GREMLIN Database
Q97VI0 - Glycerol-3-phosphate dehydrogenase chain C (Anaerobic) (GlpC)
UniProt: Q97VI0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 395 (358)
Sequences: 5761 (3980)
Seq/√Len: 210.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
382_L390_E4.8521.00
292_S320_K4.7491.00
191_E389_K4.7111.00
169_R199_E4.1861.00
188_D386_Q4.1451.00
275_L312_R3.5721.00
292_S322_D3.4411.00
268_Y276_K3.3721.00
270_A385_I3.3261.00
268_Y272_E2.9131.00
207_C249_C2.8161.00
189_L245_P2.7811.00
217_D220_R2.5661.00
363_S387_L2.5391.00
311_V323_I2.4951.00
157_R187_E2.4301.00
184_E386_Q2.3301.00
291_K361_L2.2691.00
208_C249_C2.2661.00
268_Y273_Y2.2611.00
176_C207_C2.2581.00
178_I186_G2.1921.00
293_V387_L2.1871.00
169_R240_Y2.1641.00
89_D92_S2.1391.00
226_E230_K2.1301.00
324_S354_F2.1211.00
124_R127_A2.0811.00
185_I386_Q2.0781.00
291_K360_D2.0601.00
170_V273_Y2.0531.00
168_A198_I2.0511.00
198_I273_Y2.0301.00
312_R315_R2.0261.00
172_L245_P1.9871.00
244_S250_T1.9851.00
206_V227_Y1.9691.00
297_P311_V1.9251.00
225_A256_Y1.9081.00
196_L392_M1.9001.00
340_Y344_K1.8941.00
294_Y324_S1.8551.00
190_V200_V1.8511.00
273_Y277_L1.8511.00
135_K138_L1.8031.00
222_K226_E1.7931.00
254_K272_E1.7891.00
176_C249_C1.7781.00
195_E389_K1.7731.00
311_V315_R1.7411.00
192_I388_L1.7321.00
235_L239_G1.6771.00
294_Y357_S1.6461.00
43_L345_R1.6411.00
347_G351_M1.6371.00
351_M355_K1.6351.00
272_E276_K1.6321.00
127_A131_M1.6311.00
189_L193_Y1.6131.00
131_M134_N1.6021.00
169_R201_I1.5881.00
241_D268_Y1.5841.00
188_D389_K1.5711.00
292_S360_D1.5681.00
108_T111_D1.5631.00
176_C208_C1.5571.00
189_L270_A1.5561.00
135_K142_K1.5341.00
138_L141_H1.5311.00
243_V273_Y1.5181.00
266_K276_K1.5101.00
361_L382_L1.4741.00
279_N312_R1.4671.00
152_K157_R1.4631.00
293_V319_A1.4511.00
170_V200_V1.4421.00
344_K376_S1.4361.00
274_L388_L1.4121.00
109_V112_F1.4021.00
230_K233_E1.3791.00
171_A239_G1.3721.00
269_D273_Y1.3681.00
272_E306_L1.3591.00
380_R390_E1.3551.00
170_V243_V1.3551.00
213_L252_M1.3541.00
121_K125_P1.3511.00
210_A248_T1.3481.00
298_P364_T1.3351.00
274_L313_L1.3311.00
272_E309_P1.3301.00
123_A127_A1.3291.00
235_L238_E1.3211.00
165_S199_E1.3131.00
354_F362_F1.3101.00
276_K280_E1.3071.00
192_I385_I1.3051.00
192_I392_M1.3041.00
75_Y89_D1.3011.00
103_K219_D1.2991.00
212_M220_R1.2951.00
347_G376_S1.2891.00
127_A130_I1.2881.00
382_L386_Q1.2781.00
158_V190_V1.2711.00
290_E320_K1.2711.00
348_S355_K1.2701.00
194_N200_V1.2681.00
35_F50_K1.2641.00
192_I389_K1.2601.00
198_I277_L1.2551.00
269_D272_E1.2481.00
241_D273_Y1.2401.00
147_L150_A1.2391.00
271_M275_L1.2391.00
293_V363_S1.2271.00
90_F94_M1.2141.00
94_M98_W1.2121.00
314_L363_S1.2041.00
295_Y310_G1.2011.00
370_G381_P1.1961.00
352_E356_Q1.1941.00
348_S352_E1.1931.00
171_A235_L1.1861.00
122_F125_P1.1811.00
124_R131_M1.1801.00
306_L309_P1.1781.00
365_E384_P1.1771.00
354_F373_I1.1771.00
