GREMLIN Database
Q97VG9 - Quinol oxidase (SoxABC), cytochrome aa3 subunit (SoxB)
UniProt: Q97VG9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 511 (468)
Sequences: 5239 (1827)
Seq/√Len: 84.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_G104_F4.8251.00
429_M455_E4.7401.00
253_Y388_T4.0861.00
28_S77_L3.7881.00
332_D411_M3.6741.00
394_L476_D3.5161.00
355_L370_V3.3871.00
31_W111_L3.3761.00
246_L385_G3.3521.00
258_A322_I3.1271.00
180_K183_R3.0991.00
424_G458_L3.0661.00
193_A276_S3.0471.00
190_Y272_I3.0261.00
417_W465_G2.9721.00
265_E269_R2.9471.00
332_D405_E2.8801.00
391_L414_G2.8571.00
249_A389_V2.7721.00
147_A150_G2.7591.00
410_W471_F2.6471.00
417_W468_V2.5851.00
54_N62_A2.5841.00
404_S409_K2.4611.00
85_F171_I2.4361.00
121_M146_P2.4311.00
38_A62_A2.4211.00
181_N184_L2.4131.00
22_W83_I2.4101.00
171_I192_V2.3691.00
209_T212_Y2.3521.00
376_L423_L2.3191.00
254_I342_L2.3131.00
186_I262_L2.3031.00
322_I334_V2.2651.00
449_Q453_L2.1401.00
74_F383_V2.1241.00
409_K413_I2.1191.00
257_Y392_D2.1071.00
172_A181_N2.0931.00
68_W125_M2.0871.00
289_T365_H2.0691.00
337_G414_G2.0471.00
256_K392_D2.0401.00
290_W366_N1.9691.00
308_A353_L1.9571.00
413_I468_V1.9521.00
404_S475_V1.9161.00
50_S443_A1.9111.00
457_M461_I1.9081.00
421_P461_I1.9031.00
44_T460_E1.8981.00
427_Y431_V1.8961.00
125_M227_W1.8951.00
278_G307_L1.8831.00
414_G418_W1.8531.00
475_V479_A1.8431.00
401_F480_Y1.8341.00
424_G454_L1.7971.00
193_A273_Y1.7491.00
57_E61_S1.7371.00
414_G469_T1.7131.00
234_Y238_V1.7041.00
340_I419_T1.6841.00
49_N449_Q1.6781.00
432_I451_Y1.6711.00
360_I364_F1.6681.00
417_W464_P1.6631.00
471_F475_V1.6531.00
460_E464_P1.6511.00
34_V69_A1.6441.00
387_T469_T1.6291.00
37_I41_N1.6161.00
35_L69_A1.6091.00
198_I202_L1.5941.00
390_F469_T1.5891.00
56_G442_I1.5831.00
372_G430_S1.5741.00
127_P130_A1.5711.00
457_M460_E1.5501.00
259_G329_N1.5501.00
128_P131_I1.5421.00
328_Y334_V1.5411.00
410_W468_V1.5301.00
93_S97_T1.5281.00
431_V451_Y1.5281.00
41_N62_A1.5211.00
322_I339_L1.5201.00
340_I415_M1.5080.99
338_G388_T1.5080.99
387_T414_G1.5030.99
337_G387_T1.4970.99
27_G108_N1.4790.99
391_L411_M1.4720.99
405_E412_R1.4690.99
201_T280_M1.4690.99
193_A196_I1.4600.99
147_A154_L1.4500.99
121_M130_A1.4430.99
102_I162_L1.4380.99
235_G238_V1.4370.99
421_P458_L1.4360.99
414_G465_G1.4360.99
410_W413_I1.4340.99
68_W149_M1.4300.99
474_I478_L1.4150.99
255_P262_L1.4120.99
79_A83_I1.4100.99
475_V481_A1.4080.99
131_I134_G1.4040.99
202_L206_A1.4020.99
