GREMLIN Database
Q97VE6 - Type II secretion system protein, virB homolog (GspE-2)
UniProt: Q97VE6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 515 (447)
Sequences: 4129 (2926)
Seq/√Len: 138.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
467_L477_R5.0831.00
416_E443_Y4.7341.00
262_Y290_L4.1001.00
422_R444_E3.9871.00
191_V233_F3.7571.00
265_I406_V3.7401.00
380_N383_D3.5451.00
421_N441_Y3.4051.00
232_T299_K3.3781.00
422_R442_D3.3061.00
423_K439_F3.1601.00
263_L293_L3.1561.00
298_A348_Y3.0971.00
419_K448_F3.0281.00
44_Y48_S2.9381.00
301_L341_S2.7681.00
416_E496_D2.7371.00
475_L484_L2.6641.00
486_I500_L2.6341.00
415_T458_S2.5541.00
274_F374_T2.4891.00
473_D477_R2.4751.00
408_A463_R2.4671.00
469_G477_R2.3691.00
266_I290_L2.3551.00
303_I337_L2.3511.00
98_Q102_E2.3491.00
217_H239_P2.3371.00
276_V376_F2.3341.00
259_M263_L2.3291.00
354_V362_L2.3091.00
458_S494_V2.2911.00
99_I103_K2.2881.00
162_I187_V2.2421.00
207_P330_K2.2371.00
424_M440_R2.2101.00
264_W465_R2.1941.00
474_K478_E2.1591.00
61_I87_I2.1131.00
221_V235_I2.1051.00
416_E421_N2.1011.00
226_E317_I2.0711.00
424_M442_D2.0641.00
382_T464_S2.0551.00
480_E488_G2.0521.00
174_R180_V2.0411.00
488_G492_K2.0001.00
320_Y329_S1.9621.00
198_G223_Y1.9411.00
485_L489_L1.9401.00
232_T315_Y1.9361.00
294_L348_Y1.9241.00
141_L190_L1.9091.00
149_F455_E1.8871.00
487_R491_E1.8831.00
97_K101_L1.8811.00
171_E502_R1.8731.00
443_Y496_D1.8711.00
473_D476_Y1.8551.00
257_D480_E1.8381.00
385_I404_I1.8321.00
161_P180_V1.8301.00
258_L461_L1.8191.00
57_E84_D1.8171.00
64_Y78_I1.8151.00
96_N100_D1.8141.00
46_L50_D1.8091.00
419_K455_E1.7851.00
333_S336_E1.7741.00
224_G344_Y1.7411.00
200_R225_E1.7281.00
56_A63_F1.7271.00
467_L473_D1.7241.00
92_T95_S1.7231.00
225_E233_F1.7191.00
256_S260_A1.7141.00
63_F89_S1.6981.00
258_L463_R1.6831.00
255_L258_L1.6771.00
303_I341_S1.6331.00
483_L504_L1.6241.00
78_I86_L1.6181.00
65_L91_S1.6171.00
99_I102_E1.6161.00
66_V88_Y1.6101.00
98_Q103_K1.5831.00
99_I104_L1.5671.00
268_E405_S1.5611.00
295_N300_Y1.5521.00
469_G476_Y1.5511.00
416_E441_Y1.5451.00
132_I135_E1.5431.00
389_S400_F1.5391.00
474_K479_I1.5061.00
317_I341_S1.4971.00
442_D498_D1.4871.00
174_R296_P1.4811.00
260_A264_W1.4771.00
96_N104_L1.4751.00
458_S489_L1.4721.00
55_I65_L1.4691.00
228_S315_Y1.4551.00
221_V237_K1.4401.00
238_F309_L1.4301.00
97_K102_E1.4281.00
72_D76_N1.4261.00
489_L494_V1.4261.00
468_L471_S1.4251.00
320_Y330_K1.4231.00
194_L223_Y1.4181.00
337_L341_S1.4161.00
430_N434_G1.4141.00
440_R490_A1.4101.00
464_S479_I1.4091.00
42_E47_N1.4061.00
273_T406_V1.3851.00
426_S440_R1.3711.00
136_I144_P1.3671.00
490_A500_L1.3651.00
258_L485_L1.3641.00
155_L162_I1.3601.00
96_N101_L1.3601.00
150_V168_R1.3561.00
171_E414_E1.3411.00
267_A293_L1.3401.00
416_E444_E1.3391.00
258_L261_V1.3371.00
68_E71_L1.3361.00
163_S174_R1.3331.00
