GREMLIN Database
Q97VI6 - Carbon monoxide dehydrogenase, small chain. Amino-end (CutC-2)
UniProt: Q97VI6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 163 (148)
Sequences: 6797 (3961)
Seq/√Len: 325.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_N156_D3.9861.00
130_E155_L3.8041.00
29_I38_E3.2431.00
93_H119_Y2.7111.00
43_G83_I2.5731.00
133_V155_L2.5701.00
129_S132_E2.5331.00
15_K79_E2.5251.00
23_R34_F2.4281.00
61_N78_A2.3551.00
97_E101_E2.2981.00
102_N152_K2.2511.00
118_A154_V2.0171.00
13_K22_E2.0091.00
32_V46_I1.9541.00
51_T69_T1.9491.00
57_T64_S1.9261.00
95_I115_I1.9181.00
60_L65_V1.8761.00
41_L44_T1.8411.00
101_E156_D1.8351.00
119_Y123_K1.8221.00
29_I34_F1.7991.00
34_F72_A1.7981.00
59_L116_M1.7971.00
60_L70_L1.7961.00
15_K20_L1.7751.00
83_I115_I1.7691.00
13_K20_L1.6911.00
125_N132_E1.6791.00
134_R151_V1.6591.00
46_I49_D1.5761.00
71_F74_Q1.4891.00
43_G84_E1.4731.00
95_I119_Y1.4291.00
17_N84_E1.3941.00
17_N41_L1.3771.00
64_S120_F1.3731.00
125_N128_P1.3701.00
57_T116_M1.3341.00
59_L120_F1.3251.00
130_E152_K1.3051.00
137_L154_V1.3021.00
25_V72_A1.2801.00
92_L96_Q1.2751.00
81_T85_G1.2531.00
16_V39_L1.2511.00
31_L58_V1.2511.00
104_A153_A1.2491.00
120_F124_E1.2461.00
114_M137_L1.2451.00
121_L136_G1.2391.00
60_L80_I1.2321.00
59_L119_Y1.2301.00
99_F111_T1.2211.00
14_V21_Y1.2201.00
87_S92_L1.2031.00
70_L75_A1.1331.00
60_L78_A1.1261.00
65_V70_L1.1261.00
31_L80_I1.1211.00
148_Q152_K1.1131.00
95_I118_A1.0981.00
88_V91_K1.0961.00
117_Q139_G1.0811.00
16_V21_Y1.0811.00
130_E134_R1.0651.00
95_I157_A1.0641.00
12_I76_D1.0491.00
89_D92_L1.0481.00
128_P158_S1.0231.00
149_N152_K1.0111.00
60_L75_A1.0051.00
34_F39_L0.9931.00
31_L75_A0.9891.00
44_T83_I0.9881.00
93_H96_Q0.9861.00
86_L119_Y0.9821.00
26_S29_I0.9701.00
32_V44_T0.9671.00
25_V38_E0.9641.00
41_L84_E0.9551.00
23_R39_L0.9381.00
64_S117_Q0.9271.00
104_A111_T0.9211.00
113_G140_N0.9191.00
130_E151_V0.9181.00
91_K97_E0.9151.00
30_L33_D0.9031.00
16_V41_L0.8711.00
63_K124_E0.8711.00
81_T123_K0.8671.00
87_S91_K0.8651.00
75_A78_A0.8291.00
122_L158_S0.8291.00
151_V155_L0.8271.00
95_I122_L0.8171.00
18_G79_E0.8151.00
61_N79_E0.8141.00
86_L115_I0.8071.00
59_L81_T0.8041.00
94_P157_A0.8001.00
125_N136_G0.7991.00
98_A156_D0.7901.00
118_A137_L0.7871.00
58_V67_S0.7871.00
18_G21_Y0.7861.00
103_F145_T0.7851.00
156_D159_R0.7841.00
99_F104_A0.7771.00
99_F118_A0.7741.00
30_L46_I0.7721.00
35_L58_V0.7711.00
114_M146_G0.7681.00
103_F146_G0.7671.00
99_F115_I0.7651.00
32_V47_G0.7621.00
121_L125_N0.7580.99
