GREMLIN Database
Q97VF4 - ABC transporter, ATP binding protein
UniProt: Q97VF4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (254)
Sequences: 57989 (35939)
Seq/√Len: 2255.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_D228_N4.4471.00
90_D173_R3.5711.00
26_Y29_K3.3091.00
41_L230_I3.0561.00
228_N240_R2.9321.00
36_N39_D2.9141.00
68_E75_N2.9071.00
242_D245_E2.8541.00
42_I224_F2.8161.00
72_D173_R2.7521.00
146_F149_K2.6691.00
230_I237_I2.5561.00
29_K236_R2.4831.00
123_N126_E2.3931.00
106_K110_E2.2721.00
37_Q173_R2.2061.00
218_R244_E2.1281.00
55_G210_I2.0631.00
15_D30_D2.0461.00
132_I142_P2.0321.00
132_I147_L2.0251.00
130_R171_N1.9881.00
130_R133_N1.9841.00
230_I240_R1.9751.00
241_A246_I1.9691.00
75_N78_K1.9601.00
134_L169_S1.9551.00
241_A245_E1.9461.00
55_G176_V1.9151.00
133_N137_L1.8251.00
17_V30_D1.8201.00
197_A219_Y1.7811.00
149_K153_Q1.7321.00
42_I217_A1.7161.00
109_E148_G1.7021.00
211_T217_A1.6921.00
72_D90_D1.6741.00
60_G84_F1.6561.00
199_I205_L1.6331.00
109_E147_L1.6011.00
109_E113_V1.6001.00
128_R132_I1.5991.00
245_E249_D1.5881.00
84_F88_R1.5661.00
113_V127_L1.5621.00
33_L230_I1.5541.00
113_V131_L1.5321.00
197_A200_K1.5321.00
107_T110_E1.5141.00
142_P145_E1.5031.00
40_L200_K1.4851.00
33_L54_L1.4821.00
146_F154_L1.4541.00
177_A207_M1.4531.00
141_T145_E1.4521.00
35_M41_L1.4051.00
15_D18_G1.4011.00
18_G22_K1.3751.00
112_L135_L1.3691.00
12_I34_S1.3601.00
39_D225_D1.3571.00
117_L127_L1.3551.00
171_N205_L1.3471.00
253_P256_N1.3381.00
70_V75_N1.3281.00
145_E149_K1.3261.00
256_N260_K1.3111.00
132_I136_E1.3021.00
41_L228_N1.3011.00
41_L240_R1.2971.00
60_G63_K1.2961.00
74_Y79_N1.2931.00
128_R147_L1.2921.00
12_I26_Y1.2891.00
125_D129_K1.2751.00
107_T148_G1.2721.00
200_K207_M1.2701.00
244_E248_K1.2681.00
14_E68_E1.2601.00
36_N228_N1.2601.00
31_V54_L1.2571.00
59_V93_L1.2571.00
40_L207_M1.2471.00
193_L216_I1.2461.00
129_K133_N1.2351.00
110_E113_V1.2341.00
14_E70_V1.2341.00
94_I177_A1.2341.00
118_R121_K1.2261.00
253_P257_D1.2231.00
273_N276_I1.2231.00
135_L147_L1.2131.00
99_Y159_K1.2101.00
37_Q72_D1.2041.00
126_E129_K1.1841.00
15_D20_F1.1701.00
123_N127_L1.1601.00
154_L162_L1.1541.00
133_N136_E1.1481.00
136_E141_T1.1481.00
109_E128_R1.1471.00
105_N152_H1.1471.00
40_L224_F1.1421.00
196_L207_M1.1291.00
255_T259_I1.1211.00
43_V208_V1.1171.00
57_V64_P1.1141.00
111_I166_R1.1091.00
37_Q204_N1.1051.00
124_K127_L1.1031.00
233_F238_V1.0961.00
15_D23_R1.0801.00
79_N84_F1.0771.00
141_T146_F1.0641.00
122_I127_L1.0601.00
229_T243_L1.0591.00
106_K114_A1.0571.00
175_I205_L1.0391.00
12_I24_K1.0361.00
245_E248_K1.0321.00
136_E142_P1.0291.00
200_K225_D1.0281.00
57_V62_Q1.0231.00
28_L57_V1.0211.00
43_V54_L1.0151.00
58_I208_V1.0101.00
175_I207_M1.0081.00
106_K111_I1.0081.00
