GREMLIN Database
Q97VI7 - Carbon monoxide dehydrogenase, medium chain. (CutB-2)
UniProt: Q97VI7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (272)
Sequences: 6003 (4099)
Seq/√Len: 248.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
223_R228_E3.6961.00
134_E145_S3.6351.00
70_K168_E3.3411.00
136_I170_V3.2721.00
136_I168_E2.9731.00
137_L146_V2.9721.00
61_Y75_T2.7491.00
144_R164_E2.6841.00
136_I143_N2.5101.00
116_A166_I2.5091.00
21_L29_P2.3811.00
209_D232_M2.3331.00
145_S170_V2.3111.00
68_S170_V2.1941.00
147_N150_D2.1381.00
64_S173_N2.1031.00
246_S270_K2.0891.00
60_S79_E2.0881.00
201_K208_E2.0261.00
75_T80_I1.9861.00
138_S143_N1.9371.00
10_R55_P1.9081.00
9_V49_Y1.9051.00
69_T86_V1.8911.00
136_I145_S1.8641.00
201_K209_D1.8401.00
13_S16_E1.8401.00
132_N149_L1.8331.00
137_L160_L1.8261.00
146_V159_D1.8231.00
135_I166_I1.8121.00
78_N107_N1.8011.00
138_S167_S1.7941.00
70_K170_V1.7471.00
53_L74_L1.7451.00
76_R79_E1.7291.00
12_S16_E1.7251.00
230_S247_K1.7251.00
203_R208_E1.7181.00
15_E138_S1.6881.00
64_S89_N1.6681.00
242_E274_R1.6671.00
207_I210_I1.6551.00
9_V20_F1.6151.00
134_E170_V1.6141.00
65_S70_K1.6131.00
195_S215_G1.6091.00
112_G166_I1.6011.00
63_R70_K1.6001.00
71_I80_I1.5881.00
78_N82_K1.5851.00
19_K23_S1.5791.00
141_S163_G1.5271.00
118_A158_T1.5241.00
21_L51_V1.5211.00
214_Y224_A1.5161.00
134_E147_N1.5131.00
29_P165_I1.4971.00
143_N167_S1.4771.00
236_L241_V1.4751.00
177_Y199_A1.4521.00
68_S173_N1.4391.00
229_K232_M1.4381.00
135_I148_A1.4251.00
30_L50_I1.4041.00
238_D278_K1.4031.00
226_E251_Q1.3951.00
182_K279_E1.3941.00
149_L225_L1.3861.00
20_F51_V1.3731.00
198_L212_L1.3701.00
123_D183_K1.3691.00
29_P53_L1.3641.00
230_S240_L1.3631.00
18_T139_S1.3491.00
153_K159_D1.3441.00
17_A165_I1.3411.00
26_D48_N1.3401.00
200_I210_I1.3361.00
198_L276_A1.3161.00
141_S161_R1.3081.00
256_S263_W1.3071.00
129_T148_A1.3061.00
14_S165_I1.3041.00
126_T215_G1.3041.00
31_A74_L1.2891.00
214_Y269_M1.2851.00
182_K275_K1.2791.00
226_E229_K1.2761.00
238_D242_E1.2681.00
7_T49_Y1.2531.00
224_A227_V1.2401.00
11_V53_L1.2391.00
64_S85_L1.2391.00
267_E271_V1.2381.00
18_T140_A1.2351.00
67_N173_N1.2301.00
28_R45_I1.2291.00
115_A169_I1.2281.00
77_Y124_I1.2261.00
54_N76_R1.2241.00
65_S68_S1.2131.00
77_Y109_G1.2091.00
225_L229_K1.2041.00
21_L163_G1.2031.00
14_S138_S1.1901.00
60_S76_R1.1761.00
210_I232_M1.1741.00
111_I169_I1.1731.00
8_Y52_D1.1701.00
24_H49_Y1.1701.00
18_T138_S1.1681.00
10_R52_D1.1581.00
89_N173_N1.1581.00
234_K243_E1.1571.00
27_A51_V1.1571.00
70_K136_I1.1561.00
200_I207_I1.1421.00
71_I171_L1.1341.00
122_A125_P1.1291.00
177_Y201_K1.1211.00
96_A127_V1.1191.00
243_E246_S1.1161.00
153_K157_A1.1141.00
11_V16_E1.1121.00
18_T165_I1.1121.00
249_S270_K1.1101.00
85_L89_N1.1051.00
130_A213_A1.1011.00
57_T60_S1.1011.00
237_N240_L1.0941.00
241_V245_V1.0931.00
274_R278_K1.0911.00
184_V268_V1.0891.00
93_L124_I1.0821.00
226_E250_S1.0771.00
