GREMLIN Database
Q97VD5 - Heat shock protein X, protease htpX homolog, putative (HtpX-like)
UniProt: Q97VD5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 291 (238)
Sequences: 4890 (3565)
Seq/√Len: 231.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_A208_T4.5641.00
90_D139_A4.4431.00
225_I281_S4.3871.00
137_E226_K4.2671.00
106_N127_S4.0971.00
143_S209_A3.3861.00
136_E215_D3.1241.00
210_V280_L3.0651.00
203_K275_E2.9411.00
125_V142_L2.8741.00
117_N120_F2.6161.00
209_A213_N2.4961.00
207_L211_K2.4691.00
87_M139_A2.4051.00
83_D135_Q2.3271.00
221_E277_L2.2461.00
85_T99_L2.2231.00
228_G274_K2.2181.00
136_E219_W2.2171.00
95_Y212_V2.1371.00
137_E222_S2.0961.00
153_D204_R2.0781.00
213_N219_W2.0481.00
275_E278_L1.9721.00
89_E93_K1.9681.00
88_V102_V1.9661.00
53_L57_G1.9341.00
225_I277_L1.9151.00
77_M103_Y1.8891.00
228_G273_L1.8451.00
134_V226_K1.8031.00
89_E99_L1.7911.00
132_S230_L1.7781.00
134_V222_S1.7341.00
113_F124_A1.6961.00
221_E281_S1.6681.00
140_A220_L1.6581.00
218_Y281_S1.6551.00
272_S275_E1.6351.00
207_L279_Y1.5971.00
184_I188_V1.5891.00
69_I73_L1.5861.00
127_S131_E1.5661.00
87_M135_Q1.5581.00
172_I175_L1.5251.00
215_D219_W1.5131.00
79_R103_Y1.5131.00
129_L138_L1.5021.00
38_G41_I1.5021.00
78_R106_N1.4921.00
153_D201_I1.4901.00
152_Y155_E1.4881.00
79_R101_K1.4791.00
54_I58_L1.4731.00
91_L146_I1.4581.00
278_L281_S1.4461.00
191_L195_F1.4381.00
114_A123_I1.4321.00
265_L275_E1.4201.00
173_Y176_P1.4041.00
25_K29_A1.4001.00
148_H202_E1.3991.00
26_Y29_A1.3901.00
278_L282_Q1.3771.00
133_L227_I1.3521.00
144_H202_E1.3431.00
58_L62_L1.3401.00
85_T89_E1.3321.00
171_L174_Y1.3281.00
86_F90_D1.3151.00
26_Y30_S1.3141.00
172_I176_P1.3131.00
103_Y122_G1.3131.00
279_Y282_Q1.2951.00
30_S34_I1.2901.00
195_F269_T1.2691.00
86_F89_E1.2661.00
220_L280_L1.2421.00
157_M201_I1.2381.00
203_K279_Y1.2251.00
38_G42_S1.2241.00
151_N208_T1.2211.00
22_Y29_A1.2171.00
121_R149_I1.2061.00
134_V137_E1.2021.00
22_Y26_Y1.1981.00
91_L212_V1.1841.00
144_H148_H1.1701.00
145_E202_E1.1671.00
108_N131_E1.1671.00
200_K204_R1.1621.00
170_A174_Y1.1511.00
151_N204_R1.1431.00
97_V146_I1.1421.00
141_V223_S1.1341.00
57_G61_S1.1031.00
34_I38_G1.0921.00
218_Y221_E1.0901.00
130_Y138_L1.0861.00
139_A215_D1.0771.00
218_Y222_S1.0701.00
62_L66_I1.0681.00
215_D218_Y1.0671.00
268_R272_S1.0631.00
204_R208_T1.0621.00
274_K278_L1.0531.00
82_Q85_T1.0411.00
45_N48_I1.0401.00
125_V130_Y1.0281.00
29_A33_S1.0261.00
91_L142_L1.0161.00
30_S33_S1.0091.00
24_W29_A0.9891.00
28_L32_F0.9881.00
84_V125_V0.9751.00
136_E222_S0.9741.00
23_W26_Y0.9711.00
