Q97VD5 - SULSO - GREMLIN Contacts

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Q97VD5 - Heat shock protein X, protease htpX homolog, putative (HtpX-like)

UniProt:	Q97VD5	Sequences: MIILSFYKLLERVICVHSITTYWWKYYLASFFSILVIGIVISSLNINIPYFFLIQIGLVFSLWYLISPIIMILVFKMRRAPQDVTFMVEDLSKKYNVKLSKVYIINDNFLNAFAFGNIIFRGIAVTSPLYESLVQEELAAVLSHEIAHIKNYDPEVMLLTIFSINSIYAALIYYLPLVSLFFLIIYFVILLPSVFYVHRKIEKRADLTAVKVNPDITYWLESSLIKIGYLSRSIPTNMLRYVPPIQIFLAKEFIVNHIVDEKSVLSFRTHPSLKERLLYLSQYEKQKMYYI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	291 (238)
Sequences:	4890 (3565)
Seq/√Len:	231.1

ECOLI - HTPX LOIP YCAL BEPA
BACSU - YHFN HTPX
HALSA - Q9HSA2 HTPX Q9HS47
SULSO - Q97VD5 HTPX2 HTPX1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
147_A	208_T	4.564	1.00
90_D	139_A	4.443	1.00
225_I	281_S	4.387	1.00
137_E	226_K	4.267	1.00
106_N	127_S	4.097	1.00
143_S	209_A	3.386	1.00
136_E	215_D	3.124	1.00
210_V	280_L	3.065	1.00
203_K	275_E	2.941	1.00
125_V	142_L	2.874	1.00
117_N	120_F	2.616	1.00
209_A	213_N	2.496	1.00
207_L	211_K	2.469	1.00
87_M	139_A	2.405	1.00
83_D	135_Q	2.327	1.00
221_E	277_L	2.246	1.00
85_T	99_L	2.223	1.00
228_G	274_K	2.218	1.00
136_E	219_W	2.217	1.00
95_Y	212_V	2.137	1.00
137_E	222_S	2.096	1.00
153_D	204_R	2.078	1.00
213_N	219_W	2.048	1.00
275_E	278_L	1.972	1.00
89_E	93_K	1.968	1.00
88_V	102_V	1.966	1.00
53_L	57_G	1.934	1.00
225_I	277_L	1.915	1.00
77_M	103_Y	1.889	1.00
228_G	273_L	1.845	1.00
134_V	226_K	1.803	1.00
89_E	99_L	1.791	1.00
132_S	230_L	1.778	1.00
134_V	222_S	1.734	1.00
113_F	124_A	1.696	1.00
221_E	281_S	1.668	1.00
140_A	220_L	1.658	1.00
218_Y	281_S	1.655	1.00
272_S	275_E	1.635	1.00
207_L	279_Y	1.597	1.00
184_I	188_V	1.589	1.00
69_I	73_L	1.586	1.00
127_S	131_E	1.566	1.00
87_M	135_Q	1.558	1.00
172_I	175_L	1.525	1.00
215_D	219_W	1.513	1.00
79_R	103_Y	1.513	1.00
129_L	138_L	1.502	1.00
38_G	41_I	1.502	1.00
78_R	106_N	1.492	1.00
153_D	201_I	1.490	1.00
152_Y	155_E	1.488	1.00
79_R	101_K	1.479	1.00
54_I	58_L	1.473	1.00
91_L	146_I	1.458	1.00
278_L	281_S	1.446	1.00
191_L	195_F	1.438	1.00
114_A	123_I	1.432	1.00
265_L	275_E	1.420	1.00
173_Y	176_P	1.404	1.00
25_K	29_A	1.400	1.00
148_H	202_E	1.399	1.00
26_Y	29_A	1.390	1.00
278_L	282_Q	1.377	1.00
133_L	227_I	1.352	1.00
144_H	202_E	1.343	1.00
58_L	62_L	1.340	1.00
85_T	89_E	1.332	1.00
171_L	174_Y	1.328	1.00
