GREMLIN Database
Q97VH6 - ABC transporter, ATP binding protein
UniProt: Q97VH6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 309 (239)
Sequences: 83698 (50467)
Seq/√Len: 3264.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_S205_K3.6561.00
3_K27_E3.0411.00
79_S157_P3.0191.00
19_K22_D3.0081.00
34_G207_I2.9571.00
6_D23_D2.8571.00
205_K217_E2.8261.00
5_I61_D2.7901.00
35_A203_A2.7511.00
10_T19_K2.6991.00
61_D68_S2.6941.00
29_E32_S2.5301.00
3_K63_L2.4941.00
8_S59_S2.4151.00
9_K50_M2.4081.00
219_N222_N2.3531.00
8_S19_K2.3231.00
65_N157_P2.2841.00
218_G222_N2.2471.00
5_I63_L2.2071.00
130_W133_I2.1321.00
22_D213_K2.1301.00
207_I217_E2.1251.00
207_I214_A2.1201.00
8_S23_D2.0711.00
110_S113_D2.0281.00
94_L98_E1.9751.00
4_T7_I1.9031.00
30_R157_P1.7971.00
97_L101_I1.7301.00
11_F46_T1.7151.00
48_I192_T1.7091.00
117_R155_D1.6941.00
48_I160_L1.6501.00
200_E221_D1.6311.00
117_R120_E1.6081.00
119_K127_L1.5961.00
181_R201_E1.5821.00
218_G223_L1.5781.00
133_I137_K1.5771.00
97_L132_N1.5761.00
120_E124_I1.5741.00
11_F20_A1.5501.00
155_D187_K1.5341.00
115_R119_K1.5271.00
6_D25_S1.5261.00
65_N79_S1.5261.00
9_K55_I1.5261.00
26_F207_I1.4971.00
101_I114_A1.4671.00
119_K123_E1.4511.00
68_S71_K1.4421.00
10_T17_E1.4351.00
193_S199_I1.4241.00
8_S22_D1.4171.00
96_A138_F1.4091.00
9_K58_S1.3881.00
7_I57_P1.3771.00
4_T26_F1.3691.00
101_I118_A1.3671.00
121_V153_I1.3641.00
10_T58_S1.3511.00
32_S204_E1.3421.00
63_L68_S1.3351.00
35_A199_I1.3321.00
28_I34_G1.3291.00
161_L189_I1.3241.00
230_V233_V1.3171.00
183_I187_K1.3151.00
34_G217_E1.3151.00
95_T98_E1.3151.00
123_E128_S1.3121.00
222_N226_Y1.3041.00
24_V47_I1.3001.00
26_F47_I1.2931.00
210_K215_I1.2701.00
229_K232_E1.2681.00
4_T51_L1.2611.00
215_I229_K1.2601.00
33_T184_G1.2601.00
34_G205_K1.2461.00
128_S131_G1.2361.00
29_E205_K1.2341.00
53_T56_I1.2001.00
52_S82_L1.1671.00
100_L122_L1.1581.00
97_L115_R1.1561.00
230_V234_E1.1491.00
112_S116_K1.1491.00
101_I115_R1.1491.00
5_I27_E1.1391.00
30_R65_N1.1351.00
184_G189_I1.1351.00
33_T189_I1.1251.00
105_S114_A1.1231.00
33_T203_A1.1141.00
110_S114_A1.1081.00
113_D116_K1.1011.00
116_K120_E1.0951.00
95_T132_N1.0951.00
216_A226_Y1.0911.00
67_Y72_E1.0861.00
231_I235_V1.0831.00
227_L231_I1.0801.00
50_M57_P1.0751.00
36_L47_I1.0721.00
111_L115_R1.0711.00
177_R198_D1.0661.00
98_E101_I1.0651.00
109_L113_D1.0651.00
120_E123_E1.0561.00
131_G138_F1.0391.00
5_I25_S1.0341.00
21_V50_M1.0301.00
119_K131_G1.0241.00
221_D225_N1.0241.00
174_R178_D1.0221.00
99_N150_R1.0211.00
49_K55_I1.0111.00
97_L118_A1.0081.00
206_I220_K1.0001.00
