GREMLIN Database
Q97VD4 - Acetyl-CoA c-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-8)
UniProt: Q97VD4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 376 (338)
Sequences: 15252 (8121)
Seq/√Len: 441.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_K166_N3.5101.00
216_D220_F3.4951.00
155_A285_E3.3531.00
96_T99_V3.0831.00
161_V181_L2.9431.00
84_I333_A2.8901.00
336_A348_Q2.8551.00
29_P32_G2.8511.00
214_D218_Y2.8231.00
156_F193_P2.7401.00
216_D219_S2.7191.00
169_L173_A2.6991.00
162_K165_Y2.6951.00
147_R192_D2.6671.00
27_A100_L2.5221.00
7_A334_V2.5001.00
91_L211_M2.4951.00
258_A262_A2.4891.00
3_A217_A2.4851.00
8_S33_K2.3991.00
30_L210_V2.2731.00
98_T212_V2.2571.00
91_L213_R2.2161.00
225_V337_F2.2001.00
87_A99_V2.1751.00
340_I345_G2.1331.00
152_S155_A2.1231.00
258_A363_F2.1021.00
23_A46_S2.0831.00
229_G262_A2.0701.00
37_D40_V2.0641.00
5_I212_V2.0571.00
269_F314_T1.9981.00
154_E158_L1.8991.00
264_V347_R1.8981.00
40_V220_F1.8611.00
145_Y151_A1.8591.00
207_S330_I1.8591.00
229_G258_A1.8001.00
284_A291_K1.7891.00
284_A312_I1.7841.00
184_V197_Y1.7811.00
97_K213_R1.7741.00
268_D345_G1.7461.00
212_V216_D1.7331.00
148_R245_I1.7321.00
97_K216_D1.7201.00
212_V217_A1.7141.00
256_L260_K1.7141.00
3_A226_F1.7131.00
339_Q343_Q1.6881.00
255_G351_N1.6881.00
168_S172_F1.6521.00
106_K109_E1.6401.00
183_E186_N1.6361.00
213_R216_D1.6351.00
315_S339_Q1.6311.00
264_V267_V1.6301.00
90_L96_T1.6261.00
46_S102_L1.6191.00
209_I330_I1.6161.00
267_V270_A1.6161.00
71_I86_V1.6121.00
89_S95_I1.6061.00
87_A211_M1.6061.00
30_L34_Y1.5961.00
139_G191_A1.5801.00
252_R256_L1.5791.00
161_V165_Y1.5621.00
98_T216_D1.5621.00
23_A59_I1.5611.00
21_E62_Y1.5601.00
158_L162_K1.5591.00
162_K291_K1.5271.00
339_Q342_N1.5101.00
27_A59_I1.5081.00
269_F339_Q1.5031.00
165_Y178_V1.4991.00
28_L32_G1.4871.00
26_V208_A1.4871.00
270_A349_V1.4851.00
175_I315_S1.4811.00
29_P33_K1.4671.00
158_L181_L1.4611.00
337_F341_R1.4401.00
85_L362_G1.4381.00
175_I339_Q1.4261.00
264_V363_F1.4071.00
165_Y169_L1.4051.00
231_G257_T1.4031.00
26_V206_A1.4031.00
231_G258_A1.3941.00
6_D30_L1.3801.00
267_V363_F1.3731.00
168_S178_V1.3701.00
257_T260_K1.3651.00
24_G62_Y1.3371.00
153_R195_T1.3271.00
143_K192_D1.3081.00
12_F327_A1.3081.00
85_L230_M1.3041.00
55_I104_V1.2991.00
290_L311_P1.2971.00
215_E219_S1.2781.00
42_S96_T1.2741.00
256_L286_E1.2721.00
155_A158_L1.2681.00
84_I209_I1.2531.00
48_E51_S1.2491.00
334_V338_L1.2441.00
226_F365_N1.2361.00
254_A361_A1.2301.00
314_T339_Q1.2281.00
25_E29_P1.2211.00
333_A364_G1.2211.00
78_G360_M1.2141.00
46_S208_A1.2031.00
100_L210_V1.2001.00
140_L192_D1.1941.00
41_V98_T1.1941.00
349_V363_F1.1941.00
7_A338_L1.1851.00
6_D34_Y1.1831.00
