GREMLIN Database
Q97VC5 - Hydrogenase expression/formation factor related protein
UniProt: Q97VC5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 341 (294)
Sequences: 14884 (9641)
Seq/√Len: 562.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_S299_I3.4151.00
244_R304_V3.1681.00
244_R302_E3.0731.00
158_V305_D2.7071.00
160_D218_H2.5991.00
246_Y249_R2.5871.00
280_T286_V2.5361.00
163_I299_I2.4761.00
161_S302_E2.4691.00
63_K111_E2.3801.00
48_V82_I2.3751.00
63_K104_E2.3431.00
104_E107_I2.3251.00
218_H281_D2.2921.00
236_A243_M2.2801.00
241_K303_I2.2261.00
162_V279_V2.2111.00
110_H114_K2.1651.00
232_L243_M2.1021.00
242_G304_V2.0711.00
163_I287_R2.0671.00
163_I297_A2.0541.00
63_K107_I2.0241.00
232_L245_I1.9571.00
40_D147_K1.9301.00
271_I274_G1.9301.00
62_F135_M1.9041.00
287_R297_A1.8961.00
163_I280_T1.8831.00
161_S282_K1.8761.00
77_V82_I1.8731.00
242_G306_Q1.8551.00
67_W112_A1.8121.00
50_K141_M1.8051.00
73_L141_M1.7841.00
158_V241_K1.7821.00
85_E144_I1.7711.00
162_V243_M1.7631.00
244_R311_T1.7541.00
282_K302_E1.7481.00
111_E114_K1.6921.00
235_V279_V1.6921.00
284_E288_N1.6351.00
38_A48_V1.6121.00
285_E288_N1.6091.00
49_V88_V1.6031.00
218_H279_V1.5971.00
299_I302_E1.5971.00
156_V219_M1.5971.00
21_E114_K1.5841.00
46_V147_K1.5801.00
111_E115_E1.5641.00
160_D281_D1.5501.00
45_R146_E1.5491.00
45_R144_I1.5261.00
44_G147_K1.5221.00
198_N202_K1.5161.00
157_K218_H1.5091.00
243_M303_I1.5051.00
157_K281_D1.5031.00
107_I111_E1.4991.00
14_V103_E1.4911.00
288_N292_R1.4901.00
220_M278_I1.4761.00
64_K201_W1.4321.00
156_V303_I1.4171.00
219_M235_V1.4161.00
290_L297_A1.4131.00
91_L102_F1.4121.00
151_G220_M1.4101.00
211_I215_I1.4051.00
270_S273_E1.4011.00
92_N128_Y1.3961.00
89_I109_I1.3951.00
112_A115_E1.3931.00
77_V141_M1.3881.00
44_G148_E1.3821.00
156_V279_V1.3661.00
64_K67_W1.3581.00
284_E287_R1.3511.00
83_P210_L1.3371.00
287_R291_I1.3361.00
167_G170_I1.3341.00
170_I253_N1.3291.00
37_G121_V1.3291.00
268_W273_E1.3131.00
88_V122_G1.3121.00
215_I285_E1.3111.00
36_T80_S1.3101.00
46_V150_L1.3081.00
170_I178_N1.3051.00
232_L277_I1.3031.00
279_V303_I1.3011.00
223_A277_I1.2991.00
27_V46_V1.2991.00
215_I289_T1.2971.00
289_T293_E1.2951.00
287_R299_I1.2931.00
49_V142_F1.2811.00
64_K108_G1.2801.00
86_Y121_V1.2781.00
160_D303_I1.2761.00
53_P138_G1.2731.00
242_G307_S1.2681.00
209_G213_S1.2631.00
145_G150_L1.2521.00
26_V29_G1.2471.00
70_V87_A1.2461.00
189_S192_I1.2441.00
79_T220_M1.2431.00
210_L213_S1.2371.00
163_I286_V1.2371.00
246_Y302_E1.2281.00
285_E289_T1.2281.00
70_V109_I1.2211.00
270_S274_G1.2211.00
42_Q144_I1.2161.00
22_R26_V1.2121.00
51_T90_D1.2021.00
162_V277_I1.2021.00
51_T140_T1.1911.00
69_A137_G1.1871.00
188_L191_E1.1841.00
23_R26_V1.1841.00
223_A231_A1.1611.00
220_M276_M1.1531.00
62_F101_E1.1451.00
196_A200_Y1.1441.00
113_L120_V1.1441.00
36_T48_V1.1421.00
98_K101_E1.1311.00
288_N291_I1.1281.00
161_S280_T1.1271.00
67_W115_E1.1261.00
165_T208_D1.1191.00
289_T292_R1.1101.00
187_R190_N1.1081.00
46_V145_G1.1021.00
38_A150_L1.1001.00
128_Y136_V1.0961.00
18_H107_I1.0881.00
88_V140_T1.0821.00
71_H112_A1.0751.00
208_D290_L1.0691.00
212_A286_V1.0641.00
50_K77_V1.0641.00
207_K210_L1.0471.00
