GREMLIN Database
APE1 - Probable aminopeptidase 1
UniProt: Q97VF1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 784 (761)
Sequences: 5171 (3594)
Seq/√Len: 130.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_E76_K4.0341.00
744_V748_K3.8641.00
179_D206_R3.8271.00
5_E27_N3.7021.00
10_F128_R3.6431.00
23_K72_E3.5211.00
203_N207_K3.4621.00
386_S403_N3.4561.00
124_K158_E3.3831.00
178_S187_I3.3171.00
44_S74_K3.3081.00
113_C123_F3.2241.00
21_V74_K3.1311.00
751_I755_E3.0891.00
437_S473_S3.0831.00
387_F400_S3.0271.00
128_R153_I2.9601.00
46_K72_E2.9591.00
102_F110_F2.9061.00
126_S155_R2.8951.00
616_F643_T2.8941.00
210_E214_K2.8791.00
131_K146_E2.8701.00
425_I436_F2.8681.00
8_E124_K2.8481.00
43_R76_K2.8451.00
129_V154_Y2.7601.00
382_N403_N2.7521.00
6_K122_R2.7251.00
25_Y70_E2.7131.00
382_N386_S2.7031.00
375_N405_A2.7031.00
176_E187_I2.6031.00
129_V135_V2.5951.00
131_K150_G2.5341.00
215_Y377_R2.5181.00
425_I454_V2.4901.00
436_F456_I2.4781.00
145_E153_I2.4721.00
712_M749_D2.4121.00
27_N68_E2.4061.00
122_R158_E2.4031.00
490_N511_N2.3891.00
47_S71_L2.3201.00
427_V436_F2.2901.00
127_V169_L2.2851.00
23_K70_E2.2711.00
377_R381_V2.2461.00
24_I35_L2.2301.00
638_N642_N2.2281.00
125_L167_L2.2181.00
706_E710_Y2.2041.00
218_I384_L2.1851.00
467_L476_I2.1741.00
178_S185_T2.1661.00
637_T640_D2.1561.00
48_D69_R2.1511.00
111_I167_L2.1301.00
428_N437_S2.1251.00
338_I363_I2.1241.00
140_P223_P2.1161.00
371_V375_N2.1061.00
144_I152_V2.0951.00
674_V713_N2.0931.00
217_E385_N2.0821.00
518_L521_D2.0611.00
586_N590_G2.0441.00
368_E373_E2.0401.00
141_V144_I2.0231.00
408_S411_E2.0191.00
175_E195_S2.0001.00
452_Y459_E1.9781.00
122_R161_K1.9531.00
378_R381_V1.9471.00
141_V154_Y1.9461.00
180_N219_P1.9361.00
142_E157_Q1.9351.00
574_F578_Q1.9331.00
515_E546_T1.9281.00
440_R452_Y1.9281.00
541_G544_V1.9231.00
471_K474_A1.9221.00
34_E60_K1.9131.00
175_E192_P1.9121.00
371_V401_I1.9041.00
285_K393_E1.9031.00
299_F368_E1.9011.00
227_L246_F1.8921.00
127_V135_V1.8881.00
177_I198_G1.8721.00
25_Y68_E1.8661.00
123_F164_T1.8631.00
136_I243_A1.8581.00
425_I469_L1.8551.00
139_M223_P1.8271.00
434_I438_Q1.8211.00
170_G243_A1.8201.00
575_L578_Q1.8171.00
10_F126_S1.8171.00
143_R155_R1.8131.00
587_D590_G1.7941.00
131_K152_V1.7911.00
21_V72_E1.7831.00
208_V270_A1.7801.00
435_R473_S1.7561.00
751_I770_E1.7451.00
187_I226_H1.7401.00
231_P248_E1.7381.00
12_D128_R1.7371.00
250_A264_R1.7311.00
387_F396_D1.7271.00
19_E76_K1.7171.00
640_D643_T1.7141.00
426_F498_L1.7111.00
435_R475_E1.7011.00
674_V678_S1.6941.00
454_V459_E1.6911.00
173_E192_P1.6851.00
177_I199_L1.6781.00
642_N646_E1.6741.00
614_T618_Q1.6711.00
717_E756_K1.6711.00
303_K311_Q1.6691.00
7_Y121_A1.6661.00
217_E381_V1.6641.00
113_C164_T1.6631.00
387_F390_G1.6231.00
10_F21_V1.6091.00
