APE1 - SULSO - GREMLIN Contacts

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APE1 - Probable aminopeptidase 1

UniProt:	Q97VF1	Sequences: MPNIEKYEIFLDFNGNEYEGVEKIYLNSEEEKLELDSVNLEIRSVKSDGKDTKFELKGEKLVIYGKIERELEIKFKGKASRDSILGIYVAPYDGKGMITTQFEAVYARRFIPCFDHPAMKARFKLSVRVQKGLKVISNMPVERIEEDVDGKVIYRFQETPKMSTYLLYLGIDEFEEISDNSKQPTVILATVPGKSKRGLFAINVARKVIEFYEKYFEIPYQLPKVHLIQVPEFAAGAMENWGAITFRETALLADDSSSISQKFRVAEVVAHELAHQWFGNLVTLKWWDDLWLNESFATFMSYKSIKHLFPQWDSEGHLIYDESIGALEDDSLSTTHPIEAHVKDPHEIEQMFDNISYGKGASILKMIEAYVGEENFRRGVVNYLNSFKFGNAEGKDLWNSISNAAGQSIGEIMADWITKPGYPVIFVNAYGNSIRFSQKRFTLLDSGLNEVYKVPITYEINDKFGTLLLDKESAEIRLDEGLKSIKVNINRTGFYRVLYDSLNLAFSSKLNAYEELGLVNDYWNFLLADLIDAKTYFGVIGRFVYTSNSFVSREITSQLLTLYYLFKKNYGKDFLVNQVKIFRKANDDLGKLAYSTVISALARMDEEFALGLSTLFDQYENIDSNIKEAVAIAYAVTNNDFNTLLEKYKRYTIDEEKNRILSAISSLRDPSIVVKVFSLIFERNIKAQDTRFVISSLLHNPHIREEVCSYLMNNFEEVKKFVNTVYGGPWGLGSIVRSMSFCGVDKPKDIIDFLEKVKFKEIERPIKESEERIKVYSRLKQNLP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	784 (761)
Sequences:	5171 (3594)
Seq/√Len:	130.3

ECOLI - AMPN
SULSO - APE1 APE2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
41_E	76_K	4.034	1.00
744_V	748_K	3.864	1.00
179_D	206_R	3.827	1.00
5_E	27_N	3.702	1.00
10_F	128_R	3.643	1.00
23_K	72_E	3.521	1.00
203_N	207_K	3.462	1.00
386_S	403_N	3.456	1.00
124_K	158_E	3.383	1.00
178_S	187_I	3.317	1.00
44_S	74_K	3.308	1.00
113_C	123_F	3.224	1.00
21_V	74_K	3.131	1.00
751_I	755_E	3.089	1.00
437_S	473_S	3.083	1.00
387_F	400_S	3.027	1.00
128_R	153_I	2.960	1.00
46_K	72_E	2.959	1.00
102_F	110_F	2.906	1.00
126_S	155_R	2.895	1.00
616_F	643_T	2.894	1.00
210_E	214_K	2.879	1.00
131_K	146_E	2.870	1.00
425_I	436_F	2.868	1.00
8_E	124_K	2.848	1.00
43_R	76_K	2.845	1.00
129_V	154_Y	2.760	1.00
382_N	403_N	2.752	1.00
6_K	122_R	2.725	1.00
25_Y	70_E	2.713	1.00
382_N	386_S	2.703	1.00
375_N	405_A	2.703	1.00
176_E	187_I	2.603	1.00
129_V	135_V	2.595	1.00
131_K	150_G	2.534	1.00
215_Y	377_R	2.518	1.00
425_I	454_V	2.490	1.00
436_F	456_I	2.478	1.00
145_E	153_I	2.472	1.00
712_M	749_D	2.412	1.00
27_N	68_E	2.406	1.00
122_R	158_E	2.403	1.00
490_N	511_N	2.389	1.00
47_S	71_L	2.320	1.00
427_V	436_F	2.290	1.00
127_V	169_L	2.285	1.00
23_K	70_E	2.271	1.00
377_R	381_V	2.246	1.00
24_I	35_L	2.230	1.00
638_N	642_N	2.228	1.00
125_L	167_L	2.218	1.00
706_E	710_Y	2.204	1.00
218_I	384_L	2.185	1.00
467_L	476_I	2.174	1.00
178_S	185_T	2.166	1.00
637_T	640_D	2.156	1.00
48_D	69_R	2.151	1.00
111_I	167_L	2.130	1.00
428_N	437_S	2.125	1.00
338_I	363_I	2.124	1.00
140_P	223_P	2.116	1.00
371_V	375_N	2.106	1.00
144_I	152_V	2.095	1.00
674_V	713_N	2.093	1.00
217_E	385_N	2.082	1.00
518_L	521_D	2.061	1.00
586_N	590_G	2.044	1.00
368_E	373_E	2.040	1.00
141_V	144_I	2.023	1.00
408_S	411_E	2.019	1.00
175_E	195_S	2.000	1.00
452_Y	459_E	1.978	1.00
122_R	161_K	1.953	1.00
378_R	381_V	1.947	1.00
141_V	154_Y	1.946	1.00
180_N	219_P	1.936	1.00
142_E	157_Q	1.935	1.00
574_F	578_Q	1.933	1.00
515_E	546_T	1.928	1.00
440_R	452_Y	1.928	1.00
541_G	544_V	1.923	1.00
471_K	474_A	1.922	1.00
34_E	60_K	1.913	1.00
175_E	192_P	1.912	1.00
371_V	401_I	1.904	1.00
285_K	393_E	1.903	1.00
299_F	368_E	1.901	1.00
227_L	246_F	1.892	1.00
127_V	135_V	1.888	1.00
177_I	198_G	1.872	1.00
25_Y	68_E	1.866	1.00
123_F	164_T	1.863	1.00
136_I	243_A	1.858	1.00
425_I	469_L	1.855	1.00
139_M	223_P	1.827	1.00
434_I	438_Q	1.821	1.00
170_G	243_A	1.820	1.00
575_L	578_Q	1.817	1.00
10_F	126_S	1.817	1.00
143_R	155_R	1.813	1.00
587_D	590_G	1.794	1.00
131_K	152_V	1.791	1.00
21_V	72_E	1.783	1.00
208_V	270_A	1.780	1.00