40_V216_D1.1761.00
159_V280_E1.1641.00
151_A156_F1.1641.00
255_G349_V1.1601.00
144_E148_R1.1551.00
3_A214_D1.1521.00
81_G333_A1.1471.00
175_I342_N1.1411.00
78_G354_V1.1311.00
331_A335_E1.1261.00
179_V184_V1.1261.00
45_Y99_V1.1231.00
227_I362_G1.1231.00
42_S97_K1.1181.00
267_V347_R1.1121.00
171_P177_K1.1121.00
159_V281_I1.1071.00
181_L185_L1.1041.00
233_S252_R1.1041.00
3_A212_V1.1031.00
82_S86_V1.1011.00
12_F321_K1.0991.00
180_S183_E1.0931.00
7_A337_F1.0931.00
95_I261_M1.0921.00
6_D33_K1.0901.00
245_I248_M1.0881.00
92_D95_I1.0881.00
235_D248_M1.0851.00
229_G261_M1.0811.00
268_D311_P1.0791.00
84_I211_M1.0771.00
47_G79_S1.0761.00
139_G190_I1.0721.00
233_S257_T1.0701.00
143_K147_R1.0661.00
269_F343_Q1.0651.00
8_S29_P1.0611.00
87_A101_V1.0601.00
248_M251_V1.0561.00
89_S93_S1.0551.00
161_V184_V1.0531.00
27_A65_V1.0511.00
151_A281_I1.0391.00
18_S21_E1.0371.00
346_S365_N1.0361.00
40_V219_S1.0331.00
154_E185_L1.0261.00
165_Y168_S1.0231.00
214_D226_F1.0181.00
24_G28_L1.0181.00
31_I65_V1.0171.00
16_K119_I1.0161.00
268_D340_I1.0091.00
12_F203_S1.0041.00
44_S60_T1.0041.00
187_S197_Y0.9941.00
149_Y248_M0.9931.00
336_A350_R0.9931.00
314_T343_Q0.9891.00
88_K227_I0.9701.00
228_K347_R0.9681.00
251_V286_E0.9661.00
267_V354_V0.9641.00
5_I222_K0.9641.00
289_L312_I0.9601.00
207_S327_A0.9551.00
315_S342_N0.9551.00
270_A289_L0.9511.00
65_V68_V0.9471.00
336_A355_G0.9451.00
228_K365_N0.9431.00
262_A363_F0.9431.00
130_V135_P0.9421.00
11_R25_E0.9411.00
26_V29_P0.9401.00
10_T26_V0.9401.00
248_M286_E0.9391.00
148_R238_Y0.9381.00
187_S195_T0.9371.00
161_V178_V0.9341.00
257_T261_M0.9301.00
88_K92_D0.9291.00
267_V349_V0.9251.00
146_M278_V0.9221.00
10_T25_E0.9171.00
255_G287_L0.9161.00
248_M282_V0.9071.00
101_V209_I0.9011.00
264_V354_V0.8991.00
207_S334_V0.8971.00
149_Y286_E0.8961.00
188_P196_L0.8911.00
277_T319_N0.8901.00
174_H177_K0.8881.00
212_V222_K0.8881.00
31_I36_I0.8871.00
144_E147_R0.8821.00
269_F336_A0.8811.00
272_L351_N0.8781.00
145_Y248_M0.8771.00
45_Y71_I0.8731.00
157_A198_E0.8721.00
12_F331_A0.8721.00
45_Y83_A0.8701.00
26_V30_L0.8701.00
45_Y87_A0.8691.00
332_Q350_R0.8691.00
10_T22_L0.8661.00
7_A209_I0.8661.00
214_D217_A0.8641.00
127_E130_V0.8631.00
318_L328_S0.8611.00
179_V183_E0.8551.00
333_A362_G0.8541.00
173_A342_N0.8541.00
121_S126_E0.8531.00
189_I192_D0.8521.00
18_S109_E0.8501.00
145_Y282_V0.8481.00
30_L100_L0.8471.00
4_I364_G0.8391.00
117_S121_S0.8391.00
129_I133_T0.8321.00
284_A289_L0.8321.00
227_I230_M0.8321.00
235_D252_R0.8311.00
162_K292_K0.8301.00
90_L95_I0.8291.00
75_N82_S0.8241.00
154_E181_L0.8211.00
280_E284_A0.8191.00
336_A357_S0.8191.00
40_V98_T0.8181.00
235_D249_N0.8131.00
215_E218_Y0.8101.00
