Q97VI7 - SULSO - GREMLIN Contacts

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Q97VI7 - Carbon monoxide dehydrogenase, medium chain. (CutB-2)

UniProt:	Q97VI7	Sequences: MYPPDFTYVRVSSSEEATKFLESHDDARPLAGGQSLIPMLKLRVISPNYIVDLNPITSLSYVRSSFNSTKIGALTRYNEILKNDLVRVNVPLLHQAVRVVGDMQVRNLGTIGGSAANADPSADIPTVLTALNAEIILSSASGNRSVNALDFFKGAFATDLRKGEIISEIVLPNLEGYRTIYKKVVRRAGDFALVSLALAIKLRQNEIEDIRLAYGGVGERPFRALEVEKSVMGKRLNDELVEEIVSKVSSQVNPPSDTRGSSWYRREVMKVITRKALKEVSG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	282 (272)
Sequences:	6003 (4099)
Seq/√Len:	248.6

ECOLI - XDHB YAGS YGFM
BACSU - XDHC
SULSO - Q97VI7 Q97W13

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
223_R	228_E	3.696	1.00
134_E	145_S	3.635	1.00
70_K	168_E	3.341	1.00
136_I	170_V	3.272	1.00
136_I	168_E	2.973	1.00
137_L	146_V	2.972	1.00
61_Y	75_T	2.749	1.00
144_R	164_E	2.684	1.00
136_I	143_N	2.510	1.00
116_A	166_I	2.509	1.00
21_L	29_P	2.381	1.00
209_D	232_M	2.333	1.00
145_S	170_V	2.311	1.00
68_S	170_V	2.194	1.00
147_N	150_D	2.138	1.00
64_S	173_N	2.103	1.00
246_S	270_K	2.089	1.00
60_S	79_E	2.088	1.00
201_K	208_E	2.026	1.00
75_T	80_I	1.986	1.00
138_S	143_N	1.937	1.00
10_R	55_P	1.908	1.00
9_V	49_Y	1.905	1.00
69_T	86_V	1.891	1.00
136_I	145_S	1.864	1.00
201_K	209_D	1.840	1.00
13_S	16_E	1.840	1.00
132_N	149_L	1.833	1.00
137_L	160_L	1.826	1.00
146_V	159_D	1.823	1.00
135_I	166_I	1.812	1.00
78_N	107_N	1.801	1.00
138_S	167_S	1.794	1.00
70_K	170_V	1.747	1.00
53_L	74_L	1.745	1.00
76_R	79_E	1.729	1.00
12_S	16_E	1.725	1.00
230_S	247_K	1.725	1.00
203_R	208_E	1.718	1.00
15_E	138_S	1.688	1.00
64_S	89_N	1.668	1.00
242_E	274_R	1.667	1.00
207_I	210_I	1.655	1.00
9_V	20_F	1.615	1.00
134_E	170_V	1.614	1.00
65_S	70_K	1.613	1.00
195_S	215_G	1.609	1.00
112_G	166_I	1.601	1.00
63_R	70_K	1.600	1.00
71_I	80_I	1.588	1.00
78_N	82_K	1.585	1.00
19_K	23_S	1.579	1.00
141_S	163_G	1.527	1.00
118_A	158_T	1.524	1.00
21_L	51_V	1.521	1.00
214_Y	224_A	1.516	1.00
134_E	147_N	1.513	1.00
29_P	165_I	1.497	1.00
143_N	167_S	1.477	1.00
236_L	241_V	1.475	1.00
177_Y	199_A	1.452	1.00
68_S	173_N	1.439	1.00
229_K	232_M	1.438	1.00
135_I	148_A	1.425	1.00
30_L	50_I	1.404	1.00
238_D	278_K	1.403	1.00
226_E	251_Q	1.395	1.00
182_K	279_E	1.394	1.00
149_L	225_L	1.386	1.00
20_F	51_V	1.373	1.00
198_L	212_L	1.370	1.00
123_D	183_K	1.369	1.00
29_P	53_L	1.364	1.00
230_S	240_L	1.363	1.00
18_T	139_S	1.349	1.00
153_K	159_D	1.344	1.00
17_A	165_I	1.341	1.00
26_D	48_N	1.340	1.00
200_I	210_I	1.336	1.00
198_L	276_A	1.316	1.00
141_S	161_R	1.308	1.00
256_S	263_W	1.307	1.00
129_T	148_A	1.306	1.00
14_S	165_I	1.304	1.00
126_T	215_G	1.304	1.00
