GREMLIN Database
Q97VG1 - Muconate cycloisomerase related protein
UniProt: Q97VG1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (340)
Sequences: 11696 (6842)
Seq/√Len: 371.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_N76_E3.6141.00
124_K348_Y3.3471.00
238_R267_D3.2341.00
259_Y263_E3.1391.00
203_N206_S2.9501.00
235_R239_N2.9481.00
69_N72_K2.9211.00
28_V96_A2.7101.00
258_L262_K2.6611.00
36_R104_I2.6511.00
230_D233_G2.5921.00
52_A56_K2.5831.00
8_E29_R2.4701.00
6_E31_T2.4551.00
31_T37_V2.4031.00
32_T104_I2.3761.00
236_K239_N2.3391.00
8_E31_T2.3041.00
29_R37_V2.3001.00
147_K187_A2.2691.00
212_K215_E2.2541.00
3_K33_N2.2321.00
71_E284_K2.2131.00
212_K240_N2.1201.00
235_R263_E2.0971.00
215_E242_S2.0961.00
211_A222_M2.0891.00
261_M294_V2.0711.00
254_K281_E2.0301.00
236_K240_N2.0181.00
32_T36_R2.0171.00
10_Y29_R1.9911.00
98_D280_T1.9851.00
6_E59_N1.9601.00
179_E182_K1.9591.00
232_E263_E1.9291.00
276_I285_V1.9281.00
211_A241_T1.9271.00
106_G113_L1.9091.00
147_K151_K1.9081.00
268_F295_Q1.8941.00
210_I214_L1.8781.00
36_R108_E1.8721.00
126_L155_K1.8201.00
345_D350_I1.8061.00
12_L41_E1.7841.00
73_N101_S1.7821.00
208_I240_N1.7801.00
193_D220_L1.7741.00
34_D108_E1.7741.00
5_S31_T1.7461.00
139_P143_A1.7381.00
257_A285_V1.7291.00
65_N72_K1.7111.00
182_K186_E1.7051.00
262_K292_F1.7041.00
213_R216_K1.7021.00
7_I30_V1.6991.00
29_R39_W1.6871.00
226_I237_Y1.6781.00
182_K217_Y1.6561.00
138_K141_D1.6551.00
30_V101_S1.6541.00
287_G290_E1.6021.00
42_T96_A1.5791.00
112_P115_K1.5781.00
260_F266_V1.5631.00
150_V192_V1.5591.00
288_I292_F1.5581.00
205_N236_K1.5521.00
36_R107_K1.5421.00
173_G176_I1.5271.00
5_S33_N1.5261.00
84_M255_Q1.5141.00
261_M288_I1.5061.00
183_A186_E1.4991.00
143_A187_A1.4951.00
111_A115_K1.4911.00
124_K350_I1.4841.00
204_A236_K1.4611.00
315_A351_I1.4501.00
178_E213_R1.4411.00
7_I59_N1.4381.00
204_A237_Y1.4371.00
53_N57_K1.4181.00
141_D144_E1.4141.00
113_L357_L1.4141.00
59_N63_K1.4091.00
283_K287_G1.4081.00
176_I179_E1.3891.00
153_G159_F1.3871.00
98_D102_W1.3821.00
148_E152_M1.3791.00
65_N73_N1.3691.00
68_F108_E1.3661.00
261_M292_F1.3451.00
208_I236_K1.3201.00
259_Y262_K1.3171.00
226_I233_G1.3041.00
153_G156_A1.3031.00
57_K88_L1.2971.00
188_V194_I1.2941.00
286_V317_I1.2911.00
32_T108_E1.2841.00
182_K216_K1.2741.00
152_M195_L1.2711.00
27_L39_W1.2711.00
75_L79_K1.2681.00
72_K76_E1.2641.00
111_A116_L1.2591.00
103_D107_K1.2571.00
120_K123_D1.2561.00
77_W94_Y1.2531.00
258_L288_I1.2501.00
282_T313_F1.2441.00
147_K150_V1.2431.00
105_I109_L1.2321.00
195_L221_F1.2251.00
132_W177_A1.2221.00
99_I279_V1.2191.00
209_M212_K1.2161.00
179_E183_A1.2141.00
13_G22_A1.2111.00
257_A269_L1.2091.00
212_K242_S1.2051.00
56_K59_N1.2051.00