286_V289_T1.0391.00
87_A141_M1.0371.00
61_G64_K1.0341.00
155_K218_H1.0291.00
269_I274_G1.0281.00
74_A141_M1.0281.00
93_L102_F1.0271.00
188_L192_I1.0261.00
74_A118_V1.0251.00
23_R27_V1.0221.00
219_M279_V1.0161.00
206_W210_L1.0101.00
146_E149_R1.0101.00
149_R216_G0.9981.00
115_E203_M0.9941.00
53_P90_D0.9911.00
49_V140_T0.9911.00
221_H234_E0.9901.00
192_I195_E0.9761.00
13_K17_P0.9761.00
306_Q310_V0.9721.00
156_V235_V0.9721.00
41_L144_I0.9691.00
152_M156_V0.9621.00
70_V113_L0.9611.00
42_Q45_R0.9571.00
199_M202_K0.9551.00
198_N201_W0.9491.00
149_R213_S0.9461.00
48_V77_V0.9451.00
34_V80_S0.9411.00
160_D279_V0.9351.00
252_I257_R0.9341.00
286_V290_L0.9221.00
152_M155_K0.9211.00
228_V277_I0.9161.00
66_A108_G0.9161.00
193_F196_A0.8961.00
193_F201_W0.8931.00
158_V161_S0.8921.00
24_K28_V0.8921.00
191_E194_N0.8911.00
251_F298_E0.8911.00
232_L236_A0.8891.00
203_M206_W0.8891.00
86_Y142_F0.8891.00
86_Y119_M0.8871.00
70_V74_A0.8871.00
109_I139_F0.8851.00
221_H277_I0.8841.00
187_R191_E0.8841.00
157_K160_D0.8821.00
78_M206_W0.8821.00
83_P213_S0.8811.00
87_A139_F0.8751.00
244_R247_E0.8711.00
211_I292_R0.8701.00
93_L105_M0.8701.00
67_W71_H0.8691.00
67_W111_E0.8671.00
15_I19_L0.8601.00
83_P117_G0.8551.00
48_V145_G0.8541.00
278_I286_V0.8521.00
159_G302_E0.8521.00
12_N16_Y0.8521.00
214_R289_T0.8511.00
53_P92_N0.8451.00
257_R261_K0.8421.00
149_R214_R0.8421.00
269_I272_S0.8371.00
74_A112_A0.8361.00
165_T276_M0.8331.00
61_G197_Y0.8301.00
22_R27_V0.8251.00
267_P270_S0.8231.00
40_D44_G0.8221.00
158_V304_V0.8211.00
228_V232_L0.8201.00
236_A310_V0.8201.00
200_Y204_S0.8161.00
176_L179_L0.8161.00
66_A105_M0.8151.00
40_D46_V0.8151.00
210_L214_R0.8131.00
35_D221_H0.8131.00
105_M109_I0.8121.00
308_G311_T0.8121.00
113_L118_V0.8081.00
27_V40_D0.8031.00
25_E28_V0.8031.00
236_A303_I0.8021.00
269_I273_E0.8021.00
24_K29_G0.8001.00
39_I86_Y0.7991.00
242_G308_G0.7961.00
174_G179_L0.7911.00
102_F127_V0.7891.00
70_V112_A0.7881.00
13_K16_Y0.7881.00
199_M203_M0.7861.00
38_A80_S0.7861.00
24_K27_V0.7821.00
69_A139_F0.7781.00
90_D138_G0.7761.00
87_A109_I0.7761.00
101_E105_M0.7731.00
38_A46_V0.7701.00
151_G217_I0.7681.00
95_P127_V0.7671.00
206_W209_G0.7661.00
208_D211_I0.7651.00
258_E261_K0.7611.00
59_Q134_P0.7571.00
68_F273_E0.7561.00
24_K83_P0.7561.00
178_N181_P0.7531.00
171_E272_S0.7501.00
78_M210_L0.7471.00
87_A113_L0.7441.00
211_I293_E0.7431.00
168_P171_E0.7431.00
54_V72_I0.7421.00
179_L182_E0.7381.00
12_N15_I0.7371.00
54_V69_A0.7361.00
79_T276_M0.7351.00
116_I203_M0.7341.00
99_D103_E0.7331.00
197_Y201_W0.7271.00
240_S306_Q0.7231.00
156_V239_S0.7231.00
92_N126_G0.7171.00
306_Q311_T0.7151.00
197_Y200_Y0.7141.00
194_N197_Y0.7141.00
177_T180_Y0.7131.00
192_I196_A0.7121.00
91_L137_G0.7121.00
187_R192_I0.7101.00
268_W274_G0.7071.00
231_A277_I0.7031.00
28_V152_M0.7011.00
190_N194_N0.7011.00
16_Y19_L0.7001.00
83_P144_I0.6981.00
223_A228_V0.6981.00
162_V303_I0.6971.00
174_G177_T0.6941.00
230_G234_E0.6921.00
213_S216_G0.6891.00
176_L180_Y0.6881.00
58_P131_T0.6861.00
193_F197_Y0.6821.00
242_G311_T0.6821.00
46_V148_E0.6801.00
193_F198_N0.6801.00
25_E40_D0.6801.00
66_A109_I0.6791.00
291_I296_E0.6791.00
