GREMLIN Database
Q97VD9 - Mercuric reductase (Hg(II) reductase) (MerA)
UniProt: Q97VD9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 453 (436)
Sequences: 14229 (9367)
Seq/√Len: 448.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_A247_A4.4121.00
32_Y106_K4.3781.00
280_N284_R4.3081.00
163_S186_D3.1791.00
270_E278_K3.0481.00
394_V408_A3.0461.00
186_D219_P2.9091.00
188_T221_F2.8631.00
134_S261_D2.7571.00
111_S114_A2.7081.00
356_D387_K2.6881.00
407_E426_H2.6451.00
114_A121_I2.6271.00
209_K213_E2.5801.00
16_A128_I2.4981.00
385_D388_F2.4531.00
263_N266_A2.4291.00
28_V103_K2.4191.00
134_S259_N2.4021.00
160_T185_V2.4001.00
124_A127_F2.3831.00
356_D386_K2.3791.00
108_Y116_K2.3501.00
136_N257_K2.3081.00
389_R419_D2.2821.00
163_S248_D2.2691.00
5_V122_I2.2621.00
202_P348_L2.2581.00
345_L350_A2.2541.00
358_D386_K2.2441.00
390_N415_R2.2211.00
116_K121_I2.1981.00
141_K228_E2.1901.00
165_A190_L2.1771.00
313_A317_A2.1761.00
12_A293_A2.1711.00
345_L353_E2.1301.00
4_L20_A2.1231.00
230_R238_I2.1161.00
396_M401_A2.0391.00
272_N276_G2.0281.00
5_V115_V2.0271.00
411_A416_A2.0231.00
5_V30_V2.0041.00
113_N289_N1.9771.00
228_E238_I1.9491.00
110_T116_K1.9331.00
150_T153_E1.9321.00
357_I383_V1.9201.00
174_L189_I1.9161.00
236_K244_E1.8871.00
347_A351_V1.8811.00
194_G223_N1.8671.00
134_S257_K1.8671.00
126_K289_N1.8651.00
114_A123_E1.8451.00
30_V122_I1.8371.00
105_G117_V1.8131.00
110_T121_I1.7991.00
181_K186_D1.7971.00
347_A381_K1.7781.00
236_K246_E1.7771.00
230_R236_K1.7561.00
128_I317_A1.7401.00
3_D125_K1.7401.00
348_L352_K1.7391.00
5_V124_A1.7051.00
109_F127_F1.7031.00
3_D26_K1.6841.00
7_I107_A1.6841.00
129_I296_V1.6801.00
284_R288_P1.6761.00
165_A237_I1.6721.00
382_M394_V1.6681.00
164_L180_Y1.6671.00
164_L185_V1.6591.00
350_A357_I1.6521.00
65_G68_L1.6511.00
192_R225_R1.6421.00
195_R205_S1.6151.00
71_E74_Q1.6131.00
5_V28_V1.6111.00
339_N402_A1.6081.00
238_I244_E1.5911.00
174_L336_I1.5771.00
355_Y392_L1.5691.00
148_F229_V1.5561.00
281_E324_K1.5541.00
350_A383_V1.5341.00
103_K122_I1.5331.00
4_L25_I1.5231.00
221_F224_V1.5091.00
201_E381_K1.4971.00
162_S186_D1.4901.00
417_T420_D1.4901.00
203_E361_V1.4821.00
92_E104_I1.4671.00
28_V122_I1.4661.00
149_W249_E1.4661.00
291_F316_N1.4591.00
74_Q77_Q1.4491.00
149_W157_P1.4481.00
283_L297_I1.4381.00
67_K71_E1.4361.00
19_R315_E1.4351.00
188_T219_P1.4281.00
26_K101_K1.4251.00
227_K238_I1.4251.00
382_M439_A1.4181.00
126_K317_A1.4161.00
207_S397_F1.4111.00
162_S248_D1.4071.00
232_G236_K1.4071.00
131_T296_V1.3961.00
182_R216_D1.3951.00
284_R289_N1.3891.00
181_K218_I1.3691.00
282_E316_N1.3471.00
169_G196_I1.3371.00
349_E352_K1.3311.00
359_Q383_V1.3301.00
203_E381_K1.3141.00
4_L128_I1.3071.00
224_V241_D1.3041.00
56_L59_Y1.3031.00
232_G235_G1.3001.00
