GREMLIN Database
Q97VC8 - Permease, multidrug efflux
UniProt: Q97VC8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 567 (434)
Sequences: 10993 (8281)
Seq/√Len: 397.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_P106_Q5.4001.00
87_T179_G5.3941.00
85_I117_G4.1221.00
213_S251_F3.8261.00
209_L257_V3.5451.00
94_Y173_L3.4071.00
105_I109_I3.2341.00
217_I247_G3.1701.00
54_G112_I3.0571.00
92_L110_Y2.9911.00
403_S411_A2.9181.00
5_K137_E2.8931.00
364_T380_I2.7901.00
98_G106_Q2.7521.00
220_G244_I2.7411.00
269_E407_H2.7341.00
212_V250_M2.7021.00
98_G105_I2.7001.00
334_M386_V2.6651.00
62_L116_I2.5851.00
205_V257_V2.5441.00
186_S190_L2.4591.00
80_N183_T2.4131.00
166_I170_D2.3461.00
316_T319_W2.3411.00
241_I245_V2.3111.00
330_G382_F2.2341.00
203_D206_G2.2021.00
252_I256_F2.1731.00
80_N187_Y2.1721.00
224_G235_W2.1271.00
89_A113_L2.1131.00
93_L110_Y2.0781.00
15_G79_Y2.0761.00
361_G384_I2.0661.00
75_R131_E2.0501.00
440_I444_P2.0491.00
137_E140_F2.0251.00
163_L170_D2.0071.00
80_N186_S1.9961.00
89_A117_G1.9881.00
271_F277_T1.9861.00
267_R407_H1.9601.00
261_V264_P1.9091.00
184_I188_K1.9041.00
82_G120_F1.8461.00
404_P407_H1.8431.00
255_L259_S1.8381.00
39_I104_A1.8361.00
58_V112_I1.7861.00
71_D409_G1.7761.00
254_F258_E1.7751.00
204_I208_I1.7691.00
8_A132_A1.7551.00
90_S175_S1.7491.00
291_G423_S1.7291.00
167_Y170_D1.7141.00
66_V120_F1.7081.00
213_S247_G1.7021.00
47_Y104_A1.6971.00
40_N47_Y1.6701.00
29_A164_A1.6471.00
246_A250_M1.6471.00
77_R192_Q1.6471.00
91_I95_L1.6461.00
216_S250_M1.6381.00
17_F152_G1.6321.00
106_Q110_Y1.6271.00
165_S318_F1.6061.00
39_I47_Y1.6011.00
255_L268_I1.5961.00
22_N25_V1.5891.00
302_Q320_A1.5861.00
288_L426_S1.5851.00
340_R344_R1.5541.00
223_Y233_T1.5521.00
216_S243_G1.5391.00
104_A108_I1.5271.00
357_I387_G1.5261.00
300_L309_H1.5201.00
13_S148_I1.5041.00
13_S144_L1.4891.00
84_L183_T1.4871.00
201_S263_D1.4801.00
22_N175_S1.4741.00
242_S246_A1.4611.00
93_L107_L1.4501.00
89_A110_Y1.4451.00
277_T281_V1.4451.00
259_S269_E1.4431.00
213_S250_M1.4241.00
267_R410_S1.4191.00
96_T106_Q1.4151.00
247_G251_F1.4131.00
216_S246_A1.4121.00
76_V80_N1.4101.00
256_F259_S1.4101.00
339_G343_D1.4061.00
444_P447_T1.4051.00
130_S138_R1.4001.00
319_W322_V1.3951.00
220_G247_G1.3941.00
361_G387_G1.3901.00
55_Y118_G1.3901.00
373_N376_E1.3891.00
133_F141_A1.3831.00
361_G380_I1.3731.00
139_G343_D1.3721.00
346_G349_S1.3641.00
284_I422_G1.3531.00
441_S445_V1.3521.00
354_G391_F1.3461.00
29_A171_V1.3401.00
356_L360_I1.3391.00
134_P137_E1.3371.00
92_L106_Q1.3351.00
374_Y378_A1.3351.00
349_S352_T1.3231.00
292_G430_F1.3171.00
11_N185_W1.3161.00
334_M389_G1.3141.00
68_R72_I1.3101.00
75_R192_Q1.3041.00
11_N189_S1.3001.00
96_T110_Y1.2941.00
76_V187_Y1.2921.00
257_V261_V1.2921.00