109_E131_L1.0051.00
184_V192_I1.0051.00
237_I240_R1.0021.00
36_N206_T0.9901.00
92_Q172_P0.9891.00
19_L26_Y0.9861.00
13_F53_T0.9831.00
179_E212_H0.9761.00
21_K24_K0.9731.00
252_H255_T0.9731.00
127_L131_L0.9731.00
116_I169_S0.9711.00
243_L254_Y0.9691.00
139_K198_E0.9681.00
126_E130_R0.9661.00
54_L232_M0.9651.00
92_Q167_S0.9631.00
275_K278_Y0.9541.00
87_Y91_V0.9521.00
15_D22_K0.9491.00
246_I255_T0.9481.00
112_L169_S0.9471.00
190_I194_N0.9311.00
12_I15_D0.9261.00
113_V117_L0.9191.00
40_L197_A0.9171.00
27_A53_T0.9161.00
142_P147_L0.9151.00
134_L165_A0.9111.00
137_L198_E0.9111.00
43_V230_I0.9111.00
14_E24_K0.9101.00
243_L247_L0.9091.00
177_A196_L0.9081.00
56_R61_L0.9051.00
56_R62_Q0.9041.00
134_L137_L0.9031.00
189_R213_D0.8981.00
264_S267_N0.8961.00
28_L31_V0.8921.00
94_I164_I0.8921.00
113_V128_R0.8861.00
35_M174_I0.8851.00
209_F223_L0.8781.00
130_R134_L0.8781.00
49_A232_M0.8771.00
150_Y153_Q0.8721.00
59_V176_V0.8711.00
195_T198_E0.8681.00
124_K128_R0.8661.00
209_F224_F0.8601.00
197_A223_L0.8591.00
103_P106_K0.8581.00
189_R216_I0.8571.00
12_I29_K0.8521.00
122_I126_E0.8521.00
44_L217_A0.8431.00
91_V174_I0.8371.00
57_V65_T0.8341.00
273_N278_Y0.8341.00
231_V246_I0.8261.00
257_D261_L0.8191.00
116_I121_K0.8171.00
13_F20_F0.8171.00
194_N197_A0.8141.00
102_L159_K0.8011.00
71_Y90_D0.8011.00
108_V162_L0.7981.00
250_P255_T0.7981.00
272_I275_K0.7961.00
74_Y90_D0.7941.00
233_F257_D0.7941.00
216_I223_L0.7941.00
35_M206_T0.7931.00
274_V278_Y0.7921.00
102_L111_I0.7881.00
272_I276_I0.7851.00
30_D236_R0.7811.00
109_E119_W0.7791.00
138_V165_A0.7751.00
40_L209_F0.7741.00
238_V252_H0.7721.00
75_N79_N0.7681.00
228_N239_E0.7681.00
142_P146_F0.7671.00
257_D260_K0.7661.00
119_W122_I0.7621.00
193_L219_Y0.7601.00
115_P170_V0.7601.00
139_K191_G0.7561.00
31_V237_I0.7561.00
128_R148_G0.7541.00
107_T150_Y0.7521.00
17_V22_K0.7501.00
120_E130_R0.7471.00
174_I206_T0.7461.00
68_E78_K0.7451.00
57_V69_V0.7431.00
108_V154_L0.7361.00
254_Y257_D0.7351.00
239_E249_D0.7351.00
20_F65_T0.7341.00
151_P162_L0.7341.00
12_I70_V0.7331.00
126_E142_P0.7311.00
68_E77_W0.7301.00
35_M208_V0.7291.00
46_E233_F0.7291.00
266_D269_Y0.7261.00
115_P166_R0.7241.00
140_L146_F0.7211.00
20_F57_V0.7191.00
224_F229_T0.7181.00
86_K89_K0.7151.00
40_L223_L0.7141.00
269_Y272_I0.7121.00
80_K84_F0.7111.00
17_V66_S0.7101.00
176_V208_V0.7071.00
273_N277_N0.7071.00
131_L147_L0.7061.00
156_G161_R0.7061.00
76_I87_Y0.7041.00
13_F18_G0.7031.00
214_I247_L0.7021.00
194_N219_Y0.7011.00
276_I279_E0.7011.00
181_V216_I0.6991.00
275_K279_E0.6951.00
123_N132_I0.6951.00
80_K86_K0.6921.00
12_I65_T0.6921.00
154_L158_Q0.6891.00
146_F158_Q0.6881.00
194_N198_E0.6881.00
17_V20_F0.6871.00
17_V26_Y0.6831.00
40_L225_D0.6821.00
197_A201_N0.6811.00
