GREMLIN Database
Q97VD6 - Acylaminoacyl-peptidase, putative (ApeH-3)
UniProt: Q97VD6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 591 (460)
Sequences: 4822 (3986)
Seq/√Len: 185.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
458_V467_A4.7201.00
559_Y577_D4.1961.00
186_N189_T3.9811.00
345_N350_E3.7521.00
340_E357_I3.7171.00
454_T467_A3.4381.00
390_N587_S3.4271.00
430_N463_M3.3501.00
431_T434_E3.3391.00
416_D419_G3.2061.00
443_G586_F3.1961.00
444_I457_I3.1641.00
438_L441_K3.1341.00
392_F587_S3.0821.00
232_L235_E2.9621.00
343_T350_E2.9481.00
506_E510_K2.9321.00
462_S521_K2.7591.00
577_D581_T2.6541.00
314_T317_K2.6491.00
555_T588_K2.4371.00
364_T437_S2.4221.00
325_D328_Y2.3811.00
267_L282_Q2.3441.00
282_Q289_D2.3421.00
362_A393_N2.3241.00
537_I558_R2.3211.00
520_V543_F2.3021.00
516_Y519_N2.2461.00
555_T581_T2.2271.00
355_S395_I2.1931.00
278_S282_Q2.1361.00
468_I586_F2.1311.00
125_R130_G2.0861.00
138_L141_F2.0581.00
148_R151_T2.0501.00
365_I586_F2.0081.00
126_F159_L2.0051.00
344_V353_G1.9951.00
364_T395_I1.9771.00
458_V522_T1.8991.00
504_G507_K1.8691.00
165_R184_E1.8671.00
249_V252_D1.8501.00
440_G465_S1.8421.00
250_L254_F1.8401.00
447_G470_E1.8401.00
422_F457_I1.8391.00
356_I388_V1.8371.00
518_K550_Q1.7991.00
344_V428_F1.7851.00
160_A165_R1.7821.00
509_M515_Y1.7781.00
355_S393_N1.7691.00
562_D574_N1.7541.00
455_N469_S1.7491.00
231_M236_G1.7371.00
167_V207_M1.7351.00
366_L425_L1.7281.00
251_T254_F1.7271.00
417_W476_L1.7041.00
443_G590_L1.7031.00
447_G471_R1.6961.00
557_V581_T1.6851.00
342_I353_G1.6851.00
426_M464_F1.6781.00
132_L159_L1.6771.00
395_I428_F1.6571.00
475_N542_Q1.6571.00
466_A589_Y1.6571.00
136_Q139_Y1.6491.00
164_N188_E1.6471.00
468_I582_K1.6211.00
386_F583_L1.6081.00
400_R424_D1.6021.00
170_A173_D1.5891.00
160_A164_N1.5861.00
333_N336_G1.5841.00
164_N186_N1.5711.00
267_L270_S1.5661.00
433_K437_S1.5661.00
393_N436_Y1.5621.00
458_V524_T1.5601.00
467_A522_T1.5511.00
429_V442_F1.5471.00
416_D420_K1.5451.00
194_R197_K1.5391.00
125_R129_R1.5321.00
395_I432_V1.5301.00
390_N583_L1.5301.00
307_E323_Y1.5121.00
407_E411_K1.5061.00
307_E325_D1.5061.00
459_T520_V1.4981.00
137_S141_F1.4901.00
393_N437_S1.4791.00
353_G395_I1.4751.00
284_S287_K1.4631.00
165_R186_N1.4531.00
478_S542_Q1.4411.00
124_Y131_L1.4401.00
537_I541_E1.4341.00
347_N400_R1.4291.00
161_T207_M1.4221.00
477_V509_M1.4161.00
332_P335_K1.4151.00
366_L429_V1.4071.00
147_R150_V1.3861.00
530_E558_R1.3861.00
