GREMLIN Database
Q97VE0 - Mercury resistance operon repressor, probable (MerR)
UniProt: Q97VE0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 115 (89)
Sequences: 5248 (3501)
Seq/√Len: 371.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_Q65_R4.0251.00
64_V71_S3.2301.00
63_K74_S2.7621.00
63_K76_S2.4161.00
14_A59_C2.3001.00
66_K71_S2.2421.00
6_N18_G2.2181.00
54_A58_N1.9071.00
57_R64_V1.8541.00
32_Q74_S1.8451.00
44_K49_I1.8001.00
33_A41_S1.7191.00
26_F41_S1.6801.00
39_S46_Q1.5751.00
53_M62_V1.5741.00
27_L33_A1.5251.00
45_S48_L1.4961.00
55_C59_C1.4831.00
34_T70_F1.4811.00
34_T37_E1.4401.00
10_S58_N1.4321.00
24_V61_I1.3931.00
44_K48_L1.3721.00
33_A37_E1.3701.00
82_E86_L1.3681.00
23_I38_I1.3471.00
14_A55_C1.2971.00
12_F87_S1.2961.00
26_F33_A1.2381.00
9_E18_G1.2301.00
19_T44_K1.2231.00
60_G76_S1.1941.00
38_I49_I1.1761.00
28_L81_I1.1741.00
5_T25_L1.1711.00
48_L51_H1.1671.00
35_V53_M1.1581.00
27_L62_V1.1561.00
17_D51_H1.1411.00
67_D70_F1.1171.00
42_L49_I1.1141.00
8_L87_S1.1051.00
81_I85_K1.0691.00
55_C58_N1.0571.00
82_E89_N1.0561.00
22_R26_F1.0531.00
79_E90_H1.0491.00
78_P81_I1.0421.00
19_T49_I1.0371.00
11_L61_I0.9971.00
12_F83_L0.9931.00
84_I88_I0.9811.00
32_Q67_D0.9801.00
39_S49_I0.9721.00
37_E40_K0.9661.00
24_V75_I0.9521.00
54_A57_R0.9511.00
45_S69_K0.9451.00
85_K89_N0.9261.00
51_H69_K0.9111.00
56_L62_V0.9041.00
9_E21_L0.8801.00
63_K77_T0.8781.00
32_Q72_Y0.8501.00
6_N10_S0.8411.00
37_E41_S0.8291.00
23_I27_L0.8281.00
26_F38_I0.8271.00
5_T22_R0.8261.00
88_I92_K0.8051.00
25_L28_L0.7871.00
12_F15_L0.7771.00
82_E85_K0.7721.00
45_S52_H0.7701.00
29_D33_A0.7671.00
35_V57_R0.7661.00
34_T72_Y0.7591.00
15_L24_V0.7561.00
36_D39_S0.7451.00
83_L87_S0.7411.00
86_L89_N0.7381.00
45_S51_H0.7211.00
36_D70_F0.7191.00
13_S16_A0.7070.99
57_R62_V0.7010.99
76_S79_E0.6900.99
39_S43_G0.6890.99
78_P82_E0.6860.99
36_D40_K0.6760.99
65_R74_S0.6700.99
77_T80_I0.6700.99
23_I49_I0.6680.99
51_H55_C0.6660.99
28_L75_I0.6640.99
24_V84_I0.6420.99
8_L88_I0.6410.99
7_E60_G0.6380.99
85_K88_I0.6370.99
26_F42_L0.6360.99
53_M57_R0.6280.99
19_T22_R0.6200.99
90_H94_Y0.6130.99
25_L92_K0.6070.98
13_S66_K0.6060.98
79_E93_K0.6010.98
48_L52_H0.5950.98
31_G37_E0.5880.98
19_T52_H0.5820.98
12_F16_A0.5780.98
21_L24_V0.5760.98
13_S17_D0.5740.98
17_D48_L0.5580.97
57_R71_S0.5510.97
37_E70_F0.5470.97
17_D45_S0.5460.97
35_V46_Q0.5460.97
79_E83_L0.5400.97
47_S68_G0.5380.97
77_T90_H0.5340.96
39_S45_S0.5300.96
25_L29_D0.5300.96
27_L31_G0.5300.96
14_A61_I0.5290.96
23_I53_M0.5230.96
67_D72_Y0.5230.96
84_I91_V0.5180.96
81_I94_Y0.5170.96
7_E18_G0.5170.96
80_I90_H0.5170.96
18_G22_R0.5110.96
28_L85_K0.5040.95
42_L45_S0.5030.95
11_L80_I0.5020.95
25_L88_I0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r1tA 2 0.8087 99.7 0.5 Contact Map
1u2wA 2 0.8261 99.7 0.505 Contact Map
2kkoA 2 0.8783 99.7 0.512 Contact Map
3pqkA 2 0.8435 99.6 0.515 Contact Map
2jscA 2 0.8435 99.6 0.516 Contact Map
4k2eA 2 0.8 99.6 0.521 Contact Map
3cuoA 2 0.8 99.6 0.531 Contact Map
1r1uA 2 0.8261 99.6 0.531 Contact Map
1q1hA 1 0.7043 99.6 0.534 Contact Map
3f6vA 2 0.8348 99.6 0.534 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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