Q97VH3 - SULSO - GREMLIN Contacts

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Q97VH3 - Transcriptional regulatory protein (Lrp/AsnC family)

UniProt:	Q97VH3	Sequences: MEKLTDLEFRALEILREDSRISVTELSKRLNISRSTATRLLRNLKRRGVKFTIKFQNEPFIAFAISESCQSDECYKLLDGRFINMIRANTLEDLENKLKNVKEKDLVFIGKSSFVVKCDYCGKEIYDNPLTYKVGRKTYYACCNSCLSGLKEKFARNNGLHLH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	163 (154)
Sequences:	122 (90)
Seq/√Len:	7.3

HALSA - Q9HQG1
SULSO - Q97VH3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
11_A	26_L	4.232	0.97
8_E	40_L	3.050	0.86
18_D	45_K	2.849	0.81
5_T	40_L	2.820	0.81
5_T	8_E	2.717	0.78
31_N	97_K	2.628	0.75
130_L	147_L	2.560	0.73
32_I	36_T	2.555	0.73
50_K	112_S	2.532	0.73
81_R	87_R	2.350	0.67
55_F	61_I	2.340	0.66
8_E	11_A	2.229	0.62
54_K	133_K	2.225	0.62
11_A	40_L	2.102	0.57
136_R	144_N	2.057	0.56
139_Y	150_L	2.016	0.54
64_A	88_A	2.014	0.54
5_T	11_A	1.936	0.51
141_A	150_L	1.918	0.50
56_Q	64_A	1.880	0.49
27_S	95_E	1.855	0.48
133_K	138_T	1.832	0.47
9_F	114_F	1.829	0.47
5_T	35_S	1.808	0.46
128_N	150_L	1.689	0.41
51_F	79_D	1.675	0.41
42_R	94_L	1.626	0.39
41_L	66_S	1.588	0.38
18_D	120_Y	1.483	0.34
139_Y	143_C	1.442	0.32
59_P	77_L	1.434	0.32
45_K	50_K	1.427	0.32
33_S	139_Y	1.402	0.31
39_R	59_P	1.398	0.31
28_K	137_K	1.375	0.30
25_E	34_R	1.374	0.30
93_D	147_L	1.350	0.29
35_S	56_Q	1.334	0.29
7_L	21_I	1.326	0.29
28_K	38_T	1.319	0.28
63_F	88_A	1.313	0.28
8_E	150_L	1.308	0.28
51_F	135_G	1.281	0.27
38_T	64_A	1.266	0.27
142_C	146_C	1.250	0.26
148_S	152_E	1.236	0.26
130_L	139_Y	1.220	0.25
42_R	96_N	1.220	0.25
148_S	155_A	1.214	0.25
92_E	107_V	1.207	0.25
20_R	122_G	1.203	0.25
121_C	146_C	1.191	0.25
79_D	131_T	1.181	0.24
120_Y	150_L	1.168	0.24
24_T	41_L	1.148	0.23
37_A	52_T	1.148	0.23
8_E	35_S	1.138	0.23
110_G	116_V	1.132	0.23
24_T	53_I	1.106	0.22
18_D	131_T	1.105	0.22
50_K	91_L	1.105	0.22
118_C	146_C	1.103	0.22
71_S	103_E	1.096	0.22
85_M	117_K	1.095	0.22
75_Y	140_Y	1.086	0.22
83_I	103_E	1.079	0.21
121_C	142_C	1.075	0.21
22_S	152_E	1.072	0.21
49_V	58_E	1.069	0.21
132_Y	151_K	1.060	0.21
145_S	149_G	1.055	0.21
94_L	116_V	1.045	0.21
19_S	91_L	1.040	0.20
67_E	102_K	1.039	0.20
118_C	121_C	1.039	0.20
47_R	83_I	1.032	0.20
19_S	30_L	1.019	0.20
18_D	126_Y	1.014	0.20
143_C	146_C	1.005	0.20
123_K	143_C	0.996	0.19
25_E	60_F	0.995	0.19
64_A	155_A	0.992	0.19
112_S	119_D	0.984	0.19
128_N	139_Y	0.984	0.19
125_I	129_P	0.980	0.19
118_C	142_C	0.959	0.18
76_K	87_R	0.955	0.18
16_R	95_E	0.951	0.18
14_I	108_F	0.942	0.18
132_Y	141_A	0.941	0.18
140_Y	153_K	0.938	0.18
102_K	135_G	0.931	0.18
9_F	93_D	0.930	0.18
18_D	64_A	0.926	0.18
87_R	105_D	0.920	0.18
80_G	116_V	0.913	0.17
64_A	82_F	0.910	0.17
62_A	126_Y	0.905	0.17
26_L	37_A	0.905	0.17
138_T	151_K	0.902	0.17
8_E	77_L	0.898	0.17
17_E	88_A	0.897	0.17
19_S	22_S	0.888	0.17
9_F	71_S	0.886	0.17
43_N	79_D	0.866	0.16
94_L	110_G	0.857	0.16
32_I	154_F	0.854	0.16
49_V	156_R	0.853	0.16
77_L	140_Y	0.853	0.16
12_L	41_L	0.844	0.16
49_V	65_I	0.844	0.16
97_K	101_V	0.837	0.16
9_F	13_E	0.833	0.16
74_C	136_R	0.832	0.16
60_F	149_G	0.832	0.16
