GREMLIN Database
Q97VC4 - Uncharacterized protein
UniProt: Q97VC4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 302 (246)
Sequences: 32155 (28355)
Seq/√Len: 1807.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_R225_E3.4991.00
188_K191_Q3.3571.00
125_D128_K3.3131.00
87_L90_R3.2301.00
158_K161_E3.2261.00
46_K49_R3.2171.00
210_Y229_T2.9141.00
146_H165_E2.6291.00
34_Y53_N2.6081.00
214_A230_I2.4451.00
150_G166_Y2.3761.00
117_A133_V2.3641.00
113_Y132_K2.3421.00
176_L195_Y2.3231.00
180_A196_F2.2641.00
197_N213_K2.1661.00
213_K229_T2.1481.00
38_G54_L2.1341.00
244_K262_V2.0951.00
217_L229_T2.0221.00
153_L165_E2.0201.00
134_N149_R2.0171.00
120_L132_K2.0131.00
116_M132_K2.0101.00
21_K37_M2.0031.00
179_I195_Y1.9981.00
37_M53_N1.9781.00
149_R165_E1.9141.00
217_L225_E1.9091.00
20_I36_L1.8871.00
231_K247_E1.8031.00
68_H94_E1.7941.00
133_V148_L1.7791.00
41_Y49_R1.7771.00
167_K179_I1.7671.00
41_Y53_N1.7641.00
96_Q116_M1.7481.00
193_L197_N1.7441.00
153_L161_E1.7231.00
183_Y195_Y1.7211.00
120_L128_K1.7201.00
183_Y191_Q1.7081.00
92_L96_Q1.6781.00
248_V263_L1.6581.00
95_L115_Y1.6481.00
227_Y231_K1.6481.00
196_F212_G1.6131.00
163_I167_K1.6051.00
166_Y178_A1.5081.00
130_L153_L1.5031.00
55_R71_L1.4941.00
120_L125_D1.4781.00
130_L134_N1.4681.00
230_I246_T1.4661.00
51_I55_R1.4361.00
17_L21_K1.4101.00
193_L220_M1.3931.00
251_L262_V1.3881.00
113_Y135_K1.3861.00
183_Y188_K1.3701.00
37_M41_Y1.3621.00
193_L217_L1.3561.00
92_L120_L1.3461.00
213_K217_L1.3421.00
153_L158_K1.3411.00
130_L156_L1.2911.00
210_Y232_R1.2731.00
136_A145_V1.2681.00
17_L41_Y1.2661.00
116_M120_L1.2631.00
146_H168_T1.2611.00
161_E164_E1.2481.00
41_Y46_K1.2391.00
227_Y251_L1.2381.00
233_A243_I1.2331.00
199_A209_Y1.2181.00
179_I183_Y1.2171.00
177_Y212_G1.2151.00
247_E262_V1.2091.00
247_E251_L1.1901.00
215_E246_T1.1871.00
217_L222_R1.1591.00
251_L258_E1.1581.00
54_L70_L1.1541.00
72_G95_L1.1481.00
98_S112_Y1.1281.00
71_L75_L1.1261.00
227_Y254_T1.1231.00
218_L246_T1.1221.00
163_I186_M1.1201.00
137_L146_H1.1171.00
176_L198_K1.1101.00
181_Y212_G1.0901.00
232_R235_E1.0801.00
92_L123_L1.0741.00
23_E33_L1.0731.00
193_L216_T1.0701.00
163_I183_Y1.0591.00
117_A136_A1.0591.00
17_L44_I1.0581.00
149_R153_L1.0571.00
71_L94_E1.0571.00
130_L149_R1.0531.00
163_I179_I1.0511.00
251_L256_E1.0491.00
35_Y39_L1.0491.00
64_E67_Y1.0491.00
118_N148_L1.0441.00
211_Q246_T1.0411.00
128_K131_E1.0411.00
75_L94_E1.0411.00
170_L176_L1.0251.00
232_R236_I1.0231.00
206_D209_Y1.0231.00
200_I210_Y1.0201.00
245_L249_E1.0161.00
114_Y145_V1.0121.00
99_L113_Y1.0031.00
147_K178_A0.9991.00
234_L244_K0.9991.00
34_Y56_K0.9981.00
92_L116_M0.9971.00
260_I264_T0.9881.00
56_K60_L0.9861.00