273_T371_G1.3291.00
75_E88_Y1.3251.00
138_Y144_P1.3161.00
257_D261_V1.3071.00
274_F354_V1.3051.00
446_K449_V1.3031.00
207_P332_I1.2971.00
62_G82_I1.2891.00
481_N484_L1.2891.00
417_D420_M1.2841.00
254_T286_A1.2841.00
420_M446_K1.2751.00
431_D434_G1.2701.00
367_A399_Q1.2681.00
279_T346_P1.2621.00
55_I89_S1.2541.00
417_D449_V1.2541.00
469_G473_D1.2441.00
60_G84_D1.2401.00
420_M449_V1.2391.00
363_V394_P1.2371.00
294_L373_L1.2251.00
166_H175_L1.2241.00
417_D446_K1.2221.00
418_R421_N1.2211.00
171_E297_L1.2151.00
261_V465_R1.2111.00
232_T301_L1.2111.00
131_Y135_E1.2051.00
438_V491_E1.2001.00
254_T262_Y1.1961.00
51_V67_N1.1941.00
265_I463_R1.1901.00
138_Y141_L1.1891.00
247_D251_K1.1881.00
97_K103_K1.1821.00
349_I365_A1.1791.00
424_M427_I1.1771.00
423_K441_Y1.1730.99
454_K496_D1.1700.99
197_L213_L1.1690.99
279_T370_H1.1650.99
98_Q101_L1.1550.99
454_K495_Y1.1550.99
496_D499_T1.1550.99
65_L89_S1.1430.99
51_V93_A1.1370.99
219_V237_K1.1350.99
248_L289_A1.1330.99
254_T461_L1.1320.99
423_K426_S1.1300.99
97_K100_D1.1230.99
138_Y142_Q1.1140.99
264_W268_E1.0990.99
168_R173_P1.0980.99
156_V165_V1.0960.99
100_D104_L1.0940.99
360_E394_P1.0920.99
460_Q486_I1.0920.99
354_V374_T1.0900.99
213_L221_V1.0820.99
101_L104_L1.0800.99
136_I139_S1.0730.99
258_L408_A1.0720.99
96_N99_I1.0710.99
249_I263_L1.0680.99
400_F404_I1.0610.99
470_W473_D1.0550.99
276_V378_G1.0510.99
475_L481_N1.0440.99
100_D103_K1.0260.99
407_I464_S1.0230.99
413_I495_Y1.0220.99
343_R355_R1.0180.99
488_G491_E1.0180.99
55_I63_F1.0110.98
96_N102_E1.0110.98
376_F384_L1.0090.98
218_R240_E1.0090.98
248_L263_L1.0060.98
424_M430_N1.0030.98
142_Q146_S1.0030.98
255_L488_G1.0020.98
249_I259_M1.0020.98
184_E187_V1.0010.98
295_N313_H0.9990.98
409_I482_R0.9980.98
50_D74_R0.9980.98
109_L112_S0.9920.98
341_S349_I0.9890.98
475_L478_E0.9880.98
301_L317_I0.9820.98
149_F168_R0.9810.98
140_I144_P0.9730.98
335_Y358_E0.9680.98
100_D108_V0.9680.98
161_P312_P0.9590.98
338_V361_W0.9580.98
426_S430_N0.9570.98
331_D336_E0.9550.98
404_I407_I0.9530.98
52_E78_I0.9530.98
103_K107_D0.9520.98
286_A408_A0.9490.98
437_E440_R0.9410.98
354_V360_E0.9390.98
224_G340_L0.9390.98
50_D77_K0.9370.97
255_L489_L0.9340.97
98_Q104_L0.9300.97
96_N103_K0.9300.97
427_I430_N0.9290.97
414_E499_T0.9200.97
108_V111_I0.9190.97
124_N127_K0.9190.97
104_L112_S0.9180.97
272_F372_G0.9150.97
97_K111_I0.9150.97
107_D110_K0.9140.97
52_E64_Y0.9120.97
485_L488_G0.9120.97
61_I85_G0.9110.97
487_R490_A0.9100.97
364_Q367_A0.9070.97
141_L194_L0.9070.97
491_E494_V0.9050.97
353_E377_H0.9040.97
497_Y501_A0.9010.97
224_G234_N0.8960.97
77_K80_L0.8950.97
252_Y461_L0.8950.97
255_L485_L0.8950.97
303_I319_F0.8940.97
148_P173_P0.8910.97
144_P164_V0.8900.97
41_V57_E0.8890.97
107_D112_S0.8860.96
301_L315_Y0.8850.96
275_L286_A0.8840.96
475_L479_I0.8820.96
158_P163_S0.8780.96
