GREMLIN Database
Q97VF6 - ABC transporter, permease protein
UniProt: Q97VF6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (264)
Sequences: 29088 (18908)
Seq/√Len: 1163.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_P60_S3.0261.00
56_P64_L2.8971.00
32_I61_N2.7581.00
170_V197_V2.7101.00
116_D167_R2.6881.00
183_R189_R2.3991.00
173_I178_A2.3731.00
191_Y195_R2.3181.00
104_V119_L2.2771.00
187_L191_Y2.2651.00
173_I176_S2.2641.00
85_S225_Y2.2511.00
92_L151_S2.2461.00
190_K194_F2.1991.00
96_F155_S2.1821.00
50_P55_M2.1701.00
188_S191_Y2.1661.00
24_I62_F2.1611.00
238_A242_Q2.0901.00
177_P180_E2.0721.00
10_L14_W2.0711.00
42_K46_L2.0101.00
179_V197_V1.9701.00
37_Q49_S1.9591.00
179_V192_I1.9591.00
49_S52_T1.9201.00
78_Q239_M1.9201.00
111_L189_R1.8721.00
106_I170_V1.8591.00
210_I276_S1.8521.00
59_L63_Y1.8461.00
111_L115_I1.8061.00
69_G73_E1.7881.00
107_I111_L1.7851.00
99_L103_V1.7751.00
74_S77_V1.7631.00
162_L212_N1.7461.00
25_I62_F1.7181.00
110_Y189_R1.7071.00
178_A200_T1.7031.00
33_A83_A1.6981.00
173_I201_L1.6931.00
114_I118_I1.6671.00
109_G170_V1.6561.00
43_T46_L1.6051.00
66_F260_F1.6001.00
76_L80_I1.5731.00
100_I159_W1.5681.00
174_R197_V1.5671.00
71_F78_Q1.5611.00
100_I103_V1.5471.00
115_I119_L1.5401.00
41_P44_Y1.5351.00
107_I115_I1.5271.00
75_I260_F1.5111.00
151_S155_S1.5041.00
45_S49_S1.5021.00
97_A158_S1.4961.00
88_E92_L1.4841.00
169_Q172_V1.4751.00
119_L163_A1.4741.00
60_S64_L1.4631.00
46_L49_S1.4631.00
110_Y193_I1.4521.00
81_Q84_K1.4421.00
243_A257_Y1.4411.00
98_T209_Y1.4211.00
70_P242_Q1.4151.00
123_T163_A1.4141.00
57_P60_S1.4021.00
101_G162_L1.3911.00
94_G209_Y1.3811.00
240_I261_P1.3741.00
73_E77_V1.3721.00
172_V176_S1.3681.00
181_V185_L1.3611.00
105_G166_V1.3381.00
105_G109_G1.3351.00
21_V25_I1.3231.00
121_G124_D1.3171.00
52_T55_M1.3141.00
19_S278_G1.3131.00
35_F38_I1.3051.00
167_R171_L1.3031.00
101_G166_V1.2801.00
207_I280_D1.2571.00
280_D284_N1.2531.00
173_I197_V1.2471.00
173_I179_V1.2451.00
114_I117_N1.2341.00
108_A119_L1.2331.00
16_N270_S1.2261.00
104_V163_A1.2251.00
133_I137_I1.2241.00
155_S159_W1.2111.00
148_I152_L1.2101.00
62_F65_I1.2101.00
255_I259_A1.2061.00
85_S88_E1.2051.00
109_G174_R1.2001.00
66_F76_L1.1891.00
53_I56_P1.1781.00
138_I153_I1.1751.00
165_A208_H1.1641.00
106_I193_I1.1631.00
206_A283_S1.1521.00
182_L196_E1.1481.00
79_I264_V1.1481.00
23_L266_A1.1451.00
22_G271_G1.1441.00
279_I282_I1.1431.00
89_I220_E1.1351.00
73_E78_Q1.1081.00
31_L35_F1.1061.00
170_V201_L1.0991.00
112_G174_R1.0941.00
73_E81_Q1.0911.00
22_G278_G1.0861.00
182_L192_I1.0801.00
14_W18_K1.0741.00
126_I160_A1.0681.00
102_I166_V1.0601.00
64_L74_S1.0571.00
106_I198_V1.0561.00
36_G81_Q1.0531.00
169_Q173_I1.0521.00
182_L187_L1.0511.00
66_F79_I1.0491.00
50_P53_I1.0421.00
60_S63_Y1.0421.00
166_V170_V1.0391.00
23_L27_V1.0291.00
166_V205_I1.0281.00