95_I230_M0.8071.00
132_L135_P0.8071.00
43_N90_L0.8041.00
42_S257_T0.8011.00
259_R264_V0.7941.00
116_T121_S0.7921.00
23_A102_L0.7901.00
255_G361_A0.7891.00
8_S26_V0.7881.00
198_E277_T0.7851.00
19_L104_V0.7831.00
164_H178_V0.7831.00
315_S343_Q0.7821.00
83_A330_I0.7821.00
256_L287_L0.7811.00
30_L208_A0.7811.00
229_G363_F0.7811.00
167_G171_P0.7791.00
161_V180_S0.7771.00
86_V90_L0.7751.00
238_Y245_I0.7731.00
31_I41_V0.7711.00
44_S68_V0.7711.00
251_V256_L0.7711.00
182_E186_N0.7691.00
81_G362_G0.7691.00
155_A281_I0.7671.00
161_V179_V0.7641.00
169_L175_I0.7641.00
100_L208_A0.7631.00
265_D311_P0.7631.00
142_T278_V0.7631.00
86_V89_S0.7591.00
25_E28_L0.7571.00
223_K341_R0.7561.00
166_N169_L0.7551.00
4_I337_F0.7541.00
28_L38_F0.7521.00
46_S56_N0.7511.00
41_V100_L0.7481.00
108_S204_D0.7481.00
48_E55_I0.7421.00
43_N232_A0.7381.00
272_L283_E0.7361.00
89_S92_D0.7331.00
140_L144_E0.7291.00
161_V183_E0.7231.00
340_I348_Q0.7221.00
169_L172_F0.7211.00
258_A349_V0.7171.00
127_E131_G0.7161.00
65_V100_L0.7121.00
228_K262_A0.7091.00
265_D288_G0.7091.00
268_D347_R0.7071.00
97_K261_M0.7061.00
354_V360_M0.7041.00
167_G320_S0.7021.00
255_G272_L0.6991.00
236_T245_I0.6991.00
90_L99_V0.6991.00
75_N232_A0.6981.00
157_A185_L0.6981.00
27_A63_L0.6981.00
179_V197_Y0.6961.00
49_F325_I0.6961.00
164_H319_N0.6961.00
344_A347_R0.6921.00
97_K219_S0.6881.00
45_Y86_V0.6861.00
337_F364_G0.6861.00
221_T224_P0.6861.00
23_A104_V0.6831.00
85_L360_M0.6811.00
127_E132_L0.6791.00
347_R363_F0.6781.00
209_I334_V0.6771.00
282_V286_E0.6751.00
42_S99_V0.6721.00
8_S30_L0.6701.00
211_M227_I0.6681.00
142_T146_M0.6671.00
3_A213_R0.6671.00
31_I38_F0.6611.00
168_S171_P0.6601.00
27_A208_A0.6591.00
142_T194_L0.6591.00
141_M246_L0.6581.00
84_I101_V0.6581.00
21_E24_G0.6551.00
24_G63_L0.6511.00
59_I63_L0.6500.99
39_V67_K0.6490.99
231_G261_M0.6490.99
43_N75_N0.6470.99
151_A155_A0.6470.99
46_S59_I0.6470.99
20_L62_Y0.6460.99
69_P232_A0.6460.99
123_L126_E0.6450.99
27_A31_I0.6440.99
98_T220_F0.6440.99
280_E312_I0.6410.99
5_I217_A0.6390.99
181_L184_V0.6380.99
31_I34_Y0.6380.99
194_L199_F0.6370.99
190_I196_L0.6360.99
28_L63_L0.6340.99
228_K264_V0.6340.99
60_T65_V0.6330.99
341_R344_A0.6330.99
270_A351_N0.6320.99
28_L64_S0.6320.99
164_H168_S0.6310.99
212_V220_F0.6310.99
137_L140_L0.6300.99
321_K331_A0.6290.99
87_A96_T0.6290.99
71_I82_S0.6280.99
255_G259_R0.6280.99
127_E133_T0.6280.99
60_T70_S0.6260.99
107_M325_I0.6250.99
3_A216_D0.6230.99
73_V86_V0.6220.99
31_I35_E0.6210.99
41_V65_V0.6190.99
157_A181_L0.6180.99
354_V358_L0.6160.99
131_G134_L0.6160.99
54_G358_L0.6150.99
81_G350_R0.6130.99
333_A350_R0.6110.99
44_S100_L0.6090.99
279_L283_E0.6080.99
268_D346_S0.6070.99
145_Y149_Y0.6060.99
