GREMLIN Database
Q97VI9 - Uncharacterized protein
UniProt: Q97VI9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 140 (112)
Sequences: 8557 (6227)
Seq/√Len: 588.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_G104_Y3.1301.00
24_R118_Y3.1221.00
18_V22_V2.4901.00
19_P22_V2.4101.00
110_I120_I2.3681.00
46_H114_M2.3111.00
22_V26_L2.2741.00
33_T75_N2.2331.00
112_L116_M2.1431.00
63_F67_L1.9951.00
23_I34_L1.9671.00
40_P53_L1.9201.00
20_P112_L1.9031.00
43_Y47_H1.8731.00
40_P44_E1.8541.00
79_I94_E1.8041.00
23_I106_M1.7991.00
62_L66_V1.7321.00
20_P116_M1.7211.00
76_G102_K1.6781.00
20_P118_Y1.6651.00
42_E86_R1.6231.00
26_L29_N1.6211.00
121_E125_D1.5821.00
54_L69_K1.4821.00
19_P107_L1.4801.00
87_S105_N1.3931.00
46_H122_K1.3901.00
18_V23_I1.3841.00
17_N107_L1.3831.00
72_L75_N1.3651.00
91_V105_N1.3541.00
23_I78_A1.3431.00
108_G112_L1.3301.00
18_V104_Y1.3231.00
91_V103_V1.3131.00
26_L32_I1.2511.00
26_L76_G1.2441.00
110_I114_M1.2321.00
35_I71_N1.1781.00
73_V99_K1.1721.00
79_I91_V1.1711.00
61_E64_P1.1521.00
64_P68_S1.1221.00
48_I80_I1.1111.00
80_I110_I1.0891.00
38_R82_E1.0801.00
49_P121_E1.0771.00
34_L80_I1.0731.00
24_R28_K1.0721.00
47_H80_I1.0691.00
20_P106_M1.0411.00
20_P24_R1.0411.00
37_V79_I1.0361.00
77_V94_E1.0321.00
79_I103_V1.0291.00
91_V95_P1.0201.00
79_I90_L1.0121.00
37_V90_L1.0111.00
38_R110_I0.9821.00
33_T52_I0.9791.00
61_E65_L0.9751.00
59_F65_L0.9681.00
62_L97_L0.9651.00
23_I32_I0.9591.00
65_L68_S0.9521.00
21_S118_Y0.9411.00
55_P58_Y0.9391.00
44_E124_M0.9311.00
34_L48_I0.9271.00
48_I51_S0.9261.00
95_P103_V0.9201.00
99_K102_K0.9151.00
32_I78_A0.9091.00
49_P113_W0.8951.00
106_M112_L0.8751.00
54_L65_L0.8741.00
95_P101_V0.8641.00
39_Q42_E0.8631.00
51_S80_I0.8621.00
111_E114_M0.8591.00
111_E115_I0.8541.00
18_V78_A0.8411.00
78_A106_M0.8371.00
42_E82_E0.8191.00
71_N77_V0.8061.00
16_Q95_P0.8031.00
17_N105_N0.8031.00
40_P58_Y0.7991.00
81_C84_A0.7981.00
92_Y96_S0.7941.00
65_L69_K0.7901.00
81_C87_S0.7851.00
16_Q104_Y0.7821.00
56_L89_W0.7811.00
82_E111_E0.7811.00
44_E114_M0.7681.00
21_S116_M0.7661.00
64_P67_L0.7631.00
21_S25_K0.7611.00
46_H120_I0.7611.00
83_H111_E0.7461.00
26_L30_K0.7381.00
48_I113_W0.7281.00
88_T105_N0.7271.00
62_L65_L0.7271.00
46_H110_I0.7261.00
66_V94_E0.7151.00
35_I52_I0.7111.00
77_V99_K0.7071.00
24_R119_E0.7061.00
41_W44_E0.6901.00
106_M113_W0.6901.00
23_I26_L0.6861.00
106_M109_G0.6791.00
35_I90_L0.6781.00
67_L72_L0.6741.00
54_L59_F0.6721.00
24_R27_V0.6721.00
48_I121_E0.6661.00
18_V26_L0.6621.00
113_W118_Y0.6601.00
43_Y53_L0.6551.00
94_E103_V0.6451.00
52_I125_D0.6441.00
112_L115_I0.6431.00
114_M120_I0.6421.00
56_L93_T0.6281.00
47_H121_E0.6261.00
93_T97_L0.6261.00
25_K29_N0.6251.00
37_V56_L0.6151.00
22_V25_K0.6071.00
43_Y80_I0.6071.00
41_W45_D0.6061.00
38_R86_R0.6021.00
44_E123_G0.5981.00
83_H86_R0.5971.00
85_N88_T0.5911.00
83_H87_S0.5881.00
43_Y51_S0.5831.00
59_F90_L0.5741.00
31_A76_G0.5721.00
35_I79_I0.5671.00
31_A75_N0.5641.00
82_E86_R0.5631.00
48_I110_I0.5560.99
56_L86_R0.5430.99
53_L56_L0.5370.99
98_F101_V0.5370.99
58_Y68_S0.5360.99
20_P27_V0.5360.99
121_E124_M0.5350.99
32_I76_G0.5350.99
38_R83_H0.5320.99
18_V32_I0.5250.99
82_E85_N0.5250.99
26_L78_A0.5240.99
94_E99_K0.5220.99
16_Q91_V0.5200.99
25_K28_K0.5160.99
114_M118_Y0.5100.99
109_G112_L0.5100.99
23_I27_V0.5090.99
62_L93_T0.5080.99
82_E110_I0.5050.99
28_K50_G0.5010.99
67_L99_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1urhA 1 0.9 99.9 0.268 Contact Map
3aayA 1 0.9214 99.9 0.285 Contact Map
1e0cA 1 0.9429 99.9 0.286 Contact Map
3hzuA 2 0.9714 99.9 0.287 Contact Map
1uarA 1 0.9286 99.9 0.292 Contact Map
2hhgA 2 0.8571 99.9 0.296 Contact Map
1rhsA 1 0.9357 99.9 0.301 Contact Map
1yt8A 1 0.9571 99.9 0.305 Contact Map
1qxnA 2 0.9 99.9 0.305 Contact Map
4jgtA 1 0.8929 99.9 0.316 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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