368_L372_F1.2861.00
25_V174_V1.2841.00
323_Y374_Y1.2791.00
253_G256_F1.2781.00
83_F182_G1.2741.00
81_L85_I1.2691.00
363_L366_T1.2681.00
62_L119_S1.2661.00
135_P138_R1.2591.00
70_S75_R1.2531.00
348_R352_T1.2531.00
301_L323_Y1.2521.00
244_I248_V1.2521.00
330_G334_M1.2471.00
206_G257_V1.2451.00
359_G363_L1.2301.00
125_S145_N1.2301.00
220_G240_V1.2281.00
176_V180_I1.2281.00
20_F149_G1.2261.00
64_V210_Y1.2151.00
369_P372_F1.2131.00
266_F414_I1.2131.00
32_A35_R1.2091.00
165_S316_T1.2051.00
14_L182_G1.2051.00
161_G317_P1.2041.00
361_G383_F1.1921.00
212_V216_S1.1921.00
340_R343_D1.1841.00
209_L253_G1.1811.00
235_W240_V1.1801.00
183_T187_Y1.1791.00
95_L173_L1.1781.00
79_Y186_S1.1781.00
23_A56_S1.1711.00
327_L385_G1.1701.00
185_W189_S1.1691.00
159_I162_I1.1671.00
231_Q234_G1.1631.00
375_I379_V1.1611.00
88_I92_L1.1611.00
69_I73_F1.1611.00
311_Y323_Y1.1601.00
61_I211_A1.1591.00
34_F48_L1.1571.00
201_S262_K1.1511.00
334_M390_L1.1461.00
9_L133_F1.1451.00
273_I277_T1.1421.00
319_W323_Y1.1351.00
256_F260_R1.1301.00
458_L461_I1.1231.00
89_A92_L1.1191.00
236_T241_I1.1181.00
353_I390_L1.1121.00
65_N207_N1.1041.00
367_T380_I1.1001.00
69_I78_M1.0981.00
18_M179_G1.0971.00
238_P242_S1.0961.00
441_S444_P1.0951.00
136_N140_F1.0941.00
180_I184_I1.0931.00
329_A333_I1.0861.00
376_E379_V1.0851.00
219_L223_Y1.0851.00
280_A418_L1.0781.00
67_G71_D1.0771.00
53_F222_T1.0741.00
97_P104_A1.0711.00
223_Y232_V1.0681.00
375_I378_A1.0661.00
279_S399_L1.0651.00
206_G261_V1.0641.00
233_T239_F1.0641.00
444_P450_L1.0621.00
446_L449_A1.0611.00
58_V115_G1.0611.00
30_L48_L1.0601.00
54_G58_V1.0591.00
25_V171_V1.0541.00
252_I255_L1.0531.00
447_T450_L1.0531.00
341_L345_Y1.0511.00
93_L172_F1.0481.00
91_I176_V1.0321.00
233_T240_V1.0311.00
27_L52_L1.0291.00
54_G108_I1.0291.00
71_D75_R1.0291.00
442_L445_V1.0171.00
257_V260_R1.0141.00
214_L421_T1.0121.00
220_G243_G1.0121.00
311_Y319_W1.0121.00
363_L367_T1.0111.00
87_T183_T1.0101.00
442_L446_L0.9971.00
22_N174_V0.9921.00
349_S353_I0.9891.00
251_F255_L0.9881.00
130_S408_R0.9861.00
97_P105_I0.9861.00
221_I224_G0.9841.00
354_G387_G0.9791.00
336_S340_R0.9771.00
442_L449_A0.9731.00
452_A456_P0.9681.00
162_I318_F0.9641.00
445_V448_N0.9641.00
18_M175_S0.9631.00
274_R277_T0.9621.00
209_L250_M0.9581.00
337_I340_R0.9581.00
92_L113_L0.9581.00
345_Y350_L0.9561.00
143_G147_V0.9561.00
105_I108_I0.9561.00
70_S124_N0.9551.00
78_M120_F0.9551.00
445_V449_A0.9481.00
188_K191_R0.9471.00
355_L391_F0.9461.00
51_I107_L0.9461.00
206_G258_E0.9451.00
218_L424_T0.9441.00
25_V160_G0.9431.00
354_G361_G0.9411.00
75_R193_L0.9371.00
6_W10_S0.9331.00
237_N241_I0.9301.00
87_T91_I0.9291.00
92_L95_L0.9211.00
5_K133_F0.9191.00
379_V382_F0.9191.00
80_N84_L0.9181.00
444_P448_N0.9111.00
