GREMLIN Database
Q97VI4 - Carbon monoxide dehydrogenase, large chain (CutA-4)
UniProt: Q97VI4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 749 (718)
Sequences: 5422 (3571)
Seq/√Len: 133.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_V126_K4.7031.00
181_R293_E4.2881.00
37_V127_V4.2811.00
32_L61_V4.1531.00
116_D119_S3.8981.00
390_E417_R3.7871.00
53_D128_V3.7421.00
183_E291_T3.6511.00
41_Y44_A3.6221.00
424_G427_E3.5291.00
297_K301_T3.4731.00
306_K342_D3.4071.00
296_V377_V3.3721.00
492_V532_A3.2661.00
177_D297_K3.2191.00
45_I132_E3.2161.00
57_V119_S3.1911.00
47_K130_E3.1711.00
383_L391_K3.1691.00
177_D298_R3.1301.00
171_K175_E3.1201.00
471_V498_I3.0861.00
302_I374_M3.0611.00
168_E171_K3.0381.00
37_V124_I2.9671.00
61_V115_Q2.9171.00
181_R291_T2.9141.00
44_A131_Y2.8791.00
308_K344_E2.8751.00
495_A537_E2.8731.00
41_Y133_P2.7821.00
337_K398_P2.7431.00
43_H134_L2.7071.00
387_S391_K2.6811.00
564_E574_K2.6661.00
48_R130_E2.6561.00
293_E306_K2.6371.00
210_I224_F2.5581.00
625_E688_T2.5101.00
115_Q119_S2.4851.00
533_I537_E2.4631.00
440_H614_E2.4121.00
301_T391_K2.4011.00
34_A272_W2.3951.00
209_S238_S2.3901.00
47_K132_E2.3741.00
115_Q268_R2.3711.00
733_K740_E2.3471.00
202_R211_W2.3061.00
207_T511_D2.2951.00
720_I736_T2.2851.00
308_K346_V2.2841.00
383_L388_I2.2801.00
173_F295_A2.2581.00
51_V55_L2.2551.00
113_L262_S2.2501.00
423_L610_I2.2491.00
614_E624_L2.2231.00
312_D352_T2.2221.00
723_L736_T2.2081.00
377_V388_I2.1901.00
142_E145_K2.1771.00
236_K509_D2.1551.00
294_V373_I2.0841.00
418_E421_K2.0771.00
165_K342_D2.0741.00
34_A111_I2.0371.00
418_E690_V2.0251.00
387_S390_E2.0181.00
176_S295_A2.0131.00
419_G610_I2.0101.00
465_V539_I1.9901.00
470_D502_R1.9881.00
185_I733_K1.9861.00
40_T109_V1.9821.00
649_G687_F1.9791.00
301_T337_K1.9711.00
178_K296_V1.9681.00
390_E420_V1.9491.00
417_R421_K1.9491.00
178_K298_R1.9411.00
51_V63_V1.9401.00
650_V684_A1.9341.00
463_V473_V1.9241.00
292_G373_I1.9111.00
45_I100_N1.8741.00
50_D128_V1.8711.00
25_D271_R1.8671.00
540_L544_K1.8631.00
52_S55_L1.8621.00
386_V420_V1.8611.00
8_V500_I1.8571.00
395_T398_P1.8551.00
470_D504_R1.8491.00
139_R142_E1.8481.00
395_T413_V1.8191.00
554_D557_E1.8061.00
466_D472_L1.8061.00
45_I101_K1.7911.00
576_S579_D1.7901.00
53_D126_K1.7891.00
525_V636_V1.7851.00
54_A127_V1.7811.00
442_V614_E1.7751.00
489_A505_V1.7721.00
207_T234_K1.7721.00
61_V268_R1.7661.00
491_I529_G1.7621.00
34_A270_V1.7611.00
499_D502_R1.7551.00
198_G273_T1.7321.00
41_Y131_Y1.7291.00
114_G120_V1.7261.00
297_K303_L1.7241.00
422_R688_T1.7021.00
621_A741_I1.6951.00
641_A707_V1.6911.00
9_K639_A1.6691.00
57_V123_A1.6681.00
466_D470_D1.6651.00
176_S303_L1.6541.00
192_N673_Y1.6531.00
294_V302_I1.6441.00
193_P248_A1.6361.00
113_L266_L1.6331.00
609_H626_Y1.6181.00
62_A265_I1.6091.00
294_V377_V1.6031.00
626_Y649_G1.5901.00