219_W222_S0.9681.00
198_H269_T0.9631.00
27_Y30_S0.9621.00
110_L230_L0.9551.00
133_L223_S0.9541.00
110_L132_S0.9521.00
28_L33_S0.9421.00
145_E148_H0.9351.00
83_D86_F0.9201.00
52_F169_A0.9181.00
22_Y36_V0.9161.00
90_D93_K0.9151.00
202_E205_A0.9101.00
71_M113_F0.9091.00
25_K40_V0.9071.00
214_P219_W0.9061.00
204_R207_L0.9061.00
180_L184_I0.9000.99
170_A173_Y0.8980.99
182_F186_Y0.8970.99
275_E279_Y0.8970.99
32_F36_V0.8920.99
77_M105_I0.8900.99
50_Y54_I0.8900.99
28_L31_F0.8770.99
104_I130_Y0.8720.99
222_S226_K0.8680.99
86_F135_Q0.8640.99
68_P72_I0.8580.99
39_I42_S0.8550.99
156_V204_R0.8540.99
75_F105_I0.8440.99
33_S37_I0.8410.99
193_S197_V0.8410.99
59_V63_W0.8390.99
230_L233_S0.8320.99
277_L281_S0.8240.99
65_L69_I0.8230.99
129_L133_L0.8210.99
67_S72_I0.8210.99
92_S98_K0.8200.99
182_F188_V0.8200.99
140_A219_W0.8180.99
144_H205_A0.8170.99
97_V150_K0.8120.99
92_S146_I0.8090.99
90_D94_K0.8070.99
115_F154_P0.8060.99
271_P276_R0.8050.99
135_Q139_A0.8040.99
201_I204_R0.8040.99
133_L226_K0.7920.99
40_V44_L0.7900.99
225_I228_G0.7840.99
25_K28_L0.7820.99
184_I187_F0.7770.98
88_V142_L0.7760.98
82_Q86_F0.7750.98
33_S165_N0.7710.98
196_Y199_R0.7700.98
220_L224_L0.7700.98
171_L176_P0.7700.98
26_Y33_S0.7660.98
81_P85_T0.7660.98
37_I40_V0.7650.98
156_V201_I0.7570.98
228_G232_R0.7550.98
105_I124_A0.7530.98
125_V129_L0.7520.98
29_A36_V0.7490.98
185_I188_V0.7420.98
157_M160_T0.7420.98
227_I231_S0.7410.98
84_V88_V0.7400.98
31_F35_L0.7380.98
25_K37_I0.7370.98
211_K283_Y0.7370.98
30_S35_L0.7360.98
273_L277_L0.7310.98
29_A44_L0.7280.98
94_K214_P0.7270.98
62_L65_L0.7260.98
48_I51_F0.7220.98
87_M91_L0.7220.98
92_S99_L0.7190.97
147_A212_V0.7170.97
101_K122_G0.7120.97
78_R81_P0.7070.97
111_N144_H0.7040.97
52_F56_I0.7040.97
23_W29_A0.7030.97
236_T259_V0.7030.97
71_M77_M0.7010.97
195_F268_R0.6980.97
77_M80_A0.6980.97
53_L60_F0.6980.97
93_K96_N0.6950.97
25_K38_G0.6950.97
46_I50_Y0.6940.97
202_E270_H0.6930.97
48_I52_F0.6910.97
49_P53_L0.6910.97
209_A220_L0.6880.97
210_V224_L0.6860.97
183_L187_F0.6850.97
23_W27_Y0.6840.97
107_D127_S0.6830.97
138_L142_L0.6810.96
210_V283_Y0.6780.96
25_K30_S0.6750.96
164_I194_V0.6730.96
31_F37_I0.6680.96
66_I69_I0.6640.96
154_P158_L0.6560.96
87_M90_D0.6560.96
69_I72_I0.6560.96
37_I41_I0.6550.96
35_L40_V0.6550.96
226_K229_Y0.6550.96
159_L163_S0.6540.96
29_A38_G0.6530.96
56_I166_S0.6520.96
92_S96_N0.6510.95
63_W66_I0.6480.95
56_I162_F0.6470.95
231_S234_I0.6430.95
164_I190_L0.6370.95
27_Y31_F0.6360.95
22_Y27_Y0.6330.95
36_V43_S0.6310.95
140_A221_E0.6310.95
126_T149_I0.6300.95
22_Y25_K0.6300.95