253_Y389_V1.3960.99
84_A88_Y1.3950.99
150_G154_L1.3900.99
99_L162_L1.3890.99
168_I192_V1.3840.99
119_P149_M1.3770.99
125_M130_A1.3580.99
232_W235_G1.3530.99
228_A366_N1.3430.99
84_A392_D1.3390.99
243_P247_F1.3380.99
253_Y338_G1.3340.99
414_G466_L1.3330.99
42_L62_A1.3330.99
251_Y318_L1.3310.99
123_W128_P1.3210.99
104_F108_N1.3070.99
402_N483_K1.3020.98
27_G107_S1.2990.98
423_L427_Y1.2940.98
171_I184_L1.2940.98
101_A105_W1.2930.98
257_Y333_P1.2920.98
418_W465_G1.2900.98
73_G156_L1.2860.98
268_A272_I1.2840.98
172_A196_I1.2780.98
88_Y188_G1.2700.98
124_Y231_F1.2690.98
16_N19_N1.2640.98
184_L188_G1.2580.98
172_A192_V1.2510.98
471_F474_I1.2480.98
249_A253_Y1.2440.98
179_P185_N1.2440.98
429_M432_I1.2430.98
40_M463_I1.2430.98
425_V459_A1.2340.98
344_G423_L1.2320.98
187_F191_G1.2300.98
95_V169_I1.2290.98
19_N23_L1.2280.98
34_V38_A1.2260.98
33_G470_I1.2200.98
40_M459_A1.2180.98
202_L205_L1.2170.98
247_F311_S1.2150.98
35_L70_G1.2090.98
149_M152_A1.2080.98
121_M125_M1.2050.97
45_Y52_S1.2020.97
467_L471_F1.2010.97
354_V369_Y1.1980.97
47_T453_L1.1830.97
208_S227_W1.1820.97
301_N358_N1.1810.97
85_F188_G1.1780.97
201_T241_Y1.1770.97
147_A152_A1.1730.97
387_T466_L1.1720.97
483_K486_I1.1690.97
257_Y334_V1.1690.97
453_L457_M1.1680.97
171_I188_G1.1680.97
164_T195_A1.1650.97
78_A386_F1.1620.97
179_P184_L1.1590.97
414_G472_V1.1580.97
361_N370_V1.1560.97
32_L39_A1.1560.97
240_Y245_P1.1530.97
178_K183_R1.1520.97
364_F370_V1.1510.97
128_P132_E1.1470.97
255_P261_S1.1460.97
243_P382_I1.1450.97
25_T80_A1.1440.97
418_W462_G1.1400.96
355_L364_F1.1380.96
337_G391_L1.1380.96
41_N54_N1.1370.96
204_A233_F1.1350.96
154_L209_T1.1330.96
96_H166_M1.1330.96
348_A377_M1.1280.96
304_T356_P1.1250.96
325_S329_N1.1210.96
79_A164_T1.1210.96
336_M412_R1.1160.96
23_L101_A1.1160.96
166_M170_L1.1120.96
126_Y130_A1.1110.96
414_G468_V1.1100.96
125_M149_M1.1090.96
487_F490_P1.1030.96
249_A393_M1.1030.96
123_W127_P1.1020.96
58_L62_A1.1020.96
124_Y365_H1.1000.96
98_K102_I1.0950.96
45_Y50_S1.0930.95
425_V462_G1.0830.95
125_M146_P1.0770.95
242_V378_I1.0750.95
201_T205_L1.0740.95
114_G152_A1.0740.95
75_V382_I1.0730.95
149_M154_L1.0700.95
394_L398_F1.0660.95
409_K412_R1.0650.95
385_G388_T1.0620.95
73_G111_L1.0510.94
380_T422_F1.0500.94
78_A246_L1.0480.94
102_I106_L1.0480.94
376_L427_Y1.0470.94
250_L254_I1.0470.94
475_V478_L1.0410.94
470_I474_I1.0390.94
83_I103_F1.0380.94
200_I204_A1.0330.94
194_F241_Y1.0310.94
197_V201_T1.0310.94