36_L190_L0.9981.00
100_L153_I0.9861.00
181_R184_G0.9801.00
4_T47_I0.9781.00
222_N225_N0.9771.00
51_L190_L0.9721.00
138_F146_L0.9701.00
122_L131_G0.9671.00
216_A227_L0.9651.00
179_L182_R0.9521.00
33_T191_L0.9501.00
173_A195_Y0.9491.00
93_R136_M0.9441.00
111_L114_A0.9431.00
83_V161_L0.9381.00
104_A153_I0.9331.00
159_L187_K0.9321.00
47_I209_L0.9291.00
117_R121_V0.9271.00
81_G156_P0.9231.00
104_A108_N0.9171.00
95_T134_P0.9161.00
55_I58_S0.9151.00
168_L176_F0.9141.00
161_L180_V0.9141.00
36_L207_I0.9121.00
233_V237_E0.9121.00
39_P210_K0.9071.00
125_V149_A0.8941.00
113_D117_R0.8921.00
30_R186_D0.8901.00
107_Q154_T0.8901.00
173_A198_D0.8871.00
126_G175_M0.8841.00
83_V148_L0.8811.00
33_T181_R0.8811.00
118_A121_V0.8801.00
2_I158_V0.8791.00
180_V189_I0.8751.00
85_V140_T0.8741.00
114_A118_A0.8691.00
6_D59_S0.8691.00
121_V149_A0.8681.00
96_A146_L0.8651.00
81_G151_A0.8631.00
101_I105_S0.8611.00
109_L114_A0.8561.00
94_L102_F0.8551.00
9_K46_T0.8481.00
68_S72_E0.8461.00
210_K234_E0.8451.00
49_K54_L0.8441.00
124_I182_R0.8431.00
184_G204_E0.8421.00
159_L189_I0.8401.00
88_R143_Q0.8351.00
163_E194_H0.8331.00
75_K78_E0.8301.00
10_T22_D0.8271.00
135_Y146_L0.8261.00
4_T62_A0.8241.00
52_S160_L0.8241.00
97_L119_K0.8231.00
67_Y79_S0.8171.00
134_P137_K0.8061.00
178_D181_R0.8051.00
220_K230_V0.8041.00
121_V124_I0.8021.00
7_I50_M0.7941.00
115_R118_A0.7921.00
21_V24_V0.7901.00
33_T202_L0.7891.00
191_L203_A0.7871.00
50_M55_I0.7861.00
121_V125_V0.7851.00
37_V199_I0.7841.00
29_E188_T0.7791.00
216_A228_G0.7741.00
126_G182_R0.7731.00
56_I70_T0.7701.00
28_I188_T0.7621.00
177_R201_E0.7611.00
2_I51_L0.7611.00
23_D213_K0.7611.00
76_V80_I0.7601.00
97_L131_G0.7601.00
50_M62_A0.7581.00
28_I190_L0.7551.00
42_A209_L0.7551.00
104_A114_A0.7501.00
241_T244_K0.7481.00
10_T20_A0.7461.00
223_L232_E0.7421.00
57_P70_T0.7391.00
24_V214_A0.7371.00
94_L99_N0.7371.00
181_R202_L0.7361.00
220_K224_K0.7351.00
216_A223_L0.7281.00
104_A107_Q0.7281.00
83_V151_A0.7221.00
61_D70_T0.7211.00
232_E236_N0.7201.00
214_A217_E0.7161.00
23_D59_S0.7151.00
63_L66_G0.7071.00
116_K119_K0.7051.00
21_V47_I0.7041.00
158_V188_T0.7021.00
119_K129_E0.7001.00
208_L223_L0.7001.00
234_E237_E0.6941.00
28_I158_V0.6941.00
6_D9_K0.6911.00
210_K213_K0.6901.00
95_T99_N0.6891.00
123_E129_E0.6881.00
165_T176_F0.6871.00
160_L190_L0.6861.00
138_F142_M0.6851.00
20_A46_T0.6821.00
103_F150_R0.6811.00
157_P187_K0.6801.00
72_E75_K0.6771.00
34_G190_L0.6751.00
203_A206_I0.6731.00
37_V208_L0.6721.00
198_D202_L0.6711.00
100_L118_A0.6691.00
75_K79_S0.6691.00
99_N135_Y0.6681.00
9_K21_V0.6671.00
