GREMLIN Database
Q97VH3 - Transcriptional regulatory protein (Lrp/AsnC family)
UniProt: Q97VH3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 163 (154)
Sequences: 122 (90)
Seq/√Len: 7.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_A26_L4.2320.97
8_E40_L3.0500.86
18_D45_K2.8490.81
5_T40_L2.8200.81
5_T8_E2.7170.78
31_N97_K2.6280.75
130_L147_L2.5600.73
32_I36_T2.5550.73
50_K112_S2.5320.73
81_R87_R2.3500.67
55_F61_I2.3400.66
8_E11_A2.2290.62
54_K133_K2.2250.62
11_A40_L2.1020.57
136_R144_N2.0570.56
139_Y150_L2.0160.54
64_A88_A2.0140.54
5_T11_A1.9360.51
141_A150_L1.9180.50
56_Q64_A1.8800.49
27_S95_E1.8550.48
133_K138_T1.8320.47
9_F114_F1.8290.47
5_T35_S1.8080.46
128_N150_L1.6890.41
51_F79_D1.6750.41
42_R94_L1.6260.39
41_L66_S1.5880.38
18_D120_Y1.4830.34
139_Y143_C1.4420.32
59_P77_L1.4340.32
45_K50_K1.4270.32
33_S139_Y1.4020.31
39_R59_P1.3980.31
28_K137_K1.3750.30
25_E34_R1.3740.30
93_D147_L1.3500.29
35_S56_Q1.3340.29
7_L21_I1.3260.29
28_K38_T1.3190.28
63_F88_A1.3130.28
8_E150_L1.3080.28
51_F135_G1.2810.27
38_T64_A1.2660.27
142_C146_C1.2500.26
148_S152_E1.2360.26
130_L139_Y1.2200.25
42_R96_N1.2200.25
148_S155_A1.2140.25
92_E107_V1.2070.25
20_R122_G1.2030.25
121_C146_C1.1910.25
79_D131_T1.1810.24
120_Y150_L1.1680.24
24_T41_L1.1480.23
37_A52_T1.1480.23
8_E35_S1.1380.23
110_G116_V1.1320.23
24_T53_I1.1060.22
18_D131_T1.1050.22
50_K91_L1.1050.22
118_C146_C1.1030.22
71_S103_E1.0960.22
85_M117_K1.0950.22
75_Y140_Y1.0860.22
83_I103_E1.0790.21
121_C142_C1.0750.21
22_S152_E1.0720.21
49_V58_E1.0690.21
132_Y151_K1.0600.21
145_S149_G1.0550.21
94_L116_V1.0450.21
19_S91_L1.0400.20
67_E102_K1.0390.20
118_C121_C1.0390.20
47_R83_I1.0320.20
19_S30_L1.0190.20
18_D126_Y1.0140.20
143_C146_C1.0050.20
123_K143_C0.9960.19
25_E60_F0.9950.19
64_A155_A0.9920.19
112_S119_D0.9840.19
128_N139_Y0.9840.19
125_I129_P0.9800.19
118_C142_C0.9590.18
76_K87_R0.9550.18
16_R95_E0.9510.18
14_I108_F0.9420.18
132_Y141_A0.9410.18
140_Y153_K0.9380.18
102_K135_G0.9310.18
9_F93_D0.9300.18
18_D64_A0.9260.18
87_R105_D0.9200.18
80_G116_V0.9130.17
64_A82_F0.9100.17
62_A126_Y0.9050.17
26_L37_A0.9050.17
138_T151_K0.9020.17
8_E77_L0.8980.17
17_E88_A0.8970.17
19_S22_S0.8880.17
9_F71_S0.8860.17
43_N79_D0.8660.16
94_L110_G0.8570.16
32_I154_F0.8540.16
49_V156_R0.8530.16
77_L140_Y0.8530.16
12_L41_L0.8440.16
49_V65_I0.8440.16
97_K101_V0.8370.16
9_F13_E0.8330.16
74_C136_R0.8320.16
60_F149_G0.8320.16
42_R131_T0.8170.15
31_N71_S0.8120.15
32_I78_L0.8120.15
42_R106_L0.8110.15
63_F85_M0.8030.15
76_K156_R0.8000.15
40_L43_N0.7970.15