29_P51_V1.0751.00
16_E19_K1.0671.00
137_L164_E1.0621.00
116_A151_F1.0561.00
62_V75_T1.0531.00
80_I111_I1.0491.00
207_I236_L1.0341.00
73_A112_G1.0321.00
214_Y217_V1.0311.00
248_V273_T1.0181.00
254_P266_R1.0171.00
230_S234_K1.0131.00
14_S18_T1.0091.00
78_N81_L1.0071.00
139_S142_G1.0031.00
256_S262_S1.0011.00
125_P152_F1.0011.00
206_E235_R1.0001.00
16_E20_F0.9941.00
95_Q279_E0.9891.00
227_V247_K0.9861.00
115_A128_L0.9851.00
231_V244_I0.9851.00
31_A110_T0.9821.00
234_K240_L0.9811.00
62_V83_N0.9811.00
61_Y168_E0.9801.00
30_L33_G0.9801.00
212_L227_V0.9731.00
243_E247_K0.9711.00
161_R164_E0.9681.00
227_V251_Q0.9641.00
245_V274_R0.9621.00
77_Y100_V0.9611.00
68_S172_P0.9601.00
128_L135_I0.9491.00
271_V275_K0.9401.00
199_A211_R0.9351.00
100_V109_G0.9331.00
260_G265_R0.9291.00
93_L127_V0.9291.00
84_D88_V0.9251.00
230_S243_E0.9111.00
217_V269_M0.9081.00
262_S266_R0.9081.00
176_G201_K0.9021.00
77_Y97_V0.9021.00
239_E243_E0.8941.00
15_E58_S0.8881.00
76_R110_T0.8821.00
78_N103_M0.8771.00
202_L205_N0.8751.00
22_E163_G0.8660.99
129_T152_F0.8650.99
60_S74_L0.8640.99
247_K250_S0.8600.99
64_S69_T0.8580.99
135_I151_F0.8580.99
254_P263_W0.8550.99
128_L133_A0.8540.99
53_L165_I0.8520.99
235_R240_L0.8520.99
214_Y273_T0.8490.99
129_T149_L0.8470.99
241_V277_L0.8430.99
111_I124_I0.8410.99
210_I231_V0.8340.99
35_S117_N0.8330.99
182_K276_A0.8320.99
12_S55_P0.8320.99
71_I111_I0.8320.99
14_S58_S0.8290.99
192_A195_S0.8270.99
267_E270_K0.8200.99
208_E232_M0.8190.99
196_L272_I0.8130.99
148_A152_F0.8050.99
97_V100_V0.8040.99
186_R189_G0.7980.99
183_K268_V0.7960.99
114_S124_I0.7960.99
88_V91_P0.7940.99
246_S250_S0.7930.99
90_V171_L0.7910.99
15_E19_K0.7910.99
17_A56_I0.7900.99
128_L171_L0.7870.99
75_T111_I0.7860.99
149_L223_R0.7830.99
234_K237_N0.7810.99
64_S68_S0.7790.99
65_S170_V0.7790.99
85_L88_V0.7740.99
242_E246_S0.7720.99
151_F159_D0.7710.99
185_V190_D0.7680.99
136_I167_S0.7660.99
225_L228_E0.7660.99
137_L144_R0.7650.99
54_N74_L0.7640.99
69_T173_N0.7600.99
33_G37_I0.7580.99
126_T195_S0.7550.99
227_V244_I0.7540.99
132_N211_R0.7480.98
132_N223_R0.7460.98
81_L98_R0.7450.98
245_V273_T0.7450.98
87_R94_H0.7420.98
139_S164_E0.7390.98
144_R161_R0.7380.98
22_E140_A0.7340.98
35_S119_D0.7330.98
262_S265_R0.7330.98
212_L224_A0.7250.98
115_A148_A0.7220.98
257_D265_R0.7220.98
182_K272_I0.7210.98
59_L74_L0.7200.98
130_A197_A0.7180.98
80_I124_I0.7120.98
30_L37_I0.7110.98
83_N86_V0.7090.98
266_R270_K0.7090.98
14_S59_L0.7080.98
139_S161_R0.7020.98
213_A223_R0.7020.98
151_F160_L0.7000.98
34_Q114_S0.6970.98
222_F252_V0.6960.98
207_I241_V0.6960.98
218_G222_F0.6840.97
149_L211_R0.6770.97
117_N122_A0.6760.97
77_Y101_G0.6750.97
92_L179_T0.6730.97
248_V251_Q0.6700.97
30_L36_L0.6700.97
22_E141_S0.6680.97
95_Q180_I0.6680.97
41_K102_D0.6650.97
102_D183_K0.6630.97
90_V173_N0.6630.97
19_K140_A0.6620.97
34_Q102_D0.6610.97
35_S38_P0.6590.97
75_T79_E0.6590.97
181_Y195_S0.6540.96