31_A	74_L	1.289	1.00
214_Y	269_M	1.285	1.00
182_K	275_K	1.279	1.00
226_E	229_K	1.276	1.00
238_D	242_E	1.268	1.00
7_T	49_Y	1.253	1.00
224_A	227_V	1.240	1.00
11_V	53_L	1.239	1.00
64_S	85_L	1.239	1.00
267_E	271_V	1.238	1.00
18_T	140_A	1.235	1.00
67_N	173_N	1.230	1.00
28_R	45_I	1.229	1.00
115_A	169_I	1.228	1.00
77_Y	124_I	1.226	1.00
54_N	76_R	1.224	1.00
65_S	68_S	1.213	1.00
77_Y	109_G	1.209	1.00
225_L	229_K	1.204	1.00
21_L	163_G	1.203	1.00
14_S	138_S	1.190	1.00
60_S	76_R	1.176	1.00
210_I	232_M	1.174	1.00
111_I	169_I	1.173	1.00
8_Y	52_D	1.170	1.00
24_H	49_Y	1.170	1.00
18_T	138_S	1.168	1.00
10_R	52_D	1.158	1.00
89_N	173_N	1.158	1.00
234_K	243_E	1.157	1.00
27_A	51_V	1.157	1.00
70_K	136_I	1.156	1.00
200_I	207_I	1.142	1.00
71_I	171_L	1.134	1.00
122_A	125_P	1.129	1.00
177_Y	201_K	1.121	1.00
96_A	127_V	1.119	1.00
243_E	246_S	1.116	1.00
153_K	157_A	1.114	1.00
11_V	16_E	1.112	1.00
18_T	165_I	1.112	1.00
249_S	270_K	1.110	1.00
85_L	89_N	1.105	1.00
130_A	213_A	1.101	1.00
57_T	60_S	1.101	1.00
237_N	240_L	1.094	1.00
241_V	245_V	1.093	1.00
274_R	278_K	1.091	1.00
184_V	268_V	1.089	1.00
93_L	124_I	1.082	1.00
226_E	250_S	1.077	1.00
29_P	51_V	1.075	1.00
16_E	19_K	1.067	1.00
137_L	164_E	1.062	1.00
116_A	151_F	1.056	1.00
62_V	75_T	1.053	1.00
80_I	111_I	1.049	1.00
207_I	236_L	1.034	1.00
73_A	112_G	1.032	1.00
214_Y	217_V	1.031	1.00
248_V	273_T	1.018	1.00
254_P	266_R	1.017	1.00
230_S	234_K	1.013	1.00
14_S	18_T	1.009	1.00
78_N	81_L	1.007	1.00
139_S	142_G	1.003	1.00
256_S	262_S	1.001	1.00
125_P	152_F	1.001	1.00
206_E	235_R	1.000	1.00
16_E	20_F	0.994	1.00
95_Q	279_E	0.989	1.00
227_V	247_K	0.986	1.00
115_A	128_L	0.985	1.00
231_V	244_I	0.985	1.00
31_A	110_T	0.982	1.00
234_K	240_L	0.981	1.00
62_V	83_N	0.981	1.00
61_Y	168_E	0.980	1.00
30_L	33_G	0.980	1.00
212_L	227_V	0.973	1.00
243_E	247_K	0.971	1.00
161_R	164_E	0.968	1.00
227_V	251_Q	0.964	1.00
245_V	274_R	0.962	1.00
77_Y	100_V	0.961	1.00
68_S	172_P	0.960	1.00
128_L	135_I	0.949	1.00
271_V	275_K	0.940	1.00
199_A	211_R	0.935	1.00
100_V	109_G	0.933	1.00
260_G	265_R	0.929	1.00
93_L	127_V	0.929	1.00
84_D	88_V	0.925	1.00
230_S	243_E	0.911	1.00
217_V	269_M	0.908	1.00
262_S	266_R	0.908	1.00
176_G	201_K	0.902	1.00
77_Y	97_V	0.902	1.00
239_E	243_E	0.894	1.00
15_E	58_S	0.888	1.00
76_R	110_T	0.882	1.00
78_N	103_M	0.877	1.00
202_L	205_N	0.875	1.00
22_E	163_G	0.866	0.99
129_T	152_F	0.865	0.99
60_S	74_L	0.864	0.99
247_K	250_S	0.860	0.99
64_S	69_T	0.858	0.99
135_I	151_F	0.858	0.99
254_P	263_W	0.855	0.99
128_L	133_A	0.854	0.99
53_L	165_I	0.852	0.99
235_R	240_L	0.852	0.99
214_Y	273_T	0.849	0.99
129_T	149_L	0.847	0.99