128_I293_A1.2901.00
211_Y214_E1.2791.00
225_R240_T1.2761.00
154_A180_Y1.2631.00
382_M408_A1.2601.00
35_I102_L1.2591.00
287_N290_V1.2501.00
385_D390_N1.2461.00
210_N213_E1.2451.00
204_I397_F1.2421.00
30_V107_A1.2351.00
209_K220_I1.2241.00
231_K235_G1.2161.00
202_P206_L1.2151.00
42_V152_V1.2041.00
109_F129_I1.2031.00
267_A287_N1.2021.00
340_V397_F1.1971.00
204_I379_L1.1941.00
195_R202_P1.1941.00
364_M398_G1.1891.00
235_G246_E1.1861.00
80_A84_N1.1841.00
356_D385_D1.1831.00
109_F115_V1.1811.00
109_F266_A1.1801.00
277_I296_V1.1801.00
76_F80_A1.1791.00
7_I129_I1.1791.00
116_K119_G1.1781.00
189_I220_I1.1751.00
200_W332_Q1.1721.00
347_A359_Q1.1651.00
414_F420_D1.1611.00
272_N278_K1.1601.00
270_E286_S1.1601.00
191_Q222_T1.1581.00
264_L269_I1.1581.00
269_I277_I1.1511.00
229_V250_I1.1471.00
347_A357_I1.1461.00
310_G314_A1.1421.00
293_A313_A1.1411.00
108_Y263_N1.1401.00
190_L245_V1.1401.00
29_V95_I1.1391.00
117_V122_I1.1381.00
232_G246_E1.1341.00
239_V245_V1.1281.00
406_N427_V1.1251.00
210_N214_E1.1241.00
208_V397_F1.1131.00
81_E85_S1.1111.00
149_W153_E1.1111.00
341_A405_I1.1101.00
200_W342_K1.1081.00
30_V117_V1.1081.00
209_K222_T1.1011.00
361_V379_L1.0971.00
72_F76_F1.0931.00
380_I434_S1.0901.00
408_A435_L1.0881.00
137_I150_T1.0881.00
333_V427_V1.0851.00
145_E231_K1.0841.00
350_A355_Y1.0781.00
167_I250_I1.0781.00
190_L239_V1.0781.00
110_T114_A1.0781.00
147_G231_K1.0771.00
355_Y385_D1.0731.00
208_V340_V1.0721.00
227_K240_T1.0691.00
33_G42_V1.0681.00
332_Q342_K1.0621.00
349_E353_E1.0591.00
103_K120_E1.0581.00
351_V357_I1.0521.00
195_R209_K1.0471.00
329_S412_L1.0361.00
67_K74_Q1.0341.00
416_A420_D1.0291.00
174_L212_L1.0271.00
52_R56_L1.0231.00
18_I98_Y1.0201.00
113_N117_V1.0171.00
269_I287_N1.0101.00
221_F245_V1.0081.00
163_S185_V1.0081.00
358_D389_R1.0071.00
283_L313_A1.0021.00
165_A245_V1.0021.00
77_Q81_E1.0021.00
213_E219_P0.9971.00
92_E96_N0.9961.00
73_F158_D0.9941.00
23_L315_E0.9941.00
195_R348_L0.9941.00
12_A306_A0.9931.00
109_F124_A0.9881.00
389_R418_I0.9861.00
164_L249_E0.9861.00
95_I100_I0.9841.00
163_S246_E0.9841.00
19_R23_L0.9761.00
153_E156_S0.9731.00
351_V356_D0.9721.00
149_W154_A0.9711.00
267_A290_V0.9651.00
196_I220_I0.9641.00
212_L218_I0.9611.00
346_T349_E0.9601.00
101_K120_E0.9591.00
224_V239_V0.9581.00
164_L251_L0.9551.00
142_G145_E0.9521.00
157_P161_I0.9511.00
260_V271_L0.9501.00
345_L349_E0.9491.00
25_I125_K0.9491.00
91_Y95_I0.9441.00
279_V297_I0.9441.00
333_V402_A0.9421.00
313_A316_N0.9391.00
20_A314_A0.9331.00
343_V412_L0.9331.00
23_L318_I0.9331.00
93_D97_S0.9301.00
406_N432_G0.9291.00
109_F267_A0.9291.00
9_Y35_I0.9291.00
347_A383_V0.9281.00
315_E323_R0.9281.00
95_I102_L0.9271.00
39_C44_C0.9241.00
196_I222_T0.9231.00
190_L221_F0.9231.00