42_R	131_T	0.817	0.15
31_N	71_S	0.812	0.15
32_I	78_L	0.812	0.15
42_R	106_L	0.811	0.15
63_F	85_M	0.803	0.15
76_K	156_R	0.800	0.15
40_L	43_N	0.797	0.15
88_A	102_K	0.796	0.15
23_V	38_T	0.789	0.15
13_E	131_T	0.789	0.15
12_L	94_L	0.787	0.15
63_F	96_N	0.785	0.15
135_G	139_Y	0.779	0.15
137_K	141_A	0.760	0.14
5_T	43_N	0.758	0.14
131_T	140_Y	0.755	0.14
84_N	92_E	0.755	0.14
62_A	86_I	0.754	0.14
47_R	66_S	0.748	0.14
20_R	27_S	0.743	0.14
25_E	96_N	0.738	0.14
41_L	125_I	0.737	0.14
35_S	51_F	0.737	0.14
140_Y	150_L	0.734	0.14
26_L	38_T	0.725	0.14
25_E	42_R	0.712	0.13
33_S	53_I	0.710	0.13
24_T	141_A	0.708	0.13
35_S	40_L	0.701	0.13
19_S	106_L	0.700	0.13
11_A	41_L	0.699	0.13
65_I	76_K	0.696	0.13
131_T	138_T	0.693	0.13
18_D	143_C	0.691	0.13
45_K	51_F	0.689	0.13
113_S	152_E	0.688	0.13
124_E	140_Y	0.684	0.13
26_L	107_V	0.682	0.13
81_R	134_V	0.673	0.13
95_E	99_K	0.673	0.13
6_D	46_R	0.671	0.13
120_Y	153_K	0.670	0.13
126_Y	155_A	0.664	0.12
36_T	123_K	0.657	0.12
144_N	153_K	0.656	0.12
58_E	74_C	0.656	0.12
6_D	105_D	0.655	0.12
22_S	74_C	0.654	0.12
67_E	137_K	0.652	0.12
91_L	115_V	0.651	0.12
120_Y	123_K	0.646	0.12
17_E	147_L	0.645	0.12
27_S	122_G	0.641	0.12
98_L	108_F	0.637	0.12
147_L	156_R	0.637	0.12
133_K	139_Y	0.634	0.12
75_Y	153_K	0.632	0.12
55_F	93_D	0.631	0.12
39_R	135_G	0.629	0.12
25_E	48_G	0.629	0.12
25_E	99_K	0.629	0.12
51_F	136_R	0.627	0.12
63_F	156_R	0.624	0.12
32_I	61_I	0.622	0.12
4_L	91_L	0.619	0.12
3_K	68_S	0.618	0.12
65_I	96_N	0.618	0.12
133_K	147_L	0.617	0.12
12_L	61_I	0.614	0.12
30_L	56_Q	0.610	0.12
52_T	118_C	0.609	0.12
79_D	117_K	0.605	0.12
21_I	73_E	0.604	0.11
60_F	112_S	0.602	0.11
99_K	135_G	0.602	0.11
16_R	88_A	0.599	0.11
26_L	54_K	0.599	0.11
66_S	101_V	0.595	0.11
60_F	124_E	0.594	0.11
53_I	104_K	0.592	0.11
19_S	86_I	0.591	0.11
6_D	125_I	0.589	0.11
28_K	104_K	0.587	0.11
97_K	102_K	0.584	0.11
5_T	56_Q	0.582	0.11
72_D	92_E	0.581	0.11
53_I	58_E	0.581	0.11
131_T	153_K	0.571	0.11
112_S	147_L	0.570	0.11
88_A	137_K	0.569	0.11
45_K	72_D	0.562	0.11
50_K	55_F	0.562	0.11
12_L	36_T	0.557	0.11
16_R	63_F	0.557	0.11
20_R	33_S	0.556	0.11
21_I	26_L	0.554	0.11
69_C	133_K	0.553	0.11
14_I	21_I	0.553	0.11
22_S	81_R	0.548	0.11
94_L	134_V	0.548	0.11
87_R	111_K	0.545	0.11
76_K	147_L	0.541	0.11
46_R	143_C	0.540	0.11
18_D	127_D	0.535	0.10
69_C	127_D	0.533	0.10
4_L	21_I	0.521	0.10
27_S	153_K	0.519	0.10
69_C	106_L	0.515	0.10
36_T	94_L	0.514	0.10
53_I	67_E	0.511	0.10
81_R	136_R	0.511	0.10
79_D	153_K	0.510	0.10
64_A	104_K	0.507	0.10
21_I	115_V	0.505	0.10
78_L	125_I	0.500	0.10
73_E	91_L	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ch7A	1	0.8405	99.7	0.697	Contact Map
4un1B	1	0.7791	99.7	0.704	Contact Map
4un1A	1	0.7423	99.7	0.713	Contact Map
2ia0A	2	0.7791	99.7	0.717	Contact Map
2e1cA	1	0.7669	99.7	0.72	Contact Map
2p5vA	5	0.8037	99.6	0.728	Contact Map
2dbbA	4	0.7546	99.6	0.732	Contact Map
4pcqA	2	0.7607	99.6	0.732	Contact Map
3i4pA	5	0.773	99.6	0.737	Contact Map
2cg4A	6	0.7669	99.5	0.741	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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