241_V	277_L	0.843	0.99
111_I	124_I	0.841	0.99
210_I	231_V	0.834	0.99
35_S	117_N	0.833	0.99
182_K	276_A	0.832	0.99
12_S	55_P	0.832	0.99
71_I	111_I	0.832	0.99
14_S	58_S	0.829	0.99
192_A	195_S	0.827	0.99
267_E	270_K	0.820	0.99
208_E	232_M	0.819	0.99
196_L	272_I	0.813	0.99
148_A	152_F	0.805	0.99
97_V	100_V	0.804	0.99
186_R	189_G	0.798	0.99
183_K	268_V	0.796	0.99
114_S	124_I	0.796	0.99
88_V	91_P	0.794	0.99
246_S	250_S	0.793	0.99
90_V	171_L	0.791	0.99
15_E	19_K	0.791	0.99
17_A	56_I	0.790	0.99
128_L	171_L	0.787	0.99
75_T	111_I	0.786	0.99
149_L	223_R	0.783	0.99
234_K	237_N	0.781	0.99
64_S	68_S	0.779	0.99
65_S	170_V	0.779	0.99
85_L	88_V	0.774	0.99
242_E	246_S	0.772	0.99
151_F	159_D	0.771	0.99
185_V	190_D	0.768	0.99
136_I	167_S	0.766	0.99
225_L	228_E	0.766	0.99
137_L	144_R	0.765	0.99
54_N	74_L	0.764	0.99
69_T	173_N	0.760	0.99
33_G	37_I	0.758	0.99
126_T	195_S	0.755	0.99
227_V	244_I	0.754	0.99
132_N	211_R	0.748	0.98
132_N	223_R	0.746	0.98
81_L	98_R	0.745	0.98
245_V	273_T	0.745	0.98
87_R	94_H	0.742	0.98
139_S	164_E	0.739	0.98
144_R	161_R	0.738	0.98
22_E	140_A	0.734	0.98
35_S	119_D	0.733	0.98
262_S	265_R	0.733	0.98
212_L	224_A	0.725	0.98
115_A	148_A	0.722	0.98
257_D	265_R	0.722	0.98
182_K	272_I	0.721	0.98
59_L	74_L	0.720	0.98
130_A	197_A	0.718	0.98
80_I	124_I	0.712	0.98
30_L	37_I	0.711	0.98
83_N	86_V	0.709	0.98
266_R	270_K	0.709	0.98
14_S	59_L	0.708	0.98
139_S	161_R	0.702	0.98
213_A	223_R	0.702	0.98
151_F	160_L	0.700	0.98
34_Q	114_S	0.697	0.98
222_F	252_V	0.696	0.98
207_I	241_V	0.696	0.98
218_G	222_F	0.684	0.97
149_L	211_R	0.677	0.97
117_N	122_A	0.676	0.97
77_Y	101_G	0.675	0.97
92_L	179_T	0.673	0.97
248_V	251_Q	0.670	0.97
30_L	36_L	0.670	0.97
22_E	141_S	0.668	0.97
95_Q	180_I	0.668	0.97
41_K	102_D	0.665	0.97
102_D	183_K	0.663	0.97
90_V	173_N	0.663	0.97
19_K	140_A	0.662	0.97
34_Q	102_D	0.661	0.97
35_S	38_P	0.659	0.97
75_T	79_E	0.659	0.97
181_Y	195_S	0.654	0.96
92_L	199_A	0.653	0.96
63_R	168_E	0.653	0.96
61_Y	79_E	0.653	0.96
92_L	131_L	0.651	0.96
123_D	181_Y	0.650	0.96
119_D	191_F	0.650	0.96
27_A	49_Y	0.650	0.96
111_I	128_L	0.650	0.96
194_V	217_V	0.649	0.96
148_A	151_F	0.649	0.96
214_Y	252_V	0.648	0.96
15_E	143_N	0.648	0.96
160_L	163_G	0.646	0.96
175_E	201_K	0.646	0.96
95_Q	179_T	0.644	0.96
132_N	147_N	0.643	0.96
66_F	173_N	0.643	0.96
240_L	243_E	0.640	0.96
17_A	29_P	0.638	0.96
236_L	240_L	0.634	0.96
24_H	27_A	0.634	0.96
81_L	97_V	0.633	0.96
35_S	191_F	0.632	0.96
137_L	159_D	0.630	0.96
131_L	171_L	0.629	0.96
115_A	125_P	0.626	0.95
62_V	71_I	0.623	0.95
60_S	75_T	0.620	0.95
245_V	270_K	0.617	0.95
11_V	14_S	0.616	0.95
58_S	61_Y	0.616	0.95
