GREMLIN Database
Q97VF8 - ABC transporter, permease protein
UniProt: Q97VF8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (298)
Sequences: 21515 (13613)
Seq/√Len: 788.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_R73_I3.3631.00
66_R77_N3.2351.00
29_E74_N3.1701.00
76_V80_W2.7801.00
80_W84_H2.7501.00
221_T248_I2.7201.00
52_P56_A2.6151.00
60_D65_L2.5921.00
21_I75_A2.5581.00
285_N289_N2.4611.00
114_T202_I2.4561.00
234_E240_K2.4221.00
242_I246_K2.3911.00
107_W280_Y2.3381.00
126_L142_A2.3091.00
224_V229_F2.2801.00
34_S59_I2.2231.00
230_V248_I2.2111.00
72_L76_V2.2061.00
22_V75_A2.1881.00
224_V227_E2.1491.00
139_D218_R2.0571.00
241_D245_K2.0481.00
239_K242_I2.0401.00
96_P99_E2.0091.00
261_I317_A1.9751.00
4_K8_R1.9701.00
100_L286_L1.9701.00
55_Y59_I1.9411.00
238_V242_I1.8931.00
54_L57_S1.8851.00
73_I77_N1.8821.00
121_F125_R1.8751.00
67_P72_L1.8361.00
225_L248_I1.8261.00
118_I206_T1.8261.00
51_K54_L1.8261.00
93_S100_L1.8181.00
172_F196_Y1.8181.00
57_S61_Y1.8001.00
230_V243_I1.7901.00
68_H72_L1.7561.00
56_A60_D1.7351.00
137_K141_V1.7241.00
95_V99_E1.7061.00
172_F199_F1.6991.00
166_A174_T1.6961.00
98_A102_A1.6931.00
20_T307_I1.6911.00
56_A59_I1.6871.00
17_I308_V1.6721.00
77_N80_W1.6561.00
97_V301_G1.6331.00
131_G221_T1.6131.00
228_D231_N1.6101.00
81_N86_N1.6021.00
138_T142_A1.5981.00
128_Q221_T1.5941.00
257_Y324_L1.5651.00
129_K138_T1.5651.00
122_L125_R1.5631.00
224_V252_A1.5431.00
177_A280_Y1.5301.00
285_N288_I1.5131.00
202_I206_T1.5131.00
232_F236_S1.4991.00
132_Y244_E1.4931.00
320_T323_F1.4791.00
288_I291_I1.4711.00
213_W263_S1.4691.00
122_L210_L1.4641.00
163_Y168_I1.4581.00
287_L302_V1.4491.00
11_A15_I1.4481.00
119_S209_N1.4231.00
229_F251_N1.4191.00
18_F75_A1.4171.00
258_T321_Y1.4161.00
77_N81_N1.4031.00
58_L62_L1.3991.00
34_S37_N1.3981.00
58_L61_Y1.3871.00
87_L301_G1.3851.00
156_I160_L1.3801.00
224_V230_V1.3691.00
107_W177_A1.3651.00
110_F114_T1.3591.00
110_F177_A1.3581.00
82_T87_L1.3581.00
161_L204_T1.3541.00
73_I76_V1.3501.00
95_V103_V1.3411.00
164_I168_I1.3331.00
120_F260_L1.3241.00
224_V248_I1.3201.00
132_Y240_K1.3171.00
87_L98_A1.3161.00
83_L86_N1.3111.00
18_F22_V1.3091.00
103_V106_P1.3051.00
63_N66_R1.3001.00
13_V311_I1.2981.00
123_G217_M1.2701.00
142_A214_I1.2641.00
127_G131_G1.2471.00
135_G139_D1.2391.00
288_I292_T1.2361.00
285_N291_I1.2311.00
149_L211_V1.2221.00
95_V100_L1.2201.00
290_S298_T1.2201.00
