GREMLIN Database
Q97VF5 - ABC transporter, ATP binding protein
UniProt: Q97VF5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 362 (278)
Sequences: 38115 (24042)
Seq/√Len: 1441.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_E265_R4.1421.00
47_E72_G3.4501.00
133_D215_K3.2891.00
49_H110_K3.2881.00
265_R277_E3.1481.00
50_N68_D3.1211.00
74_E77_E2.9651.00
110_K117_D2.8631.00
175_S185_P2.6481.00
279_K282_E2.6361.00
53_V95_A2.5251.00
64_K67_N2.5201.00
149_L153_E2.5151.00
52_N108_S2.5011.00
79_L267_L2.4451.00
49_H112_I2.3981.00
267_L274_V2.3541.00
114_N215_K2.3331.00
47_E112_I2.2651.00
122_T125_E2.2281.00
80_G263_A2.2271.00
52_N68_D2.2071.00
48_V51_L2.1891.00
54_I64_K2.1501.00
67_N273_Y2.0381.00
278_G283_I2.0351.00
177_L211_L2.0151.00
267_L277_E2.0091.00
180_L245_M1.9951.00
166_D169_R1.9631.00
45_I72_G1.9461.00
93_I218_L1.9151.00
93_I252_V1.9051.00
75_K215_K1.8961.00
117_D120_S1.8841.00
173_R176_E1.8761.00
287_P292_T1.7981.00
278_G282_E1.7911.00
188_V191_M1.7351.00
55_Y91_T1.7231.00
175_S179_K1.7201.00
98_R126_F1.7111.00
260_A281_E1.6801.00
52_N64_K1.6621.00
152_S156_Y1.6201.00
54_I103_P1.6141.00
80_G259_I1.5951.00
48_V71_F1.5901.00
116_M125_E1.5741.00
292_T296_V1.5731.00
175_S189_L1.5711.00
280_T291_Y1.5351.00
44_M47_E1.5331.00
44_M74_E1.5301.00
71_F267_L1.5291.00
114_N133_D1.5271.00
239_K261_Q1.5141.00
73_V79_L1.5061.00
173_R213_N1.4901.00
50_N70_S1.4861.00
54_I62_I1.4541.00
324_C330_C1.4371.00
191_M195_Q1.4331.00
253_T259_I1.4271.00
176_E180_L1.4151.00
135_S214_P1.4141.00
170_V175_S1.4121.00
322_K327_L1.4061.00
78_I263_A1.3861.00
52_N67_N1.3731.00
71_F92_L1.3681.00
213_N247_V1.3661.00
56_D62_I1.3531.00
53_V100_I1.3381.00
45_I74_E1.3241.00
98_R101_R1.3171.00
150_P153_E1.3101.00
43_V75_K1.3041.00
116_M121_M1.2981.00
51_L102_P1.2951.00
166_D170_V1.2731.00
97_L136_Y1.2721.00
81_I267_L1.2661.00
160_I170_V1.2621.00
152_S189_L1.2591.00
235_L258_N1.2581.00
78_I242_N1.2541.00
79_L265_R1.2521.00
53_V103_P1.2521.00
69_V92_L1.2421.00
55_Y65_A1.2351.00
45_I75_K1.2271.00
77_E264_N1.2161.00
48_V96_I1.2111.00
100_I103_P1.2101.00
242_N249_I1.2041.00
153_E156_Y1.1951.00
121_M126_F1.1941.00
282_E286_S1.1901.00
121_M125_E1.1901.00
152_S186_A1.1781.00
75_K114_N1.1751.00
171_I189_L1.1541.00
44_M72_G1.1451.00
78_I249_I1.1361.00
137_V219_M1.1351.00
171_I175_S1.1341.00
167_K171_I1.1271.00
81_I250_V1.1251.00
176_E179_K1.1131.00
179_K185_P1.1101.00
73_V250_V1.1041.00
49_H70_S1.1011.00
239_K242_N1.1001.00
168_K172_E1.0981.00
188_V196_L1.0971.00
273_Y325_P1.0971.00
152_S190_K1.0871.00
92_L269_M1.0861.00
74_E265_R1.0861.00
125_E128_K1.0791.00
78_I251_Y1.0761.00
156_Y170_V1.0721.00
196_L204_V1.0711.00
155_F178_L1.0701.00
155_F211_L1.0691.00
159_A164_E1.0681.00
150_P190_K1.0641.00
159_A162_H1.0611.00
156_Y174_A1.0591.00
49_H72_G1.0561.00
281_E285_K1.0531.00
112_I117_D1.0481.00
81_I92_L1.0461.00
167_K170_V1.0441.00
154_I208_L1.0381.00
219_M249_I1.0381.00
226_L234_L1.0371.00
169_R185_P1.0371.00
159_A211_L1.0341.00
266_L280_T1.0331.00