122_R157_Q1.6041.00
718_V721_F1.5991.00
613_S617_D1.5951.00
438_Q441_F1.5841.00
293_N352_F1.5831.00
303_K368_E1.5771.00
375_N378_R1.5741.00
382_N404_A1.5691.00
6_K124_K1.5581.00
486_K514_E1.5571.00
511_N514_E1.5471.00
748_K752_D1.5461.00
38_V59_E1.5411.00
385_N388_K1.5391.00
8_E23_K1.5391.00
170_G174_F1.5341.00
263_F317_H1.5331.00
602_A609_A1.5281.00
190_T198_G1.5231.00
433_S475_E1.5221.00
578_Q581_I1.5221.00
32_K64_Y1.5211.00
584_K587_D1.5181.00
186_V205_A1.5121.00
335_T420_P1.5031.00
17_E76_K1.4961.00
118_A285_K1.4941.00
215_Y373_E1.4891.00
743_G746_K1.4871.00
717_E720_K1.4871.00
647_K650_R1.4771.00
228_I243_A1.4751.00
26_L71_L1.4711.00
381_V385_N1.4701.00
625_N647_K1.4671.00
18_Y77_G1.4661.00
641_F645_L1.4641.00
126_S153_I1.4621.00
572_K576_V1.4621.00
379_G401_I1.4621.00
414_A418_T1.4591.00
667_L672_I1.4521.00
713_N753_F1.4501.00
205_A227_L1.4501.00
537_F540_I1.4431.00
135_V154_Y1.4431.00
140_P157_Q1.4391.00
632_I666_S1.4391.00
188_L202_I1.4371.00
325_G354_N1.4361.00
226_H242_G1.4351.00
407_Q468_L1.4321.00
427_V487_V1.4291.00
645_L655_E1.4271.00
170_G228_I1.4171.00
83_S86_G1.4131.00
450_E454_V1.4101.00
272_E275_H1.4071.00
452_Y455_P1.4071.00
428_N435_R1.4061.00
19_E74_K1.3981.00
107_A113_C1.3981.00
199_L203_N1.3921.00
175_E193_G1.3911.00
43_R74_K1.3911.00
237_A268_V1.3881.00
110_F169_L1.3841.00
477_R480_E1.3831.00
644_L660_I1.3821.00
714_N717_E1.3811.00
132_G173_E1.3791.00
176_E189_A1.3781.00
201_A269_V1.3781.00
455_P459_E1.3771.00
399_N402_S1.3731.00
271_H275_H1.3721.00
498_L504_L1.3701.00
522_Y531_I1.3681.00
669_D672_I1.3671.00
607_E611_G1.3671.00
523_W526_L1.3641.00
386_S400_S1.3631.00
275_H357_Y1.3571.00
180_N183_Q1.3561.00
424_V496_R1.3541.00
239_E272_E1.3531.00
436_F469_L1.3441.00
575_L579_V1.3441.00
425_I488_N1.3381.00
336_H353_D1.3371.00
239_E275_H1.3371.00
747_P770_E1.3341.00
190_T195_S1.3291.00
402_S408_S1.3221.00
424_V498_L1.3221.00
379_G400_S1.3201.00
179_D202_I1.3201.00
239_E271_H1.3151.00
196_K254_D1.3101.00
95_K173_E1.3071.00
232_E686_K1.3071.00
200_F204_V1.3051.00
500_D503_N1.2991.00
267_E301_S1.2971.00
168_Y243_A1.2941.00
271_H357_Y1.2941.00
218_I388_K1.2931.00
572_K578_Q1.2931.00
188_L201_A1.2921.00
518_L525_F1.2831.00
318_L361_A1.2801.00
399_N403_N1.2771.00
125_L137_S1.2701.00
87_I98_I1.2641.00
284_L391_N1.2641.00
194_K197_R1.2641.00
124_K155_R1.2621.00
452_Y460_I1.2581.00
83_S109_R1.2511.00
191_V194_K1.2501.00
400_S404_A1.2441.00
426_F439_K1.2411.00
10_F153_I1.2361.00
6_K158_E1.2341.00
218_I385_N1.2311.00
522_Y539_V1.2271.00
518_L531_I1.2251.00
200_F309_F1.2241.00
426_F437_S1.2231.00
8_E126_S1.2201.00
40_L77_G1.2191.00
635_A644_L1.2131.00
101_Q235_A1.2090.99
415_D450_E1.2080.99
6_K25_Y1.2070.99
583_R590_G1.2050.99
454_V461_N1.2040.99
120_K163_S1.2010.99
540_I544_V1.1990.99