354_G390_L0.9111.00
207_N265_M0.9091.00
296_M431_F0.9071.00
274_R278_S0.9071.00
61_I215_I0.9061.00
378_A382_F0.9061.00
212_V246_A0.9051.00
345_Y349_S0.9021.00
58_V62_L0.9011.00
73_F78_M0.8971.00
379_V383_F0.8961.00
248_V252_I0.8951.00
437_T441_S0.8911.00
200_Q263_D0.8891.00
76_V192_Q0.8891.00
7_I189_S0.8891.00
185_W188_K0.8861.00
376_E380_I0.8861.00
18_M83_F0.8831.00
95_L110_Y0.8781.00
32_A36_G0.8721.00
220_G224_G0.8681.00
396_M415_R0.8671.00
139_G339_G0.8631.00
440_I449_A0.8621.00
334_M338_A0.8601.00
239_F243_G0.8581.00
342_A394_P0.8571.00
276_F411_A0.8511.00
237_N240_V0.8511.00
208_I212_V0.8501.00
129_L145_N0.8491.00
253_G257_V0.8491.00
456_P460_P0.8461.00
457_Q461_I0.8451.00
224_G240_V0.8431.00
109_I112_I0.8421.00
272_K277_T0.8411.00
71_D410_S0.8361.00
275_A402_A0.8341.00
85_I89_A0.8331.00
341_L350_L0.8301.00
269_E272_K0.8251.00
301_L309_H0.8251.00
286_A391_F0.8241.00
302_Q317_P0.8241.00
259_S272_K0.8231.00
142_L146_G0.8231.00
239_F242_S0.8221.00
74_G77_R0.8191.00
142_L397_T0.8191.00
271_F276_F0.8171.00
399_L415_R0.8131.00
443_P447_T0.8121.00
298_V320_A0.8121.00
346_G350_L0.8091.00
447_T456_P0.8081.00
400_M412_S0.8061.00
444_P449_A0.8051.00
276_F280_A0.8001.00
449_A453_A0.8001.00
358_M387_G0.8001.00
126_A145_N0.8001.00
432_T436_D0.8001.00
192_Q195_K0.7951.00
29_A33_I0.7951.00
327_L384_I0.7921.00
47_Y105_I0.7901.00
73_F202_I0.7891.00
11_N182_G0.7891.00
365_L368_L0.7841.00
33_I164_A0.7811.00
450_L455_A0.7811.00
233_T237_N0.7811.00
231_Q235_W0.7811.00
81_L84_L0.7771.00
213_S255_L0.7741.00
51_I104_A0.7741.00
177_P180_I0.7741.00
19_G121_L0.7731.00
26_V51_I0.7731.00
210_Y214_L0.7721.00
444_P452_A0.7711.00
40_N46_Q0.7681.00
78_M81_L0.7681.00
136_N139_G0.7671.00
84_L88_I0.7661.00
205_V261_V0.7661.00
55_Y86_F0.7641.00
248_V251_F0.7621.00
447_T452_A0.7611.00
350_L353_I0.7611.00
335_G339_G0.7611.00
356_L359_G0.7591.00
16_A149_G0.7591.00
52_L295_L0.7581.00
450_L454_G0.7541.00
372_F376_E0.7531.00
56_S424_T0.7531.00
146_G150_I0.7521.00
449_A455_A0.7511.00
311_Y374_Y0.7511.00
170_D177_P0.7501.00
258_E261_V0.7501.00
212_V215_I0.7491.00
397_T401_N0.7481.00
244_I247_G0.7481.00
334_M337_I0.7481.00
301_L377_F0.7461.00
440_I446_L0.7421.00
280_A414_I0.7411.00
284_I425_L0.7401.00
278_S282_S0.7381.00
169_R173_L0.7301.00
275_A398_A0.7281.00
191_R194_N0.7271.00
202_I207_N0.7261.00
441_S447_T0.7261.00
12_T125_S0.7261.00
143_G335_G0.7261.00
390_L394_P0.7261.00
152_G157_I0.7261.00
110_Y113_L0.7251.00
165_S317_P0.7241.00
210_Y254_F0.7231.00
385_G389_G0.7211.00
194_N197_N0.7211.00
97_P110_Y0.7201.00
273_I404_P0.7181.00
56_S423_S0.7171.00
336_S339_G0.7161.00
283_I395_N0.7161.00
458_L462_L0.7151.00
87_T176_V0.7151.00
33_I107_L0.7141.00
259_S268_I0.7121.00
129_L141_A0.7091.00