355_Y383_V0.9201.00
204_I395_Q0.9201.00
341_A401_A0.9171.00
221_F243_G0.9151.00
231_K234_G0.9151.00
263_N267_A0.9141.00
139_N143_L0.9121.00
196_I209_K0.9111.00
271_L278_K0.9101.00
300_P330_V0.9091.00
361_V381_K0.9091.00
380_I396_M0.9081.00
25_I318_I0.9071.00
167_I252_L0.9061.00
278_K286_S0.9031.00
400_Y403_E0.9021.00
25_I126_K0.9021.00
109_F263_N0.9021.00
173_A191_Q0.9011.00
163_S188_T0.8981.00
136_N254_T0.8971.00
312_I325_I0.8931.00
326_D413_R0.8921.00
163_S247_A0.8911.00
57_Y61_S0.8911.00
312_I316_N0.8881.00
284_R316_N0.8861.00
169_G191_Q0.8851.00
292_A296_V0.8831.00
269_I286_S0.8821.00
214_E377_Y0.8821.00
391_I408_A0.8811.00
230_R244_E0.8741.00
190_L224_V0.8721.00
9_Y29_V0.8671.00
167_I254_T0.8671.00
207_S210_N0.8631.00
206_L209_K0.8611.00
3_D28_V0.8611.00
207_S211_Y0.8601.00
3_D25_I0.8601.00
279_V292_A0.8571.00
7_I262_L0.8561.00
30_V105_G0.8511.00
411_A421_L0.8511.00
284_R291_F0.8501.00
127_F290_V0.8501.00
314_A318_I0.8491.00
258_P276_G0.8471.00
144_T147_G0.8451.00
283_L316_N0.8451.00
159_K249_E0.8451.00
142_G147_G0.8441.00
358_D384_I0.8351.00
15_A307_G0.8351.00
240_T243_G0.8331.00
211_Y397_F0.8311.00
181_K216_D0.8271.00
41_N87_R0.8251.00
206_L210_N0.8241.00
76_F79_K0.8241.00
54_G182_R0.8221.00
16_A310_G0.8211.00
53_I78_D0.8201.00
126_K291_F0.8201.00
407_E410_L0.8181.00
53_I75_A0.8171.00
128_I313_A0.8141.00
194_G202_P0.8121.00
16_A314_A0.8111.00
346_T395_Q0.8111.00
108_Y266_A0.8101.00
188_T247_A0.8041.00
224_V240_T0.8041.00
58_N61_S0.8031.00
145_E153_E0.8031.00
193_S198_P0.8011.00
25_I317_A0.8001.00
282_E321_V0.7991.00
140_I143_L0.7971.00
85_S371_R0.7951.00
171_A334_V0.7951.00
146_V231_K0.7941.00
60_S68_L0.7941.00
385_D392_L0.7891.00
81_E84_N0.7881.00
55_E59_Y0.7871.00
166_I251_L0.7841.00
201_E395_Q0.7841.00
127_F289_N0.7831.00
50_M76_F0.7821.00
58_N216_D0.7811.00
6_I13_G0.7811.00
112_P289_N0.7801.00
204_I340_V0.7801.00
267_A286_S0.7801.00
416_A421_L0.7781.00
211_Y216_D0.7781.00
5_V127_F0.7751.00
267_A271_L0.7751.00
350_A392_L0.7751.00
136_N139_N0.7731.00
315_E320_N0.7711.00
343_V409_A0.7651.00
58_N62_K0.7591.00
391_I412_L0.7591.00
383_V386_K0.7581.00
84_N89_E0.7581.00
89_E93_D0.7571.00
47_S51_L0.7541.00
212_L220_I0.7531.00
83_V86_L0.7521.00
261_D265_D0.7521.00
268_G287_N0.7511.00
284_R287_N0.7511.00
264_L271_L0.7501.00
177_A189_I0.7491.00
211_Y377_Y0.7491.00
51_L179_M0.7481.00
191_Q198_P0.7471.00
77_Q158_D0.7471.00
408_A412_L0.7441.00
19_R314_A0.7431.00
90_K94_V0.7421.00
60_S63_V0.7411.00
20_A25_I0.7411.00
6_I17_L0.7391.00
276_G301_M0.7381.00
21_N100_I0.7381.00
7_I115_V0.7361.00
166_I173_A0.7361.00
177_A218_I0.7351.00
47_S176_F0.7341.00
31_G34_E0.7331.00
285_T292_A0.7331.00
113_N287_N0.7311.00
28_V101_K0.7311.00
89_E92_E0.7311.00
80_A156_S0.7311.00