136_E142_K1.1691.00
246_I366_C1.1661.00
289_I391_A1.1601.00
291_K390_E1.1581.00
49_D67_K1.1581.00
123_A126_L1.1481.00
167_K199_E1.1411.00
190_V194_N1.1391.00
113_I116_M1.1381.00
171_A240_Y1.1381.00
244_S253_I1.1341.00
54_K57_T1.1291.00
189_L385_I1.1281.00
382_L387_L1.1181.00
121_K124_R1.1131.00
351_M376_S1.1091.00
191_E195_E1.1061.00
276_K309_P1.1031.00
308_L311_V1.0991.00
174_P186_G1.0941.00
129_V133_K1.0921.00
272_E278_K1.0841.00
274_L278_K1.0841.00
72_K75_Y1.0801.00
130_I133_K1.0761.00
260_L263_E1.0761.00
224_N228_N1.0701.00
210_A214_D1.0681.00
165_S168_A1.0631.00
155_R179_E1.0631.00
329_S369_A1.0601.00
122_F126_L1.0601.00
128_K132_E1.0561.00
187_E191_E1.0541.00
129_V132_E1.0531.00
340_Y375_K1.0531.00
41_F45_F1.0491.00
308_L312_R1.0471.00
132_E135_K1.0451.00
213_L221_L1.0431.00
175_T246_I1.0421.00
213_L218_V1.0381.00
309_P312_R1.0351.00
35_F41_F1.0331.00
317_M391_A1.0331.00
47_Y51_K1.0321.00
136_E139_G1.0301.00
226_E263_E1.0301.00
47_Y52_G1.0291.00
293_V361_L1.0291.00
35_F47_Y1.0291.00
37_Y77_N1.0181.00
62_F66_S1.0131.00
312_R316_S1.0131.00
355_K377_S1.0131.00
228_N256_Y1.0121.00
334_G338_R1.0111.00
99_L218_V1.0091.00
130_I134_N1.0031.00
138_L142_K1.0021.00
212_M224_N1.0021.00
331_I336_G0.9951.00
314_L319_A0.9931.00
362_F373_I0.9901.00
341_D345_R0.9871.00
166_P199_E0.9871.00
112_F116_M0.9811.00
289_I319_A0.9741.00
43_L342_T0.9651.00
192_I313_L0.9641.00
277_L280_E0.9611.00
234_D238_E0.9601.00
257_K264_V0.9601.00
344_K348_S0.9501.00
235_L240_Y0.9480.99
191_E194_N0.9470.99
123_A131_M0.9460.99
139_G142_K0.9450.99
29_H35_F0.9450.99
145_P148_P0.9400.99
275_L279_N0.9360.99
250_T304_L0.9350.99
109_V113_I0.9320.99
347_G372_Q0.9290.99
363_S384_P0.9280.99
75_Y91_P0.9280.99
145_P149_V0.9260.99
241_D266_K0.9250.99
297_P323_I0.9250.99
137_L141_H0.9240.99
96_W99_L0.9220.99
153_G157_R0.9210.99
185_I188_D0.9180.99
101_Y105_R0.9120.99
349_K353_A0.9110.99
195_E392_M0.9100.99
111_D115_E0.9100.99
73_M77_N0.9090.99
214_D248_T0.9060.99
271_M277_L0.9000.99
46_T49_D0.8950.99
224_N227_Y0.8910.99
172_L189_L0.8870.99
153_G156_E0.8810.99
115_E118_D0.8780.99
389_K392_M0.8730.99
169_R238_E0.8730.99
297_P310_G0.8720.99
99_L103_K0.8680.99
297_P307_G0.8670.99
124_R128_K0.8670.99
42_P349_K0.8660.99
72_K303_F0.8510.99
116_M119_G0.8510.99
154_L186_G0.8500.99
100_Y104_N0.8430.99
116_M120_V0.8420.99
285_L388_L0.8410.99
232_I239_G0.8410.99
251_L303_F0.8380.99
231_I234_D0.8380.99
317_M388_L0.8370.99
121_K127_A0.8350.99
187_E190_V0.8340.99
108_T112_F0.8320.99
315_R321_V0.8310.99
270_A274_L0.8300.99
313_L388_L0.8280.99
326_N350_M0.8260.99
277_L282_K0.8250.99
92_S258_K0.8250.99
90_F93_L0.8250.99
172_L178_I0.8240.99
122_F127_A0.8200.99
352_E355_K0.8190.99
40_S53_P0.8160.98
290_E318_G0.8130.98
155_R158_V0.8120.98
154_L190_V0.8100.98
125_P128_K0.8070.98
49_D64_V0.8060.98
284_E316_S0.8030.98
228_N231_I0.7920.98
324_S357_S0.7910.98