419_G423_E1.3851.00
331_N336_G1.3781.00
130_G133_R1.3701.00
309_A323_Y1.3661.00
460_K516_Y1.3651.00
489_F492_I1.3611.00
184_E207_M1.3571.00
150_V155_D1.3561.00
580_K584_E1.3451.00
215_F220_K1.3391.00
344_V397_A1.3291.00
169_S173_D1.3261.00
231_M238_S1.3201.00
270_S273_Q1.3181.00
361_N438_L1.3171.00
426_M463_M1.3161.00
548_K554_T1.3111.00
358_K393_N1.3101.00
466_A585_W1.3091.00
353_G428_F1.3061.00
506_E509_M1.2991.00
459_T543_F1.2951.00
466_A523_P1.2951.00
217_G220_K1.2911.00
146_L150_V1.2891.00
357_I393_N1.2881.00
140_L159_L1.2831.00
235_E239_Y1.2821.00
526_L544_Y1.2801.00
527_I578_R1.2781.00
584_E588_K1.2741.00
528_H537_I1.2681.00
368_I444_I1.2651.00
249_V254_F1.2641.00
125_R132_L1.2611.00
545_V549_M1.2611.00
307_E310_Y1.2601.00
125_R159_L1.2571.00
421_D449_Y1.2421.00
456_W460_K1.2351.00
185_V190_G1.2261.00
193_N196_T1.2261.00
399_P425_L1.2221.00
366_L395_I1.2161.00
443_G466_A1.2151.00
193_N198_E1.2121.00
229_E232_L1.2091.00
471_R566_H1.2021.00
346_S349_V1.2001.00
154_F157_T1.1951.00
132_L140_L1.1881.00
561_G571_K1.1811.00
426_M430_N1.1651.00
236_G239_Y1.1621.00
125_R133_R1.1611.00
365_I387_F1.1601.00
214_A230_I1.1531.00
258_K263_F1.1531.00
467_A524_T1.1521.00
132_L166_V1.1491.00
167_V184_E1.1441.00
334_I337_Y1.1431.00
333_N337_Y1.1421.00
517_V546_A1.1401.00
546_A550_Q1.1381.00
279_H290_K1.1361.00
430_N434_E1.1351.00
364_T393_N1.1341.00
250_L255_D1.1301.00
555_T585_W1.1281.00
331_N334_I1.1271.00
232_L237_K1.1271.00
488_W492_I1.1271.00
279_H294_G1.1241.00
356_I396_Y1.1231.00
358_K362_A1.1231.00
310_Y322_K1.1201.00
130_G142_D1.1121.00
521_K552_V1.1111.00
215_F219_R1.1061.00
441_K465_S1.1021.00
167_V213_I1.1001.00
189_T192_L1.0941.00
455_N543_F1.0921.00
469_S526_L1.0911.00
216_L220_K1.0861.00
160_A163_G1.0861.00
269_L272_G1.0841.00
473_I476_L1.0831.00
476_L490_N1.0821.00
455_N474_S1.0811.00
530_E537_I1.0781.00
229_E238_S1.0771.00
264_E267_L1.0741.00
109_E112_D1.0731.00
526_L543_F1.0701.00
150_V156_V1.0611.00
250_L253_L1.0611.00
544_Y556_L1.0611.00
125_R128_S1.0591.00
119_A122_I1.0591.00
533_Y563_S1.0581.00
110_N113_K1.0561.00
310_Y324_R1.0511.00
214_A218_H1.0511.00
437_S442_F1.0501.00
455_N472_S1.0481.00
576_I580_K1.0451.00
364_T429_V1.0441.00
107_A112_D1.0381.00
341_R352_E1.0331.00
183_Y194_R1.0281.00
400_R412_A1.0281.00
107_A111_T1.0241.00
347_N423_E1.0231.00
339_P356_I1.0211.00
517_V550_Q1.0131.00
571_K574_N1.0100.99
505_I509_M1.0100.99
296_I300_G1.0090.99
216_L219_R1.0080.99