276_E286_S1.0301.00
290_P293_S1.0291.00
97_L218_L1.0281.00
67_N325_P1.0281.00
323_G327_L1.0241.00
238_I249_I1.0201.00
217_I249_I1.0171.00
198_G203_R1.0101.00
270_Y290_P1.0091.00
323_G326_F1.0081.00
166_D175_S1.0061.00
172_E176_E0.9941.00
213_N245_M0.9931.00
45_I114_N0.9891.00
231_Q255_D0.9881.00
50_N108_S0.9821.00
232_E236_K0.9811.00
44_M75_K0.9801.00
275_M290_P0.9751.00
149_L157_H0.9751.00
101_R119_F0.9721.00
156_Y160_I0.9701.00
79_L277_E0.9641.00
270_Y275_M0.9601.00
321_E328_A0.9591.00
326_F330_C0.9591.00
165_A170_V0.9571.00
54_I67_N0.9551.00
293_S297_S0.9481.00
217_I247_V0.9481.00
155_F169_R0.9441.00
251_Y262_I0.9391.00
44_M114_N0.9331.00
82_I259_I0.9241.00
276_E289_N0.9181.00
68_D273_Y0.9171.00
184_D188_V0.9161.00
276_E287_P0.9121.00
48_V111_V0.9111.00
145_L201_K0.9101.00
320_K325_P0.9051.00
163_G166_D0.9001.00
174_A177_L0.8971.00
301_S304_G0.8931.00
251_Y263_A0.8901.00
53_V91_T0.8891.00
134_I216_L0.8871.00
87_S269_M0.8871.00
95_A102_P0.8811.00
183_L188_V0.8811.00
145_L204_V0.8731.00
74_E248_T0.8701.00
169_R172_E0.8651.00
73_V248_T0.8631.00
321_E327_L0.8631.00
73_V216_L0.8571.00
282_E285_K0.8531.00
327_L330_C0.8501.00
57_E62_I0.8501.00
135_S209_S0.8501.00
97_L134_I0.8491.00
66_V69_V0.8441.00
324_C327_L0.8431.00
46_L250_V0.8391.00
152_S171_I0.8361.00
78_I239_K0.8281.00
319_S322_K0.8281.00
124_D128_K0.8251.00
179_K184_D0.8241.00
95_A111_V0.8201.00
75_K246_G0.8161.00
163_G173_R0.8161.00
51_L95_A0.8101.00
253_T258_N0.8091.00
283_I292_T0.8081.00
320_K323_G0.8031.00
178_L189_L0.8031.00
171_I190_K0.8011.00
323_G330_C0.8011.00
95_A100_I0.7971.00
291_Y294_L0.7951.00
241_I247_V0.7921.00
146_N149_L0.7891.00
82_I268_V0.7861.00
103_P108_S0.7831.00
123_I126_F0.7781.00
137_V206_I0.7761.00
170_V174_A0.7751.00
152_S165_A0.7751.00
324_C329_R0.7721.00
177_L180_L0.7721.00
313_L316_P0.7711.00
219_M238_I0.7641.00
321_E324_C0.7641.00
221_E254_H0.7581.00
163_G167_K0.7551.00
110_K120_S0.7541.00
84_E270_Y0.7471.00
69_V274_V0.7411.00
158_E208_L0.7361.00
169_R178_L0.7331.00
322_K326_F0.7331.00
113_F133_D0.7311.00
319_S323_G0.7281.00
57_E63_I0.7271.00
297_S309_I0.7261.00
116_M133_D0.7251.00
231_Q258_N0.7251.00
158_E212_L0.7191.00
320_K324_C0.7191.00
280_T284_I0.7161.00
156_Y171_I0.7151.00
156_Y165_A0.7141.00
239_K262_I0.7131.00
151_I204_V0.7101.00
177_L181_V0.7061.00
45_I113_F0.7041.00
46_L113_F0.7001.00
79_L250_V0.6981.00
286_S289_N0.6981.00
46_L96_I0.6921.00
289_N292_T0.6911.00
275_M325_P0.6901.00
173_R177_L0.6891.00
57_E318_V0.6871.00
66_V95_A0.6861.00
94_S100_I0.6851.00
294_L311_V0.6821.00
55_Y100_I0.6821.00
284_I295_L0.6801.00
216_L250_V0.6801.00
36_N39_E0.6791.00
165_A169_R0.6791.00
174_A189_L0.6781.00
325_P328_A0.6781.00
313_L317_L0.6761.00
113_F216_L0.6751.00
96_I250_V0.6741.00
190_K195_Q0.6651.00
85_S230_N0.6631.00
123_I127_R0.6611.00
80_G253_T0.6601.00
156_Y189_L0.6571.00
43_V74_E0.6571.00
85_S226_L0.6541.00
308_V311_V0.6521.00
58_G62_I0.6501.00
98_R123_I0.6491.00
53_V66_V0.6491.00
303_K306_V0.6491.00
110_K119_F0.6481.00