489_L492_K0.8740.96
91_S95_S0.8710.96
52_E74_R0.8700.96
466_E471_S0.8690.96
364_Q390_G0.8680.96
466_E470_W0.8670.96
200_R224_G0.8660.96
266_I373_L0.8610.96
219_V239_P0.8590.96
428_V432_G0.8580.96
193_R197_L0.8560.96
317_I337_L0.8520.96
470_W474_K0.8520.96
79_L85_G0.8510.96
275_L408_A0.8510.96
495_Y499_T0.8500.96
346_P370_H0.8500.96
71_L74_R0.8500.96
52_E66_V0.8480.95
97_K104_L0.8480.95
67_N70_Q0.8440.95
248_L259_M0.8400.95
169_H414_E0.8380.95
102_E107_D0.8370.95
261_V264_W0.8360.95
82_I85_G0.8350.95
198_G213_L0.8350.95
474_K477_R0.8340.95
487_R497_Y0.8340.95
255_L492_K0.8320.95
66_V71_L0.8310.95
342_L365_A0.8270.95
413_I460_Q0.8260.95
308_E377_H0.8210.95
460_Q503_E0.8200.95
109_L113_A0.8200.95
363_V399_Q0.8190.95
426_S431_D0.8180.95
440_R491_E0.8180.95
439_F442_D0.8160.94
272_F404_I0.8150.94
75_E79_L0.8140.94
307_P318_Q0.8120.94
159_T229_R0.8110.94
223_Y235_I0.8110.94
101_L107_D0.8100.94
382_T479_I0.8070.94
84_D88_Y0.8060.94
43_H46_L0.8060.94
98_Q107_D0.8040.94
239_P243_L0.8040.94
480_E484_L0.8040.94
257_D488_G0.8020.94
270_K380_N0.8000.94
130_Y135_E0.8000.94
328_G333_S0.7950.94
486_I489_L0.7940.94
378_G381_H0.7940.94
42_E78_I0.7910.93
430_N433_N0.7900.93
62_G84_D0.7880.93
283_K353_E0.7870.93
97_K107_D0.7860.93
232_T344_Y0.7850.93
130_Y133_T0.7850.93
201_S329_S0.7840.93
46_L52_E0.7810.93
420_M445_R0.7790.93
384_L407_I0.7760.93
207_P336_E0.7740.93
99_I107_D0.7730.93
98_Q108_V0.7720.93
66_V75_E0.7710.93
71_L75_E0.7710.93
102_E111_I0.7690.93
262_Y463_R0.7690.93
401_K405_S0.7670.92
217_H241_K0.7660.92
445_R449_V0.7650.92
254_T459_I0.7640.92
69_P90_A0.7640.92
129_M133_T0.7630.92
286_A410_I0.7620.92
339_R358_E0.7590.92
276_V384_L0.7580.92
501_A504_L0.7570.92
265_I273_T0.7570.92
343_R377_H0.7550.92
112_S115_L0.7530.92
279_T368_S0.7500.92
287_L350_I0.7490.92
283_K377_H0.7490.92
236_R353_E0.7490.92
128_Y132_I0.7480.91
148_P450_P0.7460.91
276_V409_I0.7460.91
333_S358_E0.7450.91
469_G472_R0.7440.91
131_Y134_R0.7440.91
292_M295_N0.7440.91
436_R439_F0.7410.91
145_M221_V0.7400.91
464_S470_W0.7380.91
460_Q504_L0.7370.91
352_G377_H0.7360.91
343_R353_E0.7340.91
126_K129_M0.7330.91
103_K108_V0.7330.91
272_F363_V0.7320.91
247_D293_L0.7310.91
160_T312_P0.7310.91
270_K405_S0.7300.90
105_Q109_L0.7290.90
299_K315_Y0.7280.90
127_K134_R0.7270.90
99_I108_V0.7250.90
464_S474_K0.7240.90
441_Y444_E0.7240.90
236_R377_H0.7240.90
105_Q113_A0.7240.90
265_I405_S0.7230.90
161_P174_R0.7140.89
499_T502_R0.7140.89
104_L107_D0.7130.89
299_K344_Y0.7130.89
266_I273_T0.7130.89
490_A497_Y0.7100.89
112_S116_G0.7090.89
278_P411_K0.7090.89
74_R78_I0.7080.89
256_S259_M0.7070.89
262_Y273_T0.7050.89
115_L118_I0.7030.89
308_E353_E0.7010.89
234_N344_Y0.6980.88
46_L81_A0.6960.88
104_L111_I0.6960.88
243_L247_D0.6940.88
67_N93_A0.6940.88
59_D84_D0.6890.88
162_I190_L0.6890.88
462_E479_I0.6880.88