260_T267_P0.6791.00
57_V68_F0.6771.00
103_E107_I0.6751.00
61_G104_E0.6751.00
268_W271_I0.6741.00
305_D308_G0.6741.00
223_A275_T0.6741.00
267_P271_I0.6731.00
92_N136_V0.6691.00
171_E199_M0.6691.00
207_K211_I0.6681.00
22_R25_E0.6651.00
82_I145_G0.6611.00
155_K162_V0.6611.00
88_V121_V0.6561.00
96_R99_D0.6561.00
173_T180_Y0.6541.00
164_M168_P0.6531.00
51_T88_V0.6531.00
97_I102_F0.6531.00
230_G269_I0.6521.00
14_V18_H0.6521.00
63_K108_G0.6511.00
165_T290_L0.6501.00
15_I18_H0.6491.00
26_V119_M0.6421.00
196_A199_M0.6421.00
265_I270_S0.6421.00
165_T278_I0.6411.00
258_E262_L0.6401.00
266_D269_I0.6391.00
204_S207_K0.6391.00
272_S275_T0.6391.00
163_I278_I0.6381.00
23_R29_G0.6361.00
105_M137_G0.6361.00
208_D212_A0.6341.00
101_E104_E0.6321.00
284_E299_I0.6311.00
41_L45_R0.6301.00
128_Y132_D0.6301.00
129_E134_P0.6281.00
160_D282_K0.6281.00
212_A216_G0.6261.00
87_A120_V0.6251.00
74_A116_I0.6241.00
34_V153_P0.6241.00
249_R298_E0.6231.00
18_H21_E0.6231.00
167_G296_E0.6231.00
50_K73_L0.6221.00
109_I137_G0.6211.00
190_N193_F0.6201.00
222_D234_E0.6201.00
76_D222_D0.6171.00
236_A239_S0.6161.00
40_D43_D0.6151.00
51_T138_G0.6121.00
23_R28_V0.6121.00
89_I106_W0.6111.00
266_D270_S0.6091.00
284_E291_I0.6051.00
153_P238_A0.6031.00
251_F257_R0.6021.00
100_E104_E0.6011.00
36_T50_K0.5991.00
211_I289_T0.5981.00
39_I49_V0.5931.00
12_N18_H0.5931.00
166_K296_E0.5921.00
209_G276_M0.5891.00
58_P105_M0.5821.00
162_V245_I0.5811.00
247_E312_M0.5801.00
161_S283_G0.5801.00
195_E198_N0.5791.00
83_P207_K0.5771.00
206_W211_I0.5761.00
173_T176_L0.5761.00
49_V86_Y0.5740.99
229_F312_M0.5700.99
164_M223_A0.5700.99
236_A241_K0.5690.99
62_F104_E0.5680.99
212_A215_I0.5680.99
172_A177_T0.5670.99
247_E268_W0.5670.99
264_N267_P0.5660.99
67_W201_W0.5630.99
209_G278_I0.5610.99
56_I134_P0.5610.99
207_K293_E0.5590.99
241_K305_D0.5590.99
166_K298_E0.5580.99
93_L101_E0.5560.99
164_M251_F0.5550.99
230_G233_T0.5530.99
18_H103_E0.5530.99
280_T283_G0.5520.99
221_H235_V0.5520.99
200_Y203_M0.5510.99
65_A105_M0.5510.99
22_R28_V0.5490.99
12_N19_L0.5480.99
52_D76_D0.5480.99
156_V218_H0.5470.99
23_R119_M0.5470.99
304_V307_S0.5450.99
107_I110_H0.5450.99
257_R260_T0.5450.99
151_G213_S0.5420.99
73_L139_F0.5400.99
167_G253_N0.5400.99
268_W272_S0.5340.99
71_H204_S0.5310.99
175_L180_Y0.5290.99
35_D222_D0.5290.99
177_T181_P0.5290.99
209_G212_A0.5280.99
108_G112_A0.5240.99
161_S164_M0.5230.99
97_I101_E0.5200.99
109_I112_A0.5180.99
26_V39_I0.5180.99
113_L139_F0.5150.99
14_V17_P0.5140.99
171_E174_G0.5110.99
146_E213_S0.5060.99
251_F254_R0.5060.99
131_T134_P0.5060.99
249_R299_I0.5050.99
254_R257_R0.5040.99
170_I198_N0.5030.99
101_E133_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mcqA 2 0.8592 100 0.281 Contact Map
3c9uA 2 0.8739 100 0.293 Contact Map
2yxzA 2 0.8622 100 0.306 Contact Map
3vtiC 2 0.871 100 0.311 Contact Map
3wjpA 2 0.9326 100 0.312 Contact Map
2z1uA 2 0.912 100 0.318 Contact Map
2rb9A 2 0.915 100 0.326 Contact Map
2z01A 2 0.8475 100 0.33 Contact Map
3fd5A 2 0.9062 100 0.33 Contact Map
2btuA 2 0.8798 100 0.332 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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