GREMLIN Database
Q97VH7 - Uncharacterized protein
UniProt: Q97VH7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 271 (240)
Sequences: 23535 (16474)
Seq/√Len: 1063.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_I219_G5.0791.00
17_L21_K3.9651.00
155_L216_A3.5531.00
165_I250_L3.2921.00
16_Y121_T3.0941.00
11_L110_G3.0851.00
12_Y117_L2.8041.00
15_L114_Y2.7581.00
19_G115_S2.7161.00
202_L206_Y2.6691.00
128_I149_I2.5961.00
13_S17_L2.5881.00
107_G110_G2.5721.00
63_N66_A2.5671.00
16_Y117_L2.4101.00
158_S244_D2.3971.00
157_L244_D2.3041.00
234_A238_I2.2391.00
92_E115_S2.1581.00
154_L241_T2.1391.00
205_R209_Y2.1301.00
21_K24_V2.0741.00
202_L205_R1.9871.00
165_I254_S1.9651.00
249_P253_F1.8961.00
235_P239_I1.8941.00
215_W236_F1.8441.00
165_I247_L1.8441.00
64_Y67_F1.8231.00
239_I242_I1.8101.00
12_Y110_G1.7901.00
24_V27_R1.7661.00
203_Y206_Y1.7621.00
12_Y16_Y1.7611.00
208_S214_T1.7451.00
147_S223_A1.7421.00
238_I242_I1.7031.00
172_V175_Q1.6841.00
158_S247_L1.6771.00
197_V208_S1.6571.00
161_G248_L1.6181.00
242_I246_V1.6141.00
161_G244_D1.6081.00
253_F257_H1.6071.00
218_E236_F1.5941.00
124_T153_V1.5931.00
133_V136_A1.5811.00
209_Y215_W1.5771.00
215_W239_I1.5521.00
243_F247_L1.5361.00
147_S233_I1.5061.00
206_Y210_G1.4741.00
155_L159_T1.4581.00
170_T179_I1.4491.00
12_Y113_L1.4491.00
235_P238_I1.4441.00
244_D248_L1.4081.00
239_I243_F1.4021.00
151_I237_I1.3991.00
246_V250_L1.3851.00
146_V150_V1.3721.00
206_Y209_Y1.3701.00
158_S240_L1.3701.00
154_L244_D1.3671.00
13_S16_Y1.3651.00
66_A69_T1.3311.00
229_P232_D1.3091.00
154_L237_I1.3071.00
147_S150_V1.2921.00
237_I241_T1.2861.00
166_A170_T1.2811.00
165_I251_G1.2781.00
168_A254_S1.2671.00
16_Y114_Y1.2601.00
151_I223_A1.2541.00
193_T217_L1.2491.00
187_T211_I1.2491.00
132_A135_F1.2411.00
169_V254_S1.2401.00
218_E222_E1.2281.00
209_Y214_T1.2251.00
21_K25_S1.2231.00
20_F24_V1.2211.00
12_Y114_Y1.2191.00
120_L153_V1.2091.00
211_I214_T1.2071.00
131_L148_A1.2061.00
114_Y118_W1.2011.00
18_R92_E1.2011.00
46_F49_T1.1961.00
109_F113_L1.1961.00
91_N94_L1.1841.00
152_I220_L1.1811.00
161_G247_L1.1681.00
246_V249_P1.1651.00
112_L251_G1.1591.00
42_F46_F1.1571.00
45_Y136_A1.1411.00
19_G22_V1.1401.00
214_T218_E1.1391.00
120_L157_L1.1371.00
218_E232_D1.1281.00
123_N156_I1.1251.00
171_M175_Q1.1141.00
14_F17_L1.0981.00
20_F118_W1.0981.00
112_L252_V1.0941.00
158_S243_F1.0711.00
222_E226_N1.0681.00
115_S119_G1.0671.00
250_L254_S1.0631.00
11_L107_G1.0611.00
152_I216_A1.0581.00
36_G40_P1.0541.00
197_V205_R1.0481.00
64_Y68_F1.0351.00
162_I247_L1.0311.00
197_V214_T1.0301.00
69_T72_L1.0231.00
16_Y118_W1.0201.00