103_F166_M1.0240.94
164_T199_A1.0240.94
74_F77_L1.0210.94
401_F476_D1.0210.94
214_L217_F1.0190.93
25_T77_L1.0140.93
214_L220_V1.0140.93
84_A397_T1.0070.93
187_F190_Y1.0070.93
336_M415_M1.0040.93
182_E270_W1.0020.93
192_V196_I1.0010.93
305_L356_P1.0000.93
69_A111_L0.9980.93
85_F89_K0.9940.93
184_L189_A0.9920.93
275_L314_T0.9820.92
29_I33_G0.9810.92
27_G30_F0.9750.92
132_E135_S0.9720.92
199_A203_P0.9710.92
127_P131_I0.9690.92
196_I199_A0.9690.92
32_L74_F0.9680.92
32_L35_L0.9670.92
48_Y51_N0.9660.92
450_P454_L0.9640.91
127_P227_W0.9630.91
145_T148_L0.9620.91
186_I189_A0.9610.91
395_K402_N0.9600.91
207_A210_L0.9580.91
193_A272_I0.9570.91
343_V347_L0.9560.91
151_M155_S0.9560.91
463_I467_L0.9550.91
128_P134_G0.9540.91
103_F162_L0.9520.91
175_Y178_K0.9520.91
269_R272_I0.9500.91
262_L265_E0.9460.91
145_T150_G0.9410.90
77_L386_F0.9390.90
167_F171_I0.9360.90
428_T451_Y0.9360.90
187_F197_V0.9290.90
268_A271_N0.9230.90
86_A89_K0.9210.89
20_V100_M0.9190.89
390_F473_A0.9170.89
40_M456_S0.9170.89
468_V471_F0.9130.89
176_A179_P0.9120.89
26_I30_F0.9060.89
401_F479_A0.9050.89
125_M128_P0.9040.89
84_A87_M0.9000.88
480_Y483_K0.8970.88
44_T456_S0.8940.88
145_T149_M0.8910.88
403_F411_M0.8900.88
288_Q301_N0.8900.88
472_V476_D0.8900.88
195_A198_I0.8880.88
22_W397_T0.8880.88
314_T318_L0.8830.87
84_A253_Y0.8830.87
146_P150_G0.8820.87
146_P149_M0.8820.87
304_T355_L0.8760.87
148_L152_A0.8740.87
131_I135_S0.8740.87
254_I322_I0.8740.87
311_S314_T0.8730.87
152_A156_L0.8720.87
387_T391_L0.8690.87
148_L153_Y0.8680.86
376_L430_S0.8670.86
383_V462_G0.8580.86
190_Y193_A0.8580.86
75_V383_V0.8570.86
27_G31_W0.8560.86
23_L104_F0.8540.86
315_V342_L0.8510.85
132_E136_N0.8510.85
68_W114_G0.8390.85
68_W227_W0.8380.84
438_L441_M0.8380.84
133_S136_N0.8360.84
398_F402_N0.8340.84
33_G37_I0.8320.84
75_V242_V0.8320.84
238_V242_V0.8320.84
251_Y314_T0.8310.84
243_P246_L0.8300.84
185_N188_G0.8280.84
322_I328_Y0.8280.84
122_G128_P0.8280.84
418_W466_L0.8270.84
250_L341_A0.8270.84
124_Y127_P0.8240.83
191_G196_I0.8220.83
199_A202_L0.8220.83
157_T206_A0.8190.83
36_G39_A0.8180.83
153_Y156_L0.8170.83
228_A290_W0.8170.83
123_W126_Y0.8150.83
289_T362_P0.8130.83
54_N58_L0.8110.83
126_Y131_I0.8070.82
301_N357_E0.8070.82
147_A151_M0.8040.82
411_M472_V0.8040.82
337_G415_M0.8030.82
189_A193_A0.8020.82
127_P132_E0.8010.82
189_A201_T0.8010.82
372_G428_T0.7900.81
27_G111_L0.7890.81
372_G429_M0.7880.81
36_G466_L0.7870.81
168_I196_I0.7850.80
81_A249_A0.7840.80