340_N354_R1.1901.00
229_E256_Q1.1891.00
157_L192_V1.1891.00
103_D309_V1.1881.00
126_L348_Y1.1881.00
287_G291_T1.1871.00
208_I237_Y1.1831.00
204_A233_G1.1741.00
153_G157_L1.1681.00
195_L220_L1.1681.00
281_E284_K1.1661.00
209_M213_R1.1641.00
283_K317_I1.1631.00
144_E147_K1.1471.00
225_P245_I1.1321.00
235_R265_L1.1301.00
196_I219_P1.1291.00
99_I309_V1.1271.00
225_P237_Y1.1271.00
7_I62_L1.1241.00
237_Y245_I1.1201.00
215_E243_L1.1161.00
156_A159_F1.1151.00
66_D69_N1.1141.00
159_F184_V1.1141.00
106_G116_L1.1131.00
56_K60_T1.1041.00
206_S209_M1.1011.00
33_N67_V1.0951.00
246_A268_F1.0951.00
68_F105_I1.0941.00
68_F109_L1.0891.00
10_Y27_L1.0891.00
254_K288_I1.0891.00
178_E217_Y1.0831.00
256_Q259_Y1.0831.00
160_D199_H1.0711.00
238_R264_G1.0631.00
284_K290_E1.0561.00
61_V76_E1.0511.00
198_H222_M1.0441.00
290_E318_P1.0431.00
207_A211_A1.0421.00
244_R321_L1.0411.00
247_L260_F1.0361.00
264_G294_V1.0351.00
273_L282_T1.0311.00
185_R189_G1.0281.00
144_E148_E1.0211.00
269_L289_A1.0191.00
185_R194_I1.0191.00
202_F207_A1.0081.00
284_K287_G1.0061.00
150_V157_L1.0061.00
71_E283_K1.0031.00
140_E144_E0.9991.00
102_W280_T0.9981.00
187_A190_D0.9921.00
65_N69_N0.9901.00
73_N76_E0.9821.00
272_D299_H0.9811.00
10_Y39_W0.9791.00
224_E270_Q0.9781.00
58_I97_V0.9761.00
27_L305_I0.9751.00
246_A270_Q0.9731.00
183_A187_A0.9711.00
202_F210_I0.9681.00
139_P179_E0.9671.00
146_A188_V0.9561.00
9_A56_K0.9491.00
219_P243_L0.9311.00
184_V188_V0.9261.00
175_D179_E0.9211.00
276_I282_T0.9151.00
49_E52_A0.9081.00
309_V357_L0.9081.00
105_I116_L0.9061.00
266_V269_L0.9041.00
185_R191_N0.9011.00
162_F177_A0.9011.00
70_V105_I0.8971.00
298_F319_N0.8941.00
49_E57_K0.8931.00
273_L310_T0.8931.00
261_M269_L0.8931.00
226_I234_L0.8891.00
109_L116_L0.8851.00
148_E151_K0.8841.00
178_E182_K0.8831.00
232_E259_Y0.8821.00
283_K316_F0.8821.00
143_A147_K0.8771.00
115_K353_E0.8771.00
156_A195_L0.8731.00
146_A157_L0.8721.00
174_L210_I0.8691.00
137_V141_D0.8691.00
253_N256_Q0.8671.00
149_I152_M0.8671.00
102_W279_V0.8641.00
178_E216_K0.8621.00
174_L178_E0.8601.00
205_N209_M0.8601.00
215_E241_T0.8581.00
177_A180_R0.8551.00
9_A55_V0.8511.00
143_A188_V0.8491.00
145_K148_E0.8451.00
55_V59_N0.8431.00
231_V265_L0.8391.00
113_L279_V0.8381.00
117_L283_K0.8361.00
181_V196_I0.8361.00
139_P183_A0.8361.00
154_Y159_F0.8361.00
234_L247_L0.8291.00
41_E305_I0.8281.00
207_A226_I0.8281.00
67_V101_S0.8271.00
258_L292_F0.8261.00
252_I256_Q0.8251.00
248_G272_D0.8251.00
114_Y312_Q0.8171.00
279_V309_V0.8141.00
181_V217_Y0.8121.00
198_H211_A0.8101.00
74_R98_D0.8101.00
239_N264_G0.8081.00
344_I349_A0.8051.00
143_A146_A0.8041.00
251_I257_A0.8001.00
188_V192_V0.7991.00
54_F93_A0.7961.00
208_I241_T0.7951.00
