GREMLIN Database
Q97VC7 - Regucalcin homolog
UniProt: Q97VC7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (226)
Sequences: 11290 (9327)
Seq/√Len: 620.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_D116_T3.4101.00
142_G161_I3.3061.00
115_G129_Y3.0911.00
148_G162_D3.0871.00
198_G211_H2.8861.00
234_P253_I2.8331.00
192_E210_A2.8231.00
210_A220_W2.7041.00
244_G247_E2.5851.00
161_I171_F2.5311.00
31_V41_N2.5021.00
30_W40_V2.4901.00
114_A151_W2.4611.00
160_L201_V2.2571.00
240_S254_T2.2171.00
209_V243_F2.1531.00
117_M123_K2.1181.00
22_D25_L2.0911.00
126_G161_I2.0811.00
221_N224_T2.0641.00
30_W62_V2.0291.00
209_V219_R2.0101.00
114_A159_F1.9911.00
130_K133_T1.9871.00
53_M71_T1.9711.00
114_A128_F1.9701.00
93_E115_G1.9371.00
105_K150_G1.9211.00
80_N83_R1.8981.00
160_L208_W1.8971.00
142_G163_S1.8601.00
77_Y86_I1.8451.00
18_G32_D1.8121.00
218_S230_E1.8011.00
160_L170_V1.7581.00
162_D196_P1.7531.00
218_S227_K1.7401.00
76_F115_G1.7241.00
217_V253_I1.7151.00
63_I106_C1.7051.00
42_D45_T1.6921.00
168_V210_A1.6801.00
116_T146_S1.6551.00
255_T258_K1.6301.00
107_D151_W1.6291.00
220_W227_K1.6081.00
127_S138_K1.5661.00
102_N118_N1.5381.00
107_D111_R1.5211.00
106_C113_W1.4281.00
61_C105_K1.3901.00
153_P201_V1.3701.00
244_G248_L1.3591.00
105_K149_L1.3541.00
209_V251_L1.3521.00
71_T79_V1.3431.00
70_A106_C1.3311.00
151_W159_F1.3271.00
211_H238_V1.3081.00
33_I36_K1.2991.00
160_L199_M1.2901.00
77_Y89_I1.2741.00
33_I37_R1.2711.00
149_L161_I1.2691.00
210_A218_S1.2671.00
70_A78_I1.2451.00
227_K230_E1.2371.00
64_D110_G1.2331.00
104_G115_G1.2331.00
115_G127_S1.2241.00
234_P255_T1.2201.00
202_D205_G1.2171.00
209_V241_V1.2081.00
151_W173_F1.2031.00
203_E248_L1.1921.00
152_D201_V1.1821.00
127_S135_K1.1741.00
111_R132_D1.1681.00
142_G165_V1.1651.00
20_V61_C1.1651.00
200_A242_T1.1571.00
108_K151_W1.1421.00
216_K230_E1.1391.00
202_D206_Y1.1361.00
31_V39_I1.1311.00
123_K127_S1.1251.00
35_G39_I1.1201.00
33_I39_I1.1181.00
116_T149_L1.1131.00
32_D36_K1.1091.00
68_V71_T1.0971.00
79_V86_I1.0961.00
163_S166_R1.0951.00
192_E212_W1.0941.00
211_H215_G1.0911.00
152_D156_T1.0911.00
117_M125_T1.0891.00
169_F188_D1.0891.00
243_F251_L1.0881.00
61_C104_G1.0881.00
115_G123_K1.0871.00
200_A241_V1.0811.00
147_N164_P1.0631.00
192_E196_P1.0571.00
185_V188_D1.0561.00
32_D57_I1.0551.00
153_P205_G1.0531.00
108_K155_N1.0521.00
197_D213_G1.0521.00
212_W216_K1.0451.00
64_D106_C1.0451.00
244_G249_D1.0421.00
162_D199_M1.0381.00
117_M124_P1.0251.00