130_L152_I0.9781.00
184_F216_T0.9781.00
193_L213_K0.9771.00
214_A233_A0.9761.00
165_E168_T0.9751.00
191_Q194_E0.9681.00
151_D178_A0.9671.00
114_Y148_L0.9651.00
237_D240_N0.9621.00
215_E219_F0.9541.00
211_Q215_E0.9541.00
248_V259_A0.9481.00
207_P233_A0.9481.00
180_A199_A0.9481.00
146_H169_N0.9471.00
225_E228_N0.9401.00
211_Q243_I0.9391.00
132_K135_K0.9361.00
69_C72_G0.9341.00
30_D33_L0.9341.00
135_K139_I0.9341.00
150_G162_A0.9331.00
218_L230_I0.9331.00
203_N206_D0.9331.00
143_S169_N0.9311.00
184_F212_G0.9301.00
159_Y182_T0.9281.00
137_L149_R0.9191.00
24_I34_Y0.9161.00
229_T232_R0.9121.00
244_K265_E0.9031.00
117_A129_A0.9021.00
245_L248_V0.9001.00
127_E156_L0.8971.00
38_G50_A0.8951.00
126_Y156_L0.8911.00
198_K202_A0.8871.00
150_G169_N0.8841.00
110_K136_A0.8831.00
137_L145_V0.8791.00
177_Y181_Y0.8771.00
19_R22_E0.8751.00
88_I119_I0.8731.00
49_R52_D0.8681.00
27_K30_D0.8661.00
17_L37_M0.8661.00
168_T171_N0.8651.00
31_P57_A0.8651.00
102_D109_E0.8641.00
90_R93_K0.8591.00
240_N243_I0.8561.00
14_N44_I0.8551.00
126_Y152_I0.8541.00
227_Y247_E0.8521.00
184_F219_F0.8511.00
212_G215_E0.8491.00
113_Y136_A0.8421.00
207_P237_D0.8361.00
176_L199_A0.8351.00
40_V44_I0.8321.00
51_I75_L0.8311.00
73_Y77_M0.8311.00
70_L73_Y0.8301.00
89_R123_L0.8281.00
163_I182_T0.8241.00
51_I78_E0.8201.00
98_S101_M0.8181.00
113_Y139_I0.8171.00
94_E97_L0.8171.00
246_T249_E0.8161.00
147_K151_D0.8151.00
198_K201_S0.8151.00
182_T186_M0.8121.00
210_Y233_A0.8101.00
195_Y198_K0.8101.00
121_Y148_L0.8101.00
163_I188_K0.8091.00
224_N254_T0.8061.00
252_T259_A0.8051.00
152_I156_L0.8051.00
75_L90_R0.8021.00
56_K59_R0.8011.00
218_L253_E0.8001.00
189_Y216_T0.7991.00
218_L226_A0.7981.00
216_T220_M0.7971.00
135_K138_E0.7951.00
214_A226_A0.7941.00
58_I68_H0.7941.00
252_T263_L0.7891.00
38_G57_A0.7881.00
227_Y250_I0.7851.00
200_I209_Y0.7801.00
190_D220_M0.7751.00
109_E112_Y0.7731.00
160_N186_M0.7701.00
36_L39_L0.7691.00
223_T253_E0.7691.00
177_Y209_Y0.7671.00
39_L70_L0.7631.00
180_A192_A0.7631.00
154_F182_T0.7621.00
258_E261_K0.7601.00
74_S78_E0.7601.00
15_E18_K0.7501.00
115_Y118_N0.7481.00
181_Y184_F0.7481.00
97_L101_M0.7451.00
121_Y152_I0.7441.00
119_I123_L0.7391.00
35_Y67_Y0.7321.00
215_E218_L0.7321.00
69_C73_Y0.7281.00
114_Y118_N0.7261.00
42_F70_L0.7251.00
53_N56_K0.7221.00
42_F50_A0.7201.00
176_L202_A0.7191.00
263_L267_L0.7181.00
223_T250_I0.7171.00
151_D154_F0.7141.00
250_I254_T0.7061.00
210_Y236_I0.7051.00
121_Y155_Q0.7031.00
130_L158_K0.7021.00
148_L151_D0.6981.00
199_A202_A0.6971.00
159_Y163_I0.6971.00
99_L116_M0.6961.00
159_Y185_T0.6951.00
223_T254_T0.6951.00
39_L43_K0.6941.00
17_L40_V0.6931.00
181_Y185_T0.6921.00
151_D155_Q0.6901.00