134_R240_K1.2181.00
218_R222_I1.2141.00
100_L298_T1.2131.00
123_G213_W1.2081.00
236_S247_Y1.2061.00
206_T210_L1.2061.00
107_W110_F1.2061.00
36_A55_Y1.1991.00
216_Q259_S1.1971.00
21_I78_Y1.1971.00
116_I260_L1.1941.00
26_A29_E1.1881.00
89_F96_P1.1821.00
7_I11_A1.1681.00
164_I169_Y1.1611.00
127_G217_M1.1561.00
39_I42_F1.1471.00
130_L142_A1.1431.00
126_L214_I1.1401.00
286_L298_T1.1341.00
152_V157_Y1.1341.00
137_K140_S1.1301.00
146_L214_I1.1161.00
131_G225_L1.1141.00
254_L321_Y1.0881.00
37_N55_Y1.0871.00
63_N77_N1.0871.00
217_M256_L1.0801.00
233_A238_V1.0771.00
289_N293_S1.0741.00
302_V306_I1.0641.00
321_Y325_D1.0611.00
199_F203_L1.0581.00
90_S95_V1.0551.00
110_F198_A1.0531.00
319_L323_F1.0531.00
204_T208_V1.0481.00
99_E103_V1.0451.00
165_L169_Y1.0441.00
67_P73_I1.0371.00
57_S60_D1.0351.00
265_G310_V1.0201.00
233_A243_I1.0201.00
81_N84_H1.0161.00
221_T252_A1.0121.00
217_M221_T1.0041.00
66_R72_L1.0011.00
285_N290_S1.0001.00
102_A106_P0.9991.00
128_Q244_E0.9991.00
145_S149_L0.9991.00
115_S206_T0.9981.00
6_L319_L0.9901.00
131_G222_I0.9811.00
11_A319_L0.9811.00
313_G317_A0.9811.00
296_Y300_M0.9751.00
18_F79_I0.9701.00
154_I274_V0.9631.00
286_L290_S0.9621.00
100_L103_V0.9601.00
10_L14_I0.9601.00
158_A204_T0.9581.00
60_D66_R0.9441.00
240_K243_I0.9441.00
125_R128_Q0.9421.00
160_L164_I0.9321.00
53_E57_S0.9291.00
90_S295_D0.9281.00
195_L199_F0.9261.00
89_F94_N0.9261.00
172_F200_L0.9121.00
92_I293_S0.9101.00
21_I304_I0.9081.00
264_I313_G0.9031.00
161_L200_L0.9021.00
17_I311_I0.8931.00
112_V267_S0.8871.00
223_Y227_E0.8841.00
198_A202_I0.8841.00
257_Y317_A0.8831.00
22_V26_A0.8821.00
99_E102_A0.8801.00
25_W29_E0.8771.00
139_D222_I0.8731.00
36_A40_M0.8721.00
13_V315_L0.8711.00
242_I245_K0.8701.00
234_E243_I0.8691.00
238_V243_I0.8681.00
143_T214_I0.8681.00
110_F113_V0.8661.00
316_I320_T0.8661.00
252_A255_P0.8621.00
80_W83_L0.8611.00
40_M58_L0.8581.00
118_I202_I0.8541.00
82_T304_I0.8471.00
233_A247_Y0.8471.00
10_L315_L0.8471.00
33_Y294_N0.8451.00
135_G140_S0.8441.00
115_S205_L0.8401.00
115_S119_S0.8341.00
97_V298_T0.8341.00
123_G127_G0.8311.00
312_V316_I0.8261.00
322_S328_A0.8241.00
165_L172_F0.8241.00
210_L214_I0.8241.00
128_Q249_G0.8231.00
120_F125_R0.8211.00
22_V72_L0.8211.00
124_I217_M0.8201.00
5_W322_S0.8191.00
220_N223_Y0.8191.00
203_L206_T0.8181.00
104_A286_L0.8181.00
243_I248_I0.8161.00
29_E68_H0.8151.00