17_K20_R1.0261.00
117_N121_G1.0231.00
103_V106_I1.0211.00
46_L50_P1.0211.00
21_V62_F1.0151.00
122_I126_I1.0111.00
180_E183_R1.0111.00
153_I157_T1.0081.00
191_Y194_F1.0051.00
239_M257_Y1.0031.00
26_T271_G0.9991.00
25_I29_Y0.9991.00
146_N149_F0.9961.00
261_P265_V0.9891.00
36_G39_I0.9871.00
75_I239_M0.9831.00
185_L196_E0.9821.00
213_V272_L0.9811.00
129_L134_L0.9731.00
58_Q63_Y0.9721.00
159_W163_A0.9711.00
14_W20_R0.9711.00
93_A155_S0.9681.00
135_I153_I0.9621.00
278_G282_I0.9591.00
75_I257_Y0.9581.00
243_A258_L0.9571.00
48_P51_T0.9561.00
116_D171_L0.9541.00
182_L185_L0.9541.00
256_Y260_F0.9481.00
183_R192_I0.9461.00
40_F77_V0.9401.00
113_G116_D0.9391.00
120_M163_A0.9381.00
166_V201_L0.9351.00
18_K21_V0.9331.00
82_G239_M0.9261.00
84_K88_E0.9261.00
203_S280_D0.9241.00
112_G175_N0.9211.00
78_Q257_Y0.9211.00
260_F263_I0.9201.00
116_D120_M0.9201.00
55_M58_Q0.9161.00
68_T74_S0.9131.00
39_I45_S0.9071.00
77_V81_Q0.9041.00
88_E147_P0.9041.00
118_I122_I0.8981.00
115_I118_I0.8961.00
48_P52_T0.8951.00
241_Q245_S0.8931.00
148_I151_S0.8921.00
187_L192_I0.8871.00
88_E91_F0.8871.00
79_I260_F0.8841.00
271_G275_L0.8811.00
117_N120_M0.8801.00
93_A97_A0.8721.00
56_P59_L0.8711.00
102_I205_I0.8681.00
21_V24_I0.8661.00
189_R192_I0.8631.00
272_L276_S0.8611.00
93_A154_L0.8591.00
131_S219_A0.8591.00
8_E12_L0.8561.00
105_G170_V0.8461.00
142_F149_F0.8451.00
201_L204_Y0.8381.00
24_I28_F0.8381.00
123_T160_A0.8291.00
206_A276_S0.8241.00
113_G117_N0.8231.00
50_P56_P0.8171.00
25_I271_G0.8151.00
28_F32_I0.8131.00
16_N274_L0.8131.00
58_Q61_N0.8111.00
143_K149_F0.8101.00
147_P151_S0.8041.00
98_T102_I0.7941.00
152_L155_S0.7941.00
154_L219_A0.7941.00
99_L102_I0.7881.00
80_I84_K0.7881.00
22_G26_T0.7861.00
168_S171_L0.7821.00
54_F57_P0.7791.00
51_T55_M0.7791.00
109_G171_L0.7791.00
208_H212_N0.7781.00
104_V159_W0.7781.00
92_L225_Y0.7771.00
14_W17_K0.7751.00
42_K77_V0.7721.00
83_A268_F0.7711.00
77_V80_I0.7711.00
98_T162_L0.7701.00
131_S135_I0.7691.00
78_Q81_Q0.7691.00
24_I65_I0.7661.00
189_R193_I0.7661.00
22_G25_I0.7641.00
144_T149_F0.7621.00
11_R14_W0.7611.00
98_T103_V0.7611.00
37_Q84_K0.7571.00
176_S180_E0.7511.00
103_V107_I0.7501.00
239_M261_P0.7471.00
35_F39_I0.7471.00
68_T72_A0.7461.00
42_K45_S0.7461.00
149_F152_L0.7431.00
86_V90_S0.7431.00
20_R267_G0.7421.00
194_F197_V0.7391.00
138_I149_F0.7391.00
92_L95_L0.7381.00
242_Q245_S0.7371.00
170_V174_R0.7331.00
108_A116_D0.7311.00
259_A263_I0.7301.00
24_I263_I0.7281.00
173_I200_T0.7251.00
91_F95_L0.7221.00
187_L196_E0.7161.00
29_Y268_F0.7161.00
80_I83_A0.7111.00
265_V269_M0.7051.00
180_E184_V0.7051.00
53_I64_L0.7021.00
93_A216_A0.7011.00
259_A262_T0.6981.00
260_F264_V0.6971.00
61_N65_I0.6951.00
32_I80_I0.6941.00
8_E281_E0.6921.00
242_Q246_Y0.6871.00
17_K21_V0.6791.00
23_L275_L0.6781.00
42_K63_Y0.6771.00
27_V31_L0.6751.00