195_I198_E1.0070.99
139_Y148_R1.0070.99
547_L552_V1.0030.99
214_A217_G1.0000.99
429_V463_M0.9990.99
386_F390_N0.9990.99
368_I453_M0.9970.99
136_Q141_F0.9940.99
182_L185_V0.9940.99
312_Y317_K0.9880.99
137_S148_R0.9870.99
162_N211_G0.9850.99
471_R565_E0.9840.99
148_R152_G0.9820.99
152_G156_V0.9810.99
468_I525_M0.9810.99
517_V520_V0.9770.99
285_D288_V0.9760.99
524_T554_T0.9730.99
109_E113_K0.9730.99
488_W491_A0.9690.99
108_E112_D0.9690.99
150_V157_T0.9670.99
541_E558_R0.9640.99
160_A167_V0.9630.99
301_F308_L0.9610.99
466_A586_F0.9590.99
523_P589_Y0.9590.99
151_T154_F0.9570.99
537_I556_L0.9560.99
293_S296_I0.9540.99
268_I273_Q0.9540.99
397_A428_F0.9510.99
352_E405_Y0.9510.99
151_T157_T0.9490.99
230_I239_Y0.9490.99
524_T543_F0.9480.99
539_Q542_Q0.9470.99
444_I467_A0.9450.99
262_V265_K0.9440.99
433_K439_K0.9440.99
544_Y554_T0.9430.99
581_T584_E0.9430.99
270_S274_E0.9420.99
168_I192_L0.9420.99
208_N212_K0.9420.99
130_G140_L0.9390.99
459_T516_Y0.9330.99
290_K293_S0.9310.99
524_T552_V0.9290.99
332_P336_G0.9290.99
137_S152_G0.9280.99
367_F396_Y0.9250.99
447_G578_R0.9240.99
139_Y142_D0.9240.99
376_Y396_Y0.9230.99
284_S288_V0.9230.99
559_Y581_T0.9210.99
423_E427_N0.9210.99
527_I557_V0.9190.99
526_L540_A0.9190.99
531_E561_G0.9170.99
386_F389_D0.9170.99
133_R146_L0.9170.99
474_S543_F0.9170.99
332_P337_Y0.9160.99
418_G421_D0.9140.99
469_S472_S0.9130.99
355_S436_Y0.9110.99
472_S540_A0.9100.99
110_N114_T0.9100.99
159_L163_G0.9090.99
452_F456_W0.9080.99
381_F384_F0.9030.99
232_L236_G0.9000.99
312_Y315_P0.8990.99
186_N191_E0.8970.99
445_T582_K0.8970.99
274_E279_H0.8950.99
212_K234_E0.8930.99
321_L324_R0.8840.99
553_P588_K0.8830.99
498_D501_S0.8830.99
135_R139_Y0.8790.99
251_T257_V0.8780.99
107_A110_N0.8760.99
193_N197_K0.8750.99
268_I272_G0.8750.99
159_L166_V0.8740.99
428_F432_V0.8680.98
296_I299_R0.8680.98
313_S319_V0.8680.98
302_D310_Y0.8630.98
143_G146_L0.8610.98
124_Y132_L0.8570.98
427_N430_N0.8540.98
553_P589_Y0.8530.98
370_G399_P0.8500.98
235_E238_S0.8450.98
351_V409_F0.8440.98
471_R528_H0.8400.98
126_F130_G0.8390.98
540_A556_L0.8380.98
281_Y290_K0.8360.98
108_E113_K0.8340.98
207_M233_P0.8310.98
304_S307_E0.8310.98
151_T155_D0.8280.98
231_M235_E0.8280.98
212_K232_L0.8240.98
527_I559_Y0.8230.98
525_M557_V0.8230.98
364_T442_F0.8230.98
108_E116_P0.8230.98
126_F133_R0.8210.98
230_I233_P0.8210.98
418_G452_F0.8180.98
454_T524_T0.8170.98
124_Y130_G0.8140.98
302_D307_E0.8140.98
205_I215_F0.8130.98
121_K124_Y0.8130.98