16_Y20_F0.9991.00
70_I75_Q0.9881.00
156_I160_L0.9871.00
63_N67_F0.9841.00
232_D235_P0.9841.00
197_V209_Y0.9801.00
200_L205_R0.9771.00
45_Y137_L0.9771.00
163_G167_G0.9731.00
94_L173_T0.9681.00
67_F71_G0.9671.00
38_V133_V0.9661.00
203_Y207_I0.9641.00
146_V149_I0.9631.00
19_G118_W0.9591.00
241_T245_I0.9541.00
62_S66_A0.9511.00
182_F186_F0.9491.00
170_T175_Q0.9471.00
143_V146_V0.9371.00
116_A161_G0.9261.00
161_G251_G0.9231.00
61_V66_A0.9221.00
236_F240_L0.9201.00
150_V237_I0.9191.00
215_W218_E0.9161.00
181_F185_T0.9161.00
231_T235_P0.9151.00
230_I233_I0.9061.00
92_E97_T0.9061.00
241_T244_D0.9031.00
223_A233_I0.8891.00
40_P44_Y0.8861.00
90_R93_Q0.8851.00
150_V154_L0.8841.00
41_V45_Y0.8681.00
162_I183_F0.8641.00
250_L253_F0.8521.00
201_P205_R0.8501.00
116_A248_L0.8491.00
233_I236_F0.8461.00
74_F213_L0.8411.00
109_F252_V0.8401.00
164_M251_G0.8381.00
215_W219_G0.8361.00
142_N146_V0.8321.00
233_I237_I0.8311.00
236_F239_I0.8291.00
72_L76_G0.8271.00
90_R94_L0.8231.00
148_A220_L0.8211.00
20_F121_T0.8201.00
238_I241_T0.8191.00
31_V35_L0.8131.00
219_G236_F0.8121.00
217_L221_R0.8091.00
60_G64_Y0.8061.00
197_V200_L0.8061.00
145_I149_I0.8011.00
124_T128_I0.7971.00
245_I249_P0.7921.00
26_Y29_Q0.7921.00
38_V42_F0.7861.00
69_T134_G0.7821.00
177_N181_F0.7781.00
247_L251_G0.7771.00
42_F45_Y0.7761.00
205_R208_S0.7751.00
216_A240_L0.7681.00
27_R30_T0.7671.00
33_T37_W0.7601.00
144_N147_S0.7581.00
79_S83_S0.7541.00
240_L244_D0.7501.00
42_F133_V0.7461.00
131_L152_I0.7461.00
222_E228_A0.7461.00
106_T111_F0.7421.00
192_G196_P0.7421.00
249_P252_V0.7401.00
62_S65_T0.7381.00
71_G74_F0.7361.00
72_L75_Q0.7351.00
151_I216_A0.7311.00
110_G114_Y0.7311.00
129_I132_A0.7251.00
232_D236_F0.7241.00
41_V134_G0.7211.00
228_A232_D0.7201.00
97_T100_Y0.7191.00
127_A152_I0.7181.00
200_L208_S0.7181.00
215_W243_F0.7161.00
18_R22_V0.7121.00
132_A145_I0.7111.00
88_R94_L0.7031.00
44_Y48_G0.7011.00
222_E232_D0.7001.00
74_F216_A0.6981.00
69_T73_A0.6921.00
128_I132_A0.6921.00
184_N188_N0.6911.00
49_T136_A0.6841.00
149_I153_V0.6781.00
76_G80_S0.6761.00
88_R93_Q0.6751.00
67_F221_R0.6731.00
18_R100_Y0.6721.00
23_W33_T0.6681.00
253_F256_N0.6671.00
119_G123_N0.6651.00
93_Q171_M0.6591.00
221_R225_L0.6581.00
60_G63_N0.6571.00
116_A160_L0.6551.00
41_V130_I0.6511.00
62_S67_F0.6481.00
97_T101_Y0.6481.00
164_M168_A0.6411.00
248_L252_V0.6391.00
71_G221_R0.6391.00
234_A237_I0.6391.00
85_I119_G0.6391.00
252_V256_N0.6371.00
76_G79_S0.6351.00
100_Y104_S0.6351.00
90_R176_G0.6351.00
131_L145_I0.6341.00
80_S84_T0.6331.00
207_I211_I0.6331.00
67_F72_L0.6321.00
138_N141_Y0.6321.00
121_T125_I0.6311.00