173_F293_E1.5901.00
471_V496_L1.5861.00
60_I114_G1.5831.00
635_V691_F1.5811.00
418_E422_R1.5801.00
463_V536_A1.5791.00
379_D724_E1.5781.00
165_K168_E1.5761.00
124_I127_V1.5741.00
737_T740_E1.5691.00
43_H101_K1.5661.00
473_V492_V1.5611.00
411_D414_G1.5581.00
634_K693_D1.5571.00
611_A626_Y1.5501.00
53_D56_K1.5331.00
449_Y607_G1.5321.00
170_D174_S1.5261.00
24_V198_G1.5231.00
495_A702_T1.5231.00
413_V417_R1.5221.00
67_K100_N1.5131.00
178_K380_E1.5131.00
291_T308_K1.5011.00
209_S236_K1.5001.00
461_A532_A1.5001.00
641_A691_F1.4961.00
170_D342_D1.4951.00
420_V426_Y1.4881.00
179_V293_E1.4841.00
422_R690_V1.4831.00
632_I635_V1.4801.00
55_L62_A1.4791.00
434_E438_K1.4631.00
178_K297_K1.4601.00
178_K381_L1.4591.00
390_E413_V1.4491.00
101_K152_E1.4391.00
178_K377_V1.4361.00
36_F258_A1.4331.00
652_A715_G1.4281.00
230_I235_I1.4241.00
161_K344_E1.4181.00
111_I262_S1.4161.00
419_G608_V1.4121.00
379_D725_D1.4111.00
493_A503_V1.4071.00
561_E566_K1.4001.00
36_F272_W1.3951.00
173_F304_G1.3911.00
623_V653_V1.3891.00
534_K538_K1.3851.00
224_F235_I1.3831.00
46_I49_I1.3811.00
538_K541_D1.3751.00
415_L608_V1.3741.00
375_S721_R1.3691.00
25_D273_T1.3681.00
495_A533_I1.3681.00
65_T97_F1.3671.00
488_I532_A1.3641.00
544_K558_V1.3641.00
299_D391_K1.3581.00
225_A235_I1.3571.00
231_P234_K1.3561.00
29_I200_V1.3501.00
32_L268_R1.3501.00
302_I338_I1.3381.00
627_R688_T1.3371.00
122_D126_K1.3321.00
169_V173_F1.3301.00
172_A340_N1.3261.00
611_A718_V1.3261.00
440_H622_R1.3231.00
558_V565_F1.3221.00
654_G679_P1.3211.00
621_A723_L1.3211.00
487_A525_V1.3091.00
381_L388_I1.3091.00
201_S210_I1.3091.00
46_I129_V1.3081.00
182_V376_T1.3011.00
21_S241_D1.2981.00
545_R555_V1.2971.00
172_A304_G1.2971.00
64_F266_L1.2961.00
371_E389_R1.2911.00
206_G234_K1.2901.00
296_V381_L1.2881.00
559_Q566_K1.2851.00
662_L671_V1.2841.00
101_K134_L1.2821.00
491_I525_V1.2821.00
358_Y651_Q1.2771.00
208_L230_I1.2761.00
615_V621_A1.2691.00
368_Y720_I1.2641.00
109_V129_V1.2581.00
222_S232_E1.2561.00
635_V641_A1.2521.00
29_I202_R1.2521.00
619_G741_I1.2511.00
173_F179_V1.2491.00
11_I489_A1.2451.00
290_F369_I1.2421.00
422_R629_Y1.2331.00
35_G124_I1.2311.00
40_T131_Y1.2221.00
423_L627_R1.2221.00
170_D306_K1.2201.00
45_I134_L1.2171.00
169_V172_A1.2161.00
375_S385_D1.2111.00
192_N678_V1.2051.00
201_S263_S1.2041.00
11_I486_T1.2041.00
284_E356_T1.2021.00
38_R278_E1.2021.00
419_G629_Y1.2021.00
288_N312_D1.2011.00
182_V380_E1.2001.00
731_F736_T1.1991.00
538_K542_K1.1910.99
313_L320_T1.1900.99
530_S533_I1.1860.99
657_L719_I1.1840.99
621_A657_L1.1840.99
439_G616_D1.1800.99
35_G121_R1.1800.99
66_A99_E1.1790.99
123_A126_K1.1790.99
376_T732_T1.1780.99
310_L346_V1.1770.99
171_K174_S1.1760.99
393_L416_L1.1760.99
434_E437_K1.1700.99
557_E569_N1.1680.99
103_K107_E1.1660.99
35_G117_K1.1620.99
211_W238_S1.1610.99
442_V612_T1.1580.99