248_K251_T0.8120.98
342_I431_T0.8090.98
456_W459_T0.8080.98
303_Y310_Y0.8080.98
259_D262_V0.8070.98
232_L239_Y0.8050.97
366_L464_F0.8030.97
310_Y315_P0.8010.97
364_T432_V0.8010.97
160_A207_M0.8000.97
161_T167_V0.7990.97
185_V189_T0.7990.97
271_L278_S0.7980.97
208_N211_G0.7970.97
109_E114_T0.7970.97
111_T118_R0.7950.97
119_A123_K0.7950.97
227_S231_M0.7940.97
270_S281_Y0.7940.97
229_E240_M0.7870.97
445_T586_F0.7870.97
445_T470_E0.7860.97
181_N185_V0.7840.97
230_I263_F0.7800.97
449_Y453_M0.7790.97
583_L587_S0.7790.97
272_G281_Y0.7740.97
228_L231_M0.7740.97
507_K510_K0.7740.97
228_L232_L0.7740.97
449_Y452_F0.7720.97
365_I445_T0.7700.97
469_S524_T0.7700.97
455_N524_T0.7700.97
416_D510_K0.7680.97
422_F453_M0.7680.97
433_K442_F0.7680.97
192_L195_I0.7670.97
168_I172_K0.7670.97
225_W229_E0.7660.97
113_K119_A0.7580.96
420_K423_E0.7570.96
232_L238_S0.7560.96
234_E237_K0.7530.96
269_L273_Q0.7530.96
146_L151_T0.7530.96
546_A549_M0.7500.96
149_L153_N0.7500.96
215_F231_M0.7480.96
510_K515_Y0.7480.96
223_T226_A0.7450.96
171_T178_G0.7450.96
302_D306_S0.7420.96
130_G163_G0.7410.96
125_R131_L0.7400.96
257_V260_R0.7390.96
124_Y133_R0.7350.96
114_T118_R0.7320.96
462_S522_T0.7310.96
415_G497_A0.7310.96
470_E566_H0.7280.95
368_I425_L0.7270.95
209_S263_F0.7250.95
448_S564_H0.7250.95
195_I199_D0.7250.95
111_T114_T0.7240.95
559_Y562_D0.7240.95
112_D116_P0.7220.95
161_T211_G0.7220.95
470_E578_R0.7200.95
317_K320_I0.7200.95
192_L199_D0.7190.95
294_G297_M0.7190.95
325_D329_D0.7180.95
367_F445_T0.7160.95
342_I395_I0.7150.95
159_L165_R0.7150.95
119_A124_Y0.7140.95
184_E193_N0.7140.95
491_A494_S0.7130.95
186_N190_G0.7130.95
419_G510_K0.7130.95
442_F463_M0.7130.95
270_S276_G0.7110.95
259_D263_F0.7100.95
129_R133_R0.7100.95
249_V253_L0.7080.95
365_I392_F0.7080.95
454_T458_V0.7060.95
351_V405_Y0.7050.95
146_L149_L0.7040.95
153_N156_V0.7040.95
369_H399_P0.7030.95
540_A544_Y0.7030.95
256_G274_E0.7010.94
412_A420_K0.7010.94
471_R535_C0.7000.94
442_F465_S0.7000.94
429_V433_K0.7000.94
213_I219_R0.6940.94
306_S327_E0.6940.94
165_R211_G0.6940.94
181_N194_R0.6930.94
544_Y548_K0.6930.94
401_G424_D0.6920.94
497_A501_S0.6910.94
417_W449_Y0.6890.94
142_D147_R0.6890.94
194_R198_E0.6880.94
292_T296_I0.6880.94
369_H402_S0.6860.94
520_V524_T0.6860.94
152_G155_D0.6860.94
585_W589_Y0.6860.94
109_E119_A0.6850.94
480_C508_L0.6820.94
344_V427_N0.6820.94
309_A321_L0.6820.94
478_S539_Q0.6810.94
312_Y322_K0.6800.94
421_D476_L0.6800.94
