GREMLIN Database
Q97VH2 - Uncharacterized protein
UniProt: Q97VH2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 219 (181)
Sequences: 5873 (4505)
Seq/√Len: 334.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_S178_W4.4311.00
94_G131_L3.9091.00
138_V185_A3.8701.00
102_A123_Y3.3201.00
90_A135_V2.9991.00
103_Q172_L2.9041.00
142_L189_T2.9011.00
89_I184_I2.5491.00
97_S101_M2.4791.00
125_Y176_V2.4081.00
31_N103_Q2.3771.00
130_A160_S2.3741.00
47_N165_Y2.3321.00
90_A131_L2.2911.00
177_G181_G2.2321.00
138_V182_I2.2111.00
134_A156_A2.1731.00
50_M161_Y2.0661.00
21_K24_G2.0211.00
134_A178_W1.9481.00
70_F74_G1.8921.00
134_A160_S1.8831.00
130_A178_W1.8811.00
15_I19_V1.8751.00
32_V36_Y1.8411.00
133_V159_T1.8281.00
15_I18_I1.8241.00
86_G135_V1.7941.00
35_F164_V1.7701.00
130_A134_A1.7041.00
17_S20_V1.7011.00
137_A156_A1.6591.00
160_S174_V1.6241.00
35_F171_P1.6081.00
186_L190_N1.6001.00
55_K58_R1.5821.00
130_A177_G1.5671.00
13_Y17_S1.5621.00
126_P180_L1.5241.00
164_V174_V1.5151.00
11_A15_I1.5061.00
181_G185_A1.4831.00
53_F159_T1.4461.00
184_I188_A1.4221.00
61_I64_P1.4031.00
54_S162_S1.3991.00
141_L149_S1.3971.00
97_S126_P1.3791.00
56_Y155_E1.3381.00
37_L41_S1.3351.00
71_I75_K1.3131.00
39_N42_Q1.3021.00
98_K128_G1.2791.00
103_Q170_W1.2771.00
60_Y64_P1.2561.00
43_L46_L1.2501.00
50_M162_S1.2441.00
16_I20_V1.2391.00
77_R81_L1.2391.00
141_L152_L1.2291.00
137_A152_L1.2061.00
124_S173_D1.1911.00
48_P51_I1.1701.00
134_A185_A1.1651.00
124_S170_W1.1561.00
13_Y20_V1.1521.00
131_L180_L1.1371.00
64_P67_A1.1211.00
14_I18_I1.1191.00
46_L50_M1.1141.00
48_P52_F1.0931.00
95_E99_Y1.0891.00
53_F158_L1.0861.00
19_V22_I1.0791.00
33_Y37_L1.0641.00
96_V100_V1.0581.00
149_S152_L1.0411.00
137_A155_E1.0371.00
35_F39_N1.0181.00
164_V171_P1.0101.00
126_P176_V1.0061.00
60_Y63_I1.0051.00
50_M54_S1.0021.00
182_I186_L0.9931.00
99_Y123_Y0.9811.00
120_P168_V0.9761.00
94_G128_G0.9741.00
144_L152_L0.9671.00
138_V142_L0.9501.00
85_G88_I0.9431.00
101_M125_Y0.9411.00
60_Y66_T0.9371.00
17_S21_K0.9361.00
49_I53_F0.9311.00
47_N51_I0.9241.00
20_V24_G0.9201.00
189_T193_K0.9171.00
142_L185_A0.9141.00
89_I188_A0.9071.00
28_F32_V0.8971.00
15_I22_I0.8921.00
54_S166_V0.8851.00
79_S83_L0.8841.00
90_A94_G0.8811.00
130_A174_V0.8791.00
129_H169_H0.8741.00
82_L139_I0.8691.00
38_I164_V0.8641.00
107_F111_H0.8621.00
37_L40_H0.8611.00
83_L139_I0.8591.00
59_E64_P0.8581.00
160_S164_V0.8551.00
146_Y150_I0.8551.00
103_Q124_S0.8481.00
153_F156_A0.8471.00
91_I95_E0.8451.00
158_L162_S0.8441.00
138_V181_G0.8421.00
139_I142_L0.8421.00
98_K105_R0.8421.00
34_F37_L0.8401.00
86_G89_I0.8361.00
183_A186_L0.8311.00
49_I158_L0.8251.00
133_V156_A0.8191.00
14_I23_I0.8171.00
80_S83_L0.8131.00
19_V23_I0.8131.00
31_N172_L0.8061.00
117_V168_V0.8051.00
142_L193_K0.8051.00
68_I72_M0.8041.00
82_L188_A0.8011.00
138_V153_F0.7911.00
90_A184_I0.7911.00
104_P108_L0.7861.00
171_P175_L0.7861.00
20_V23_I0.7781.00
145_P149_S0.7781.00
71_I74_G0.7771.00
157_L178_W0.7741.00
82_L142_L0.7611.00