114_Y351_I0.7951.00
82_F85_T0.7931.00
11_I52_A0.7931.00
55_V60_T0.7911.00
234_L245_I0.7911.00
286_V296_M0.7871.00
271_A282_T0.7851.00
153_G158_K0.7821.00
11_I158_K0.7791.00
204_A208_I0.7781.00
78_Y281_E0.7771.00
286_V298_F0.7771.00
74_R280_T0.7711.00
181_V214_L0.7701.00
279_V283_K0.7701.00
49_E53_N0.7701.00
143_A186_E0.7691.00
232_E235_R0.7691.00
298_F314_D0.7681.00
73_N77_W0.7651.00
109_L112_P0.7641.00
110_G355_P0.7631.00
5_S34_D0.7631.00
208_I226_I0.7601.00
247_L266_V0.7601.00
30_V38_G0.7601.00
57_K60_T0.7581.00
288_I291_T0.7571.00
50_A53_N0.7561.00
175_D213_R0.7551.00
62_L65_N0.7511.00
238_R245_I0.7511.00
286_V290_E0.7471.00
251_I256_Q0.7461.00
254_K284_K0.7461.00
202_F222_M0.7461.00
350_I353_E0.7441.00
237_Y241_T0.7411.00
273_L313_F0.7391.00
67_V108_E0.7381.00
53_N56_K0.7361.00
74_R77_W0.7351.00
198_H202_F0.7351.00
190_D218_N0.7321.00
257_A289_A0.7291.00
67_V105_I0.7281.00
52_A55_V0.7271.00
311_L351_I0.7231.00
127_V130_N0.7231.00
85_T88_L0.7221.00
120_K353_E0.7201.00
231_V260_F0.7181.00
295_Q321_L0.7171.00
13_G24_L0.7171.00
311_L349_A0.7161.00
71_E75_L0.7141.00
181_V188_V0.7131.00
315_A352_P0.7121.00
39_W305_I0.7080.99
231_V259_Y0.7080.99
231_V263_E0.7030.99
236_K264_G0.7030.99
31_T35_G0.7000.99
323_Q326_F0.6990.99
9_A52_A0.6990.99
58_I77_W0.6980.99
117_L316_F0.6970.99
71_E280_T0.6930.99
271_A286_V0.6930.99
172_K176_I0.6920.99
117_L279_V0.6920.99
329_W332_S0.6900.99
31_T39_W0.6890.99
3_K66_D0.6890.99
345_D348_Y0.6880.99
102_W117_L0.6850.99
176_I180_R0.6840.99
94_Y278_G0.6830.99
30_V62_L0.6820.99
129_A149_I0.6810.99
102_W113_L0.6790.99
146_A184_V0.6780.99
204_A226_I0.6760.99
143_A183_A0.6760.99
269_L294_V0.6760.99
180_R185_R0.6750.99
69_N115_K0.6730.99
38_G107_K0.6720.99
144_E187_A0.6710.99
74_R78_Y0.6700.99
76_E79_K0.6700.99
61_V65_N0.6670.99
255_Q258_L0.6660.99
4_I30_V0.6660.99
254_K285_V0.6660.99
174_L177_A0.6640.99
70_V73_N0.6620.99
271_A296_M0.6610.99
111_A119_G0.6590.99
330_F333_W0.6570.99
61_V80_H0.6560.99
300_N307_N0.6560.99
177_A202_F0.6540.99
55_V97_V0.6530.99
75_L284_K0.6530.99
290_E319_N0.6530.99
185_R218_N0.6510.99
146_A198_H0.6480.99
40_G96_A0.6470.99
129_A154_Y0.6460.99
211_A243_L0.6450.99
209_M240_N0.6450.99
50_A57_K0.6450.99
254_K258_L0.6440.99
106_G111_A0.6430.99
106_G109_L0.6410.99
106_G355_P0.6400.99
185_R190_D0.6400.99
233_G236_K0.6390.99
156_A193_D0.6380.99
289_A294_V0.6370.99
124_K346_N0.6370.99
270_Q299_H0.6360.99
161_P198_H0.6350.99
257_A294_V0.6340.99
330_F334_K0.6330.99
32_T67_V0.6300.99
309_V313_F0.6270.99
266_V294_V0.6260.99
177_A185_R0.6230.99
326_F333_W0.6230.99
186_E190_D0.6200.99
11_I46_L0.6200.99
257_A271_A0.6190.99
113_L117_L0.6170.99
251_I260_F0.6150.99
101_S105_I0.6140.99
113_L116_L0.6120.99