150_G200_A1.0221.00
244_G252_F1.0211.00
163_S167_K1.0151.00
211_H241_V1.0111.00
19_P31_V1.0081.00
86_I89_I1.0031.00
168_V199_M0.9941.00
142_G146_S0.9921.00
200_A243_F0.9911.00
141_E171_F0.9891.00
241_V253_I0.9861.00
114_A149_L0.9861.00
244_G250_Q0.9851.00
202_D243_F0.9841.00
70_A113_W0.9841.00
20_V60_L0.9831.00
39_I48_E0.9721.00
170_V201_V0.9491.00
76_F104_G0.9441.00
53_M57_I0.9361.00
31_V35_G0.9341.00
21_Y29_F0.9331.00
41_N48_E0.9321.00
150_G199_M0.9301.00
67_R80_N0.9271.00
165_V169_F0.9251.00
234_P238_V0.9201.00
234_P257_G0.9181.00
106_C131_L0.9111.00
61_C106_C0.9111.00
203_E243_F0.9101.00
202_D207_I0.9081.00
199_M210_A0.9011.00
30_W69_I0.8981.00
212_W218_S0.8971.00
146_S163_S0.8951.00
63_I67_R0.8951.00
145_V164_P0.8911.00
73_R77_Y0.8801.00
129_Y135_K0.8791.00
172_D182_N0.8771.00
192_E214_G0.8771.00
161_I169_F0.8761.00
27_K42_D0.8731.00
216_K232_K0.8691.00
22_D62_V0.8651.00
21_Y106_C0.8621.00
30_W60_L0.8591.00
214_G218_S0.8561.00
135_K138_K0.8501.00
102_N147_N0.8491.00
53_M79_V0.8481.00
254_T258_K0.8451.00
142_G169_F0.8451.00
195_N213_G0.8441.00
233_V253_I0.8441.00
241_V251_L0.8431.00
208_W222_P0.8371.00
212_W215_G0.8311.00
99_N118_N0.8241.00
152_D155_N0.8231.00
207_I219_R0.8221.00
107_D112_Y0.8201.00
63_I66_K0.8171.00
206_Y221_N0.8151.00
59_S104_G0.8141.00
147_N197_D0.8121.00
25_L28_L0.8121.00
62_V81_L0.8031.00
242_T252_F0.7941.00
202_D209_V0.7901.00
213_G237_Y0.7881.00
23_K62_V0.7861.00
38_I71_T0.7861.00
70_A104_G0.7841.00
118_N124_P0.7731.00
239_T256_A0.7731.00
93_E117_M0.7731.00
117_M127_S0.7701.00
200_A209_V0.7701.00
191_N220_W0.7671.00
105_K151_W0.7601.00
156_T174_D0.7581.00
198_G241_V0.7561.00
152_D158_M0.7501.00
23_K66_K0.7481.00
32_D35_G0.7441.00
191_N218_S0.7371.00
101_F117_M0.7341.00
22_D30_W0.7341.00
22_D27_K0.7321.00
103_D149_L0.7321.00
105_K114_A0.7301.00
38_I60_L0.7251.00
212_W220_W0.7181.00
169_F185_V0.7151.00
80_N87_Q0.7151.00
30_W38_I0.7101.00
21_Y43_L0.6981.00
101_F115_G0.6981.00
126_G149_L0.6971.00
207_I228_L0.6951.00
101_F104_G0.6931.00
104_G113_W0.6931.00
185_V189_F0.6921.00
42_D46_G0.6911.00
192_E218_S0.6911.00
20_V30_W0.6861.00
70_A79_V0.6841.00
201_V208_W0.6751.00
106_C151_W0.6741.00
163_S169_F0.6731.00
40_V62_V0.6691.00
29_F43_L0.6681.00
247_E250_Q0.6661.00
107_D110_G0.6651.00
172_D184_R0.6631.00
92_V115_G0.6631.00
201_V222_P0.6601.00
151_W201_V0.6571.00
22_D66_K0.6521.00
107_D114_A0.6501.00
113_W131_L0.6501.00
28_L40_V0.6471.00
59_S103_D0.6471.00