483_L487_R0.6860.88
200_R233_F0.6850.87
482_R486_I0.6830.87
484_L487_R0.6810.87
195_A231_T0.6800.87
425_I439_F0.6800.87
465_R479_I0.6800.87
66_V74_R0.6750.87
236_R308_E0.6750.87
104_L114_K0.6740.87
42_E52_E0.6740.87
47_N52_E0.6740.87
294_L298_A0.6740.87
330_K333_S0.6710.86
332_I337_L0.6710.86
467_L474_K0.6690.86
187_V191_V0.6680.86
103_K115_L0.6680.86
272_F364_Q0.6670.86
102_E115_L0.6650.86
413_I458_S0.6650.86
464_S481_N0.6620.86
435_F438_V0.6600.85
303_I317_I0.6590.85
156_V205_A0.6580.85
341_S351_V0.6570.85
105_Q115_L0.6560.85
76_N79_L0.6550.85
79_L83_L0.6540.85
108_V114_K0.6540.85
111_I115_L0.6510.85
151_E234_N0.6500.85
415_T494_V0.6490.85
73_Q77_K0.6480.84
212_M220_A0.6460.84
192_E202_V0.6460.84
355_R377_H0.6450.84
417_D445_R0.6450.84
287_L373_L0.6440.84
290_L303_I0.6420.84
279_T343_R0.6420.84
144_P153_I0.6420.84
147_D215_E0.6390.84
303_I361_W0.6380.84
88_Y92_T0.6380.84
99_I110_K0.6370.83
284_T309_L0.6370.83
42_E54_Y0.6370.83
154_E234_N0.6360.83
406_V463_R0.6360.83
168_R175_L0.6360.83
220_A240_E0.6350.83
383_D386_T0.6350.83
494_V500_L0.6340.83
63_F87_I0.6340.83
57_E60_G0.6310.83
114_K120_D0.6300.83
71_L77_K0.6300.83
54_Y57_E0.6290.83
67_N91_S0.6290.83
66_V72_D0.6280.83
163_S296_P0.6270.82
214_P218_R0.6270.82
50_D71_L0.6260.82
123_R126_K0.6250.82
284_T311_L0.6230.82
343_R352_G0.6220.82
104_L118_I0.6210.82
240_E309_L0.6210.82
311_L314_K0.6210.82
98_Q111_I0.6200.82
264_W267_A0.6190.82
140_I181_L0.6190.82
236_R343_R0.6190.82
85_G88_Y0.6190.82
58_K63_F0.6190.82
350_I374_T0.6180.82
78_I82_I0.6180.82
43_H47_N0.6180.82
240_E243_L0.6170.81
416_E422_R0.6160.81
257_D260_A0.6160.81
363_V367_A0.6160.81
336_E340_L0.6150.81
47_N54_Y0.6120.81
279_T355_R0.6120.81
294_L300_Y0.6120.81
108_V112_S0.6110.81
236_R283_K0.6100.81
490_A495_Y0.6080.80
101_L105_Q0.6080.80
330_K336_E0.6070.80
258_L480_E0.6060.80
82_I86_L0.6060.80
270_K285_T0.6060.80
155_L187_V0.6050.80
194_L233_F0.6050.80
428_V431_D0.6040.80
49_F77_K0.6030.80
346_P387_R0.6030.80
156_V204_T0.6030.80
154_E345_R0.6020.80
136_I142_Q0.6020.80
210_D224_G0.6010.80
340_L344_Y0.6010.80
157_S344_Y0.6000.80
265_I465_R0.5990.80
305_D318_Q0.5980.79
273_T405_S0.5970.79
351_V359_I0.5960.79
145_M153_I0.5960.79
140_I190_L0.5960.79
272_F342_L0.5950.79
113_A117_V0.5950.79
44_Y47_N0.5940.79
152_E343_R0.5940.79
440_R443_Y0.5940.79
427_I431_D0.5930.79
426_S438_V0.5920.79
328_G332_I0.5910.79
58_K61_I0.5890.78
454_K498_D0.5890.78
435_F439_F0.5890.78
73_Q459_I0.5870.78
288_N311_L0.5870.78
447_N451_D0.5850.78
272_F405_S0.5850.78
341_S471_S0.5840.78
461_L465_R0.5820.78
268_E468_L0.5820.78
122_K127_K0.5810.77
483_L500_L0.5810.77
269_A379_S0.5800.77
207_P331_D0.5790.77
272_F366_V0.5780.77
405_S471_S0.5780.77
158_P161_P0.5750.77
284_T288_N0.5740.77
138_Y193_R0.5730.76
242_P247_D0.5710.76
125_L128_Y0.5680.76
141_L144_P0.5680.76