435_R	473_S	1.756	1.00
751_I	770_E	1.745	1.00
187_I	226_H	1.740	1.00
231_P	248_E	1.738	1.00
12_D	128_R	1.737	1.00
250_A	264_R	1.731	1.00
387_F	396_D	1.727	1.00
19_E	76_K	1.717	1.00
640_D	643_T	1.714	1.00
426_F	498_L	1.711	1.00
435_R	475_E	1.701	1.00
674_V	678_S	1.694	1.00
454_V	459_E	1.691	1.00
173_E	192_P	1.685	1.00
177_I	199_L	1.678	1.00
642_N	646_E	1.674	1.00
614_T	618_Q	1.671	1.00
717_E	756_K	1.671	1.00
303_K	311_Q	1.669	1.00
7_Y	121_A	1.666	1.00
217_E	381_V	1.664	1.00
113_C	164_T	1.663	1.00
387_F	390_G	1.623	1.00
10_F	21_V	1.609	1.00
122_R	157_Q	1.604	1.00
718_V	721_F	1.599	1.00
613_S	617_D	1.595	1.00
438_Q	441_F	1.584	1.00
293_N	352_F	1.583	1.00
303_K	368_E	1.577	1.00
375_N	378_R	1.574	1.00
382_N	404_A	1.569	1.00
6_K	124_K	1.558	1.00
486_K	514_E	1.557	1.00
511_N	514_E	1.547	1.00
748_K	752_D	1.546	1.00
38_V	59_E	1.541	1.00
385_N	388_K	1.539	1.00
8_E	23_K	1.539	1.00
170_G	174_F	1.534	1.00
263_F	317_H	1.533	1.00
602_A	609_A	1.528	1.00
190_T	198_G	1.523	1.00
433_S	475_E	1.522	1.00
578_Q	581_I	1.522	1.00
32_K	64_Y	1.521	1.00
584_K	587_D	1.518	1.00
186_V	205_A	1.512	1.00
335_T	420_P	1.503	1.00
17_E	76_K	1.496	1.00
118_A	285_K	1.494	1.00
215_Y	373_E	1.489	1.00
743_G	746_K	1.487	1.00
717_E	720_K	1.487	1.00
647_K	650_R	1.477	1.00
228_I	243_A	1.475	1.00
26_L	71_L	1.471	1.00
381_V	385_N	1.470	1.00
625_N	647_K	1.467	1.00
18_Y	77_G	1.466	1.00
641_F	645_L	1.464	1.00
126_S	153_I	1.462	1.00
572_K	576_V	1.462	1.00
379_G	401_I	1.462	1.00
414_A	418_T	1.459	1.00
667_L	672_I	1.452	1.00
713_N	753_F	1.450	1.00
205_A	227_L	1.450	1.00
537_F	540_I	1.443	1.00
135_V	154_Y	1.443	1.00
140_P	157_Q	1.439	1.00
632_I	666_S	1.439	1.00
188_L	202_I	1.437	1.00
325_G	354_N	1.436	1.00
226_H	242_G	1.435	1.00
407_Q	468_L	1.432	1.00
427_V	487_V	1.429	1.00
645_L	655_E	1.427	1.00
170_G	228_I	1.417	1.00
83_S	86_G	1.413	1.00
450_E	454_V	1.410	1.00
272_E	275_H	1.407	1.00
452_Y	455_P	1.407	1.00
428_N	435_R	1.406	1.00
19_E	74_K	1.398	1.00
107_A	113_C	1.398	1.00
199_L	203_N	1.392	1.00
175_E	193_G	1.391	1.00
43_R	74_K	1.391	1.00
237_A	268_V	1.388	1.00
110_F	169_L	1.384	1.00
477_R	480_E	1.383	1.00
644_L	660_I	1.382	1.00
714_N	717_E	1.381	1.00
132_G	173_E	1.379	1.00
176_E	189_A	1.378	1.00
201_A	269_V	1.378	1.00
455_P	459_E	1.377	1.00
399_N	402_S	1.373	1.00
271_H	275_H	1.372	1.00
498_L	504_L	1.370	1.00
522_Y	531_I	1.368	1.00
669_D	672_I	1.367	1.00
607_E	611_G	1.367	1.00
523_W	526_L	1.364	1.00
386_S	400_S	1.363	1.00
275_H	357_Y	1.357	1.00
180_N	183_Q	1.356	1.00
424_V	496_R	1.354	1.00
239_E	272_E	1.353	1.00
436_F	469_L	1.344	1.00
575_L	579_V	1.344	1.00
425_I	488_N	1.338	1.00
336_H	353_D	1.337	1.00
239_E	275_H	1.337	1.00
747_P	770_E	1.334	1.00
190_T	195_S	1.329	1.00
402_S	408_S	1.322	1.00
424_V	498_L	1.322	1.00
379_G	400_S	1.320	1.00
179_D	202_I	1.320	1.00
239_E	271_H	1.315	1.00
196_K	254_D	1.310	1.00
95_K	173_E	1.307	1.00
232_E	686_K	1.307	1.00
200_F	204_V	1.305	1.00
500_D	503_N	1.299	1.00
267_E	301_S	1.297	1.00
168_Y	243_A	1.294	1.00
271_H	357_Y	1.294	1.00
218_I	388_K	1.293	1.00
572_K	578_Q	1.293	1.00
188_L	201_A	1.292	1.00
518_L	525_F	1.283	1.00
318_L	361_A	1.280	1.00
399_N	403_N	1.277	1.00
125_L	137_S	1.270	1.00
87_I	98_I	1.264	1.00
284_L	391_N	1.264	1.00
194_K	197_R	1.264	1.00
124_K	155_R	1.262	1.00
452_Y	460_I	1.258	1.00
83_S	109_R	1.251	1.00
191_V	194_K	1.250	1.00
400_S	404_A	1.244	1.00
426_F	439_K	1.241	1.00
10_F	153_I	1.236	1.00
6_K	158_E	1.234	1.00
218_I	385_N	1.231	1.00
522_Y	539_V	1.227	1.00
518_L	531_I	1.225	1.00
200_F	309_F	1.224	1.00