86_F	90_D	1.315	1.00
26_Y	30_S	1.314	1.00
172_I	176_P	1.313	1.00
103_Y	122_G	1.313	1.00
279_Y	282_Q	1.295	1.00
30_S	34_I	1.290	1.00
195_F	269_T	1.269	1.00
86_F	89_E	1.266	1.00
220_L	280_L	1.242	1.00
157_M	201_I	1.238	1.00
203_K	279_Y	1.225	1.00
38_G	42_S	1.224	1.00
151_N	208_T	1.221	1.00
22_Y	29_A	1.217	1.00
121_R	149_I	1.206	1.00
134_V	137_E	1.202	1.00
22_Y	26_Y	1.198	1.00
91_L	212_V	1.184	1.00
144_H	148_H	1.170	1.00
145_E	202_E	1.167	1.00
108_N	131_E	1.167	1.00
200_K	204_R	1.162	1.00
170_A	174_Y	1.151	1.00
151_N	204_R	1.143	1.00
97_V	146_I	1.142	1.00
141_V	223_S	1.134	1.00
57_G	61_S	1.103	1.00
34_I	38_G	1.092	1.00
218_Y	221_E	1.090	1.00
130_Y	138_L	1.086	1.00
139_A	215_D	1.077	1.00
218_Y	222_S	1.070	1.00
62_L	66_I	1.068	1.00
215_D	218_Y	1.067	1.00
268_R	272_S	1.063	1.00
204_R	208_T	1.062	1.00
274_K	278_L	1.053	1.00
82_Q	85_T	1.041	1.00
45_N	48_I	1.040	1.00
125_V	130_Y	1.028	1.00
29_A	33_S	1.026	1.00
91_L	142_L	1.016	1.00
30_S	33_S	1.009	1.00
24_W	29_A	0.989	1.00
28_L	32_F	0.988	1.00
84_V	125_V	0.975	1.00
136_E	222_S	0.974	1.00
23_W	26_Y	0.971	1.00
219_W	222_S	0.968	1.00
198_H	269_T	0.963	1.00
27_Y	30_S	0.962	1.00
110_L	230_L	0.955	1.00
133_L	223_S	0.954	1.00
110_L	132_S	0.952	1.00
28_L	33_S	0.942	1.00
145_E	148_H	0.935	1.00
83_D	86_F	0.920	1.00
52_F	169_A	0.918	1.00
22_Y	36_V	0.916	1.00
90_D	93_K	0.915	1.00
202_E	205_A	0.910	1.00
71_M	113_F	0.909	1.00
25_K	40_V	0.907	1.00
214_P	219_W	0.906	1.00
204_R	207_L	0.906	1.00
180_L	184_I	0.900	0.99
170_A	173_Y	0.898	0.99
182_F	186_Y	0.897	0.99
275_E	279_Y	0.897	0.99
32_F	36_V	0.892	0.99
77_M	105_I	0.890	0.99
50_Y	54_I	0.890	0.99
28_L	31_F	0.877	0.99
104_I	130_Y	0.872	0.99
222_S	226_K	0.868	0.99
86_F	135_Q	0.864	0.99
68_P	72_I	0.858	0.99
39_I	42_S	0.855	0.99
156_V	204_R	0.854	0.99
75_F	105_I	0.844	0.99
33_S	37_I	0.841	0.99
193_S	197_V	0.841	0.99
59_V	63_W	0.839	0.99
230_L	233_S	0.832	0.99
277_L	281_S	0.824	0.99
65_L	69_I	0.823	0.99
129_L	133_L	0.821	0.99
67_S	72_I	0.821	0.99
92_S	98_K	0.820	0.99
182_F	188_V	0.820	0.99
140_A	219_W	0.818	0.99
144_H	205_A	0.817	0.99
97_V	150_K	0.812	0.99
92_S	146_I	0.809	0.99
90_D	94_K	0.807	0.99
115_F	154_P	0.806	0.99
271_P	276_R	0.805	0.99
135_Q	139_A	0.804	0.99
201_I	204_R	0.804	0.99
133_L	226_K	0.792	0.99
40_V	44_L	0.790	0.99
225_I	228_G	0.784	0.99
25_K	28_L	0.782	0.99