162_F166_S0.6280.95
180_L187_F0.6280.95
145_E270_H0.6260.94
52_F55_Q0.6250.94
150_K208_T0.6250.94
29_A32_F0.6230.94
123_I142_L0.6220.94
26_Y34_I0.6220.94
264_V275_E0.6210.94
24_W28_L0.6200.94
105_I126_T0.6190.94
265_L268_R0.6170.94
221_E225_I0.6160.94
36_V41_I0.6160.94
159_L166_S0.6130.94
182_F185_I0.6120.94
99_L102_V0.6120.94
61_S65_L0.6100.94
56_I60_F0.6090.94
148_H270_H0.6070.93
84_V130_Y0.6070.93
155_E159_L0.6050.93
26_Y37_I0.6050.93
24_W33_S0.6040.93
210_V215_D0.6040.93
25_K33_S0.6040.93
157_M198_H0.6030.93
161_I165_N0.5960.93
39_I44_L0.5950.93
54_I57_G0.5950.93
29_A37_I0.5940.93
60_F63_W0.5940.93
148_H205_A0.5940.93
95_Y146_I0.5930.93
114_A149_I0.5920.93
264_V268_R0.5910.93
72_I77_M0.5890.92
28_L41_I0.5870.92
91_L95_Y0.5870.92
115_F122_G0.5860.92
32_F40_V0.5860.92
223_S273_L0.5830.92
190_L193_S0.5830.92
22_Y33_S0.5800.92
146_I149_I0.5800.92
68_P101_K0.5800.92
161_I167_I0.5780.92
87_M142_L0.5770.92
80_A85_T0.5750.92
59_V62_L0.5740.91
133_L138_L0.5740.91
222_S225_I0.5740.91
206_D276_R0.5710.91
114_A121_R0.5690.91
192_P267_F0.5680.91
279_Y283_Y0.5670.91
51_F55_Q0.5650.91
107_D110_L0.5640.91
66_I70_I0.5630.91
28_L42_S0.5600.90
111_N114_A0.5600.90
98_K119_I0.5590.90
117_N121_R0.5590.90
225_I229_Y0.5580.90
24_W32_F0.5580.90
207_L283_Y0.5550.90
139_A143_S0.5540.90
224_L273_L0.5470.89
22_Y34_I0.5450.89
105_I109_F0.5430.89
115_F124_A0.5410.89
224_L280_L0.5390.89
164_I167_I0.5390.89
91_L139_A0.5380.89
140_A224_L0.5360.88
172_I183_L0.5340.88
151_N266_S0.5340.88
31_F38_G0.5340.88
159_L162_F0.5330.88
210_V214_P0.5310.88
26_Y36_V0.5310.88
25_K43_S0.5280.88
164_I188_V0.5260.88
208_T211_K0.5250.87
171_L175_L0.5250.87
109_F231_S0.5210.87
25_K42_S0.5200.87
85_T102_V0.5200.87
208_T212_V0.5180.87
235_P259_V0.5170.87
28_L40_V0.5160.87
150_K211_K0.5150.86
66_I113_F0.5140.86
47_N50_Y0.5120.86
22_Y38_G0.5110.86
128_P153_D0.5110.86
23_W31_F0.5110.86
196_Y200_K0.5100.86
167_I193_S0.5090.86
110_L128_P0.5090.86
72_I76_K0.5080.86
86_F93_K0.5080.86
72_I75_F0.5060.85
116_G154_P0.5030.85
108_N127_S0.5010.85
110_L220_L0.5000.85
39_I43_S0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4il3A 1 0.8866 100 0.249 Contact Map
4aw6A 2 0.89 100 0.256 Contact Map
3c37A 1 0.6632 100 0.486 Contact Map
3cqbA 4 0.3368 99.8 0.673 Contact Map
4qhjA 2 0.3505 97.5 0.868 Contact Map
4jixA 2 0.3711 96.8 0.882 Contact Map
4jiuA 1 0.3471 96.7 0.882 Contact Map
3dteA 2 0.5052 93.7 0.904 Contact Map
4o66A 2 0.2405 12 0.955 Contact Map
3e11A 1 0.3505 8.4 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.009 seconds.