426_F	437_S	1.223	1.00
8_E	126_S	1.220	1.00
40_L	77_G	1.219	1.00
635_A	644_L	1.213	1.00
101_Q	235_A	1.209	0.99
415_D	450_E	1.208	0.99
6_K	25_Y	1.207	0.99
583_R	590_G	1.205	0.99
454_V	461_N	1.204	0.99
120_K	163_S	1.201	0.99
540_I	544_V	1.199	0.99
34_E	62_V	1.196	0.99
686_K	689_D	1.195	0.99
446_S	449_N	1.194	0.99
252_L	255_D	1.194	0.99
44_S	72_E	1.193	0.99
295_S	360_G	1.192	0.99
314_S	318_L	1.191	0.99
395_K	410_G	1.190	0.99
101_Q	104_A	1.190	0.99
124_K	142_E	1.189	0.99
589_L	592_L	1.186	0.99
182_K	219_P	1.185	0.99
275_H	294_E	1.184	0.99
586_N	591_K	1.183	0.99
470_D	474_A	1.177	0.99
218_I	381_V	1.174	0.99
488_N	497_V	1.173	0.99
709_S	713_N	1.172	0.99
36_D	60_K	1.172	0.99
573_D	577_N	1.170	0.99
450_E	459_E	1.169	0.99
430_Y	433_S	1.163	0.99
339_E	418_T	1.163	0.99
588_D	592_L	1.162	0.99
452_Y	461_N	1.161	0.99
645_L	649_K	1.159	0.99
20_G	77_G	1.154	0.99
752_D	755_E	1.154	0.99
272_E	357_Y	1.145	0.99
526_L	533_A	1.144	0.99
454_V	460_I	1.140	0.99
451_V	454_V	1.138	0.99
583_R	586_N	1.137	0.99
46_K	51_D	1.136	0.99
367_I	398_W	1.136	0.99
239_E	357_Y	1.135	0.99
447_G	450_E	1.130	0.99
147_D	153_I	1.130	0.99
282_V	384_L	1.130	0.99
522_Y	525_F	1.129	0.99
752_D	756_K	1.129	0.99
278_F	296_F	1.129	0.99
672_I	675_K	1.128	0.99
429_A	482_L	1.127	0.99
130_Q	151_K	1.127	0.99
253_A	257_S	1.126	0.99
572_K	579_V	1.124	0.99
26_L	69_R	1.123	0.99
143_R	153_I	1.120	0.99
99_T	230_V	1.118	0.99
90_A	232_E	1.117	0.99
519_V	522_Y	1.117	0.99
26_L	47_S	1.116	0.99
45_V	73_I	1.113	0.99
44_S	51_D	1.113	0.99
204_V	266_A	1.112	0.99
456_I	487_V	1.112	0.99
210_E	213_E	1.111	0.99
429_A	500_D	1.109	0.99
225_V	273_L	1.108	0.99
20_G	112_P	1.107	0.99
296_F	380_V	1.106	0.99
510_L	514_E	1.104	0.99
415_D	452_Y	1.102	0.99
212_Y	304_S	1.100	0.99
746_K	749_D	1.098	0.99
606_E	609_A	1.096	0.99
521_D	525_F	1.096	0.99
12_D	151_K	1.091	0.99
124_K	157_Q	1.090	0.99
443_L	446_S	1.087	0.99
186_V	206_R	1.085	0.99
50_K	53_K	1.081	0.99
295_S	364_L	1.081	0.99
106_Y	109_R	1.080	0.99
257_S	261_Q	1.078	0.99
748_K	751_I	1.078	0.99
452_Y	457_T	1.076	0.99
590_G	594_Y	1.074	0.99
551_V	559_L	1.073	0.99
211_F	303_K	1.070	0.99
7_Y	11_L	1.065	0.99
502_L	505_A	1.062	0.99
425_I	495_Y	1.059	0.99
602_A	612_L	1.057	0.99
86_G	89_V	1.056	0.99
433_S	477_R	1.056	0.99
5_E	68_E	1.054	0.99
396_D	399_N	1.054	0.99
574_F	577_N	1.052	0.99
379_G	404_A	1.051	0.99
79_A	98_I	1.049	0.99
235_A	293_N	1.048	0.99
382_N	400_S	1.048	0.99
485_I	501_S	1.048	0.99
8_E	155_R	1.046	0.99
16_N	89_V	1.043	0.98
378_R	404_A	1.040	0.98
459_E	489_I	1.037	0.98
453_K	459_E	1.033	0.98
575_L	581_I	1.032	0.98
501_S	505_A	1.032	0.98
134_K	176_E	1.032	0.98
354_N	358_G	1.029	0.98
627_K	631_A	1.026	0.98
400_S	403_N	1.025	0.98
251_L	254_D	1.024	0.98
449_N	452_Y	1.022	0.98
660_I	696_S	1.020	0.98
61_L	65_G	1.017	0.98
453_K	468_L	1.015	0.98
18_Y	75_F	1.015	0.98
518_L	522_Y	1.013	0.98
454_V	458_Y	1.012	0.98
244_I	273_L	1.010	0.98
709_S	712_M	1.007	0.98
518_L	532_D	1.006	0.98
767_K	771_E	1.005	0.98
750_I	773_I	1.004	0.98
145_E	155_R	1.002	0.98
222_L	241_W	1.002	0.98
450_E	453_K	0.995	0.98
577_N	580_K	0.994	0.98
625_N	648_Y	0.994	0.98
278_F	282_V	0.993	0.98
89_V	98_I	0.992	0.98
611_G	614_T	0.992	0.98
147_D	151_K	0.985	0.98
45_V	63_I	0.984	0.98
452_Y	456_I	0.983	0.98
375_N	404_A	0.982	0.98
128_R	151_K	0.982	0.98
674_V	710_Y	0.981	0.98
646_E	649_K	0.978	0.98
615_L	618_Q	0.977	0.98
194_K	248_E	0.977	0.98
41_E	78_K	0.976	0.98
249_T	264_R	0.975	0.98
645_L	679_L	0.974	0.98
211_F	307_H	0.972	0.98
378_R	382_N	0.971	0.98
7_Y	24_I	0.969	0.98