230_K234_D0.7900.98
67_K342_T0.7890.98
298_P366_C0.7880.98
146_T149_V0.7870.98
267_V271_M0.7850.98
348_S351_M0.7800.98
364_T370_G0.7800.98
343_A372_Q0.7790.98
294_Y362_F0.7760.98
163_I166_P0.7750.98
149_V153_G0.7740.98
295_Y321_V0.7740.98
207_C211_P0.7710.98
267_V273_Y0.7700.98
193_Y198_I0.7670.98
168_A277_L0.7660.98
220_R223_K0.7660.98
147_L151_E0.7640.98
44_M342_T0.7620.98
148_P151_E0.7610.98
247_P298_P0.7590.98
261_D265_P0.7590.98
47_Y50_K0.7580.98
126_L129_V0.7570.98
250_T254_K0.7540.97
151_E157_R0.7530.97
193_Y243_V0.7530.97
386_Q389_K0.7520.97
111_D114_F0.7520.97
148_P152_K0.7500.97
345_R348_S0.7480.97
227_Y230_K0.7480.97
174_P205_F0.7440.97
154_L158_V0.7420.97
182_F367_P0.7420.97
215_S334_G0.7400.97
380_R386_Q0.7380.97
308_L315_R0.7380.97
193_Y270_A0.7360.97
128_K131_M0.7350.97
131_M135_K0.7340.97
107_L217_D0.7340.97
70_H300_H0.7340.97
190_V202_I0.7330.97
172_L186_G0.7320.97
196_L277_L0.7310.97
228_N253_I0.7290.97
69_F346_V0.7290.97
182_F185_I0.7290.97
42_P327_G0.7280.97
225_A259_V0.7260.97
271_M384_P0.7220.97
112_F115_E0.7210.97
110_R117_L0.7190.97
152_K156_E0.7190.97
242_V267_V0.7160.97
254_K304_L0.7140.96
29_H80_Y0.7130.96
285_L392_M0.7120.96
290_E319_A0.7120.96
223_K226_E0.7090.96
52_G65_A0.7070.96
142_K146_T0.7070.96
351_M377_S0.7070.96
172_L200_V0.7060.96
161_K166_P0.7050.96
271_M365_E0.7010.96
183_P187_E0.7010.96
294_Y354_F0.7000.96
59_D62_F0.6940.96
174_P202_I0.6930.96
40_S49_D0.6920.96
189_L243_V0.6910.96
192_I274_L0.6900.96
43_L349_K0.6880.96
221_L252_M0.6860.96
322_D357_S0.6860.96
248_T366_C0.6850.96
147_L157_R0.6840.96
215_S338_R0.6840.96
125_P129_V0.6820.95
182_F371_L0.6820.95
182_F386_Q0.6810.95
264_V273_Y0.6810.95
223_K227_Y0.6800.95
114_F117_L0.6790.95
87_N93_L0.6780.95
173_F228_N0.6780.95
267_V272_E0.6780.95
137_L140_I0.6760.95
294_Y359_A0.6750.95
184_E187_E0.6730.95
124_R134_N0.6720.95
46_T51_K0.6720.95
321_V324_S0.6720.95
152_K155_R0.6710.95
212_M217_D0.6700.95
220_R224_N0.6690.95
178_I245_P0.6650.95
295_Y307_G0.6640.95
95_E98_W0.6640.95
229_I233_E0.6630.95
123_A130_I0.6600.95
47_Y53_P0.6540.94
250_T267_V0.6540.94
278_K313_L0.6530.94
28_C34_C0.6530.94
275_L313_L0.6530.94
120_V124_R0.6480.94
146_T150_A0.6480.94
150_A183_P0.6460.94
248_T300_H0.6460.94
50_K53_P0.6430.94
204_N235_L0.6420.94
110_R113_I0.6410.94
355_K378_G0.6410.94
97_A101_Y0.6400.94
170_V241_D0.6390.94
91_P94_M0.6390.94
30_G41_F0.6350.93
288_K319_A0.6350.93
136_E140_I0.6350.93
218_V222_K0.6310.93
270_A273_Y0.6310.93
300_H367_P0.6290.93
110_R115_E0.6290.93
110_R114_F0.6290.93
171_A203_P0.6280.93
34_C38_C0.6270.93
162_R194_N0.6250.93
40_S366_C0.6230.93
353_A356_Q0.6210.93
93_L96_W0.6210.93
54_K58_L0.6190.92
58_L61_L0.6190.92
331_I372_Q0.6190.92
145_P150_A0.6160.92
173_F208_C0.6150.92
41_F51_K0.6140.92
299_C328_C0.6120.92
269_D277_L0.6110.92
141_H147_L0.6080.92
96_W100_Y0.6080.92
275_L309_P0.6060.92
24_Q27_V0.6050.92