131_E135_D0.7580.99
98_A157_A0.7580.99
13_K76_D0.7560.99
87_S96_Q0.7560.99
114_M150_I0.7560.99
70_L74_Q0.7530.99
131_E134_R0.7500.99
49_D52_T0.7490.99
124_E136_G0.7260.99
42_T112_P0.7190.99
117_Q136_G0.7170.99
133_V151_V0.7120.99
64_S136_G0.7040.99
33_D46_I0.7010.99
34_F38_E0.6990.99
17_N85_G0.6970.99
29_I37_E0.6960.99
152_K156_D0.6940.99
99_F114_M0.6920.99
87_S90_S0.6910.99
14_V34_F0.6830.99
28_R73_V0.6810.99
99_F105_L0.6800.99
66_K70_L0.6740.99
102_N153_A0.6730.99
132_E136_G0.6730.99
114_M140_N0.6720.99
25_V34_F0.6680.99
105_L111_T0.6660.99
121_L133_V0.6660.99
30_L71_F0.6600.99
33_D37_E0.6580.99
121_L128_P0.6550.99
122_L125_N0.6520.98
122_L128_P0.6510.98
121_L126_P0.6500.98
12_I25_V0.6490.98
42_T45_K0.6470.98
35_L39_L0.6450.98
92_L100_K0.6430.98
45_K112_P0.6390.98
81_T119_Y0.6340.98
59_L64_S0.6340.98
12_I72_A0.6300.98
114_M139_G0.6300.98
53_C56_C0.6290.98
29_I72_A0.6280.98
35_L44_T0.6270.98
48_C53_C0.6250.98
122_L157_A0.6250.98
57_T117_Q0.6220.98
48_C56_C0.6190.98
23_R38_E0.6140.98
117_Q140_N0.6110.98
14_V23_R0.6110.98
21_Y34_F0.6100.98
103_F149_N0.6090.98
45_K66_K0.6070.98
30_L50_T0.6050.98
86_L116_M0.6040.97
88_V92_L0.5990.97
62_G79_E0.5970.97
145_T148_Q0.5900.97
46_I52_T0.5900.97
122_L126_P0.5840.97
100_K105_L0.5810.97
70_L78_A0.5790.97
52_T66_K0.5770.97
139_G147_Y0.5750.97
50_T66_K0.5730.97
116_M136_G0.5710.96
133_V154_V0.5680.96
59_L123_K0.5670.96
44_T84_E0.5630.96
37_E42_T0.5580.96
62_G78_A0.5570.96
35_L42_T0.5540.96
45_K103_F0.5510.96
86_L93_H0.5490.96
72_A75_A0.5450.95
46_I66_K0.5430.95
31_L70_L0.5370.95
16_V35_L0.5320.95
128_P136_G0.5300.95
57_T140_N0.5300.95
46_I109_F0.5280.95
114_M145_T0.5210.94
28_R71_F0.5210.94
49_D66_K0.5170.94
90_S93_H0.5150.94
27_P73_V0.5130.94
127_N159_R0.5130.94
56_C68_C0.5120.94
30_L49_D0.5100.94
90_S96_Q0.5100.94
85_G92_L0.5090.93
43_G96_Q0.5090.93
48_C68_C0.5080.93
25_V73_V0.5080.93
14_V76_D0.5060.93
66_K117_Q0.5040.93
117_Q121_L0.5030.93
50_T69_T0.5030.93
14_V75_A0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uncA 2 0.9202 100 0.06 Contact Map
3zyvA 3 0.9264 100 0.064 Contact Map
3nvwA 1 0.9325 100 0.106 Contact Map
2w3sA 1 0.9141 100 0.106 Contact Map
1dgjA 1 0.9509 100 0.122 Contact Map
4usaA 2 0.9509 100 0.135 Contact Map
1n62A 1 0.9509 100 0.187 Contact Map
3hrdD 1 0.9632 100 0.194 Contact Map
1rm6C 1 0.9571 100 0.245 Contact Map
1t3qA 1 0.9632 100 0.249 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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