211_F	304_S	0.969	0.98
542_R	546_T	0.968	0.98
238_M	275_H	0.967	0.98
37_S	40_L	0.967	0.98
521_D	526_L	0.966	0.97
55_E	64_Y	0.965	0.97
745_D	749_D	0.962	0.97
381_V	384_L	0.961	0.97
638_N	672_I	0.961	0.97
271_H	294_E	0.958	0.97
141_V	187_I	0.956	0.97
455_P	461_N	0.954	0.97
101_Q	106_Y	0.954	0.97
646_E	650_R	0.953	0.97
437_S	472_E	0.952	0.97
419_K	450_E	0.951	0.97
298_T	301_S	0.951	0.97
535_T	538_G	0.950	0.97
294_E	357_Y	0.950	0.97
398_W	413_M	0.949	0.97
114_F	119_M	0.949	0.97
522_Y	526_L	0.949	0.97
463_K	481_G	0.947	0.97
265_V	268_V	0.947	0.97
136_I	189_A	0.945	0.97
162_M	166_L	0.942	0.97
573_D	576_V	0.940	0.97
451_V	455_P	0.936	0.97
370_Y	468_L	0.933	0.97
554_E	558_Q	0.933	0.97
452_Y	458_Y	0.933	0.97
641_F	676_V	0.933	0.97
254_D	257_S	0.931	0.97
182_K	213_E	0.930	0.97
132_G	152_V	0.926	0.97
720_K	757_V	0.926	0.97
443_L	449_N	0.926	0.97
233_F	236_G	0.924	0.97
200_F	266_A	0.922	0.97
250_A	268_V	0.920	0.97
613_S	616_F	0.918	0.97
101_Q	240_N	0.917	0.97
233_F	247_R	0.917	0.97
518_L	526_L	0.916	0.97
643_T	647_K	0.914	0.96
461_N	483_K	0.914	0.96
264_R	268_V	0.913	0.96
88_Y	233_F	0.913	0.96
142_E	155_R	0.913	0.96
747_P	751_I	0.911	0.96
307_H	373_E	0.910	0.96
743_G	747_P	0.910	0.96
446_S	456_I	0.910	0.96
586_N	589_L	0.909	0.96
453_K	456_I	0.909	0.96
289_D	339_E	0.909	0.96
369_A	492_T	0.908	0.96
521_D	528_A	0.907	0.96
237_A	357_Y	0.907	0.96
136_I	228_I	0.906	0.96
632_I	640_D	0.906	0.96
225_V	244_I	0.903	0.96
340_A	351_M	0.902	0.96
238_M	271_H	0.902	0.96
97_M	230_V	0.898	0.96
16_N	78_K	0.897	0.96
673_V	697_L	0.897	0.96
627_K	647_K	0.896	0.96
596_T	600_A	0.896	0.96
274_A	300_M	0.896	0.96
191_V	248_E	0.896	0.96
329_D	768_E	0.894	0.96
745_D	748_K	0.893	0.96
610_L	613_S	0.893	0.96
83_S	89_V	0.892	0.96
536_Y	540_I	0.892	0.96
680_I	697_L	0.891	0.96
9_I	125_L	0.890	0.96
434_I	485_I	0.889	0.96
616_F	619_Y	0.889	0.96
263_F	588_D	0.886	0.96
450_E	455_P	0.881	0.96
541_G	546_T	0.879	0.96
37_S	77_G	0.878	0.96
24_I	114_F	0.877	0.96
20_G	75_F	0.876	0.96
200_F	262_K	0.875	0.96
588_D	597_V	0.875	0.96
430_Y	435_R	0.874	0.95
436_F	487_V	0.871	0.95
253_A	256_S	0.871	0.95
456_I	461_N	0.870	0.95
239_E	294_E	0.870	0.95
588_D	591_K	0.870	0.95
52_T	55_E	0.869	0.95
563_Y	603_R	0.869	0.95
586_N	594_Y	0.868	0.95
710_Y	714_N	0.868	0.95
323_S	494_F	0.867	0.95
582_F	587_D	0.867	0.95
665_S	696_S	0.867	0.95
229_Q	252_L	0.866	0.95
583_R	588_D	0.866	0.95
341_H	418_T	0.865	0.95
292_L	383_Y	0.864	0.95
120_K	283_T	0.861	0.95
38_V	109_R	0.860	0.95
103_E	293_N	0.859	0.95
429_A	485_I	0.859	0.95
635_A	667_L	0.858	0.95
47_S	52_T	0.857	0.95
574_F	581_I	0.857	0.95
582_F	586_N	0.856	0.95
673_V	703_I	0.852	0.95
238_M	272_E	0.851	0.95
39_N	83_S	0.850	0.95
577_N	581_I	0.850	0.95
147_D	150_G	0.847	0.95
157_Q	223_P	0.846	0.95
10_F	23_K	0.842	0.94
63_I	66_K	0.841	0.94
95_K	192_P	0.840	0.94
736_V	739_M	0.839	0.94
755_E	759_F	0.839	0.94
496_R	524_N	0.838	0.94
456_I	469_L	0.835	0.94
753_F	756_K	0.834	0.94
677_F	710_Y	0.834	0.94
284_L	293_N	0.833	0.94
384_L	392_A	0.832	0.94
589_L	593_A	0.828	0.94
729_P	732_L	0.827	0.94
35_L	63_I	0.826	0.94
380_V	384_L	0.825	0.94
671_S	674_V	0.823	0.94
617_D	643_T	0.822	0.94
282_V	400_S	0.820	0.94
237_A	275_H	0.820	0.94
708_C	712_M	0.820	0.94
672_I	676_V	0.818	0.94
559_L	567_K	0.816	0.93
402_S	405_A	0.815	0.93
453_K	470_D	0.814	0.93
237_A	272_E	0.814	0.93
504_L	522_Y	0.813	0.93
272_E	294_E	0.813	0.93
522_Y	536_Y	0.813	0.93
708_C	749_D	0.812	0.93
189_A	226_H	0.811	0.93
543_F	546_T	0.811	0.93
212_Y	274_A	0.810	0.93
457_T	460_I	0.808	0.93
502_L	506_F	0.808	0.93