5_I216_D0.6050.99
275_M323_H0.6050.99
92_D230_M0.6040.99
151_A285_E0.6030.99
255_G283_E0.6030.99
167_G321_K0.6020.99
83_A101_V0.6020.99
136_S238_Y0.5990.99
327_A330_I0.5980.99
102_L208_A0.5970.99
122_L125_P0.5960.99
328_S332_Q0.5940.99
51_S72_R0.5930.99
254_A258_A0.5920.99
321_K335_E0.5910.99
256_L288_G0.5870.99
43_N96_T0.5840.99
162_K280_E0.5840.99
259_R262_A0.5830.99
3_A220_F0.5820.99
149_Y282_V0.5810.99
146_M151_A0.5790.99
4_I211_M0.5790.99
121_S124_S0.5770.99
45_Y90_L0.5770.99
57_N61_T0.5760.99
225_V340_I0.5740.99
178_V183_E0.5720.99
136_S144_E0.5720.99
278_V282_V0.5720.99
112_T116_T0.5710.99
42_S68_V0.5700.99
38_F66_D0.5690.99
160_A277_T0.5690.99
117_S120_A0.5680.99
136_S140_L0.5660.99
160_A164_H0.5650.99
82_S232_A0.5630.99
82_S85_L0.5630.99
59_I104_V0.5630.99
281_I285_E0.5620.99
112_T117_S0.5610.99
232_A360_M0.5600.99
84_I227_I0.5590.98
349_V352_A0.5590.98
345_G348_Q0.5560.98
82_S90_L0.5560.98
166_N291_K0.5560.98
284_A290_L0.5560.98
36_I210_V0.5550.98
160_A184_V0.5550.98
317_G320_S0.5540.98
269_F355_G0.5520.98
146_M193_P0.5510.98
272_L280_E0.5510.98
164_H201_P0.5500.98
43_N99_V0.5470.98
158_L291_K0.5450.98
143_K194_L0.5440.98
169_L346_S0.5420.98
50_N110_K0.5420.98
122_L126_E0.5400.98
131_G135_P0.5390.98
149_Y245_I0.5390.98
90_L93_S0.5380.98
101_V330_I0.5370.98
285_E288_G0.5350.98
182_E185_L0.5340.98
258_A267_V0.5340.98
5_I98_T0.5340.98
158_L161_V0.5320.98
52_L58_L0.5310.98
348_Q364_G0.5310.98
79_S326_G0.5300.98
157_A184_V0.5300.98
85_L89_S0.5300.98
334_V337_F0.5290.98
49_F76_T0.5280.98
275_M279_L0.5280.98
81_G360_M0.5270.98
227_I364_G0.5270.98
6_D210_V0.5260.98
330_I334_V0.5260.98
149_Y285_E0.5260.98
88_K230_M0.5230.98
217_A220_F0.5220.98
159_V317_G0.5190.98
164_H179_V0.5180.98
266_K347_R0.5170.98
34_Y210_V0.5170.98
262_A267_V0.5160.97
213_R217_A0.5150.97
85_L232_A0.5140.97
45_Y73_V0.5130.97
180_S184_V0.5130.97
165_Y181_L0.5120.97
259_R267_V0.5110.97
42_S69_P0.5110.97
84_I330_I0.5100.97
327_A331_A0.5100.97
20_L24_G0.5070.97
54_G76_T0.5060.97
56_N72_R0.5060.97
81_G352_A0.5050.97
231_G262_A0.5040.97
97_K215_E0.5040.97
127_E135_P0.5030.97
123_L137_L0.5010.97
53_S76_T0.5000.97
145_Y278_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbgA 2 0.9894 100 0.238 Contact Map
4u4eA 1 0.9229 100 0.297 Contact Map
1wdkC 2 0.9043 100 0.354 Contact Map
1ulqA 4 0.9149 100 0.357 Contact Map
2wu9A 2 0.9096 100 0.358 Contact Map
4e1lA 4 0.891 100 0.362 Contact Map
2vu1A 4 0.9069 100 0.363 Contact Map
3goaA 2 0.8883 100 0.366 Contact Map
1wl4A 4 0.9069 100 0.367 Contact Map
4n46A 4 0.9096 100 0.367 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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