16_A313_A0.7301.00
236_K239_V0.7291.00
382_M438_A0.7291.00
21_N27_P0.7281.00
105_G118_N0.7271.00
167_I226_V0.7271.00
54_G57_Y0.7251.00
360_R438_A0.7251.00
413_R423_D0.7251.00
145_E148_F0.7201.00
64_I68_L0.7181.00
112_P268_G0.7181.00
147_G249_E0.7171.00
79_K83_V0.7171.00
428_F433_E0.7171.00
195_R206_L0.7161.00
394_V412_L0.7131.00
200_W340_V0.7111.00
271_L275_G0.7091.00
113_N123_E0.7081.00
4_L314_A0.7071.00
410_L416_A0.7071.00
114_A117_V0.7061.00
19_R22_E0.7061.00
95_I99_D0.7031.00
192_R198_P0.7011.00
52_R55_E0.7011.00
208_V336_I0.6991.00
173_A192_R0.6971.00
163_S235_G0.6941.00
339_N400_Y0.6931.00
410_L424_T0.6901.00
390_N417_T0.6861.00
137_I252_L0.6861.00
137_I143_L0.6851.00
376_N399_K0.6831.00
133_S256_R0.6811.00
79_K156_S0.6811.00
388_F415_R0.6801.00
63_V68_L0.6781.00
305_L330_V0.6771.00
138_P252_L0.6761.00
93_D96_N0.6731.00
396_M404_V0.6721.00
260_V276_G0.6711.00
277_I292_A0.6671.00
84_N87_R0.6661.00
80_A83_V0.6661.00
364_M434_S0.6661.00
197_L208_V0.6641.00
82_I86_L0.6641.00
283_L312_I0.6641.00
179_M183_L0.6611.00
363_K366_N0.6611.00
410_L414_F0.6601.00
77_Q80_A0.6591.00
60_S66_K0.6581.00
62_K374_R0.6571.00
271_L276_G0.6561.00
420_D423_D0.6551.00
328_L353_E0.6541.00
140_I226_V0.6541.00
394_V435_L0.6531.00
200_W334_V0.6531.00
36_G40_V0.6531.00
58_N182_R0.6521.00
139_N144_T0.6521.00
357_I392_L0.6511.00
308_R311_S0.6491.00
418_I422_I0.6481.00
224_V243_G0.6461.00
264_L267_A0.6450.99
260_V296_V0.6450.99
141_K144_T0.6440.99
403_E432_G0.6440.99
23_L314_A0.6430.99
276_G298_G0.6430.99
73_F77_Q0.6420.99
182_R337_E0.6410.99
178_Q182_R0.6400.99
309_Q327_M0.6400.99
410_L421_L0.6370.99
30_V103_K0.6370.99
137_I142_G0.6370.99
360_R384_I0.6360.99
34_E42_V0.6350.99
23_L320_N0.6340.99
142_G146_V0.6330.99
279_V283_L0.6310.99
207_S379_L0.6300.99
18_I22_E0.6300.99
20_A27_P0.6280.99
394_V405_I0.6260.99
269_I290_V0.6260.99
141_K145_E0.6250.99
204_I207_S0.6250.99
75_A78_D0.6250.99
20_A317_A0.6250.99
174_L220_I0.6250.99
81_E86_L0.6230.99
369_K372_I0.6180.99
339_N431_M0.6170.99
188_T245_V0.6170.99
273_D278_K0.6150.99
180_Y185_V0.6150.99
282_E324_K0.6120.99
143_L150_T0.6110.99
152_V256_R0.6110.99
171_A332_Q0.6100.99
178_Q216_D0.6090.99
277_I285_T0.6080.99
174_L196_I0.6080.99
128_I314_A0.6070.99
75_A183_L0.6060.99
157_P249_E0.6060.99
354_G357_I0.6050.99
297_I309_Q0.6040.99
22_E98_Y0.6040.99
239_V242_K0.6030.99
384_I418_I0.6020.99
32_Y259_N0.6020.99
51_L55_E0.6020.99
305_L327_M0.6020.99
78_D81_E0.5980.99
216_D337_E0.5980.99
271_L277_I0.5970.99
74_Q78_D0.5970.99
178_Q212_L0.5960.99
34_E87_R0.5950.99
143_L252_L0.5940.99
112_P267_A0.5930.99
12_A130_A0.5930.99
76_F158_D0.5910.99
91_Y94_V0.5910.99
37_G40_V0.5900.99
370_A431_M0.5890.99
384_I389_R0.5880.99
140_I144_T0.5880.99
315_E319_M0.5850.99