85_S221_E0.6481.00
242_N264_N0.6481.00
274_V277_E0.6451.00
149_L154_I0.6431.00
163_G170_V0.6431.00
223_T258_N0.6421.00
111_V119_F0.6421.00
158_E161_S0.6361.00
319_S327_L0.6351.00
259_I263_A0.6331.00
196_L200_M0.6321.00
78_I262_I0.6311.00
43_V114_N0.6311.00
218_L250_V0.6311.00
117_D121_M0.6301.00
236_K240_N0.6281.00
150_P154_I0.6241.00
162_H212_L0.6221.00
162_H211_L0.6211.00
50_N53_V0.6201.00
284_I287_P0.6141.00
210_L247_V0.6121.00
124_D127_R0.6121.00
96_I111_V0.6111.00
39_E42_C0.6101.00
263_A280_T0.6061.00
123_I128_K0.6061.00
325_P329_R0.6011.00
58_G63_I0.5981.00
278_G284_I0.5961.00
65_A91_T0.5951.00
87_S315_E0.5941.00
197_S200_M0.5921.00
312_P315_E0.5911.00
56_D63_I0.5911.00
270_Y273_Y0.5901.00
177_L207_A0.5891.00
320_K327_L0.5891.00
102_P118_I0.5881.00
183_L200_M0.5871.00
293_S296_V0.5871.00
182_G240_N0.5861.00
203_R226_L0.5851.00
48_V92_L0.5831.00
322_K328_A0.5831.00
166_D179_K0.5831.00
294_L297_S0.5821.00
240_N245_M0.5811.00
185_P188_V0.5791.00
318_V322_K0.5751.00
206_I234_L0.5721.00
77_E277_E0.5681.00
79_L274_V0.5671.00
84_E87_S0.5661.00
155_F204_V0.5651.00
233_L236_K0.5641.00
256_I284_I0.5631.00
320_K326_F0.5621.00
179_K186_A0.5611.00
128_K133_D0.5611.00
323_G328_A0.5611.00
182_G233_L0.5601.00
237_L240_N0.5601.00
95_A103_P0.5591.00
159_A165_A0.5571.00
54_I108_S0.5571.00
85_S203_R0.5551.00
269_M274_V0.5551.00
311_V315_E0.5531.00
94_S97_L0.5521.00
155_F174_A0.5491.00
64_K103_P0.5461.00
169_R173_R0.5461.00
125_E133_D0.5451.00
94_S99_A0.5451.00
172_E179_K0.5441.00
288_L293_S0.5441.00
189_L193_P0.5431.00
171_I174_A0.5421.00
84_E290_P0.5411.00
318_V323_G0.5401.00
155_F158_E0.5391.00
322_K330_C0.5391.00
317_L320_K0.5391.00
190_K193_P0.5391.00
169_R175_S0.5381.00
68_D108_S0.5361.00
180_L240_N0.5361.00
164_E167_K0.5351.00
144_A205_M0.5351.00
276_E292_T0.5341.00
75_K248_T0.5331.00
324_C328_A0.5321.00
173_R233_L0.5311.00
141_S205_M0.5281.00
54_I65_A0.5281.00
294_L298_S0.5281.00
319_S324_C0.5271.00
45_I216_L0.5251.00
316_P321_E0.5231.00
118_I121_M0.5221.00
289_N294_L0.5211.00
311_V314_D0.5211.00
286_S290_P0.5181.00
94_S136_Y0.5181.00
98_R119_F0.5171.00
155_F208_L0.5171.00
188_V200_M0.5161.00
287_P296_V0.5141.00
326_F329_R0.5141.00
178_L185_P0.5131.00
160_I167_K0.5131.00
235_L253_T0.5111.00
156_Y159_A0.5091.00
72_G277_E0.5091.00
321_E325_P0.5081.00
315_E328_A0.5071.00
314_D317_L0.5051.00
82_I256_I0.5051.00
257_L261_Q0.5041.00
159_A212_L0.5021.00
316_P319_S0.5021.00
268_V283_I0.5011.00
290_P294_L0.5001.00
118_I134_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ry2A 2 0.7459 100 0.214 Contact Map
4f4cA 1 0.7459 100 0.227 Contact Map
4q9hA 1 0.7845 100 0.242 Contact Map
4a82A 2 0.7762 100 0.244 Contact Map
3zdqA 2 0.7486 100 0.248 Contact Map
4mrsA 2 0.7983 100 0.249 Contact Map
3b5xA 2 0.7707 100 0.251 Contact Map
3b60A 2 0.7707 100 0.253 Contact Map
3tuiC 2 0.8536 100 0.255 Contact Map
4q4hB 1 0.7707 100 0.256 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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