GREMLIN Database
Q97VH9 - Uncharacterized protein
UniProt: Q97VH9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 188 (180)
Sequences: 189 (153)
Seq/√Len: 11.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_L75_K4.6671.00
8_D48_R3.4830.98
41_L44_L3.4420.98
41_L91_L3.2480.97
48_R52_L3.2410.97
44_L91_L3.1700.96
138_F142_Q3.1310.96
74_I78_S3.0620.95
4_I67_N2.9590.95
6_L67_N2.6390.90
41_L160_V2.3840.85
8_D52_L2.3570.84
98_F102_D2.2170.80
101_L143_Y2.1360.78
29_V47_N2.0950.76
52_L67_N1.9620.71
121_N157_E1.9230.69
4_I8_D1.9010.69
154_T180_I1.8920.68
113_N133_D1.8840.68
34_R42_T1.6910.59
42_T74_I1.6640.58
10_L18_V1.6610.58
124_I152_K1.6450.57
16_E60_Y1.6340.56
41_L93_I1.6340.56
114_S125_Q1.6020.55
112_Y138_F1.5510.52
4_I52_L1.5240.51
116_F144_L1.5230.51
68_E164_K1.5120.50
104_V107_N1.5070.50
87_I117_L1.4800.49
8_D44_L1.4730.49
127_I147_D1.4670.48
86_K147_D1.4520.47
8_D89_A1.4370.47
132_R142_Q1.4310.46
7_Q21_D1.4160.46
10_L42_T1.4100.45
6_L70_I1.4100.45
7_Q68_E1.4000.45
172_D175_L1.3990.45
79_T112_Y1.3960.45
38_G73_E1.3580.43
23_I74_I1.3530.43
116_F159_H1.3410.42
3_K114_S1.3260.41
118_R123_L1.3170.41
113_N126_G1.3110.41
137_E143_Y1.3100.41
3_K28_E1.2880.40
78_S81_L1.2790.39
87_I158_V1.2730.39
7_Q113_N1.2700.39
44_L92_Y1.2080.36
64_K69_D1.2000.36
123_L129_E1.1990.36
7_Q177_E1.1930.35
83_C86_K1.1920.35
47_N111_I1.1900.35
8_D67_N1.1890.35
39_D167_Y1.1890.35
64_K76_I1.1810.35
76_I79_T1.1690.34
42_T117_L1.1530.33
60_Y78_S1.1520.33
162_H165_Y1.1470.33
51_V78_S1.1460.33
122_K155_D1.1360.33
86_K95_S1.1350.33
60_Y66_K1.1330.33
92_Y157_E1.1310.33
70_I108_L1.1270.32
132_R139_S1.1160.32
29_V83_C1.1110.32
35_I175_L1.1090.32
89_A146_F1.0760.30
29_V49_D1.0660.30
37_L167_Y1.0620.30
84_D112_Y1.0560.29
31_N117_L1.0470.29
36_E42_T1.0450.29
30_K118_R1.0340.29
130_G145_T1.0240.28
134_Q140_T1.0150.28
5_T175_L1.0060.27
38_G165_Y0.9990.27
120_G164_K0.9890.27
154_T161_I0.9850.27
117_L175_L0.9830.27
81_L91_L0.9630.26
163_E166_R0.9570.26
174_S177_E0.9550.25
70_I132_R0.9510.25
96_Y122_K0.9500.25
58_M73_E0.9470.25
109_K134_Q0.9450.25
113_N171_I0.9440.25
36_E74_I0.9440.25
4_I99_K0.9420.25
4_I55_I0.9320.25
93_I111_I0.9290.25
153_S156_M0.9210.24
101_L137_E0.9200.24
72_E76_I0.9100.24
88_K132_R0.9070.24
37_L132_R0.9070.24
65_E143_Y0.9070.24
13_R70_I0.8970.23
11_P14_T0.8930.23
129_E161_I0.8890.23
16_E66_K0.8810.23
61_L150_G0.8760.23
8_D34_R0.8720.23
9_I29_V0.8720.23
12_W130_G0.8710.22
45_F77_Y0.8700.22
119_V148_L0.8510.22
117_L159_H0.8500.22
26_I124_I0.8490.22
9_I95_S0.8470.22
156_M180_I0.8460.22
125_Q173_K0.8440.22
167_Y172_D0.8420.21
84_D143_Y0.8410.21
99_K102_D0.8400.21
67_N99_K0.8380.21
55_I67_N0.8340.21
144_L163_E0.8300.21
109_K136_R0.8230.21
97_D156_M0.8220.21
139_S159_H0.8150.21
109_K113_N0.8130.21
48_R171_I0.8120.21
40_R95_S0.8090.20
10_L35_I0.8050.20
7_Q171_I0.7980.20
22_R25_R0.7950.20
85_G157_E0.7860.20
35_I117_L0.7850.20
53_Q88_K0.7830.20