151_N256_R0.5850.99
293_A310_G0.5840.99
398_G401_A0.5840.99
73_F76_F0.5830.99
109_F116_K0.5830.99
176_F251_L0.5820.99
337_E399_K0.5810.99
138_P142_G0.5810.99
185_V248_D0.5790.99
291_F317_A0.5790.99
176_F179_M0.5770.99
131_T262_L0.5770.99
229_V252_L0.5770.99
368_A372_I0.5740.99
44_C48_K0.5740.99
221_F239_V0.5720.99
410_L426_H0.5710.99
94_V98_Y0.5700.99
190_L247_A0.5690.99
14_F29_V0.5680.99
308_R312_I0.5660.99
76_F81_E0.5640.99
421_L439_A0.5620.99
348_L351_V0.5620.99
308_R436_R0.5610.99
345_L355_Y0.5610.99
404_V431_M0.5600.99
192_R254_T0.5560.99
357_I386_K0.5550.98
101_K104_I0.5550.98
151_N172_L0.5550.98
34_E41_N0.5540.98
305_L309_Q0.5520.98
55_E58_N0.5490.98
371_R376_N0.5480.98
191_Q226_V0.5470.98
342_K349_E0.5460.98
33_G152_V0.5440.98
281_E323_R0.5440.98
409_A413_R0.5440.98
45_V368_A0.5430.98
47_S50_M0.5430.98
53_I56_L0.5420.98
350_A354_G0.5420.98
360_R382_M0.5400.98
412_L416_A0.5400.98
70_P75_A0.5400.98
345_L393_G0.5390.98
110_T266_A0.5390.98
130_A293_A0.5370.98
226_V237_I0.5360.98
307_G436_R0.5350.98
72_F160_T0.5350.98
64_I67_K0.5340.98
109_F289_N0.5330.98
368_A371_R0.5330.98
129_I277_I0.5330.98
78_D82_I0.5330.98
342_K395_Q0.5300.98
148_F250_I0.5290.98
413_R424_T0.5280.98
39_C48_K0.5280.98
163_S249_E0.5270.98
138_P143_L0.5270.98
72_F158_D0.5270.98
163_S181_K0.5270.98
79_K155_L0.5240.98
246_E249_E0.5230.98
38_T151_N0.5230.98
53_I57_Y0.5220.98
143_L148_F0.5220.98
173_A198_P0.5210.98
367_I370_A0.5210.98
271_L274_K0.5200.98
169_G222_T0.5190.98
178_Q337_E0.5180.98
36_G39_C0.5180.98
364_M431_M0.5180.98
346_T383_V0.5160.98
29_V102_L0.5150.98
92_E102_L0.5150.98
395_Q408_A0.5150.98
133_S301_M0.5150.98
308_R325_I0.5140.98
56_L60_S0.5130.98
135_P151_N0.5130.98
50_M53_I0.5120.97
436_R440_L0.5120.97
258_P271_L0.5120.97
196_I205_S0.5120.97
126_K284_R0.5110.97
293_A317_A0.5110.97
9_Y31_G0.5100.97
82_I85_S0.5100.97
52_R373_L0.5100.97
45_V428_F0.5090.97
113_N127_F0.5090.97
152_V155_L0.5090.97
78_D374_R0.5070.97
72_F75_A0.5070.97
363_K379_L0.5060.97
151_N155_L0.5050.97
329_S343_V0.5050.97
111_S266_A0.5050.97
409_A424_T0.5040.97
205_S209_K0.5030.97
229_V237_I0.5030.97
20_A318_I0.5020.97
90_K93_D0.5020.97
407_E432_G0.5020.97
181_K217_S0.5020.97
124_A289_N0.5010.97
165_A250_I0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xdiA 3 0.9735 100 0.211 Contact Map
3ladA 2 0.9868 100 0.217 Contact Map
1ojtA 2 0.9912 100 0.217 Contact Map
1lvlA 2 0.9735 100 0.221 Contact Map
1fecA 2 0.9823 100 0.223 Contact Map
2r9zA 2 0.9735 100 0.23 Contact Map
3ic9A 2 0.9956 100 0.23 Contact Map
2a8xA 2 0.9845 100 0.23 Contact Map
3o0hA 2 0.9845 100 0.23 Contact Map
2hqmA 2 0.9581 100 0.231 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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