889 99.6 0.667 Contact Map
2hy5B 1 0.9048 99.5 0.689 Contact Map
1l1sA 3 0.8413 99.4 0.699 Contact Map
2d1pB 1 0.9048 99.3 0.721 Contact Map
2hy5A 2 0.8968 99.2 0.729 Contact Map
2pd2A 3 0.8254 99 0.747 Contact Map
2d1pA 2 0.8968 98.9 0.757 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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