14_D18_T1.1560.99
613_V723_L1.1550.99
64_F265_I1.1550.99
629_Y690_V1.1530.99
557_E568_K1.1530.99
645_I649_G1.1490.99
119_S123_A1.1460.99
193_P279_E1.1450.99
163_P344_E1.1450.99
489_A500_I1.1430.99
566_K574_K1.1420.99
43_H351_N1.1420.99
15_K20_R1.1420.99
48_R128_V1.1300.99
421_K426_Y1.1250.99
553_V567_L1.1240.99
35_G120_V1.1230.99
296_V388_I1.1220.99
547_A580_V1.1210.99
43_H135_K1.1180.99
60_I120_V1.1180.99
611_A623_V1.1170.99
543_M580_V1.1170.99
553_V557_E1.1120.99
184_A373_I1.1090.99
387_S426_Y1.1040.99
49_I129_V1.1030.99
490_Q637_N1.1030.99
32_L266_L1.1010.99
163_P342_D1.0980.99
36_F111_I1.0950.99
109_V131_Y1.0950.99
440_H616_D1.0930.99
462_E474_V1.0910.99
296_V302_I1.0900.99
60_I123_A1.0890.99
161_K346_V1.0880.99
294_V305_I1.0880.99
550_T583_I1.0870.99
175_E303_L1.0850.99
415_L629_Y1.0840.99
140_M310_L1.0820.99
141_E185_I1.0810.99
589_D592_L1.0790.99
386_V446_L1.0760.99
739_E743_R1.0760.99
544_K560_Y1.0730.99
46_I109_V1.0710.99
428_L612_T1.0700.99
31_A268_R1.0640.99
472_L506_I1.0590.99
175_E297_K1.0580.99
418_E629_Y1.0570.99
557_E567_L1.0500.99
429_K432_A1.0490.99
180_V380_E1.0490.99
442_V624_L1.0470.99
414_G418_E1.0460.99
61_V113_L1.0460.99
245_A480_H1.0430.99
117_K121_R1.0420.99
663_L669_L1.0410.99
295_A304_G1.0410.99
430_K434_E1.0400.99
57_V122_D1.0360.99
144_E348_V1.0350.99
502_R563_G1.0340.99
173_F306_K1.0330.98
111_I258_A1.0330.98
546_I580_V1.0320.98
541_D545_R1.0320.98
44_A134_L1.0310.98
204_E209_S1.0290.98
151_H349_Y1.0270.98
242_V480_H1.0270.98
473_V503_V1.0270.98
474_V506_I1.0260.98
203_F264_I1.0250.98
295_A303_L1.0230.98
202_R209_S1.0210.98
492_V536_A1.0190.98
664_N668_Q1.0190.98
204_E207_T1.0130.98
374_M388_I1.0130.98
64_F262_S1.0120.98
112_V124_I1.0070.98
172_A295_A1.0040.98
102_V131_Y1.0020.98
62_A266_L1.0020.98
658_Y683_E1.0020.98
177_D303_L1.0010.98
61_V119_S0.9990.98
393_L413_V0.9990.98
631_D694_Q0.9990.98
180_V296_V0.9980.98
537_E541_D0.9980.98
660_Q740_E0.9960.98
110_A127_V0.9950.98
560_Y565_F0.9950.98
495_A536_A0.9930.98
169_V306_K0.9780.98
213_S249_K0.9750.98
736_T741_I0.9720.98
310_L348_V0.9690.98
672_T675_D0.9680.98
64_F113_L0.9680.98
203_F263_S0.9660.98
543_M577_W0.9650.98
653_V684_A0.9640.98
191_P248_A0.9640.98
141_E183_E0.9630.98
190_I661_A0.9600.98
44_A129_V0.9570.98
736_T740_E0.9550.97
202_R263_S0.9530.97
51_V127_V0.9520.97
495_A540_L0.9520.97
169_V340_N0.9480.97
414_G692_A0.9480.97
63_V110_A0.9480.97
110_A129_V0.9470.97
416_L446_L0.9470.97
203_F206_G0.9450.97
58_N115_Q0.9450.97
59_G123_A0.9410.97
66_A100_N0.9410.97
169_V304_G0.9380.97
107_E316_Y0.9370.97
221_R232_E0.9340.97
287_H365_E0.9340.97
180_V294_V0.9320.97
144_E310_L0.9320.97
429_K725_D0.9320.97
375_S389_R0.9310.97
486_T490_Q0.9300.97
33_Y271_R0.9300.97
97_F108_P0.9270.97
613_V623_V0.9260.97
465_V577_W0.9240.97
7_P642_E0.9230.97