184_I	187_F	0.777	0.98
88_V	142_L	0.776	0.98
82_Q	86_F	0.775	0.98
33_S	165_N	0.771	0.98
196_Y	199_R	0.770	0.98
220_L	224_L	0.770	0.98
171_L	176_P	0.770	0.98
26_Y	33_S	0.766	0.98
81_P	85_T	0.766	0.98
37_I	40_V	0.765	0.98
156_V	201_I	0.757	0.98
228_G	232_R	0.755	0.98
105_I	124_A	0.753	0.98
125_V	129_L	0.752	0.98
29_A	36_V	0.749	0.98
185_I	188_V	0.742	0.98
157_M	160_T	0.742	0.98
227_I	231_S	0.741	0.98
84_V	88_V	0.740	0.98
31_F	35_L	0.738	0.98
25_K	37_I	0.737	0.98
211_K	283_Y	0.737	0.98
30_S	35_L	0.736	0.98
273_L	277_L	0.731	0.98
29_A	44_L	0.728	0.98
94_K	214_P	0.727	0.98
62_L	65_L	0.726	0.98
48_I	51_F	0.722	0.98
87_M	91_L	0.722	0.98
92_S	99_L	0.719	0.97
147_A	212_V	0.717	0.97
101_K	122_G	0.712	0.97
78_R	81_P	0.707	0.97
111_N	144_H	0.704	0.97
52_F	56_I	0.704	0.97
23_W	29_A	0.703	0.97
236_T	259_V	0.703	0.97
71_M	77_M	0.701	0.97
195_F	268_R	0.698	0.97
77_M	80_A	0.698	0.97
53_L	60_F	0.698	0.97
93_K	96_N	0.695	0.97
25_K	38_G	0.695	0.97
46_I	50_Y	0.694	0.97
202_E	270_H	0.693	0.97
48_I	52_F	0.691	0.97
49_P	53_L	0.691	0.97
209_A	220_L	0.688	0.97
210_V	224_L	0.686	0.97
183_L	187_F	0.685	0.97
23_W	27_Y	0.684	0.97
107_D	127_S	0.683	0.97
138_L	142_L	0.681	0.96
210_V	283_Y	0.678	0.96
25_K	30_S	0.675	0.96
164_I	194_V	0.673	0.96
31_F	37_I	0.668	0.96
66_I	69_I	0.664	0.96
154_P	158_L	0.656	0.96
87_M	90_D	0.656	0.96
69_I	72_I	0.656	0.96
37_I	41_I	0.655	0.96
35_L	40_V	0.655	0.96
226_K	229_Y	0.655	0.96
159_L	163_S	0.654	0.96
29_A	38_G	0.653	0.96
56_I	166_S	0.652	0.96
92_S	96_N	0.651	0.95
63_W	66_I	0.648	0.95
56_I	162_F	0.647	0.95
231_S	234_I	0.643	0.95
164_I	190_L	0.637	0.95
27_Y	31_F	0.636	0.95
22_Y	27_Y	0.633	0.95
36_V	43_S	0.631	0.95
140_A	221_E	0.631	0.95
126_T	149_I	0.630	0.95
22_Y	25_K	0.630	0.95
162_F	166_S	0.628	0.95
180_L	187_F	0.628	0.95
145_E	270_H	0.626	0.94
52_F	55_Q	0.625	0.94
150_K	208_T	0.625	0.94
29_A	32_F	0.623	0.94
123_I	142_L	0.622	0.94
26_Y	34_I	0.622	0.94
264_V	275_E	0.621	0.94
24_W	28_L	0.620	0.94
105_I	126_T	0.619	0.94
265_L	268_R	0.617	0.94
221_E	225_I	0.616	0.94
36_V	41_I	0.616	0.94
159_L	166_S	0.613	0.94
182_F	185_I	0.612	0.94
99_L	102_V	0.612	0.94
61_S	65_L	0.610	0.94
56_I	60_F	0.609	0.94
148_H	270_H	0.607	0.93
84_V	130_Y	0.607	0.93
155_E	159_L	0.605	0.93
26_Y	37_I	0.605	0.93
24_W	33_S	0.604	0.93
210_V	215_D	0.604	0.93
25_K	33_S	0.604	0.93
157_M	198_H	0.603	0.93