28_L54_L0.6801.00
224_F243_L0.6761.00
44_L231_V0.6731.00
231_V250_P0.6721.00
134_L168_L0.6721.00
89_K120_E0.6711.00
94_I167_S0.6711.00
174_I208_V0.6711.00
102_L162_L0.6641.00
219_Y223_L0.6631.00
41_L208_V0.6601.00
118_R122_I0.6591.00
79_N87_Y0.6581.00
119_W123_N0.6551.00
254_Y258_L0.6491.00
56_R93_L0.6491.00
26_Y30_D0.6441.00
239_E250_P0.6411.00
127_L132_I0.6391.00
71_Y174_I0.6391.00
70_V73_G0.6381.00
267_N270_K0.6341.00
30_D66_S0.6331.00
160_Q183_M0.6311.00
131_L134_L0.6301.00
117_L124_K0.6281.00
191_G194_N0.6261.00
261_L264_S0.6241.00
274_V277_N0.6231.00
71_Y87_Y0.6211.00
225_D228_N0.6191.00
107_T111_I0.6191.00
52_T56_R0.6171.00
268_L272_I0.6171.00
117_L121_K0.6161.00
69_V77_W0.6161.00
233_F236_R0.6161.00
21_K26_Y0.6161.00
247_L250_P0.6111.00
120_E127_L0.6071.00
111_I151_P0.6051.00
63_K77_W0.6011.00
218_R247_L0.6011.00
46_E49_A0.5981.00
218_R243_L0.5951.00
140_L158_Q0.5941.00
211_T216_I0.5931.00
134_L138_V0.5871.00
164_I192_I0.5871.00
59_V91_V0.5861.00
86_K90_D0.5861.00
17_V32_S0.5821.00
76_I91_V0.5811.00
71_Y76_I0.5811.00
125_D128_R0.5781.00
168_L205_L0.5771.00
116_I120_E0.5761.00
13_F33_L0.5751.00
234_A278_Y0.5731.00
249_D252_H0.5711.00
112_L131_L0.5711.00
129_K132_I0.5701.00
61_L95_P0.5681.00
173_R205_L0.5651.00
18_G64_P0.5631.00
120_E123_N0.5621.00
47_S179_E0.5621.00
101_T163_S0.5611.00
128_R131_L0.5581.00
256_N259_I0.5571.00
217_A224_F0.5561.00
241_A247_L0.5561.00
120_E124_K0.5541.00
46_E254_Y0.5531.00
37_Q206_T0.5521.00
258_L262_T0.5521.00
130_R137_L0.5501.00
259_I263_P0.5491.00
265_I268_L0.5471.00
181_V192_I0.5461.00
22_K27_A0.5451.00
20_F53_T0.5431.00
58_I69_V0.5431.00
249_D253_P0.5431.00
38_G206_T0.5411.00
19_L66_S0.5411.00
117_L120_E0.5371.00
113_V147_L0.5371.00
262_T265_I0.5371.00
267_N271_E0.5361.00
129_K136_E0.5341.00
274_V279_E0.5341.00
241_A250_P0.5331.00
113_V116_I0.5321.00
14_E23_R0.5301.00
15_D32_S0.5251.00
19_L22_K0.5211.00
258_L261_L0.5201.00
33_L41_L0.5171.00
34_S240_R0.5161.00
250_P259_I0.5161.00
245_E251_L0.5161.00
239_E251_L0.5141.00
244_E247_L0.5071.00
135_L146_F0.5071.00
20_F62_Q0.5071.00
56_R59_V0.5041.00
238_V253_P0.5041.00
39_D240_R0.5041.00
251_L256_N0.5021.00
149_K154_L0.5021.00
145_E148_G0.5011.00
97_D159_K0.5011.00
196_L209_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.929 100 0.21 Contact Map
4ry2A 2 0.75 100 0.227 Contact Map
4fwiB 1 0.9228 100 0.23 Contact Map
4f4cA 1 0.7253 100 0.235 Contact Map
1oxxK 1 0.9259 100 0.236 Contact Map
4huqB 1 0.8488 100 0.238 Contact Map
4ymuJ 2 0.7407 100 0.239 Contact Map
4mkiB 2 0.8704 100 0.242 Contact Map
4huqA 1 0.8642 100 0.242 Contact Map
2oljA 2 0.7469 100 0.243 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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