175_M178_D0.6661.00
80_I158_V0.6651.00
196_M224_K0.6641.00
104_A109_L0.6641.00
114_A119_K0.6621.00
103_F154_T0.6621.00
210_K229_K0.6611.00
234_E238_Y0.6561.00
181_R185_R0.6541.00
103_F106_L0.6491.00
110_S119_K0.6481.00
200_E224_K0.6471.00
178_D182_R0.6441.00
105_S111_L0.6431.00
121_V152_L0.6361.00
87_E147_A0.6351.00
10_T59_S0.6341.00
113_D122_L0.6321.00
222_N228_G0.6311.00
115_R132_N0.6281.00
200_E220_K0.6271.00
37_V196_M0.6271.00
127_L131_G0.6231.00
140_T145_K0.6211.00
113_D127_L0.6211.00
178_D201_E0.6191.00
19_K23_D0.6171.00
81_G154_T0.6161.00
165_T198_D0.6131.00
109_L117_R0.6131.00
64_V79_S0.6111.00
126_G129_E0.6081.00
50_M58_S0.6041.00
224_K227_L0.6031.00
229_K233_V0.6021.00
191_L202_L0.6021.00
27_E217_E0.6001.00
203_A220_K0.5981.00
89_L143_Q0.5971.00
67_Y75_K0.5971.00
230_V235_V0.5941.00
52_S80_I0.5931.00
122_L127_L0.5901.00
172_S175_M0.5861.00
53_T70_T0.5851.00
51_L62_A0.5821.00
238_Y241_T0.5771.00
53_T57_P0.5761.00
180_V191_L0.5751.00
45_T49_K0.5741.00
15_N18_I0.5741.00
193_S198_D0.5721.00
64_V158_V0.5691.00
64_V76_V0.5681.00
231_I234_E0.5671.00
61_D71_K0.5661.00
2_I64_V0.5641.00
33_T204_E0.5641.00
10_T18_I0.5621.00
72_E76_V0.5621.00
102_F106_L0.5611.00
49_K82_L0.5601.00
139_S142_M0.5571.00
199_I203_A0.5561.00
90_F143_Q0.5541.00
32_S217_E0.5541.00
19_K59_S0.5521.00
120_E155_D0.5511.00
31_N188_T0.5511.00
232_E235_V0.5491.00
69_I76_V0.5471.00
103_F107_Q0.5461.00
205_K219_N0.5451.00
152_L187_K0.5451.00
97_L100_L0.5431.00
11_F55_I0.5421.00
18_I211_K0.5391.00
227_L230_V0.5371.00
184_G187_K0.5361.00
40_N163_E0.5341.00
86_S89_L0.5321.00
158_V190_L0.5311.00
116_K123_E0.5291.00
40_N172_S0.5291.00
92_Y143_Q0.5281.00
83_V147_A0.5271.00
238_Y242_L0.5251.00
208_L227_L0.5231.00
10_T16_K0.5191.00
218_G224_K0.5191.00
65_N158_V0.5171.00
74_K77_R0.5161.00
226_Y229_K0.5151.00
3_K66_G0.5131.00
97_L128_S0.5121.00
84_T87_E0.5091.00
112_S115_R0.5081.00
22_D211_K0.5051.00
199_I206_I0.5051.00
227_L232_E0.5041.00
100_L113_D0.5041.00
54_L84_T0.5041.00
96_A100_L0.5031.00
199_I220_K0.5001.00
195_Y198_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yerA 2 0.8803 100 0.178 Contact Map
3tuiC 2 0.9935 100 0.198 Contact Map
1vplA 2 0.7605 100 0.214 Contact Map
4rvcA 4 0.7702 100 0.215 Contact Map
4u00A 1 0.7638 100 0.217 Contact Map
2yyzA 1 0.9644 100 0.218 Contact Map
4ymuJ 2 0.7605 100 0.219 Contact Map
4mkiB 2 0.8835 100 0.22 Contact Map
1v43A 2 0.8576 100 0.22 Contact Map
1z47A 2 0.9838 100 0.221 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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