92_L199_A0.6530.96
63_R168_E0.6530.96
61_Y79_E0.6530.96
92_L131_L0.6510.96
123_D181_Y0.6500.96
119_D191_F0.6500.96
27_A49_Y0.6500.96
111_I128_L0.6500.96
194_V217_V0.6490.96
148_A151_F0.6490.96
214_Y252_V0.6480.96
15_E143_N0.6480.96
160_L163_G0.6460.96
175_E201_K0.6460.96
95_Q179_T0.6440.96
132_N147_N0.6430.96
66_F173_N0.6430.96
240_L243_E0.6400.96
17_A29_P0.6380.96
236_L240_L0.6340.96
24_H27_A0.6340.96
81_L97_V0.6330.96
35_S191_F0.6320.96
137_L159_D0.6300.96
131_L171_L0.6290.96
115_A125_P0.6260.95
62_V71_I0.6230.95
60_S75_T0.6200.95
245_V270_K0.6170.95
11_V14_S0.6160.95
58_S61_Y0.6160.95
224_A248_V0.6140.95
31_A53_L0.6080.95
69_T90_V0.6070.95
117_N191_F0.6060.95
121_S216_G0.6020.94
152_F221_P0.5970.94
35_S190_D0.5970.94
211_R223_R0.5960.94
249_S269_M0.5950.94
154_G219_E0.5920.94
133_A169_I0.5920.94
133_A171_L0.5910.94
81_L103_M0.5860.94
75_T112_G0.5860.94
41_K183_K0.5850.93
252_V269_M0.5830.93
184_V272_I0.5820.93
174_L177_Y0.5820.93
186_R264_Y0.5770.93
101_G105_V0.5770.93
170_V173_N0.5770.93
129_T221_P0.5760.93
59_L73_A0.5760.93
95_Q99_V0.5710.93
129_T213_A0.5700.93
191_F216_G0.5700.93
217_V252_V0.5690.93
224_A251_Q0.5690.93
35_S39_M0.5680.92
87_R91_P0.5680.92
68_S171_L0.5670.92
224_A244_I0.5650.92
77_Y111_I0.5640.92
268_V271_V0.5640.92
21_L162_K0.5630.92
110_T113_G0.5610.92
271_V274_R0.5610.92
137_L161_R0.5590.92
64_S67_N0.5570.92
86_V89_N0.5570.92
210_I228_E0.5560.92
22_E139_S0.5550.92
71_I75_T0.5530.91
249_S266_R0.5520.91
9_V24_H0.5510.91
268_V272_I0.5510.91
118_A152_F0.5490.91
238_D274_R0.5490.91
81_L94_H0.5480.91
86_V91_P0.5470.91
181_Y185_V0.5450.91
263_W267_E0.5450.91
135_I146_V0.5440.91
68_S90_V0.5430.91
14_S29_P0.5420.91
77_Y80_I0.5420.91
241_V244_I0.5380.90
86_V94_H0.5380.90
102_D105_V0.5340.90
202_L207_I0.5340.90
53_L59_L0.5340.90
212_L244_I0.5320.90
132_N172_P0.5310.90
9_V16_E0.5290.90
21_L28_R0.5290.90
34_Q123_D0.5280.90
207_I232_M0.5280.90
180_I279_E0.5270.89
114_S191_F0.5240.89
86_V90_V0.5230.89
146_V151_F0.5220.89
29_P163_G0.5220.89
122_A191_F0.5210.89
205_N236_L0.5210.89
102_D123_D0.5170.89
151_F158_T0.5160.88
39_M117_N0.5160.88
180_I184_V0.5130.88
14_S17_A0.5110.88
186_R190_D0.5110.88
52_D108_L0.5080.88
193_L260_G0.5080.88
117_N156_F0.5080.88
142_G161_R0.5080.88
61_Y72_G0.5070.88
39_M42_L0.5060.87
80_I128_L0.5040.87
39_M45_I0.5020.87
245_V248_V0.5010.87
254_P259_R0.5010.87
34_Q156_F0.5010.87
28_R117_N0.5000.87
79_E82_K0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t3qC 1 0.9965 100 0.076 Contact Map
1rm6B 1 0.9894 100 0.086 Contact Map
1n62C 1 1 100 0.097 Contact Map
1ffvC 1 1 100 0.12 Contact Map
3zyvA 3 0.9894 100 0.123 Contact Map
2w3sA 1 0.9716 100 0.138 Contact Map
3hrdC 1 0.9929 100 0.141 Contact Map
3nvzB 1 1 100 0.158 Contact Map
3uncA 2 1 100 0.159 Contact Map
4pytA 1 0.8652 98.2 0.871 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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