122_G126_Y0.7840.80
243_P381_L0.7830.80
206_A209_T0.7810.80
156_L159_A0.7810.80
237_P240_Y0.7800.80
96_H169_I0.7780.80
247_F314_T0.7760.80
268_A317_N0.7760.80
128_P135_S0.7760.80
110_F152_A0.7750.80
175_Y183_R0.7740.79
44_T53_P0.7710.79
340_I384_M0.7700.79
34_V111_L0.7680.79
382_I386_F0.7670.79
87_M93_S0.7670.79
72_F234_Y0.7670.79
405_E411_M0.7650.79
452_N456_S0.7640.79
28_S74_F0.7620.78
401_F477_A0.7620.78
351_Q430_S0.7610.78
189_A198_I0.7600.78
314_T317_N0.7600.78
456_S460_E0.7580.78
188_G199_A0.7560.78
261_S266_K0.7540.78
437_M452_N0.7540.78
187_F199_A0.7530.78
152_A155_S0.7510.77
192_V199_A0.7510.77
247_F318_L0.7490.77
404_S471_F0.7480.77
41_N53_P0.7470.77
190_Y198_I0.7460.77
353_L356_P0.7460.77
250_L385_G0.7450.77
402_N484_Q0.7440.77
85_F191_G0.7440.77
40_M44_T0.7440.77
315_V346_I0.7420.77
481_A484_Q0.7410.76
368_Y437_M0.7380.76
189_A197_V0.7380.76
329_N489_S0.7370.76
346_I350_V0.7370.76
124_Y129_L0.7360.76
113_I148_L0.7350.76
198_I201_T0.7330.76
486_I490_P0.7310.75
394_L477_A0.7310.75
421_P465_G0.7300.75
433_G436_G0.7300.75
484_Q487_F0.7290.75
29_I470_I0.7280.75
134_G137_F0.7270.75
326_Q329_N0.7270.75
350_V353_L0.7220.75
148_L151_M0.7210.74
19_N101_A0.7190.74
200_I203_P0.7190.74
33_G467_L0.7190.74
479_A482_S0.7160.74
41_N45_Y0.7140.74
237_P245_P0.7130.74
38_A41_N0.7100.73
483_K488_S0.7100.73
119_P125_M0.7100.73
316_L320_L0.7060.73
257_Y331_K0.7040.73
123_W132_E0.7030.73
341_A385_G0.7020.73
17_T21_V0.7020.73
82_V191_G0.7020.73
424_G461_I0.7020.73
44_T48_Y0.7010.72
324_L329_N0.6990.72
322_I326_Q0.6990.72
96_H99_L0.6970.72
97_T100_M0.6960.72
35_L71_M0.6950.72
279_S366_N0.6950.72
417_W461_I0.6950.72
190_Y194_F0.6920.71
59_Y63_L0.6910.71
193_A198_I0.6890.71
284_V292_L0.6870.71
128_P136_N0.6870.71
203_P206_A0.6860.71
332_D412_R0.6860.71
188_G192_V0.6860.71
190_Y196_I0.6860.71
175_Y179_P0.6840.71
346_I381_L0.6830.70
404_S410_W0.6830.70
398_F476_D0.6820.70
384_M415_M0.6810.70
467_L474_I0.6800.70
225_L290_W0.6790.70
259_G489_S0.6790.70
46_L368_Y0.6780.70
236_H285_H0.6750.70
229_L430_S0.6750.70
321_T436_G0.6730.69
25_T397_T0.6720.69
420_A482_S0.6690.69
236_H373_H0.6670.69
336_M416_I0.6650.68
402_N480_Y0.6650.68
45_Y443_A0.6640.68
186_I268_A0.6640.68
254_I354_V0.6630.68
205_L209_T0.6630.68
488_S494_T0.6610.68
331_K334_V0.6610.68
309_S313_L0.6600.68
151_M154_L0.6580.68
86_A170_L0.6570.67
297_R362_P0.6560.67
253_Y333_P0.6550.67
394_L473_A0.6540.67
394_L403_F0.6540.67
103_F167_F0.6540.67