224_A	248_V	0.614	0.95
31_A	53_L	0.608	0.95
69_T	90_V	0.607	0.95
117_N	191_F	0.606	0.95
121_S	216_G	0.602	0.94
152_F	221_P	0.597	0.94
35_S	190_D	0.597	0.94
211_R	223_R	0.596	0.94
249_S	269_M	0.595	0.94
154_G	219_E	0.592	0.94
133_A	169_I	0.592	0.94
133_A	171_L	0.591	0.94
81_L	103_M	0.586	0.94
75_T	112_G	0.586	0.94
41_K	183_K	0.585	0.93
252_V	269_M	0.583	0.93
184_V	272_I	0.582	0.93
174_L	177_Y	0.582	0.93
186_R	264_Y	0.577	0.93
101_G	105_V	0.577	0.93
170_V	173_N	0.577	0.93
129_T	221_P	0.576	0.93
59_L	73_A	0.576	0.93
95_Q	99_V	0.571	0.93
129_T	213_A	0.570	0.93
191_F	216_G	0.570	0.93
217_V	252_V	0.569	0.93
224_A	251_Q	0.569	0.93
35_S	39_M	0.568	0.92
87_R	91_P	0.568	0.92
68_S	171_L	0.567	0.92
224_A	244_I	0.565	0.92
77_Y	111_I	0.564	0.92
268_V	271_V	0.564	0.92
21_L	162_K	0.563	0.92
110_T	113_G	0.561	0.92
271_V	274_R	0.561	0.92
137_L	161_R	0.559	0.92
64_S	67_N	0.557	0.92
86_V	89_N	0.557	0.92
210_I	228_E	0.556	0.92
22_E	139_S	0.555	0.92
71_I	75_T	0.553	0.91
249_S	266_R	0.552	0.91
9_V	24_H	0.551	0.91
268_V	272_I	0.551	0.91
118_A	152_F	0.549	0.91
238_D	274_R	0.549	0.91
81_L	94_H	0.548	0.91
86_V	91_P	0.547	0.91
181_Y	185_V	0.545	0.91
263_W	267_E	0.545	0.91
135_I	146_V	0.544	0.91
68_S	90_V	0.543	0.91
14_S	29_P	0.542	0.91
77_Y	80_I	0.542	0.91
241_V	244_I	0.538	0.90
86_V	94_H	0.538	0.90
102_D	105_V	0.534	0.90
202_L	207_I	0.534	0.90
53_L	59_L	0.534	0.90
212_L	244_I	0.532	0.90
132_N	172_P	0.531	0.90
9_V	16_E	0.529	0.90
21_L	28_R	0.529	0.90
34_Q	123_D	0.528	0.90
207_I	232_M	0.528	0.90
180_I	279_E	0.527	0.89
114_S	191_F	0.524	0.89
86_V	90_V	0.523	0.89
146_V	151_F	0.522	0.89
29_P	163_G	0.522	0.89
122_A	191_F	0.521	0.89
205_N	236_L	0.521	0.89
102_D	123_D	0.517	0.89
151_F	158_T	0.516	0.88
39_M	117_N	0.516	0.88
180_I	184_V	0.513	0.88
14_S	17_A	0.511	0.88
186_R	190_D	0.511	0.88
52_D	108_L	0.508	0.88
193_L	260_G	0.508	0.88
117_N	156_F	0.508	0.88
142_G	161_R	0.508	0.88
61_Y	72_G	0.507	0.88
39_M	42_L	0.506	0.87
80_I	128_L	0.504	0.87
39_M	45_I	0.502	0.87
245_V	248_V	0.501	0.87
254_P	259_R	0.501	0.87
34_Q	156_F	0.501	0.87
28_R	117_N	0.500	0.87
79_E	82_K	0.500	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1t3qC	1	0.9965	100	0.076	Contact Map
1rm6B	1	0.9894	100	0.086	Contact Map
1n62C	1	1	100	0.097	Contact Map
1ffvC	1	1	100	0.12	Contact Map
3zyvA	3	0.9894	100	0.123	Contact Map
2w3sA	1	0.9716	100	0.138	Contact Map
3hrdC	1	0.9929	100	0.141	Contact Map
3nvzB	1	1	100	0.158	Contact Map
3uncA	2	1	100	0.159	Contact Map
4pytA	1	0.8652	98.2	0.871	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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