161_I	165_N	0.596	0.93
39_I	44_L	0.595	0.93
54_I	57_G	0.595	0.93
29_A	37_I	0.594	0.93
60_F	63_W	0.594	0.93
148_H	205_A	0.594	0.93
95_Y	146_I	0.593	0.93
114_A	149_I	0.592	0.93
264_V	268_R	0.591	0.93
72_I	77_M	0.589	0.92
28_L	41_I	0.587	0.92
91_L	95_Y	0.587	0.92
115_F	122_G	0.586	0.92
32_F	40_V	0.586	0.92
223_S	273_L	0.583	0.92
190_L	193_S	0.583	0.92
22_Y	33_S	0.580	0.92
146_I	149_I	0.580	0.92
68_P	101_K	0.580	0.92
161_I	167_I	0.578	0.92
87_M	142_L	0.577	0.92
80_A	85_T	0.575	0.92
59_V	62_L	0.574	0.91
133_L	138_L	0.574	0.91
222_S	225_I	0.574	0.91
206_D	276_R	0.571	0.91
114_A	121_R	0.569	0.91
192_P	267_F	0.568	0.91
279_Y	283_Y	0.567	0.91
51_F	55_Q	0.565	0.91
107_D	110_L	0.564	0.91
66_I	70_I	0.563	0.91
28_L	42_S	0.560	0.90
111_N	114_A	0.560	0.90
98_K	119_I	0.559	0.90
117_N	121_R	0.559	0.90
225_I	229_Y	0.558	0.90
24_W	32_F	0.558	0.90
207_L	283_Y	0.555	0.90
139_A	143_S	0.554	0.90
224_L	273_L	0.547	0.89
22_Y	34_I	0.545	0.89
105_I	109_F	0.543	0.89
115_F	124_A	0.541	0.89
224_L	280_L	0.539	0.89
164_I	167_I	0.539	0.89
91_L	139_A	0.538	0.89
140_A	224_L	0.536	0.88
172_I	183_L	0.534	0.88
151_N	266_S	0.534	0.88
31_F	38_G	0.534	0.88
159_L	162_F	0.533	0.88
210_V	214_P	0.531	0.88
26_Y	36_V	0.531	0.88
25_K	43_S	0.528	0.88
164_I	188_V	0.526	0.88
208_T	211_K	0.525	0.87
171_L	175_L	0.525	0.87
109_F	231_S	0.521	0.87
25_K	42_S	0.520	0.87
85_T	102_V	0.520	0.87
208_T	212_V	0.518	0.87
235_P	259_V	0.517	0.87
28_L	40_V	0.516	0.87
150_K	211_K	0.515	0.86
66_I	113_F	0.514	0.86
47_N	50_Y	0.512	0.86
22_Y	38_G	0.511	0.86
128_P	153_D	0.511	0.86
23_W	31_F	0.511	0.86
196_Y	200_K	0.510	0.86
167_I	193_S	0.509	0.86
110_L	128_P	0.509	0.86
72_I	76_K	0.508	0.86
86_F	93_K	0.508	0.86
72_I	75_F	0.506	0.85
116_G	154_P	0.503	0.85
108_N	127_S	0.501	0.85
110_L	220_L	0.500	0.85
39_I	43_S	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4il3A	1	0.8866	100	0.249	Contact Map
4aw6A	2	0.89	100	0.256	Contact Map
3c37A	1	0.6632	100	0.486	Contact Map
3cqbA	4	0.3368	99.8	0.673	Contact Map
4qhjA	2	0.3505	97.5	0.868	Contact Map
4jixA	2	0.3711	96.8	0.882	Contact Map
4jiuA	1	0.3471	96.7	0.882	Contact Map
3dteA	2	0.5052	93.7	0.904	Contact Map
4o66A	2	0.2405	12	0.955	Contact Map
3e11A	1	0.3505	8.4	0.958	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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