127_L160_A0.6721.00
13_L17_K0.6701.00
69_G254_A0.6691.00
169_Q204_Y0.6691.00
53_I57_P0.6661.00
65_I76_L0.6651.00
192_I197_V0.6651.00
281_E287_I0.6641.00
19_S23_L0.6611.00
267_G271_G0.6601.00
241_Q244_L0.6591.00
29_Y33_A0.6541.00
210_I272_L0.6521.00
40_F44_Y0.6501.00
218_Y221_V0.6501.00
280_D287_I0.6491.00
100_I155_S0.6461.00
275_L279_I0.6461.00
166_V169_Q0.6461.00
169_Q201_L0.6431.00
32_I255_I0.6421.00
158_S161_G0.6411.00
20_R270_S0.6391.00
79_I261_P0.6371.00
96_F151_S0.6351.00
269_M273_I0.6341.00
112_G116_D0.6321.00
190_K193_I0.6311.00
120_M123_T0.6291.00
32_I58_Q0.6281.00
150_L220_E0.6281.00
247_G258_L0.6281.00
64_L68_T0.6261.00
97_A155_S0.6231.00
61_N64_L0.6231.00
101_G105_G0.6221.00
118_I121_G0.6221.00
27_V262_T0.6211.00
220_E224_Y0.6171.00
9_Y278_G0.6171.00
29_Y32_I0.6161.00
13_L274_L0.6151.00
144_T148_I0.6141.00
18_K22_G0.6131.00
157_T160_A0.6111.00
258_L262_T0.6091.00
36_G247_G0.6051.00
108_A120_M0.6041.00
52_T64_L0.5961.00
49_S55_M0.5891.00
40_F81_Q0.5881.00
87_I91_F0.5871.00
13_L19_S0.5861.00
131_S134_L0.5851.00
123_T159_W0.5821.00
100_I104_V0.5821.00
219_A222_G0.5801.00
171_L174_R0.5801.00
112_G171_L0.5781.00
218_Y222_G0.5771.00
161_G212_N0.5751.00
119_L123_T0.5741.00
137_I141_A0.5731.00
149_F153_I0.5731.00
94_G213_V0.5731.00
83_A87_I0.5721.00
20_R24_I0.5711.00
110_Y194_F0.5711.00
70_P246_Y0.5671.00
41_P76_L0.5611.00
101_G163_A0.5601.00
162_L208_H0.5601.00
70_P256_Y0.5591.00
217_V221_V0.5581.00
110_Y174_R0.5571.00
42_K64_L0.5561.00
111_L193_I0.5551.00
162_L166_V0.5551.00
240_I265_V0.5531.00
94_G212_N0.5521.00
277_Y280_D0.5501.00
158_S212_N0.5501.00
134_L157_T0.5491.00
90_S216_A0.5491.00
126_I159_W0.5481.00
25_I58_Q0.5441.00
156_I159_W0.5431.00
131_S156_I0.5411.00
8_E287_I0.5391.00
109_G116_D0.5371.00
187_L190_K0.5371.00
179_V183_R0.5361.00
216_A219_A0.5361.00
139_V143_K0.5331.00
25_I267_G0.5321.00
89_I150_L0.5311.00
221_V241_Q0.5301.00
16_N278_G0.5291.00
98_T205_I0.5271.00
29_Y58_Q0.5231.00
11_R15_D0.5231.00
207_I210_I0.5231.00
41_P77_V0.5221.00
25_I59_L0.5171.00
194_F199_P0.5161.00
50_P57_P0.5161.00
29_Y267_G0.5141.00
161_G208_H0.5131.00
152_L156_I0.5111.00
165_A169_Q0.5101.00
95_L99_L0.5081.00
108_A167_R0.5071.00
84_K87_I0.5061.00
244_L247_G0.5051.00
221_V238_A0.5031.00
120_M124_D0.5031.00
26_T272_L0.5001.00
121_G125_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.8724 99.9 0.6 Contact Map
3tuiA 2 0.7 99.9 0.626 Contact Map
3d31C 2 0.8 99.9 0.636 Contact Map
2onkC 2 0.8172 99.8 0.652 Contact Map
3rlfF 1 0.8931 99.8 0.658 Contact Map
4ymuD 2 0.7207 99.8 0.661 Contact Map
4tquN 1 0.9103 99.8 0.673 Contact Map
3rlfG 1 0.8862 99.8 0.677 Contact Map
3j9pD 4 0.7724 44.1 0.941 Contact Map
3j5pB 3 0.8241 5.3 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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