282_S355_L0.7091.00
58_V117_G0.7061.00
440_I452_A0.7061.00
21_M25_V0.7061.00
246_A253_G0.7061.00
299_L303_A0.7051.00
67_G413_G0.7041.00
211_A215_I0.7041.00
76_V191_R0.7021.00
364_T367_T0.7021.00
70_S409_G0.7021.00
39_I108_I0.7011.00
98_G104_A0.6951.00
273_I407_H0.6951.00
60_A421_T0.6941.00
240_V243_G0.6931.00
352_T359_G0.6931.00
162_I166_I0.6931.00
223_Y240_V0.6921.00
326_P330_G0.6921.00
304_I309_H0.6901.00
282_S395_N0.6860.99
139_G143_G0.6860.99
173_L177_P0.6840.99
422_G426_S0.6820.99
70_S127_A0.6810.99
322_V325_L0.6810.99
184_I187_Y0.6800.99
342_A350_L0.6790.99
293_L384_I0.6780.99
255_L271_F0.6760.99
209_L254_F0.6750.99
163_L174_V0.6740.99
83_F183_T0.6710.99
129_L132_A0.6710.99
205_V209_L0.6700.99
457_Q460_P0.6690.99
338_A390_L0.6690.99
451_T456_P0.6690.99
22_N90_S0.6670.99
109_I113_L0.6670.99
367_T376_E0.6660.99
297_L381_I0.6650.99
333_I336_S0.6620.99
152_G156_G0.6610.99
91_I173_L0.6610.99
160_G164_A0.6600.99
245_V249_G0.6600.99
77_R81_L0.6600.99
78_M124_N0.6590.99
446_L450_L0.6590.99
352_T356_L0.6580.99
22_N177_P0.6580.99
254_F266_F0.6580.99
135_P139_G0.6580.99
9_L141_A0.6570.99
223_Y239_F0.6560.99
366_T369_P0.6560.99
210_Y265_M0.6550.99
338_A389_G0.6530.99
163_L166_I0.6530.99
127_A409_G0.6520.99
128_I132_A0.6510.99
93_L114_Q0.6500.99
362_V384_I0.6490.99
455_A460_P0.6490.99
82_G117_G0.6480.99
66_V123_A0.6480.99
48_L299_L0.6480.99
351_A398_A0.6470.99
357_I383_F0.6470.99
67_G124_N0.6440.99
6_W140_F0.6430.99
22_N55_Y0.6410.99
450_L456_P0.6410.99
93_L96_T0.6390.99
276_F399_L0.6390.99
40_N45_F0.6390.99
181_L185_W0.6380.99
273_I402_A0.6380.99
193_L196_P0.6370.99
71_D74_G0.6360.99
196_P199_N0.6350.99
283_I415_R0.6350.99
354_G394_P0.6330.99
323_Y326_P0.6330.99
364_T379_V0.6310.99
442_L447_T0.6300.99
50_W54_G0.6290.99
12_T132_A0.6270.99
150_I331_F0.6270.99
360_I363_L0.6270.99
213_S216_S0.6260.99
126_A412_S0.6260.99
443_P453_A0.6250.99
184_I189_S0.6250.99
360_I364_T0.6250.99
11_N186_S0.6250.99
33_I37_I0.6230.99
382_F386_V0.6230.99
452_A455_A0.6210.99
214_L417_M0.6210.99
295_L427_I0.6200.99
72_I201_S0.6200.99
362_V366_T0.6180.99
147_V151_F0.6180.99
207_N211_A0.6180.99
456_P459_A0.6180.99
53_F431_F0.6170.99
368_L380_I0.6160.99
440_I445_V0.6160.99
447_T451_T0.6150.99
28_I320_A0.6150.99
216_S247_G0.6140.99
83_F186_S0.6130.99
131_E408_R0.6130.99
45_F49_L0.6100.99
155_A159_I0.6090.99
452_A460_P0.6080.99
75_R127_A0.6080.99
236_T239_F0.6050.99
161_G321_G0.6050.99
149_G153_G0.6050.99
249_G253_G0.6040.99
451_T460_P0.6020.99
127_A412_S0.6010.99
456_P461_I0.6000.99
447_T453_A0.6000.99
22_N26_V0.5970.99
438_L442_L0.5970.99
219_L243_G0.5960.99
195_K199_N0.5960.99
37_I104_A0.5960.99
24_N157_I0.5950.99
429_I432_T0.5940.99
443_P446_L0.5930.99
30_L52_L0.5930.99