60_G63_F0.5670.76
275_L287_L0.5670.76
338_V342_L0.5670.76
210_D351_V0.5660.76
486_I495_Y0.5650.75
127_K130_Y0.5640.75
103_K112_S0.5640.75
45_T49_F0.5630.75
129_M132_I0.5630.75
154_E306_T0.5620.75
58_K62_G0.5620.75
285_T309_L0.5620.75
226_E344_Y0.5610.75
111_I114_K0.5610.75
284_T289_A0.5610.75
291_L350_I0.5610.75
426_S429_E0.5600.75
194_L235_I0.5580.75
42_E45_T0.5560.74
236_R355_R0.5560.74
195_A209_Q0.5540.74
366_V403_L0.5540.74
352_G355_R0.5530.74
339_R356_G0.5480.73
477_R480_E0.5480.73
64_Y88_Y0.5480.73
283_K343_R0.5480.73
343_R387_R0.5470.73
104_L115_L0.5470.73
65_L69_P0.5460.73
239_P242_P0.5460.73
152_E377_H0.5460.73
308_E355_R0.5450.73
68_E78_I0.5440.73
332_I340_L0.5440.73
283_K308_E0.5430.73
308_E343_R0.5410.72
419_K447_N0.5410.72
260_A429_E0.5410.72
79_L86_L0.5410.72
128_Y135_E0.5410.72
57_E62_G0.5410.72
210_D343_R0.5400.72
101_L117_V0.5390.72
145_M213_L0.5390.72
315_Y344_Y0.5390.72
279_T353_E0.5390.72
283_K352_G0.5380.72
460_Q489_L0.5360.72
139_S329_S0.5350.71
106_E109_L0.5340.71
46_L49_F0.5330.71
279_T377_H0.5320.71
364_Q395_E0.5310.71
483_L486_I0.5310.71
196_S202_V0.5300.71
162_I181_L0.5300.71
449_V457_T0.5290.71
243_L284_T0.5290.71
368_S379_S0.5280.70
338_V341_S0.5280.70
76_N397_S0.5280.70
291_L314_K0.5270.70
90_A95_S0.5270.70
68_E317_I0.5270.70
189_R196_S0.5260.70
239_P309_L0.5260.70
226_E341_S0.5260.70
239_P288_N0.5250.70
68_E76_N0.5250.70
270_K504_L0.5240.70
391_L461_L0.5240.70
162_I191_V0.5230.70
213_L223_Y0.5230.70
243_L289_A0.5220.70
431_D438_V0.5210.69
108_V113_A0.5210.69
261_V463_R0.5210.69
127_K131_Y0.5200.69
98_Q105_Q0.5200.69
476_Y479_I0.5190.69
229_R310_K0.5190.69
175_L180_V0.5190.69
156_V344_Y0.5180.69
212_M364_Q0.5170.69
157_S388_I0.5170.69
463_R466_E0.5170.69
103_K111_I0.5170.69
158_P232_T0.5160.69
158_P181_L0.5150.69
367_A403_L0.5150.69
100_D109_L0.5130.68
182_G225_E0.5120.68
334_Y359_I0.5110.68
66_V69_P0.5100.68
129_M135_E0.5100.68
220_A302_T0.5100.68
356_G359_I0.5090.68
355_R387_R0.5090.68
355_R375_T0.5080.68
391_L395_E0.5080.68
81_A84_D0.5080.68
91_S94_V0.5080.68
104_L109_L0.5060.67
102_E106_E0.5060.67
465_R468_L0.5060.67
73_Q76_N0.5050.67
489_L500_L0.5030.67
232_T317_I0.5030.67
288_N354_V0.5030.67
422_R425_I0.5020.67
264_W448_F0.5020.67
114_K117_V0.5010.67
249_I256_S0.5010.67
370_H387_R0.5000.66
167_S345_R0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4phtA 1 0.8058 100 0.391 Contact Map
4ksrA 3 0.6699 100 0.449 Contact Map
2oap1 3 0.9437 100 0.471 Contact Map
1p9rA 1 0.6951 100 0.473 Contact Map
4ihqA 3 0.9476 100 0.497 Contact Map
2ewvA 3 0.6194 100 0.595 Contact Map
3jvvA 3 0.6058 100 0.605 Contact Map
2gzaA 3 0.5825 100 0.687 Contact Map
2eyuA 1 0.4272 100 0.714 Contact Map
4bloA 4 0.4893 100 0.749 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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