125_R129_K0.8121.00
220_N224_V0.8121.00
217_M252_A0.8041.00
25_W28_L0.8031.00
75_A79_I0.8021.00
101_I301_G0.8011.00
165_L200_L0.8011.00
134_R138_T0.8001.00
126_L210_L0.7921.00
29_E296_Y0.7901.00
15_I18_F0.7891.00
76_V79_I0.7881.00
140_S143_T0.7881.00
92_I289_N0.7871.00
53_E56_A0.7831.00
141_V145_S0.7811.00
132_Y245_K0.7811.00
138_T141_V0.7801.00
78_Y82_T0.7781.00
87_L101_I0.7771.00
287_L290_S0.7761.00
113_V117_L0.7751.00
245_K248_I0.7721.00
52_P55_Y0.7721.00
116_I264_I0.7681.00
108_T112_V0.7671.00
287_L291_I0.7661.00
114_T280_Y0.7601.00
22_V68_H0.7591.00
308_V312_V0.7571.00
79_I82_T0.7551.00
158_A277_T0.7391.00
79_I83_L0.7391.00
127_G221_T0.7341.00
26_A68_H0.7341.00
271_S274_V0.7341.00
240_K244_E0.7321.00
265_G313_G0.7311.00
319_L322_S0.7281.00
122_L126_L0.7251.00
36_A59_I0.7241.00
150_R211_V0.7241.00
50_Q55_Y0.7231.00
124_I256_L0.7211.00
36_A58_L0.7201.00
199_F202_I0.7191.00
233_A236_S0.7191.00
146_L211_V0.7181.00
321_Y328_A0.7171.00
209_N212_G0.7091.00
24_S303_F0.7071.00
134_R226_G0.7061.00
24_S28_L0.7041.00
231_N234_E0.7021.00
119_S206_T0.7011.00
123_G214_I0.7011.00
24_S105_L0.7011.00
300_M303_F0.6991.00
106_P110_F0.6991.00
40_M50_Q0.6981.00
28_L31_S0.6961.00
301_G305_I0.6951.00
113_V264_I0.6951.00
142_A146_L0.6861.00
39_I58_L0.6861.00
111_I202_I0.6841.00
109_L113_V0.6841.00
154_I158_A0.6841.00
102_A105_L0.6831.00
168_I171_I0.6821.00
289_N292_T0.6821.00
157_Y207_I0.6821.00
165_L171_I0.6801.00
276_Q285_N0.6781.00
36_A62_L0.6781.00
220_N252_A0.6751.00
80_W85_G0.6751.00
238_V247_Y0.6751.00
37_N41_Q0.6731.00
122_L206_T0.6711.00
54_L58_L0.6711.00
106_P109_L0.6681.00
120_F213_W0.6671.00
101_I302_V0.6661.00
276_Q288_I0.6661.00
290_S299_E0.6631.00
144_V147_S0.6621.00
322_S329_K0.6601.00
306_I310_V0.6591.00
111_I275_E0.6581.00
176_G197_H0.6571.00
177_A198_A0.6571.00
14_I312_V0.6541.00
121_F124_I0.6521.00
217_M220_N0.6471.00
231_N235_I0.6461.00
13_V16_A0.6461.00
154_I157_Y0.6451.00
26_A30_F0.6431.00
175_G279_S0.6381.00
310_V314_N0.6371.00
141_V144_V0.6341.00
154_I207_I0.6331.00
115_S271_S0.6321.00
50_Q54_L0.6251.00
24_S29_E0.6201.00
204_T274_V0.6191.00
259_S263_S0.6171.00
286_L302_V0.6171.00
300_M304_I0.6161.00
14_I18_F0.6161.00
90_S93_S0.6131.00
140_S144_V0.6131.00
285_N293_S0.6121.00
130_L139_D0.6101.00
144_V148_I0.6081.00
212_G263_S0.6071.00
281_P285_N0.6061.00
139_D143_T0.6051.00
162_I174_T0.6031.00
149_L207_I0.6001.00