97_D103_W0.7800.20
39_D135_G0.7720.19
17_K67_N0.7670.19
27_I100_D0.7650.19
88_K145_T0.7610.19
97_D143_Y0.7600.19
17_K48_R0.7590.19
21_D25_R0.7520.19
8_D91_L0.7520.19
5_T71_L0.7500.19
107_N157_E0.7480.19
85_G153_S0.7460.18
56_Q141_V0.7440.18
95_S101_L0.7440.18
67_N72_E0.7360.18
28_E151_E0.7350.18
55_I94_H0.7350.18
5_T120_G0.7320.18
126_G129_E0.7310.18
8_D81_L0.7220.18
23_I78_S0.7210.18
144_L158_V0.7170.18
4_I17_K0.7100.17
115_V161_I0.7080.17
48_R67_N0.7050.17
171_I175_L0.7030.17
83_C88_K0.7010.17
32_K174_S0.7010.17
88_K92_Y0.7000.17
62_D105_Y0.6980.17
87_I182_E0.6940.17
3_K133_D0.6920.17
82_P108_L0.6920.17
79_T143_Y0.6880.17
168_S181_R0.6830.17
34_R173_K0.6810.17
115_V160_V0.6810.17
22_R48_R0.6810.17
39_D51_V0.6800.17
72_E92_Y0.6790.17
107_N120_G0.6790.17
18_V181_R0.6790.17
120_G150_G0.6740.16
73_E137_E0.6730.16
17_K126_G0.6730.16
86_K128_P0.6720.16
71_L81_L0.6710.16
10_L25_R0.6670.16
41_L92_Y0.6660.16
10_L17_K0.6550.16
96_Y111_I0.6540.16
84_D88_K0.6530.16
109_K133_D0.6500.16
91_L144_L0.6490.16
4_I48_R0.6470.16
11_P95_S0.6450.16
9_I47_N0.6440.16
100_D120_G0.6430.16
65_E145_T0.6380.16
37_L160_V0.6370.15
14_T55_I0.6360.15
21_D68_E0.6310.15
51_V74_I0.6290.15
9_I60_Y0.6270.15
44_L167_Y0.6270.15
93_I163_E0.6270.15
15_Y19_R0.6190.15
31_N169_T0.6190.15
18_V24_R0.6170.15
42_T72_E0.6170.15
97_D101_L0.6160.15
100_D130_G0.6150.15
21_D24_R0.6140.15
9_I65_E0.6140.15
39_D69_D0.6120.15
11_P172_D0.6120.15
14_T85_G0.6100.15
71_L173_K0.6090.15
114_S161_I0.6090.15
55_I85_G0.6080.15
171_I176_A0.6070.15
25_R28_E0.6020.15
101_L128_P0.6000.15
7_Q31_N0.5990.15
59_V137_E0.5970.14
160_V170_K0.5970.14
85_G150_G0.5970.14
84_D137_E0.5930.14
114_S181_R0.5920.14
113_N129_E0.5890.14
86_K145_T0.5880.14
30_K74_I0.5870.14
30_K104_V0.5860.14
51_V167_Y0.5860.14
65_E86_K0.5830.14
84_D128_P0.5730.14
62_D77_Y0.5700.14
34_R135_G0.5690.14
10_L26_I0.5640.14
87_I116_F0.5620.14
9_I56_Q0.5620.14
16_E145_T0.5620.14
13_R132_R0.5600.14
36_E135_G0.5570.14
6_L97_D0.5540.13
44_L160_V0.5500.13
85_G119_V0.5480.13
58_M162_H0.5440.13
17_K20_M0.5430.13
17_K93_I0.5410.13
34_R44_L0.5360.13
102_D154_T0.5340.13
160_V175_L0.5320.13
86_K138_F0.5320.13
31_N68_E0.5290.13
32_K55_I0.5270.13
43_L159_H0.5260.13
97_D155_D0.5260.13
153_S157_E0.5240.13
175_L181_R0.5180.13
144_L151_E0.5170.13
43_L60_Y0.5120.13
149_E178_D0.5100.13
58_M165_Y0.5090.12
21_D28_E0.5080.12
6_L13_R0.5060.12
13_R127_I0.5050.12
13_R86_K0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fjvA 2 0.9734 100 0.11 Contact Map
4a4zA 1 0.7819 8.1 0.968 Contact Map
2w4sA 2 0.1064 7.2 0.969 Contact Map
2a1vA 1 0.484 7 0.969 Contact Map
3ixqA 4 0.6968 5.9 0.97 Contact Map
2wvlA 2 0.4309 5.8 0.97 Contact Map
2fkiA 1 0.4468 5.3 0.97 Contact Map
3s6eA 1 0.5798 5 0.971 Contact Map
2lxiA 1 0.4415 5 0.971 Contact Map
4jifB 1 0.1011 4.9 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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