34_E62_V1.1960.99
686_K689_D1.1950.99
446_S449_N1.1940.99
252_L255_D1.1940.99
44_S72_E1.1930.99
295_S360_G1.1920.99
314_S318_L1.1910.99
395_K410_G1.1900.99
101_Q104_A1.1900.99
124_K142_E1.1890.99
589_L592_L1.1860.99
182_K219_P1.1850.99
275_H294_E1.1840.99
586_N591_K1.1830.99
470_D474_A1.1770.99
218_I381_V1.1740.99
488_N497_V1.1730.99
709_S713_N1.1720.99
36_D60_K1.1720.99
573_D577_N1.1700.99
450_E459_E1.1690.99
430_Y433_S1.1630.99
339_E418_T1.1630.99
588_D592_L1.1620.99
452_Y461_N1.1610.99
645_L649_K1.1590.99
20_G77_G1.1540.99
752_D755_E1.1540.99
272_E357_Y1.1450.99
526_L533_A1.1440.99
454_V460_I1.1400.99
451_V454_V1.1380.99
583_R586_N1.1370.99
46_K51_D1.1360.99
367_I398_W1.1360.99
239_E357_Y1.1350.99
447_G450_E1.1300.99
147_D153_I1.1300.99
282_V384_L1.1300.99
522_Y525_F1.1290.99
752_D756_K1.1290.99
278_F296_F1.1290.99
672_I675_K1.1280.99
429_A482_L1.1270.99
130_Q151_K1.1270.99
253_A257_S1.1260.99
572_K579_V1.1240.99
26_L69_R1.1230.99
143_R153_I1.1200.99
99_T230_V1.1180.99
90_A232_E1.1170.99
519_V522_Y1.1170.99
26_L47_S1.1160.99
45_V73_I1.1130.99
44_S51_D1.1130.99
204_V266_A1.1120.99
456_I487_V1.1120.99
210_E213_E1.1110.99
429_A500_D1.1090.99
225_V273_L1.1080.99
20_G112_P1.1070.99
296_F380_V1.1060.99
510_L514_E1.1040.99
415_D452_Y1.1020.99
212_Y304_S1.1000.99
746_K749_D1.0980.99
606_E609_A1.0960.99
521_D525_F1.0960.99
12_D151_K1.0910.99
124_K157_Q1.0900.99
443_L446_S1.0870.99
186_V206_R1.0850.99
50_K53_K1.0810.99
295_S364_L1.0810.99
106_Y109_R1.0800.99
257_S261_Q1.0780.99
748_K751_I1.0780.99
452_Y457_T1.0760.99
590_G594_Y1.0740.99
551_V559_L1.0730.99
211_F303_K1.0700.99
7_Y11_L1.0650.99
502_L505_A1.0620.99
425_I495_Y1.0590.99
602_A612_L1.0570.99
86_G89_V1.0560.99
433_S477_R1.0560.99
5_E68_E1.0540.99
396_D399_N1.0540.99
574_F577_N1.0520.99
379_G404_A1.0510.99
79_A98_I1.0490.99
235_A293_N1.0480.99
382_N400_S1.0480.99
485_I501_S1.0480.99
8_E155_R1.0460.99
16_N89_V1.0430.98
378_R404_A1.0400.98
459_E489_I1.0370.98
453_K459_E1.0330.98
575_L581_I1.0320.98
501_S505_A1.0320.98
134_K176_E1.0320.98
354_N358_G1.0290.98
627_K631_A1.0260.98
400_S403_N1.0250.98
251_L254_D1.0240.98
449_N452_Y1.0220.98
660_I696_S1.0200.98
61_L65_G1.0170.98
453_K468_L1.0150.98
18_Y75_F1.0150.98
518_L522_Y1.0130.98
454_V458_Y1.0120.98
244_I273_L1.0100.98
709_S712_M1.0070.98
518_L532_D1.0060.98
767_K771_E1.0050.98
750_I773_I1.0040.98
145_E155_R1.0020.98
222_L241_W1.0020.98
450_E453_K0.9950.98
577_N580_K0.9940.98
625_N648_Y0.9940.98
278_F282_V0.9930.98
89_V98_I0.9920.98
611_G614_T0.9920.98
147_D151_K0.9850.98
45_V63_I0.9840.98
452_Y456_I0.9830.98
375_N404_A0.9820.98
128_R151_K0.9820.98
674_V710_Y0.9810.98
646_E649_K0.9780.98
615_L618_Q0.9770.98
194_K248_E0.9770.98
41_E78_K0.9760.98
249_T264_R0.9750.98
645_L679_L0.9740.98
211_F307_H0.9720.98