112_Y128_F0.6441.00
42_D47_T0.6441.00
22_D26_N0.6441.00
78_I90_A0.6421.00
163_S171_F0.6421.00
154_D205_G0.6381.00
204_E207_I0.6341.00
53_M77_Y0.6331.00
27_K44_N0.6321.00
149_L159_F0.6321.00
20_V62_V0.6251.00
196_P199_M0.6251.00
171_F185_V0.6241.00
183_R186_A0.6211.00
221_N228_L0.6191.00
142_G171_F0.6191.00
43_L46_G0.6181.00
16_G41_N0.6151.00
183_R187_V0.6141.00
215_G237_Y0.6131.00
63_I69_I0.6121.00
206_Y223_K0.6121.00
162_D166_R0.6091.00
182_N185_V0.6061.00
99_N117_M0.6061.00
125_T138_K0.6051.00
196_P210_A0.6021.00
58_S72_I0.5991.00
150_G201_V0.5991.00
192_E220_W0.5961.00
186_A189_F0.5961.00
57_I60_L0.5931.00
78_I106_C0.5911.00
152_D160_L0.5861.00
60_L69_I0.5861.00
130_K134_G0.5841.00
18_G60_L0.5821.00
28_L32_D0.5801.00
146_S161_I0.5781.00
160_L168_V0.5781.00
148_G196_P0.5751.00
126_G159_F0.5751.00
111_R130_K0.5751.00
112_Y116_T0.5751.00
67_R82_D0.5741.00
238_V253_I0.5711.00
114_A126_G0.5711.00
196_P214_G0.5661.00
253_I257_G0.5651.00
238_V241_V0.5631.00
58_S102_N0.5611.00
116_T126_G0.5611.00
168_V196_P0.5601.00
62_V69_I0.5571.00
118_N145_V0.5561.00
184_R187_V0.5551.00
53_M73_R0.5551.00
166_R195_N0.5541.00
81_L84_G0.5511.00
100_R118_N0.5511.00
222_P225_G0.5511.00
63_I68_V0.5460.99
16_G33_I0.5460.99
102_N145_V0.5450.99
55_D73_R0.5440.99
16_G31_V0.5440.99
30_W68_V0.5430.99
150_G160_L0.5410.99
246_Q249_D0.5390.99
141_E169_F0.5390.99
52_E77_Y0.5390.99
217_V238_V0.5370.99
36_K56_L0.5360.99
92_V129_Y0.5350.99
60_L71_T0.5340.99
221_N226_K0.5340.99
72_I75_G0.5340.99
63_I110_G0.5310.99
154_D158_M0.5310.99
112_Y151_W0.5300.99
92_V127_S0.5290.99
126_G139_I0.5240.99
128_F151_W0.5240.99
128_F137_T0.5220.99
32_D60_L0.5220.99
167_K188_D0.5210.99
52_E79_V0.5180.99
62_V106_C0.5160.99
55_D72_I0.5140.99
80_N84_G0.5140.99
112_Y136_I0.5140.99
103_D148_G0.5110.99
76_F113_W0.5090.99
16_G35_G0.5070.99
197_D239_T0.5070.99
239_T242_T0.5060.99
144_T164_P0.5030.99
16_G19_P0.5030.99
93_E129_Y0.5010.99
57_I71_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vyhC 1 0.8632 100 0.195 Contact Map
4wjuA 1 0.8632 100 0.218 Contact Map
4j73A 1 0.9228 100 0.22 Contact Map
4u1eI 1 0.9123 100 0.221 Contact Map
1gotB 1 0.8632 100 0.225 Contact Map
3sfzA 1 0.9404 100 0.225 Contact Map
3ow8A 3 0.8702 100 0.226 Contact Map
3dm0A 1 0.9123 100 0.23 Contact Map
3j60g 1 0.9053 100 0.237 Contact Map
5a1uD 1 0.9088 100 0.239 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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