15_I20_V0.7521.00
59_E132_I0.7511.00
134_A153_F0.7501.00
38_I167_G0.7501.00
79_S82_L0.7490.99
193_K196_T0.7410.99
161_Y165_Y0.7410.99
156_A178_W0.7390.99
97_S180_L0.7380.99
13_Y18_I0.7380.99
16_I23_I0.7350.99
41_S44_P0.7320.99
45_A50_M0.7250.99
93_L184_I0.7240.99
107_F170_W0.7220.99
30_G33_Y0.7180.99
131_L177_G0.7160.99
150_I154_I0.7160.99
11_A16_I0.7120.99
180_L184_I0.7110.99
54_S57_G0.7100.99
148_I152_L0.7060.99
54_S163_R0.7060.99
125_Y173_D0.7050.99
83_L87_F0.7030.99
29_L33_Y0.7000.99
100_V104_P0.6990.99
72_M75_K0.6990.99
133_V137_A0.6950.99
69_L73_G0.6930.99
17_S24_G0.6890.99
86_G185_A0.6870.99
17_S23_I0.6860.99
45_A49_I0.6840.99
85_G192_E0.6820.99
42_Q47_N0.6800.99
71_I76_F0.6790.99
78_R82_L0.6780.99
172_L176_V0.6760.99
45_A48_P0.6670.99
62_W66_T0.6670.99
12_L22_I0.6660.99
102_A122_D0.6640.99
12_L19_V0.6550.99
19_V24_G0.6550.99
134_A157_L0.6520.99
134_A182_I0.6460.99
188_A192_E0.6460.99
44_P48_P0.6430.98
139_I185_A0.6430.98
14_I20_V0.6420.98
25_E28_F0.6400.98
178_W182_I0.6390.98
62_W65_V0.6360.98
137_A141_L0.6360.98
41_S161_Y0.6360.98
22_I27_N0.6330.98
18_I21_K0.6280.98
16_I21_K0.6270.98
16_I19_V0.6270.98
18_I22_I0.6220.98
34_F38_I0.6190.98
128_G169_H0.6180.98
91_I94_G0.6170.98
15_I23_I0.6100.98
175_L178_W0.6100.98
87_F136_G0.6090.98
131_L156_A0.6080.98
107_F120_P0.6060.98
47_N50_M0.6050.98
139_I189_T0.6010.98
57_G159_T0.6010.98
13_Y21_K0.6000.98
162_S166_V0.5980.98
87_F90_A0.5980.98
92_I96_V0.5940.97
92_I95_E0.5940.97
107_F168_V0.5920.97
13_Y22_I0.5910.97
24_G27_N0.5900.97
52_F55_K0.5870.97
93_L180_L0.5840.97
108_L111_H0.5820.97
108_L121_T0.5820.97
60_Y71_I0.5820.97
34_F164_V0.5790.97
139_I143_T0.5790.97
63_I66_T0.5790.97
130_A133_V0.5770.97
11_A18_I0.5770.97
26_V29_L0.5760.97
12_L21_K0.5720.97
13_Y16_I0.5720.97
107_F119_E0.5700.97
20_V25_E0.5690.97
94_G180_L0.5620.96
16_I22_I0.5610.96
141_L153_F0.5590.96
11_A14_I0.5590.96
131_L135_V0.5570.96
14_I17_S0.5560.96
110_L167_G0.5560.96
86_G139_I0.5550.96
60_Y80_S0.5550.96
32_V38_I0.5520.96
35_F166_V0.5500.96
141_L144_L0.5500.96
90_A132_I0.5490.96
68_I73_G0.5480.96
34_F171_P0.5450.96
61_I65_V0.5450.96
46_L49_I0.5450.96
12_L16_I0.5430.96
172_L175_L0.5430.96
68_I71_I0.5410.96
179_I182_I0.5360.95
42_Q46_L0.5340.95
86_G93_L0.5320.95
51_I55_K0.5320.95
111_H120_P0.5290.95
64_P73_G0.5160.94
43_L47_N0.5150.94
12_L15_I0.5130.94
144_L148_I0.5100.94
110_L118_P0.5080.94
14_I19_V0.5070.94
88_I92_I0.5020.94
82_L143_T0.5020.94
14_I21_K0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4px7A 1 0.9315 100 0.389 Contact Map
1d2tA 5 0.9406 99.9 0.498 Contact Map
4citA 1 0.8858 99.9 0.508 Contact Map
1qi9A 2 0.8995 99.9 0.522 Contact Map
1up8A 9 0.895 99.9 0.524 Contact Map
2ipbA 2 0.9498 99.9 0.526 Contact Map
3w36A 2 0.8813 99.8 0.556 Contact Map
3bb0A 1 0.968 99.7 0.609 Contact Map
2kluA 1 0.242 48.9 0.921 Contact Map
2kncB 1 0.2237 19.7 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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