294_Y321_V0.6030.91
117_L120_V0.6030.91
275_L316_S0.6010.91
341_D344_K0.5990.91
361_L390_E0.5960.91
242_V253_I0.5920.91
225_A260_L0.5900.91
351_M373_I0.5900.91
120_V123_A0.5890.91
142_K149_V0.5870.90
89_D94_M0.5860.90
273_Y276_K0.5840.90
150_A153_G0.5840.90
188_D192_I0.5800.90
335_W339_N0.5790.90
206_V231_I0.5780.90
283_I286_K0.5780.90
161_K199_E0.5780.90
298_P365_E0.5780.90
89_D93_L0.5780.90
283_I392_M0.5780.90
161_K164_D0.5770.90
175_T249_C0.5760.90
44_M49_D0.5760.90
154_L157_R0.5730.89
139_G147_L0.5730.89
36_N77_N0.5710.89
150_A155_R0.5690.89
151_E158_V0.5690.89
282_K285_L0.5680.89
125_P131_M0.5680.89
107_L111_D0.5670.89
41_F47_Y0.5670.89
278_K316_S0.5670.89
273_Y278_K0.5650.89
88_M94_M0.5650.89
75_Y92_S0.5650.89
373_I376_S0.5650.89
250_T269_D0.5640.89
88_M93_L0.5640.89
349_K352_E0.5630.88
137_L142_K0.5620.88
53_P366_C0.5610.88
141_H146_T0.5600.88
336_G368_L0.5570.88
41_F50_K0.5550.88
176_C246_I0.5540.88
221_L259_V0.5540.88
59_D63_N0.5530.88
61_L65_A0.5530.88
306_L310_G0.5520.88
121_K130_I0.5510.87
134_N138_L0.5500.87
246_I367_P0.5480.87
292_S380_R0.5470.87
35_F51_K0.5470.87
247_P303_F0.5460.87
315_R320_K0.5460.87
72_K91_P0.5450.87
141_H145_P0.5440.87
229_I260_L0.5440.87
35_F77_N0.5420.87
98_W101_Y0.5400.86
254_K306_L0.5400.86
121_K126_L0.5380.86
30_G50_K0.5360.86
265_P268_Y0.5360.86
170_V193_Y0.5350.86
201_I235_L0.5340.86
193_Y200_V0.5340.86
289_I317_M0.5340.86
202_I205_F0.5320.86
40_S52_G0.5320.86
279_N316_S0.5320.86
387_L390_E0.5310.85
351_M354_F0.5310.85
162_R166_P0.5310.85
160_P163_I0.5310.85
251_L255_E0.5310.85
41_F46_T0.5300.85
104_N111_D0.5300.85
135_K139_G0.5290.85
325_N353_A0.5260.85
373_I377_S0.5260.85
61_L64_V0.5250.85
147_L158_V0.5220.84
126_L132_E0.5220.84
43_L346_V0.5220.84
268_Y278_K0.5210.84
211_P246_I0.5210.84
168_A240_Y0.5210.84
230_K260_L0.5200.84
355_K359_A0.5170.84
246_I249_C0.5170.84
186_G190_V0.5160.84
102_K106_G0.5160.84
129_V134_N0.5150.84
291_K319_A0.5150.84
28_C38_C0.5150.84
21_F25_A0.5150.84
230_K263_E0.5150.84
357_S361_L0.5140.84
267_V270_A0.5120.83
80_Y88_M0.5100.83
289_I292_S0.5100.83
62_F105_R0.5060.83
92_S96_W0.5060.83
321_V384_P0.5050.82
210_A368_L0.5050.82
173_F253_I0.5050.82
270_A277_L0.5040.82
222_K261_D0.5030.82
301_L306_L0.5030.82
136_E141_H0.5020.82
126_L131_M0.5010.82
142_K150_A0.5010.82
211_P214_D0.5010.82
31_C34_C0.5000.82
295_Y365_E0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.8304 100 0.491 Contact Map
3cf4A 2 0.8532 100 0.573 Contact Map
3c8yA 1 0.8051 99.7 0.812 Contact Map
2h88B 1 0.2506 99.2 0.864 Contact Map
2wdqB 1 0.2532 99.2 0.864 Contact Map
1kf6B 1 0.2684 99.2 0.865 Contact Map
4ysxB 1 0.281 99.1 0.869 Contact Map
4p6vA 1 0.1924 99 0.872 Contact Map
2bs2B 1 0.2481 98.9 0.878 Contact Map
1hfeL 2 0.7468 98.5 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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