254_L328_A0.6001.00
213_W217_M0.6001.00
36_A39_I0.6001.00
17_I21_I0.5981.00
299_E303_F0.5941.00
134_R222_I0.5941.00
112_V271_S0.5931.00
217_M249_G0.5931.00
73_I80_W0.5891.00
101_I305_I0.5881.00
85_G96_P0.5861.00
173_P176_G0.5861.00
212_G259_S0.5851.00
100_L104_A0.5841.00
290_S293_S0.5791.00
6_L12_S0.5791.00
104_A285_N0.5781.00
200_L204_T0.5761.00
130_L143_T0.5741.00
114_T117_L0.5701.00
97_V286_L0.5681.00
114_T199_F0.5651.00
163_Y167_F0.5651.00
114_T195_L0.5641.00
286_L291_I0.5631.00
114_T118_I0.5621.00
216_Q220_N0.5611.00
288_I293_S0.5611.00
257_Y320_T0.5591.00
12_S15_I0.5591.00
211_V214_I0.5581.00
105_L109_L0.5581.00
120_F124_I0.5561.00
206_T209_N0.5561.00
85_G89_F0.5551.00
42_F50_Q0.5551.00
241_D244_E0.5551.00
28_L299_E0.5541.00
129_K134_R0.5521.00
105_L309_A0.5521.00
11_A14_I0.5511.00
227_E231_N0.5501.00
61_Y94_N0.5481.00
117_L121_F0.5471.00
317_A321_Y0.5471.00
197_H200_L0.5431.00
23_I102_A0.5431.00
286_L289_N0.5431.00
230_V234_E0.5401.00
93_S298_T0.5381.00
42_F49_A0.5361.00
245_K250_K0.5361.00
196_Y199_F0.5351.00
154_I208_V0.5351.00
239_K243_I0.5351.00
276_Q289_N0.5351.00
136_T139_D0.5341.00
82_T85_G0.5331.00
65_L68_H0.5331.00
116_I120_F0.5321.00
8_R11_A0.5301.00
261_I313_G0.5301.00
166_A200_L0.5301.00
326_P329_K0.5281.00
67_P81_N0.5271.00
220_N255_P0.5261.00
213_W259_S0.5241.00
12_S16_A0.5231.00
207_I210_L0.5231.00
287_L306_I0.5231.00
200_L203_L0.5231.00
27_L31_S0.5221.00
131_G139_D0.5221.00
224_V251_N0.5221.00
208_V211_V0.5211.00
15_I19_V0.5211.00
173_P197_H0.5191.00
19_V23_I0.5191.00
136_T141_V0.5171.00
156_I159_V0.5171.00
13_V17_I0.5171.00
195_L198_A0.5161.00
21_I79_I0.5131.00
128_Q245_K0.5131.00
221_T225_L0.5081.00
272_V276_Q0.5071.00
273_F276_Q0.5061.00
118_I203_L0.5061.00
16_A311_I0.5061.00
134_R244_E0.5041.00
309_A313_G0.5031.00
245_K249_G0.5031.00
212_G266_F0.5031.00
112_V116_I0.5021.00
263_S266_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.6276 99.9 0.671 Contact Map
4tquM 1 0.8108 99.9 0.688 Contact Map
3rlfF 1 0.8198 99.9 0.692 Contact Map
4ymuD 2 0.6306 99.8 0.705 Contact Map
3d31C 2 0.7417 99.8 0.705 Contact Map
2onkC 2 0.7508 99.8 0.709 Contact Map
4tquN 1 0.7718 99.8 0.726 Contact Map
3rlfG 1 0.8288 99.7 0.743 Contact Map
2yevC 1 0.0931 9.1 0.964 Contact Map
4ds7E 2 0.0511 5.2 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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