37_V107_K0.6120.99
234_L237_Y0.6120.99
62_L101_S0.6090.98
114_Y120_K0.6080.98
155_K191_N0.6070.98
314_D323_Q0.6050.98
178_E188_V0.6050.98
255_Q259_Y0.5980.98
140_E143_A0.5970.98
131_G149_I0.5970.98
105_I108_E0.5940.98
104_I108_E0.5940.98
157_L188_V0.5940.98
178_E181_V0.5940.98
84_M87_S0.5910.98
159_F181_V0.5900.98
71_E123_D0.5900.98
7_I97_V0.5880.98
20_Q23_S0.5870.98
207_A237_Y0.5870.98
279_V313_F0.5850.98
314_D320_F0.5850.98
154_Y158_K0.5840.98
283_K313_F0.5830.98
129_A133_Y0.5800.98
78_Y94_Y0.5800.98
322_I325_S0.5780.98
224_E248_G0.5770.98
7_I28_V0.5740.98
221_F297_A0.5740.98
38_G103_D0.5740.98
70_V280_T0.5730.98
343_P350_I0.5730.98
174_L180_R0.5720.98
189_G192_V0.5720.98
150_V188_V0.5710.98
67_V104_I0.5690.98
289_A296_M0.5690.98
308_A359_V0.5660.98
155_K346_N0.5660.98
12_L305_I0.5630.97
224_E250_R0.5620.97
47_R50_A0.5590.97
75_L78_Y0.5580.97
73_N97_V0.5570.97
57_K61_V0.5560.97
70_V116_L0.5560.97
124_K345_D0.5550.97
115_K120_K0.5550.97
173_G177_A0.5550.97
11_I24_L0.5510.97
129_A152_M0.5500.97
176_I185_R0.5480.97
241_T245_I0.5480.97
256_Q265_L0.5470.97
335_R339_Y0.5460.97
40_G43_V0.5450.97
70_V101_S0.5450.97
60_T63_K0.5450.97
119_G123_D0.5440.97
282_T298_F0.5440.97
304_P338_I0.5430.97
274_Y301_A0.5410.97
121_T318_P0.5390.97
286_V319_N0.5390.97
26_V51_V0.5390.97
107_K110_G0.5390.97
143_A184_V0.5370.97
38_G100_A0.5320.96
332_S336_E0.5310.96
173_G180_R0.5310.96
208_I212_K0.5310.96
273_L279_V0.5310.96
161_P196_I0.5300.96
114_Y353_E0.5280.96
42_T92_T0.5280.96
150_V187_A0.5280.96
174_L185_R0.5280.96
128_Y131_G0.5270.96
322_I326_F0.5270.96
211_A214_L0.5260.96
51_V54_F0.5260.96
9_A26_V0.5260.96
311_L352_P0.5250.96
265_L294_V0.5250.96
66_D115_K0.5240.96
103_D308_A0.5230.96
113_L312_Q0.5230.96
194_I219_P0.5220.96
175_D190_D0.5220.96
185_R188_V0.5200.96
290_E296_M0.5190.96
46_L51_V0.5190.96
232_E236_K0.5190.96
62_L73_N0.5160.96
238_R265_L0.5150.96
224_E249_E0.5150.96
31_T34_D0.5120.96
126_L193_D0.5110.96
210_I213_R0.5110.96
146_A210_I0.5100.95
54_F89_E0.5100.95
26_V52_A0.5100.95
161_P202_F0.5090.95
5_S32_T0.5080.95
234_L266_V0.5070.95
33_N36_R0.5060.95
340_N343_P0.5050.95
133_Y136_C0.5030.95
198_H207_A0.5010.95
46_L50_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rcyA 5 0.9669 100 0.211 Contact Map
3bjsA 5 0.9186 100 0.225 Contact Map
3s5sA 2 0.8855 100 0.228 Contact Map
3ozyA 2 0.944 100 0.229 Contact Map
2qdeA 5 0.9084 100 0.23 Contact Map
2qddA 5 0.916 100 0.231 Contact Map
4dwdA 5 0.9389 100 0.232 Contact Map
3rr1A 5 0.9186 100 0.232 Contact Map
3i6eA 4 0.8855 100 0.233 Contact Map
2qgyA 2 0.9313 100 0.235 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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