253_Y385_G0.6520.67
154_L206_A0.6520.67
455_E458_L0.6510.67
235_G242_V0.6500.67
37_I112_A0.6500.67
124_Y128_P0.6490.67
126_Y129_L0.6450.66
98_K101_A0.6440.66
484_Q488_S0.6430.66
413_I417_W0.6430.66
160_F198_I0.6420.66
93_S100_M0.6420.66
77_L387_T0.6410.66
55_V58_L0.6390.65
210_L216_F0.6380.65
257_Y488_S0.6370.65
121_M135_S0.6360.65
189_A196_I0.6350.65
90_S178_K0.6340.65
203_P207_A0.6340.65
477_A480_Y0.6340.65
186_I438_L0.6330.65
194_F198_I0.6320.64
431_V435_L0.6320.64
477_A481_A0.6320.64
394_L404_S0.6310.64
168_I199_A0.6310.64
190_Y197_V0.6310.64
193_A201_T0.6290.64
43_R46_L0.6260.64
150_G155_S0.6260.64
179_P183_R0.6220.63
398_F401_F0.6220.63
148_L154_L0.6210.63
65_I119_P0.6190.63
422_F462_G0.6180.63
47_T52_S0.6180.63
46_L452_N0.6180.63
98_K223_N0.6170.63
204_A208_S0.6160.63
254_I338_G0.6160.63
330_W334_V0.6150.62
242_V382_I0.6150.62
243_P377_M0.6130.62
89_K188_G0.6120.62
485_G488_S0.6120.62
486_I489_S0.6070.61
59_Y371_V0.6060.61
330_W339_L0.6060.61
74_F191_G0.6050.61
127_P135_S0.6050.61
285_H373_H0.6050.61
189_A199_A0.6040.61
271_N274_L0.6030.61
200_I205_L0.6020.61
256_K494_T0.6020.61
71_M242_V0.6020.61
490_P494_T0.6010.61
190_Y199_A0.6010.61
242_V245_P0.6000.60
482_S486_I0.6000.60
86_A93_S0.6000.60
277_I281_L0.5980.60
123_W130_A0.5980.60
391_L472_V0.5960.60
53_P58_L0.5960.60
128_P133_S0.5950.60
247_F312_G0.5950.60
161_I165_A0.5940.60
39_A380_T0.5940.60
110_F156_L0.5930.60
44_T51_N0.5920.59
17_T87_M0.5920.59
50_S53_P0.5910.59
75_V378_I0.5910.59
368_Y452_N0.5910.59
319_G339_L0.5910.59
418_W474_I0.5900.59
225_L366_N0.5890.59
197_V200_I0.5860.59
121_M127_P0.5850.59
78_A102_I0.5850.59
83_I397_T0.5850.59
286_H373_H0.5840.58
308_A314_T0.5840.58
187_F200_I0.5840.58
190_Y244_F0.5830.58
20_V23_L0.5810.58
248_G371_V0.5790.58
378_I382_I0.5780.58
458_L461_I0.5780.58
435_L448_F0.5770.58
354_V360_I0.5770.58
65_I149_M0.5770.58
204_A207_A0.5770.58
111_L114_G0.5760.57
61_S118_S0.5760.57
201_T206_A0.5750.57
131_I136_N0.5750.57
18_L396_S0.5750.57
24_Y159_A0.5740.57
495_S498_N0.5730.57
474_I479_A0.5720.57
119_P146_P0.5720.57
189_A192_V0.5700.57
193_A234_Y0.5700.57
21_V80_A0.5690.56
66_H375_H0.5690.56
350_V380_T0.5690.56
33_G466_L0.5680.56
190_Y262_L0.5670.56
334_V338_G0.5670.56
57_E120_D0.5650.56
130_A133_S0.5650.56
199_A205_L0.5640.56
95_V170_L0.5630.56
432_I437_M0.5620.56
437_M444_Y0.5620.56
468_V472_V0.5620.56
224_P228_A0.5610.55
413_I471_F0.5600.55
333_P392_D0.5590.55
188_G198_I0.5590.55