378_R382_N0.9710.98
7_Y24_I0.9690.98
211_F304_S0.9690.98
542_R546_T0.9680.98
238_M275_H0.9670.98
37_S40_L0.9670.98
521_D526_L0.9660.97
55_E64_Y0.9650.97
745_D749_D0.9620.97
381_V384_L0.9610.97
638_N672_I0.9610.97
271_H294_E0.9580.97
141_V187_I0.9560.97
455_P461_N0.9540.97
101_Q106_Y0.9540.97
646_E650_R0.9530.97
437_S472_E0.9520.97
419_K450_E0.9510.97
298_T301_S0.9510.97
535_T538_G0.9500.97
294_E357_Y0.9500.97
398_W413_M0.9490.97
114_F119_M0.9490.97
522_Y526_L0.9490.97
463_K481_G0.9470.97
265_V268_V0.9470.97
136_I189_A0.9450.97
162_M166_L0.9420.97
573_D576_V0.9400.97
451_V455_P0.9360.97
370_Y468_L0.9330.97
554_E558_Q0.9330.97
452_Y458_Y0.9330.97
641_F676_V0.9330.97
254_D257_S0.9310.97
182_K213_E0.9300.97
132_G152_V0.9260.97
720_K757_V0.9260.97
443_L449_N0.9260.97
233_F236_G0.9240.97
200_F266_A0.9220.97
250_A268_V0.9200.97
613_S616_F0.9180.97
101_Q240_N0.9170.97
233_F247_R0.9170.97
518_L526_L0.9160.97
643_T647_K0.9140.96
461_N483_K0.9140.96
264_R268_V0.9130.96
88_Y233_F0.9130.96
142_E155_R0.9130.96
747_P751_I0.9110.96
307_H373_E0.9100.96
743_G747_P0.9100.96
446_S456_I0.9100.96
586_N589_L0.9090.96
453_K456_I0.9090.96
289_D339_E0.9090.96
369_A492_T0.9080.96
521_D528_A0.9070.96
237_A357_Y0.9070.96
136_I228_I0.9060.96
632_I640_D0.9060.96
225_V244_I0.9030.96
340_A351_M0.9020.96
238_M271_H0.9020.96
97_M230_V0.8980.96
16_N78_K0.8970.96
673_V697_L0.8970.96
627_K647_K0.8960.96
596_T600_A0.8960.96
274_A300_M0.8960.96
191_V248_E0.8960.96
329_D768_E0.8940.96
745_D748_K0.8930.96
610_L613_S0.8930.96
83_S89_V0.8920.96
536_Y540_I0.8920.96
680_I697_L0.8910.96
9_I125_L0.8900.96
434_I485_I0.8890.96
616_F619_Y0.8890.96
263_F588_D0.8860.96
450_E455_P0.8810.96
541_G546_T0.8790.96
37_S77_G0.8780.96
24_I114_F0.8770.96
20_G75_F0.8760.96
200_F262_K0.8750.96
588_D597_V0.8750.96
430_Y435_R0.8740.95
436_F487_V0.8710.95
253_A256_S0.8710.95
456_I461_N0.8700.95
239_E294_E0.8700.95
588_D591_K0.8700.95
52_T55_E0.8690.95
563_Y603_R0.8690.95
586_N594_Y0.8680.95
710_Y714_N0.8680.95
323_S494_F0.8670.95
582_F587_D0.8670.95
665_S696_S0.8670.95
229_Q252_L0.8660.95
583_R588_D0.8660.95
341_H418_T0.8650.95
292_L383_Y0.8640.95
120_K283_T0.8610.95
38_V109_R0.8600.95
103_E293_N0.8590.95
429_A485_I0.8590.95
635_A667_L0.8580.95
47_S52_T0.8570.95
574_F581_I0.8570.95
582_F586_N0.8560.95
673_V703_I0.8520.95
238_M272_E0.8510.95
39_N83_S0.8500.95
577_N581_I0.8500.95
147_D150_G0.8470.95
157_Q223_P0.8460.95
10_F23_K0.8420.94
63_I66_K0.8410.94
95_K192_P0.8400.94
736_V739_M0.8390.94
755_E759_F0.8390.94
496_R524_N0.8380.94
456_I469_L0.8350.94
753_F756_K0.8340.94
677_F710_Y0.8340.94
284_L293_N0.8330.94
384_L392_A0.8320.94
589_L593_A0.8280.94
729_P732_L0.8270.94
35_L63_I0.8260.94
380_V384_L0.8250.94
671_S674_V0.8230.94
617_D643_T0.8220.94