386_S	399_N	0.807	0.93
720_K	756_K	0.807	0.93
135_V	156_F	0.806	0.93
40_L	78_K	0.806	0.93
514_E	517_G	0.806	0.93
60_K	65_G	0.803	0.93
440_R	443_L	0.803	0.93
642_N	645_L	0.803	0.93
236_G	239_E	0.803	0.93
32_K	62_V	0.801	0.93
697_L	703_I	0.801	0.93
11_L	169_L	0.800	0.93
162_M	241_W	0.800	0.93
104_A	349_E	0.800	0.93
507_S	542_R	0.800	0.93
62_V	65_G	0.800	0.93
551_V	555_I	0.798	0.93
631_A	635_A	0.798	0.93
518_L	533_A	0.797	0.93
559_L	563_Y	0.797	0.93
236_G	357_Y	0.797	0.93
172_D	228_I	0.797	0.93
649_K	684_N	0.796	0.93
165_Y	271_H	0.795	0.93
552_S	559_L	0.795	0.93
66_K	69_R	0.795	0.93
371_V	379_G	0.794	0.93
595_S	615_L	0.794	0.93
716_E	720_K	0.793	0.93
8_E	25_Y	0.790	0.92
215_Y	303_K	0.790	0.92
590_G	593_A	0.790	0.92
319_I	365_K	0.788	0.92
415_D	453_K	0.787	0.92
375_N	407_Q	0.786	0.92
216_F	376_F	0.786	0.92
423_P	438_Q	0.785	0.92
102_F	107_A	0.784	0.92
456_I	488_N	0.783	0.92
165_Y	239_E	0.782	0.92
716_E	757_V	0.782	0.92
60_K	66_K	0.782	0.92
303_K	373_E	0.782	0.92
281_L	388_K	0.782	0.92
518_L	528_A	0.782	0.92
165_Y	357_Y	0.781	0.92
730_W	765_P	0.781	0.92
240_N	275_H	0.781	0.92
749_D	753_F	0.780	0.92
19_E	43_R	0.776	0.92
79_A	87_I	0.775	0.92
438_Q	442_T	0.775	0.92
53_K	56_L	0.775	0.92
398_W	414_A	0.774	0.92
290_L	336_H	0.774	0.92
298_T	361_A	0.774	0.92
255_D	262_K	0.773	0.92
455_P	460_I	0.773	0.92
551_V	567_K	0.773	0.92
240_N	271_H	0.772	0.91
520_N	525_F	0.771	0.91
439_K	530_L	0.771	0.91
22_E	75_F	0.771	0.91
491_R	517_G	0.771	0.91
230_V	245_T	0.770	0.91
520_N	523_W	0.769	0.91
429_A	499_Y	0.769	0.91
427_V	456_I	0.769	0.91
134_K	174_F	0.769	0.91
487_V	499_Y	0.769	0.91
100_T	168_Y	0.768	0.91
675_K	678_S	0.767	0.91
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238_M	357_Y	0.765	0.91
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541_G	545_Y	0.764	0.91
411_E	470_D	0.761	0.91
325_G	358_G	0.760	0.91
139_M	159_T	0.760	0.91
263_F	305_I	0.759	0.91
591_K	594_Y	0.759	0.91
402_S	409_I	0.758	0.91
462_D	483_K	0.758	0.91
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236_G	275_H	0.756	0.91
755_E	758_K	0.756	0.91
156_F	159_T	0.752	0.90
35_L	71_L	0.752	0.90
250_A	265_V	0.751	0.90
196_K	199_L	0.750	0.90
525_F	528_A	0.749	0.90
120_K	391_N	0.748	0.90
192_P	195_S	0.748	0.90
236_G	272_E	0.747	0.90
352_F	357_Y	0.747	0.90
299_F	303_K	0.747	0.90
449_N	453_K	0.746	0.90
633_A	636_V	0.743	0.90
534_K	540_I	0.743	0.90
456_I	467_L	0.742	0.90
402_S	414_A	0.740	0.90
17_E	78_K	0.740	0.90
519_V	526_L	0.740	0.90
278_F	380_V	0.739	0.90
201_A	265_V	0.737	0.89
237_A	246_F	0.736	0.89
31_E	64_Y	0.736	0.89
509_K	514_E	0.736	0.89
322_E	358_G	0.735	0.89
240_N	272_E	0.734	0.89
371_V	405_A	0.734	0.89
454_V	457_T	0.734	0.89
576_V	579_V	0.734	0.89
553_R	557_S	0.734	0.89
446_S	450_E	0.733	0.89
535_T	544_V	0.732	0.89
585_A	589_L	0.732	0.89
402_S	406_G	0.731	0.89
35_L	73_I	0.731	0.89
468_L	471_K	0.730	0.89
165_Y	294_E	0.729	0.89
585_A	594_Y	0.728	0.89
261_Q	264_R	0.728	0.89
42_I	112_P	0.728	0.89
33_L	114_F	0.727	0.89
137_S	156_F	0.727	0.89
709_S	749_D	0.726	0.89
235_A	247_R	0.725	0.89
736_V	769_S	0.725	0.89
440_R	449_N	0.725	0.89
742_C	747_P	0.725	0.89
37_S	112_P	0.724	0.89
471_K	475_E	0.723	0.89
444_L	449_N	0.721	0.88
338_I	394_G	0.720	0.88
535_T	540_I	0.720	0.88
166_L	357_Y	0.718	0.88
56_L	112_P	0.717	0.88
188_L	227_L	0.717	0.88
459_E	463_K	0.716	0.88
165_Y	272_E	0.716	0.88
712_M	716_E	0.715	0.88
49_G	70_E	0.715	0.88
696_S	699_H	0.714	0.88
606_E	611_G	0.714	0.88
267_E	298_T	0.714	0.88
98_I	133_L	0.713	0.88
372_G	375_N	0.712	0.88