517_V543_F0.6800.94
419_G511_M0.6790.93
360_P393_N0.6790.93
132_L138_L0.6790.93
249_V255_D0.6780.93
524_T547_L0.6770.93
215_F218_H0.6730.93
349_V409_F0.6720.93
150_V153_N0.6690.93
430_N439_K0.6680.93
301_F304_S0.6680.93
220_K223_T0.6670.93
374_M402_S0.6670.93
497_A504_G0.6670.93
171_T179_L0.6670.93
579_L582_K0.6660.93
423_E460_K0.6660.93
192_L198_E0.6650.93
169_S172_K0.6650.93
124_Y128_S0.6650.93
466_A522_T0.6610.93
430_N433_K0.6610.93
148_R157_T0.6580.92
514_I542_Q0.6580.92
426_M429_V0.6580.92
168_I183_Y0.6550.92
207_M211_G0.6530.92
148_R153_N0.6510.92
275_G290_K0.6500.92
456_W516_Y0.6490.92
458_V543_F0.6480.92
270_S282_Q0.6480.92
263_F268_I0.6420.91
193_N199_D0.6420.91
398_N402_S0.6370.91
111_T119_A0.6370.91
150_V154_F0.6360.91
365_I443_G0.6350.91
205_I208_N0.6330.91
363_P438_L0.6320.91
269_L282_Q0.6310.91
375_A404_G0.6290.91
127_D130_G0.6280.91
113_K116_P0.6280.91
110_N119_A0.6270.90
387_F394_V0.6270.90
208_N263_F0.6270.90
362_A436_Y0.6200.90
468_I527_I0.6190.90
439_K465_S0.6190.90
152_G157_T0.6180.90
107_A113_K0.6180.90
566_H578_R0.6170.90
308_L324_R0.6160.90
415_G504_G0.6150.90
148_R156_V0.6140.90
387_F582_K0.6130.89
290_K296_I0.6130.89
475_N478_S0.6130.89
533_Y565_E0.6130.89
228_L239_Y0.6120.89
562_D571_K0.6110.89
148_R155_D0.6100.89
183_Y192_L0.6090.89
114_T119_A0.6080.89
413_C417_W0.6070.89
469_S543_F0.6050.89
110_N115_L0.6040.89
126_F132_L0.6040.89
254_F263_F0.6030.89
277_T295_N0.6030.89
477_V505_I0.6020.89
170_A178_G0.6020.89
201_T204_A0.6020.89
160_A168_I0.6010.89
476_L512_S0.5990.88
106_I122_I0.5980.88
112_D117_F0.5980.88
527_I582_K0.5970.88
134_A137_S0.5970.88
226_A231_M0.5970.88
303_Y308_L0.5950.88
422_F426_M0.5950.88
229_E235_E0.5930.88
122_I134_A0.5920.88
447_G566_H0.5920.88
252_D255_D0.5920.88
137_S140_L0.5920.88
326_I329_D0.5920.88
146_L156_V0.5910.88
324_R329_D0.5910.88
183_Y186_N0.5900.88
231_M239_Y0.5900.88
141_F146_L0.5860.87
118_R121_K0.5850.87
331_N335_K0.5830.87
108_E114_T0.5820.87
269_L291_V0.5810.87
138_L142_D0.5810.87
199_D202_V0.5810.87
112_D118_R0.5800.87
233_P238_S0.5800.87
346_S427_N0.5790.87
254_F258_K0.5790.87
149_L152_G0.5770.86
255_D259_D0.5770.86
126_F163_G0.5760.86
471_R534_R0.5760.86
108_E111_T0.5750.86
489_F494_S0.5750.86
267_L284_S0.5730.86
122_I131_L0.5710.86
113_K118_R0.5710.86
133_R139_Y0.5700.86
201_T205_I0.5670.86
294_G298_V0.5670.86
349_V408_E0.5660.85
264_E269_L0.5660.85
370_G453_M0.5660.85
278_S283_I0.5650.85
162_N165_R0.5650.85