282_V400_S0.8200.94
237_A275_H0.8200.94
708_C712_M0.8200.94
672_I676_V0.8180.94
559_L567_K0.8160.93
402_S405_A0.8150.93
453_K470_D0.8140.93
237_A272_E0.8140.93
504_L522_Y0.8130.93
272_E294_E0.8130.93
522_Y536_Y0.8130.93
708_C749_D0.8120.93
189_A226_H0.8110.93
543_F546_T0.8110.93
212_Y274_A0.8100.93
457_T460_I0.8080.93
502_L506_F0.8080.93
386_S399_N0.8070.93
720_K756_K0.8070.93
135_V156_F0.8060.93
40_L78_K0.8060.93
514_E517_G0.8060.93
60_K65_G0.8030.93
440_R443_L0.8030.93
642_N645_L0.8030.93
236_G239_E0.8030.93
32_K62_V0.8010.93
697_L703_I0.8010.93
11_L169_L0.8000.93
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382_N385_N0.5400.70
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548_N551_V0.5360.69
160_P222_L0.5350.69
550_F553_R0.5340.69
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741_F746_K0.5330.69
275_H352_F0.5330.69
551_V554_E0.5320.69
588_D594_Y0.5320.69
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35_L61_L0.5240.68
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592_L595_S0.5230.67
273_L280_N0.5220.67
459_E509_K0.5220.67
303_K306_K0.5220.67
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496_R528_A0.5200.67
645_L648_Y0.5200.67
84_I89_V0.5200.67
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238_M352_F0.5180.67
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287_W290_L0.5150.66
377_R380_V0.5150.66
588_D593_A0.5140.66
250_A261_Q0.5140.66
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296_F357_Y0.5130.66
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248_E265_V0.5130.66
165_Y283_T0.5130.66
121_A163_S0.5100.65
272_E293_N0.5100.65
526_L530_L0.5100.65
536_Y558_Q0.5100.65
489_I492_T0.5100.65
376_F380_V0.5100.65
534_K537_F0.5100.65
512_A548_N0.5090.65
24_I121_A0.5080.65
104_A156_F0.5080.65
515_E518_L0.5070.65
58_G65_G0.5070.65
296_F300_M0.5060.65
87_I100_T0.5060.65
146_E152_V0.5060.65
302_Y361_A0.5060.65
259_I588_D0.5060.65
166_L239_E0.5050.65
58_G66_K0.5050.65
540_I545_Y0.5040.65
39_N109_R0.5040.65
214_K377_R0.5040.65
750_I769_S0.5040.65
238_M296_F0.5040.65
592_L597_V0.5030.64
99_T170_G0.5030.64
583_R592_L0.5030.64
123_F162_M0.5020.64
638_N669_D0.5020.64
694_I697_L0.5020.64
349_E729_P0.5020.64
261_Q657_K0.5020.64
15_G89_V0.5010.64
409_I413_M0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yd0A 1 0.9872 100 0.146 Contact Map
4jbsA 1 0.9898 100 0.146 Contact Map
4pj6A 2 0.9898 100 0.148 Contact Map
4kx7A 1 0.9885 100 0.148 Contact Map
4fkeA 1 0.9923 100 0.149 Contact Map
4wz9A 2 0.9898 100 0.16 Contact Map
1z5hA 3 0.9745 100 0.172 Contact Map
4x2uA 1 0.9732 100 0.395 Contact Map
3b34A 1 0.9732 100 0.405 Contact Map
4qhpA 1 0.9745 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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