573_D	578_Q	0.712	0.88
469_L	473_S	0.712	0.88
763_E	767_K	0.711	0.88
367_I	412_I	0.711	0.88
352_F	356_S	0.710	0.88
36_D	116_H	0.710	0.88
267_E	305_I	0.709	0.88
101_Q	238_M	0.709	0.88
237_A	240_N	0.709	0.88
451_V	459_E	0.708	0.88
643_T	646_E	0.705	0.87
240_N	357_Y	0.705	0.87
238_M	294_E	0.704	0.87
441_F	528_A	0.702	0.87
75_F	111_I	0.702	0.87
469_L	474_A	0.702	0.87
97_M	174_F	0.702	0.87
572_K	575_L	0.701	0.87
526_L	532_D	0.701	0.87
305_I	314_S	0.700	0.87
193_G	231_P	0.700	0.87
86_G	90_A	0.700	0.87
195_S	198_G	0.697	0.87
758_K	770_E	0.697	0.87
188_L	198_G	0.695	0.87
451_V	472_E	0.695	0.87
750_I	753_F	0.695	0.87
89_V	96_G	0.695	0.87
585_A	588_D	0.695	0.87
434_I	440_R	0.694	0.87
39_N	56_L	0.694	0.87
720_K	724_T	0.693	0.86
165_Y	275_H	0.692	0.86
53_K	66_K	0.691	0.86
126_S	145_E	0.689	0.86
95_K	132_G	0.688	0.86
708_C	741_F	0.688	0.86
685_I	688_Q	0.687	0.86
57_K	62_V	0.686	0.86
103_E	290_L	0.686	0.86
520_N	524_N	0.685	0.86
200_F	203_N	0.685	0.86
379_G	405_A	0.685	0.86
427_V	499_Y	0.684	0.86
212_Y	216_F	0.684	0.86
268_V	653_I	0.684	0.86
586_N	593_A	0.682	0.86
125_L	169_L	0.680	0.85
45_V	49_G	0.679	0.85
107_A	164_T	0.679	0.85
144_I	154_Y	0.679	0.85
746_K	750_I	0.678	0.85
309_F	312_W	0.677	0.85
715_F	750_I	0.674	0.85
364_L	367_I	0.672	0.85
681_F	710_Y	0.672	0.85
638_N	675_K	0.672	0.85
574_F	579_V	0.672	0.85
429_A	503_N	0.672	0.85
526_L	536_Y	0.671	0.85
137_S	169_L	0.671	0.85
218_I	281_L	0.670	0.85
227_L	244_I	0.669	0.84
679_L	682_E	0.669	0.84
451_V	458_Y	0.669	0.84
587_D	593_A	0.669	0.84
313_D	316_G	0.667	0.84
236_G	271_H	0.667	0.84
202_I	206_R	0.665	0.84
216_F	303_K	0.664	0.84
555_I	559_L	0.664	0.84
582_F	588_D	0.664	0.84
561_T	565_L	0.663	0.84
518_L	523_W	0.663	0.84
264_R	321_D	0.663	0.84
253_A	265_V	0.661	0.84
675_K	679_L	0.661	0.84
572_K	577_N	0.661	0.84
101_Q	349_E	0.661	0.84
166_L	275_H	0.661	0.84
678_S	682_E	0.661	0.84
185_T	224_K	0.658	0.83
336_H	351_M	0.658	0.83
266_A	309_F	0.658	0.83
101_Q	168_Y	0.656	0.83
166_L	212_Y	0.656	0.83
539_V	542_R	0.655	0.83
215_Y	368_E	0.654	0.83
120_K	293_N	0.653	0.83
518_L	527_L	0.653	0.83
448_L	451_V	0.653	0.83
651_Y	656_E	0.653	0.83
462_D	465_G	0.653	0.83
339_E	394_G	0.652	0.83
602_A	605_D	0.652	0.83
371_V	409_I	0.652	0.83
47_S	69_R	0.651	0.83
61_L	66_K	0.650	0.83
267_E	302_Y	0.650	0.83
595_S	602_A	0.650	0.83
556_T	600_A	0.649	0.83
49_G	72_E	0.649	0.83
373_E	377_R	0.649	0.83
87_I	110_F	0.649	0.83
55_E	62_V	0.646	0.82
233_F	238_M	0.645	0.82
719_K	757_V	0.644	0.82
323_S	362_S	0.644	0.82
12_D	15_G	0.644	0.82
648_Y	657_K	0.644	0.82
453_K	460_I	0.642	0.82
249_T	261_Q	0.642	0.82
33_L	71_L	0.641	0.82
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177_I	195_S	0.639	0.82
741_F	749_D	0.639	0.82
587_D	591_K	0.639	0.82
714_N	718_V	0.638	0.82
330_D	359_K	0.637	0.81
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84_I	90_A	0.632	0.81
410_G	414_A	0.632	0.81
642_N	675_K	0.630	0.81
411_E	415_D	0.629	0.81
291_W	338_I	0.629	0.81
730_W	733_G	0.628	0.81
247_R	688_Q	0.626	0.80
239_E	283_T	0.626	0.80
197_R	254_D	0.625	0.80
538_G	541_G	0.625	0.80
616_F	640_D	0.624	0.80
451_V	461_N	0.624	0.80
448_L	452_Y	0.624	0.80
225_V	269_V	0.623	0.80
445_D	449_N	0.622	0.80
700_N	703_I	0.622	0.80
346_H	767_K	0.621	0.80
587_D	592_L	0.621	0.80
614_T	617_D	0.621	0.80
216_F	380_V	0.621	0.80
139_M	158_E	0.621	0.80
685_I	689_D	0.621	0.80
134_K	175_E	0.620	0.80
448_L	453_K	0.619	0.80
450_E	460_I	0.619	0.80
336_H	355_I	0.619	0.80
438_Q	443_L	0.618	0.79
624_S	627_K	0.618	0.79
742_C	750_I	0.618	0.79
251_L	269_V	0.617	0.79