88_A102_K0.7960.15
23_V38_T0.7890.15
13_E131_T0.7890.15
12_L94_L0.7870.15
63_F96_N0.7850.15
135_G139_Y0.7790.15
137_K141_A0.7600.14
5_T43_N0.7580.14
131_T140_Y0.7550.14
84_N92_E0.7550.14
62_A86_I0.7540.14
47_R66_S0.7480.14
20_R27_S0.7430.14
25_E96_N0.7380.14
41_L125_I0.7370.14
35_S51_F0.7370.14
140_Y150_L0.7340.14
26_L38_T0.7250.14
25_E42_R0.7120.13
33_S53_I0.7100.13
24_T141_A0.7080.13
35_S40_L0.7010.13
19_S106_L0.7000.13
11_A41_L0.6990.13
65_I76_K0.6960.13
131_T138_T0.6930.13
18_D143_C0.6910.13
45_K51_F0.6890.13
113_S152_E0.6880.13
124_E140_Y0.6840.13
26_L107_V0.6820.13
81_R134_V0.6730.13
95_E99_K0.6730.13
6_D46_R0.6710.13
120_Y153_K0.6700.13
126_Y155_A0.6640.12
36_T123_K0.6570.12
144_N153_K0.6560.12
58_E74_C0.6560.12
6_D105_D0.6550.12
22_S74_C0.6540.12
67_E137_K0.6520.12
91_L115_V0.6510.12
120_Y123_K0.6460.12
17_E147_L0.6450.12
27_S122_G0.6410.12
98_L108_F0.6370.12
147_L156_R0.6370.12
133_K139_Y0.6340.12
75_Y153_K0.6320.12
55_F93_D0.6310.12
39_R135_G0.6290.12
25_E48_G0.6290.12
25_E99_K0.6290.12
51_F136_R0.6270.12
63_F156_R0.6240.12
32_I61_I0.6220.12
4_L91_L0.6190.12
3_K68_S0.6180.12
65_I96_N0.6180.12
133_K147_L0.6170.12
12_L61_I0.6140.12
30_L56_Q0.6100.12
52_T118_C0.6090.12
79_D117_K0.6050.12
21_I73_E0.6040.11
60_F112_S0.6020.11
99_K135_G0.6020.11
16_R88_A0.5990.11
26_L54_K0.5990.11
66_S101_V0.5950.11
60_F124_E0.5940.11
53_I104_K0.5920.11
19_S86_I0.5910.11
6_D125_I0.5890.11
28_K104_K0.5870.11
97_K102_K0.5840.11
5_T56_Q0.5820.11
72_D92_E0.5810.11
53_I58_E0.5810.11
131_T153_K0.5710.11
112_S147_L0.5700.11
88_A137_K0.5690.11
45_K72_D0.5620.11
50_K55_F0.5620.11
12_L36_T0.5570.11
16_R63_F0.5570.11
20_R33_S0.5560.11
21_I26_L0.5540.11
69_C133_K0.5530.11
14_I21_I0.5530.11
22_S81_R0.5480.11
94_L134_V0.5480.11
87_R111_K0.5450.11
76_K147_L0.5410.11
46_R143_C0.5400.11
18_D127_D0.5350.10
69_C127_D0.5330.10
4_L21_I0.5210.10
27_S153_K0.5190.10
69_C106_L0.5150.10
36_T94_L0.5140.10
53_I67_E0.5110.10
81_R136_R0.5110.10
79_D153_K0.5100.10
64_A104_K0.5070.10
21_I115_V0.5050.10
78_L125_I0.5000.10
73_E91_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.8405 99.7 0.697 Contact Map
4un1B 1 0.7791 99.7 0.704 Contact Map
4un1A 1 0.7423 99.7 0.713 Contact Map
2ia0A 2 0.7791 99.7 0.717 Contact Map
2e1cA 1 0.7669 99.7 0.72 Contact Map
2p5vA 5 0.8037 99.6 0.728 Contact Map
2dbbA 4 0.7546 99.6 0.732 Contact Map
4pcqA 2 0.7607 99.6 0.732 Contact Map
3i4pA 5 0.773 99.6 0.737 Contact Map
2cg4A 6 0.7669 99.5 0.741 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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