231_T234_A0.6301.00
70_I74_F0.6301.00
175_Q178_P0.6261.00
127_A153_V0.6251.00
152_I156_I0.6241.00
187_T213_L0.6221.00
230_I235_P0.6221.00
12_Y109_F0.6211.00
89_L92_E0.6191.00
218_E228_A0.6181.00
174_K178_P0.6181.00
91_N95_Y0.6181.00
166_A180_S0.6161.00
181_F184_N0.6111.00
154_L240_L0.6111.00
244_D247_L0.6101.00
46_F136_A0.6101.00
67_F74_F0.6091.00
65_T68_F0.6071.00
35_L38_V0.6061.00
216_A219_G0.6021.00
73_A76_G0.6021.00
192_G197_V0.6021.00
190_L204_V0.6001.00
113_L117_L0.5991.00
183_F187_T0.5981.00
70_I73_A0.5971.00
168_A251_G0.5971.00
222_E236_F0.5961.00
64_Y69_T0.5961.00
243_F246_V0.5941.00
17_L20_F0.5931.00
74_F155_L0.5911.00
85_I163_G0.5901.00
61_V67_F0.5901.00
43_T47_T0.5891.00
65_T69_T0.5861.00
19_G119_G0.5851.00
183_F186_F0.5851.00
117_L121_T0.5841.00
141_Y145_I0.5821.00
254_S257_H0.5741.00
122_L126_N0.5741.00
67_F73_A0.5711.00
11_L14_F0.5701.00
15_L110_G0.5681.00
32_L36_G0.5681.00
74_F217_L0.5671.00
230_I234_A0.5671.00
128_I131_L0.5661.00
62_S70_I0.5661.00
235_P242_I0.5661.00
101_Y106_T0.5651.00
77_Y84_T0.5631.00
180_S184_N0.5631.00
119_G160_L0.5621.00
92_E111_F0.5611.00
147_S237_I0.5611.00
69_T74_F0.5601.00
88_R91_N0.5581.00
132_A136_A0.5561.00
148_A223_A0.5561.00
100_Y163_G0.5541.00
45_Y49_T0.5541.00
219_G233_I0.5531.00
157_L161_G0.5501.00
78_V159_T0.5481.00
64_Y70_I0.5471.00
43_T46_F0.5461.00
135_F141_Y0.5451.00
165_I169_V0.5371.00
37_W40_P0.5351.00
178_P181_F0.5351.00
120_L123_N0.5341.00
83_S86_S0.5341.00
147_S151_I0.5331.00
196_P200_L0.5321.00
82_I85_I0.5291.00
167_G176_G0.5291.00
89_L94_L0.5281.00
100_Y106_T0.5271.00
96_G99_E0.5261.00
23_W29_Q0.5241.00
210_G215_W0.5231.00
204_V207_I0.5221.00
195_F199_V0.5201.00
102_V108_T0.5171.00
245_I248_L0.5161.00
74_F77_Y0.5151.00
190_L211_I0.5151.00
164_M167_G0.5141.00
166_A183_F0.5141.00
101_Y104_S0.5121.00
222_E233_I0.5111.00
75_Q81_V0.5111.00
98_I111_F0.5101.00
218_E221_R0.5101.00
211_I215_W0.5101.00
185_T188_N0.5071.00
166_A169_V0.5071.00
81_V159_T0.5061.00
153_V157_L0.5051.00
66_A71_G0.5051.00
162_I165_I0.5051.00
120_L160_L0.5031.00
212_P216_A0.5011.00
97_T111_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.1513 49.2 0.913 Contact Map
2k1eA 3 0.3653 17.4 0.931 Contact Map
2ks1B 1 0.1624 16.2 0.932 Contact Map
2kluA 1 0.1624 14.5 0.934 Contact Map
2l2tA 2 0.1587 10.6 0.938 Contact Map
4cadC 1 0.738 10.5 0.938 Contact Map
3effK 4 0.3801 9.8 0.938 Contact Map
4wfeA 2 0.6827 9.3 0.939 Contact Map
2jwaA 2 0.1513 8.2 0.941 Contact Map
3wdoA 1 0.797 8 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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