263_S266_L0.9220.97
49_I127_V0.9200.97
575_M583_I0.9150.97
215_Q245_A0.9150.97
43_H136_P0.9110.97
386_V416_L0.9100.97
492_V503_V0.9100.97
324_Q345_S0.9070.97
664_N670_I0.9060.97
414_G417_R0.9040.97
628_A649_G0.9010.96
559_Q568_K0.8990.96
584_A588_H0.8970.96
230_I234_K0.8960.96
149_I153_E0.8950.96
137_V143_A0.8930.96
336_Y389_R0.8920.96
425_Y446_L0.8900.96
15_K485_E0.8890.96
228_L260_V0.8890.96
230_I264_I0.8870.96
55_L67_K0.8850.96
336_Y371_E0.8840.96
642_E646_H0.8840.96
642_E691_F0.8820.96
293_E342_D0.8810.96
172_A303_L0.8810.96
477_T524_S0.8790.96
262_S270_V0.8760.96
36_F108_P0.8760.96
433_E437_K0.8750.96
652_A712_L0.8730.96
306_K344_E0.8720.96
236_K511_D0.8700.96
250_V520_Y0.8690.96
577_W588_H0.8670.96
564_E576_S0.8660.96
328_I343_I0.8660.96
169_V342_D0.8650.96
552_N567_L0.8650.96
372_R720_I0.8600.95
661_A669_L0.8590.95
289_V311_L0.8570.95
472_L504_R0.8560.95
579_D582_S0.8550.95
612_T625_E0.8550.95
179_V295_A0.8540.95
464_R474_V0.8540.95
37_V110_A0.8530.95
120_V124_I0.8510.95
459_E528_G0.8500.95
534_K537_E0.8500.95
37_V129_V0.8490.95
262_S266_L0.8480.95
46_I131_Y0.8480.95
176_S304_G0.8460.95
213_S242_V0.8460.95
184_A376_T0.8450.95
16_F23_Y0.8400.95
51_V54_A0.8400.95
471_V539_I0.8370.95
482_Q519_T0.8360.95
15_K241_D0.8360.95
431_W434_E0.8340.95
590_P593_V0.8340.95
490_Q638_P0.8340.95
453_C603_T0.8340.95
483_G640_L0.8330.94
138_I667_G0.8320.94
439_G617_D0.8320.94
197_R279_E0.8320.94
44_A102_V0.8300.94
632_I641_A0.8290.94
296_V373_I0.8290.94
540_L560_Y0.8280.94
565_F580_V0.8270.94
41_Y102_V0.8260.94
477_T484_T0.8260.94
611_A717_A0.8250.94
49_I109_V0.8220.94
150_I351_N0.8190.94
184_A372_R0.8180.94
625_E686_K0.8180.94
546_I584_A0.8150.94
51_V65_T0.8150.94
31_A269_P0.8140.94
673_Y678_V0.8140.94
121_R275_T0.8120.94
38_R282_A0.8120.94
300_G383_L0.8120.94
420_V425_Y0.8120.94
700_Y704_S0.8100.94
684_A687_F0.8090.94
595_K598_Y0.8090.94
33_Y117_K0.8070.94
67_K99_E0.8070.94
289_V327_I0.8050.93
575_M580_V0.8050.93
103_K316_Y0.8020.93
727_I744_A0.8010.93
314_G354_P0.8010.93
373_I377_V0.7990.93
274_A279_E0.7990.93
491_I636_V0.7980.93
8_V489_A0.7970.93
541_D555_V0.7960.93
368_Y372_R0.7940.93
487_A640_L0.7940.93
729_T744_A0.7940.93
117_K275_T0.7940.93
370_I373_I0.7910.93
626_Y687_F0.7900.93
417_R420_V0.7890.93
416_L448_Y0.7890.93
196_P273_T0.7880.93
303_L340_N0.7880.93
616_D620_V0.7880.93
98_P102_V0.7870.93
290_F307_G0.7870.93
609_H714_V0.7860.93
305_I338_I0.7860.93
55_L68_E0.7850.93
218_H510_T0.7820.92
292_G369_I0.7820.92
212_Y220_M0.7810.92
552_N557_E0.7810.92
52_S56_K0.7800.92
441_R615_V0.7800.92
68_E265_I0.7800.92
168_E340_N0.7790.92
220_M224_F0.7780.92
181_R306_K0.7780.92
384_D425_Y0.7750.92
427_E430_K0.7750.92
7_P639_A0.7750.92
184_A732_T0.7750.92
465_V543_M0.7750.92
631_D695_Y0.7740.92
48_R52_S0.7740.92
492_V495_A0.7740.92
498_I502_R0.7740.92