24_N153_G0.5920.99
106_Q109_I0.5910.99
440_I448_N0.5900.98
298_V324_L0.5880.98
351_A395_N0.5850.98
284_I418_L0.5840.98
154_V328_L0.5840.98
140_F143_G0.5840.98
337_I341_L0.5830.98
59_S420_N0.5830.98
442_L448_N0.5820.98
55_Y111_R0.5820.98
286_A395_N0.5800.98
15_G121_L0.5790.98
446_L452_A0.5780.98
440_I443_P0.5760.98
34_F39_I0.5740.98
57_I215_I0.5730.98
358_M384_I0.5730.98
286_A290_F0.5730.98
441_S446_L0.5730.98
111_R114_Q0.5720.98
364_T383_F0.5720.98
342_A397_T0.5710.98
97_P169_R0.5690.98
242_S245_V0.5650.98
20_F153_G0.5640.98
329_A332_G0.5630.98
86_F160_G0.5620.98
50_W57_I0.5620.98
259_S262_K0.5610.98
353_I357_I0.5600.98
86_F118_G0.5580.98
130_S400_M0.5580.98
187_Y191_R0.5570.98
325_L328_L0.5570.98
85_I113_L0.5550.98
454_G458_L0.5550.98
451_T455_A0.5540.98
204_I207_N0.5520.98
67_G409_G0.5510.98
437_T440_I0.5490.98
287_Q419_T0.5490.98
330_G333_I0.5480.98
240_V244_I0.5470.98
140_F340_R0.5470.98
442_L453_A0.5460.98
83_F179_G0.5460.98
22_N111_R0.5450.97
290_F392_V0.5430.97
440_I450_L0.5410.97
290_F388_N0.5400.97
275_A278_S0.5400.97
448_N455_A0.5400.97
19_G122_M0.5360.97
147_V150_I0.5350.97
447_T454_G0.5350.97
296_M434_V0.5350.97
63_V417_M0.5340.97
454_G460_P0.5340.97
63_V416_A0.5340.97
209_L213_S0.5340.97
301_L311_Y0.5320.97
175_S179_G0.5320.97
61_I207_N0.5320.97
140_F144_L0.5310.97
355_L359_G0.5290.97
60_A424_T0.5270.97
300_L304_I0.5260.97
17_F148_I0.5260.97
441_S458_L0.5260.97
27_L295_L0.5260.97
86_F111_R0.5250.97
59_S118_G0.5250.97
56_S420_N0.5250.97
453_A457_Q0.5240.97
451_T457_Q0.5240.97
150_I335_G0.5240.97
311_Y316_T0.5230.97
115_G119_S0.5190.97
330_G378_A0.5190.97
454_G459_A0.5170.97
146_G335_G0.5160.97
33_I48_L0.5160.97
9_L129_L0.5160.97
131_E193_L0.5160.97
8_A11_N0.5160.97
203_D257_V0.5140.96
16_A125_S0.5130.96
453_A456_P0.5110.96
433_I437_T0.5110.96
192_Q196_P0.5100.96
27_L30_L0.5090.96
39_I48_L0.5090.96
17_F155_A0.5080.96
396_M400_M0.5060.96
217_I251_F0.5060.96
58_V116_I0.5050.96
224_G233_T0.5050.96
268_I271_F0.5040.96
413_G417_M0.5040.96
280_A415_R0.5040.96
66_V119_S0.5030.96
130_S142_L0.5030.96
153_G291_G0.5030.96
206_G254_F0.5030.96
450_L458_L0.5030.96
156_G160_G0.5020.96
455_A459_A0.5020.96
408_R412_S0.5010.96
181_L184_I0.5000.96
115_G413_G0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.716 100 0.566 Contact Map
3wdoA 1 0.7831 100 0.57 Contact Map
4j05A 3 0.6808 100 0.573 Contact Map
4pypA 1 0.7372 100 0.577 Contact Map
2gfpA 2 0.6596 100 0.587 Contact Map
4zw9A 1 0.7619 100 0.589 Contact Map
4gc0A 1 0.7584 100 0.589 Contact Map
4ldsA 2 0.7213 100 0.599 Contact Map
4w6vA 1 0.7619 100 0.6 Contact Map
2cfqA 1 0.7178 100 0.603 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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