135_R141_F0.5650.85
206_A216_L0.5630.85
447_G565_E0.5600.85
215_F238_S0.5570.85
490_N493_E0.5560.84
498_D505_I0.5560.84
563_S567_A0.5560.84
123_K159_L0.5550.84
311_F319_V0.5550.84
214_A219_R0.5540.84
369_H534_R0.5530.84
562_D566_H0.5520.84
133_R137_S0.5500.84
469_S474_S0.5490.84
121_K134_A0.5490.84
205_I211_G0.5490.84
418_G456_W0.5480.84
357_I362_A0.5480.84
261_I264_E0.5480.84
413_C420_K0.5470.83
173_D179_L0.5430.83
127_D163_G0.5420.83
373_H410_A0.5410.83
422_F456_W0.5410.83
124_Y159_L0.5390.83
523_P585_W0.5380.82
488_W494_S0.5380.82
528_H540_A0.5380.82
497_A500_W0.5370.82
262_V266_D0.5370.82
305_N310_Y0.5360.82
340_E346_S0.5350.82
305_N308_L0.5350.82
272_G279_H0.5340.82
406_G424_D0.5340.82
399_P421_D0.5340.82
204_A219_R0.5340.82
311_F321_L0.5320.82
361_N437_S0.5310.82
349_V412_A0.5300.82
114_T117_F0.5300.82
371_G398_N0.5290.81
327_E330_P0.5270.81
352_E409_F0.5270.81
505_I508_L0.5260.81
340_E343_T0.5260.81
286_N292_T0.5250.81
369_H448_S0.5250.81
542_Q546_A0.5250.81
561_G574_N0.5230.81
461_T522_T0.5230.81
255_D263_F0.5220.81
292_T298_V0.5210.80
108_E115_L0.5200.80
562_D567_A0.5200.80
399_P453_M0.5190.80
308_L326_I0.5190.80
301_F310_Y0.5170.80
255_D262_V0.5170.80
530_E561_G0.5170.80
366_L428_F0.5160.80
447_G534_R0.5160.80
143_G152_G0.5160.80
114_T121_K0.5150.80
214_A220_K0.5150.80
411_K414_V0.5130.79
530_E560_Q0.5130.79
482_T536_P0.5130.79
118_R124_Y0.5130.79
267_L272_G0.5120.79
127_D132_L0.5120.79
346_S353_G0.5110.79
459_T519_N0.5110.79
452_F476_L0.5090.79
223_T231_M0.5080.79
499_P508_L0.5080.79
250_L258_K0.5080.79
559_Y578_R0.5070.79
201_T218_H0.5070.79
201_T206_A0.5060.78
481_G490_N0.5050.78
274_E281_Y0.5050.78
226_A229_E0.5050.78
373_H376_Y0.5040.78
188_E191_E0.5030.78
187_I190_G0.5030.78
116_P124_Y0.5030.78
252_D258_K0.5030.78
293_S297_M0.5030.78
111_T115_L0.5020.78
364_T435_R0.5010.78
425_L453_M0.5010.78
306_S326_I0.5010.78
419_G460_K0.5010.78
228_L235_E0.5010.78
471_R563_S0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hxfB 4 0.8765 100 0.47 Contact Map
1yr2A 1 0.9442 100 0.471 Contact Map
3iujA 1 0.9543 100 0.471 Contact Map
1xfdA 2 0.9171 100 0.473 Contact Map
2bklA 1 0.9679 100 0.474 Contact Map
2xe4A 1 0.9712 100 0.477 Contact Map
4bp8A 1 0.9729 100 0.478 Contact Map
2z3zA 2 0.868 100 0.48 Contact Map
4hvtA 1 0.9662 100 0.483 Contact Map
3azoA 1 0.9357 100 0.483 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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