188_G193_A0.5580.55
378_I381_L0.5580.55
386_F390_F0.5570.55
424_G457_M0.5560.55
258_A326_Q0.5560.55
460_E463_I0.5550.55
387_T418_W0.5540.55
482_S485_G0.5530.54
395_K398_F0.5530.54
78_A382_I0.5520.54
181_N192_V0.5520.54
432_I448_F0.5520.54
239_V245_P0.5510.54
250_L338_G0.5500.54
123_W129_L0.5500.54
74_F338_G0.5500.54
441_M452_N0.5500.54
119_P227_W0.5480.54
29_I473_A0.5480.54
464_P468_V0.5470.54
337_G469_T0.5470.54
424_G428_T0.5460.53
95_V166_M0.5460.53
490_P495_S0.5430.53
298_I302_L0.5430.53
376_L381_L0.5430.53
189_A194_F0.5420.53
42_L63_L0.5420.53
182_E265_E0.5410.53
117_G144_T0.5400.53
256_K488_S0.5380.52
100_M166_M0.5380.52
487_F495_S0.5370.52
454_L458_L0.5370.52
475_V482_S0.5370.52
346_I367_T0.5360.52
119_P145_T0.5360.52
180_K184_L0.5350.52
236_H239_V0.5350.52
404_S413_I0.5320.52
476_D480_Y0.5320.52
116_A136_N0.5320.52
156_L160_F0.5320.52
444_Y448_F0.5310.51
130_A134_G0.5300.51
243_P378_I0.5290.51
447_V454_L0.5280.51
201_T207_A0.5260.51
359_S364_F0.5250.51
402_N487_F0.5250.51
22_W26_I0.5230.50
198_I203_P0.5230.50
338_G342_L0.5230.50
480_Y487_F0.5230.50
270_W274_L0.5230.50
228_A231_F0.5230.50
337_G384_M0.5220.50
191_G195_A0.5220.50
441_M444_Y0.5210.50
54_N57_E0.5210.50
483_K487_F0.5210.50
42_L67_G0.5190.50
202_L269_R0.5180.50
170_L174_A0.5170.50
466_L470_I0.5170.50
331_K412_R0.5160.49
256_K259_G0.5160.49
396_S497_S0.5150.49
303_S392_D0.5150.49
268_A313_L0.5150.49
30_F112_A0.5140.49
176_A464_P0.5140.49
39_A379_W0.5130.49
451_Y454_L0.5130.49
293_P297_R0.5130.49
370_V374_F0.5120.49
494_T498_N0.5110.49
200_I280_M0.5100.49
267_W317_N0.5090.49
367_T371_V0.5090.49
441_M445_P0.5080.48
67_G374_F0.5070.48
257_Y411_M0.5070.48
404_S476_D0.5070.48
160_F304_T0.5050.48
165_A169_I0.5040.48
478_L482_S0.5040.48
86_A90_S0.5030.48
62_A65_I0.5020.48
84_A284_V0.5020.48
88_Y93_S0.5020.48
154_L161_I0.5010.47
158_L459_A0.5010.47
196_I200_I0.5010.47
229_L287_L0.5010.47
184_L265_E0.5010.47
188_G196_I0.5000.47
164_T201_T0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fftA 1 0.9393 100 0.097 Contact Map
2gsmA 1 0.953 100 0.107 Contact Map
2yevA 1 0.9589 100 0.11 Contact Map
1v54A 1 0.9628 100 0.122 Contact Map
3s8fA 1 0.9393 100 0.243 Contact Map
3ayfA 2 0.8787 100 0.305 Contact Map
3mk7A 1 0.8493 100 0.321 Contact Map
3wfdB 1 0.816 100 0.334 Contact Map
2ao6B 1 0.0215 9.6 0.982 Contact Map
1eysL 1 0.1155 3.8 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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