594_Y	598_I	0.616	0.79
542_R	551_V	0.616	0.79
237_A	271_H	0.615	0.79
496_R	520_N	0.615	0.79
720_K	723_N	0.615	0.79
58_G	62_V	0.614	0.79
660_I	664_I	0.614	0.79
13_F	16_N	0.614	0.79
449_N	458_Y	0.613	0.79
641_F	664_I	0.613	0.79
146_E	149_D	0.613	0.79
86_G	92_Y	0.613	0.79
486_K	517_G	0.612	0.79
103_E	236_G	0.612	0.79
501_S	535_T	0.611	0.79
520_N	527_L	0.611	0.79
485_I	500_D	0.611	0.79
523_W	527_L	0.611	0.79
519_V	523_W	0.610	0.79
711_L	715_F	0.610	0.79
120_K	392_A	0.609	0.79
353_D	356_S	0.608	0.78
90_A	247_R	0.608	0.78
46_K	52_T	0.608	0.78
387_F	392_A	0.608	0.78
236_G	268_V	0.608	0.78
457_T	461_N	0.608	0.78
520_N	532_D	0.607	0.78
319_I	324_I	0.607	0.78
14_N	98_I	0.606	0.78
326_A	494_F	0.605	0.78
453_K	461_N	0.604	0.78
449_N	454_V	0.604	0.78
264_R	267_E	0.603	0.78
37_S	42_I	0.603	0.78
8_E	70_E	0.603	0.78
499_Y	521_D	0.603	0.78
199_L	255_D	0.602	0.78
542_R	545_Y	0.602	0.78
221_Q	389_F	0.601	0.78
9_I	22_E	0.599	0.77
190_T	193_G	0.599	0.77
182_K	223_P	0.599	0.77
260_S	264_R	0.599	0.77
168_Y	240_N	0.599	0.77
429_A	497_V	0.599	0.77
125_L	139_M	0.598	0.77
681_F	717_E	0.598	0.77
460_I	463_K	0.597	0.77
295_S	356_S	0.597	0.77
139_M	222_L	0.597	0.77
232_E	235_A	0.596	0.77
40_L	76_K	0.596	0.77
298_T	322_E	0.596	0.77
433_S	438_Q	0.594	0.77
191_V	231_P	0.593	0.77
22_E	73_I	0.593	0.77
395_K	399_N	0.592	0.77
239_E	293_N	0.592	0.77
608_F	611_G	0.592	0.77
556_T	559_L	0.592	0.77
591_K	595_S	0.592	0.77
306_K	315_E	0.591	0.76
272_E	280_N	0.590	0.76
316_G	512_A	0.589	0.76
440_R	446_S	0.589	0.76
467_L	474_A	0.589	0.76
442_T	449_N	0.589	0.76
633_A	661_L	0.588	0.76
55_E	58_G	0.586	0.76
457_T	466_T	0.586	0.76
645_L	681_F	0.586	0.76
449_N	455_P	0.585	0.76
585_A	592_L	0.585	0.76
429_A	434_I	0.584	0.76
395_K	414_A	0.584	0.76
582_F	585_A	0.583	0.75
251_L	255_D	0.583	0.75
583_R	587_D	0.583	0.75
387_F	399_N	0.583	0.75
509_K	518_L	0.582	0.75
523_W	528_A	0.581	0.75
411_E	453_K	0.580	0.75
677_F	680_I	0.580	0.75
166_L	238_M	0.580	0.75
451_V	471_K	0.580	0.75
503_N	506_F	0.580	0.75
331_S	422_Y	0.580	0.75
129_V	152_V	0.580	0.75
234_A	247_R	0.579	0.75
689_D	693_V	0.579	0.75
302_Y	314_S	0.578	0.75
284_L	289_D	0.578	0.75
374_E	378_R	0.578	0.75
520_N	526_L	0.578	0.75
705_E	712_M	0.577	0.75
661_L	693_V	0.577	0.75
266_A	305_I	0.577	0.75
336_H	340_A	0.576	0.75
240_N	294_E	0.576	0.75
165_Y	383_Y	0.576	0.75
105_V	345_P	0.575	0.74
552_S	555_I	0.575	0.74
585_A	590_G	0.575	0.74
559_L	571_G	0.575	0.74
540_I	546_T	0.574	0.74
336_H	356_S	0.573	0.74
175_E	191_V	0.573	0.74
487_V	497_V	0.572	0.74
93_D	96_G	0.571	0.74
326_A	330_D	0.571	0.74
536_Y	544_V	0.571	0.74
161_K	390_G	0.570	0.74
293_N	391_N	0.570	0.74
97_M	232_E	0.570	0.74
111_I	125_L	0.569	0.74
271_H	283_T	0.569	0.74
61_L	67_I	0.568	0.74
450_E	461_N	0.568	0.74
710_Y	713_N	0.568	0.74
314_S	317_H	0.568	0.74
145_E	152_V	0.568	0.74
677_F	718_V	0.568	0.74
39_N	78_K	0.567	0.73
676_V	680_I	0.567	0.73
178_S	189_A	0.566	0.73
397_L	401_I	0.566	0.73
275_H	280_N	0.566	0.73
306_K	311_Q	0.565	0.73
239_E	280_N	0.565	0.73
528_A	531_I	0.563	0.73
286_W	289_D	0.562	0.73
237_A	280_N	0.562	0.73
455_P	458_Y	0.562	0.73
165_Y	238_M	0.561	0.73
401_I	405_A	0.561	0.73
209_I	220_Y	0.560	0.73
11_L	20_G	0.559	0.72
450_E	457_T	0.558	0.72
668_R	702_H	0.558	0.72
187_I	224_K	0.557	0.72
5_E	25_Y	0.557	0.72
139_M	160_P	0.557	0.72
367_I	401_I	0.556	0.72
290_L	293_N	0.556	0.72
589_L	594_Y	0.555	0.72
392_A	396_D	0.555	0.72
454_V	469_L	0.555	0.72
228_I	305_I	0.555	0.72
674_V	677_F	0.554	0.72
758_K	767_K	0.554	0.72
703_I	706_E	0.554	0.72