61_K64_E0.6881.00
99_L112_Y0.6871.00
93_K97_L0.6841.00
248_V266_Y0.6821.00
51_I74_S0.6791.00
16_A20_I0.6731.00
261_K265_E0.6731.00
57_A67_Y0.6701.00
34_Y57_A0.6691.00
189_Y220_M0.6671.00
194_E198_K0.6661.00
24_I33_L0.6611.00
31_P61_K0.6591.00
164_E168_T0.6581.00
154_F178_A0.6561.00
103_K109_E0.6541.00
114_Y136_A0.6511.00
154_F162_A0.6501.00
126_Y130_L0.6481.00
55_R59_R0.6451.00
35_Y70_L0.6431.00
92_L119_I0.6431.00
225_E229_T0.6391.00
126_Y155_Q0.6371.00
97_L100_E0.6341.00
13_Y40_V0.6321.00
47_Y51_I0.6311.00
189_Y219_F0.6301.00
184_F189_Y0.6241.00
178_A181_Y0.6231.00
23_E26_Q0.6231.00
131_E135_K0.6221.00
211_Q240_N0.6171.00
218_L223_T0.6161.00
57_A60_L0.6151.00
231_K235_E0.6141.00
196_F216_T0.6111.00
248_V252_T0.6101.00
76_Y115_Y0.6081.00
262_V265_E0.6071.00
234_L243_I0.6071.00
226_A250_I0.6061.00
162_A182_T0.6021.00
170_L179_I0.6021.00
19_R23_E0.6011.00
48_R78_E0.5971.00
42_F47_Y0.5961.00
189_Y193_L0.5961.00
228_N232_R0.5941.00
211_Q233_A0.5931.00
154_F185_T0.5911.00
260_I263_L0.5901.00
193_L222_R0.5901.00
234_L247_E0.5891.00
68_H97_L0.5871.00
42_F54_L0.5851.00
34_Y60_L0.5841.00
168_T172_D0.5811.00
110_K114_Y0.5811.00
230_I250_I0.5791.00
91_A95_L0.5781.00
118_N121_Y0.5761.00
35_Y64_E0.5741.00
75_L87_L0.5741.00
90_R94_E0.5681.00
184_F196_F0.5661.00
78_E87_L0.5621.00
154_F159_Y0.5601.00
161_E165_E0.5571.00
20_I24_I0.5551.00
35_Y57_A0.5541.00
24_I37_M0.5541.00
121_Y126_Y0.5531.00
128_K132_K0.5521.00
159_Y186_M0.5511.00
95_L119_I0.5501.00
227_Y256_E0.5491.00
197_N217_L0.5491.00
264_T267_L0.5461.00
18_K22_E0.5461.00
49_R53_N0.5421.00
118_N122_E0.5411.00
167_K171_N0.5391.00
132_K136_A0.5371.00
218_L250_I0.5321.00
262_V266_Y0.5321.00
13_Y43_K0.5321.00
233_A236_I0.5311.00
20_I37_M0.5311.00
244_K266_Y0.5291.00
136_A139_I0.5271.00
217_L220_M0.5271.00
98_S102_D0.5221.00
257_K260_I0.5211.00
22_E26_Q0.5211.00
134_N137_L0.5171.00
22_E25_E0.5161.00
207_P211_Q0.5161.00
92_L125_D0.5161.00
13_Y44_I0.5151.00
96_Q100_E0.5151.00
169_N172_D0.5111.00
151_D166_Y0.5091.00
20_I23_E0.5091.00
200_I213_K0.5071.00
191_Q195_Y0.5061.00
121_Y129_A0.5041.00
134_N153_L0.5041.00
224_N227_Y0.5011.00
51_I71_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w3bA 2 0.9636 100 0.209 Contact Map
2xpiA 2 0.9073 100 0.236 Contact Map
4ui9J 2 0.9338 100 0.244 Contact Map
4ui9C 2 0.9106 100 0.246 Contact Map
4l9pA 1 0.8113 100 0.246 Contact Map
3dssA 1 0.8377 100 0.247 Contact Map
4rg9A 2 0.7252 100 0.252 Contact Map
4eqfA 1 0.8278 100 0.257 Contact Map
4kvmA 3 0.9636 100 0.261 Contact Map
1fchA 3 0.8808 100 0.261 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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