236_K510_T0.7730.92
24_V27_I0.7730.92
137_V351_N0.7720.92
613_V621_A0.7710.92
632_I707_V0.7700.92
430_K433_E0.7700.92
208_L264_I0.7690.92
463_V539_I0.7690.92
114_G123_A0.7690.92
473_V532_A0.7690.92
333_P341_L0.7680.92
724_E730_R0.7660.92
214_T220_M0.7660.92
173_F303_L0.7650.92
43_H150_I0.7640.92
54_A60_I0.7640.92
321_A325_P0.7630.91
49_I63_V0.7620.91
388_I391_K0.7600.91
138_I142_E0.7580.91
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484_T519_T0.5450.71
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612_T624_L0.5320.70
34_A258_A0.5310.69
429_K444_V0.5310.69
542_K591_G0.5310.69
250_V357_M0.5310.69
460_Y514_A0.5300.69
124_I128_V0.5300.69
437_K442_V0.5300.69
650_V653_V0.5300.69
289_V365_E0.5290.69
385_D429_K0.5290.69
68_E71_P0.5290.69
96_A245_A0.5290.69
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386_V425_Y0.5280.69
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42_P664_N0.5250.69
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320_T324_Q0.5220.68
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175_E340_N0.5220.68
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423_L426_Y0.5210.68
401_N604_F0.5210.68
319_V322_G0.5200.68
296_V380_E0.5200.68
552_N558_V0.5200.68
32_L270_V0.5200.68
101_K150_I0.5190.68
238_S511_D0.5190.68
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474_V512_T0.5180.68
390_E416_L0.5180.68
130_E133_P0.5180.68
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299_D303_L0.5140.67
97_F111_I0.5140.67
200_V211_W0.5140.67
172_A179_V0.5130.67
305_I341_L0.5130.67
191_P285_A0.5120.67
219_Y250_V0.5120.67
740_E744_A0.5120.67
725_D729_T0.5110.67
103_K349_Y0.5110.67
8_V486_T0.5110.67
521_G648_G0.5110.67
40_T44_A0.5090.66
257_L260_V0.5090.66
580_V583_I0.5090.66
159_S349_Y0.5090.66
332_I343_I0.5090.66
41_Y129_V0.5080.66
561_E574_K0.5080.66
12_Y241_D0.5080.66
477_T488_I0.5080.66
652_A656_A0.5080.66
105_V669_L0.5070.66
66_A97_F0.5060.66
506_I513_V0.5050.66
45_I48_R0.5050.66
30_P200_V0.5050.66
548_A558_V0.5040.65
533_I702_T0.5040.65
360_G712_L0.5040.65
15_K205_A0.5040.65
73_L76_G0.5040.65
655_Q734_T0.5040.65
47_K51_V0.5030.65
331_M452_I0.5030.65
112_V123_A0.5030.65
180_V381_L0.5020.65
421_K424_G0.5020.65
217_P516_S0.5020.65
335_P448_Y0.5010.65
567_L573_K0.5010.65
420_V446_L0.5010.65
224_F257_L0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rm6A 2 0.968 100 0.112 Contact Map
1t3qB 2 0.9907 100 0.113 Contact Map
1ffvB 2 0.98 100 0.124 Contact Map
1n62B 2 0.9826 100 0.126 Contact Map
2w3sB 2 0.9626 100 0.136 Contact Map
3uncA 2 0.9546 100 0.143 Contact Map
3zyvA 3 0.9466 100 0.157 Contact Map
3nvzC 2 0.9533 100 0.158 Contact Map
4usaA 2 0.9479 100 0.162 Contact Map
1dgjA 1 0.9466 100 0.162 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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