757_V	766_I	0.553	0.72
296_F	376_F	0.553	0.72
198_G	202_I	0.552	0.71
296_F	364_L	0.552	0.71
262_K	265_V	0.552	0.71
135_V	171_I	0.551	0.71
274_A	293_N	0.550	0.71
12_D	19_E	0.550	0.71
424_V	525_F	0.550	0.71
218_I	282_V	0.548	0.71
453_K	457_T	0.548	0.71
528_A	533_A	0.548	0.71
236_G	293_N	0.547	0.71
612_L	615_L	0.547	0.71
639_N	642_N	0.547	0.71
379_G	409_I	0.547	0.71
162_M	222_L	0.547	0.71
626_I	630_V	0.546	0.71
459_E	490_N	0.545	0.71
394_G	418_T	0.545	0.71
323_S	491_R	0.545	0.71
454_V	463_K	0.545	0.71
120_K	284_L	0.543	0.70
767_K	770_E	0.543	0.70
764_R	768_E	0.542	0.70
442_T	446_S	0.542	0.70
458_Y	487_V	0.541	0.70
288_D	339_E	0.541	0.70
352_F	360_G	0.541	0.70
609_A	612_L	0.541	0.70
87_I	169_L	0.541	0.70
451_V	457_T	0.540	0.70
456_I	459_E	0.540	0.70
382_N	385_N	0.540	0.70
141_V	155_R	0.539	0.70
415_D	419_K	0.539	0.70
548_N	551_V	0.536	0.69
160_P	222_L	0.535	0.69
550_F	553_R	0.534	0.69
160_P	389_F	0.534	0.69
697_L	710_Y	0.534	0.69
741_F	746_K	0.533	0.69
275_H	352_F	0.533	0.69
551_V	554_E	0.532	0.69
588_D	594_Y	0.532	0.69
346_H	349_E	0.532	0.69
15_G	78_K	0.532	0.69
24_I	73_I	0.531	0.69
523_W	536_Y	0.531	0.69
95_K	232_E	0.530	0.68
84_I	88_Y	0.530	0.68
549_S	553_R	0.528	0.68
332_L	768_E	0.528	0.68
208_V	304_S	0.527	0.68
754_L	766_I	0.527	0.68
216_F	300_M	0.527	0.68
526_L	529_D	0.527	0.68
690_T	721_F	0.527	0.68
387_F	403_N	0.527	0.68
57_K	60_K	0.526	0.68
534_K	538_G	0.526	0.68
75_F	112_P	0.526	0.68
481_G	502_L	0.526	0.68
730_W	735_I	0.525	0.68
523_W	532_D	0.525	0.68
615_L	619_Y	0.525	0.68
215_Y	270_A	0.524	0.68
35_L	61_L	0.524	0.68
58_G	61_L	0.524	0.68
592_L	595_S	0.523	0.67
273_L	280_N	0.522	0.67
459_E	509_K	0.522	0.67
303_K	306_K	0.522	0.67
676_V	679_L	0.522	0.67
620_E	640_D	0.522	0.67
52_T	63_I	0.521	0.67
376_F	379_G	0.521	0.67
496_R	528_A	0.520	0.67
645_L	648_Y	0.520	0.67
84_I	89_V	0.520	0.67
38_V	108_R	0.520	0.67
582_F	590_G	0.519	0.67
697_L	707_V	0.519	0.67
455_P	463_K	0.519	0.67
108_R	123_F	0.518	0.67
238_M	352_F	0.518	0.67
653_I	656_E	0.517	0.67
287_W	290_L	0.515	0.66
377_R	380_V	0.515	0.66
588_D	593_A	0.514	0.66
250_A	261_Q	0.514	0.66
275_H	279_G	0.513	0.66
296_F	357_Y	0.513	0.66
257_S	265_V	0.513	0.66
248_E	265_V	0.513	0.66
165_Y	283_T	0.513	0.66
121_A	163_S	0.510	0.65
272_E	293_N	0.510	0.65
526_L	530_L	0.510	0.65
536_Y	558_Q	0.510	0.65
489_I	492_T	0.510	0.65
376_F	380_V	0.510	0.65
534_K	537_F	0.510	0.65
512_A	548_N	0.509	0.65
24_I	121_A	0.508	0.65
104_A	156_F	0.508	0.65
515_E	518_L	0.507	0.65
58_G	65_G	0.507	0.65
296_F	300_M	0.506	0.65
87_I	100_T	0.506	0.65
146_E	152_V	0.506	0.65
302_Y	361_A	0.506	0.65
259_I	588_D	0.506	0.65
166_L	239_E	0.505	0.65
58_G	66_K	0.505	0.65
540_I	545_Y	0.504	0.65
39_N	109_R	0.504	0.65
214_K	377_R	0.504	0.65
750_I	769_S	0.504	0.65
238_M	296_F	0.504	0.65
592_L	597_V	0.503	0.64
99_T	170_G	0.503	0.64
583_R	592_L	0.503	0.64
123_F	162_M	0.502	0.64
638_N	669_D	0.502	0.64
694_I	697_L	0.502	0.64
349_E	729_P	0.502	0.64
261_Q	657_K	0.502	0.64
15_G	89_V	0.501	0.64
409_I	413_M	0.500	0.64

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yd0A	1	0.9872	100	0.146	Contact Map
4jbsA	1	0.9898	100	0.146	Contact Map
4pj6A	2	0.9898	100	0.148	Contact Map
4kx7A	1	0.9885	100	0.148	Contact Map
4fkeA	1	0.9923	100	0.149	Contact Map
4wz9A	2	0.9898	100	0.16	Contact Map
1z5hA	3	0.9745	100	0.172	Contact Map
4x2uA	1	0.9732	100	0.395	Contact Map
3b34A	1	0.9732	100	0.405	Contact Map
4qhpA	1	0.9745	100	0.41	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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