GREMLIN Database
Q97VC1 - ABC transporter, ATP binding protein
UniProt: Q97VC1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (241)
Sequences: 57033 (34689)
Seq/√Len: 2234.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_E201_R3.7581.00
74_D151_K3.0401.00
3_T23_N3.0031.00
30_F203_G2.9141.00
6_E19_S2.9101.00
15_K18_D2.8891.00
5_K57_K2.8631.00
31_V199_A2.8531.00
124_L127_K2.5911.00
57_K64_D2.5761.00
9_K46_L2.5721.00
10_F15_K2.4771.00
61_S151_K2.4431.00
25_E28_E2.3771.00
215_I218_D2.3671.00
3_T59_L2.3291.00
201_R213_V2.3121.00
8_T55_S2.2761.00
203_G210_L2.2441.00
214_G218_D2.1511.00
104_N107_D2.1231.00
18_D209_R2.0531.00
5_K59_L2.0151.00
8_T15_K1.9471.00
4_L7_V1.9421.00
8_T19_S1.9411.00
113_I125_M1.9291.00
196_L217_E1.9131.00
26_K151_K1.8691.00
111_R114_E1.8541.00
111_R149_R1.8291.00
203_G213_V1.7621.00
11_F42_T1.7391.00
44_L154_L1.7191.00
44_L188_V1.6851.00
127_K131_Q1.6751.00
177_V183_I1.6641.00
91_F126_D1.6281.00
91_F125_M1.6251.00
114_E118_Q1.5941.00
214_G219_I1.5771.00
64_D67_D1.5741.00
9_K51_E1.5701.00
11_F16_V1.5671.00
31_V195_A1.5541.00
115_I147_V1.5541.00
189_T195_A1.5371.00
175_K197_A1.5181.00
109_E113_I1.5181.00
9_K54_S1.5121.00
95_M112_I1.4631.00
91_F95_M1.4621.00
7_V53_V1.4501.00
61_S74_D1.4491.00
6_E21_S1.4221.00
218_D222_N1.3951.00
89_K92_E1.3941.00
8_T18_D1.3931.00
175_K178_Q1.3791.00
88_K92_E1.3701.00
116_S125_M1.3691.00
4_L22_L1.3671.00
22_L203_G1.3531.00
95_M108_K1.3501.00
94_L116_S1.3461.00
155_M185_T1.3411.00
10_F54_S1.3231.00
124_L132_L1.3191.00
24_V30_F1.3081.00
20_I43_L1.2931.00
59_L64_D1.2931.00
29_F178_Q1.2921.00
4_L47_I1.2821.00
99_E108_K1.2651.00
30_F213_V1.2641.00
149_R183_I1.2561.00
91_F109_E1.2401.00
28_E200_D1.2391.00
110_E114_E1.2211.00
211_L225_S1.1921.00
22_L43_L1.1911.00
89_K126_D1.1831.00
117_K122_Y1.1711.00
105_K108_K1.1701.00
63_E68_L1.1621.00
206_D211_L1.1591.00
29_F185_T1.1571.00
113_I117_K1.1571.00
226_K230_S1.1501.00
30_F201_R1.1491.00
171_R194_E1.1461.00
25_E201_R1.1451.00
91_F112_I1.1431.00
106_K110_E1.1431.00
26_K61_S1.1381.00
49_G52_K1.1351.00
48_A77_M1.1261.00
78_V155_M1.1251.00
46_L53_V1.1241.00
5_K23_N1.1081.00
5_K21_S1.1041.00
109_E125_M1.1031.00
216_P220_Y1.1001.00
178_Q185_T1.1001.00
226_K229_A1.0981.00
51_E54_S1.0941.00
93_N144_K1.0871.00
217_E221_N1.0871.00
95_M99_E1.0851.00
32_I186_I1.0791.00
107_D110_E1.0741.00
229_A233_G1.0591.00
17_I46_L1.0541.00
45_R50_L1.0501.00
103_I107_D1.0471.00
119_L143_A1.0441.00
90_V132_L1.0311.00
178_Q200_D1.0271.00
132_L140_V1.0241.00
26_K182_N1.0171.00
76_G145_A1.0121.00
202_I216_P1.0121.00
92_E95_M1.0121.00
45_R51_E0.9951.00
218_D221_N0.9941.00
111_R115_I0.9921.00
113_I121_I0.9921.00
95_M109_E0.9861.00
114_E117_K0.9851.00
174_I185_T0.9801.00
89_K128_Y0.9791.00
87_N130_A0.9771.00
162_L170_A0.9761.00
115_I118_Q0.9741.00
94_L147_V0.9711.00
29_F199_A0.9611.00
120_E169_S0.9571.00
206_D230_S0.9521.00
128_Y131_Q0.9451.00
210_L213_V0.9421.00
47_I186_I0.9411.00
6_E55_S0.9401.00
173_L176_K0.9371.00
88_K93_N0.9321.00
228_V232_V0.9241.00
167_R191_D0.9221.00
98_L147_V0.9221.00
91_F113_I0.9171.00
103_I108_K0.9111.00
38_S205_I0.9101.00
25_E184_T0.9101.00
115_I143_A0.9071.00
96_I100_N0.8961.00
97_A100_N0.8921.00
220_Y223_P0.8911.00
10_F18_D0.8891.00
118_Q176_K0.8881.00
76_G150_P0.8871.00
48_A154_L0.8841.00
171_R197_A0.8841.00
78_V142_I0.8751.00
104_N108_K0.8711.00
43_L205_I0.8701.00
32_I43_L0.8701.00
88_K96_I0.8651.00
153_L183_I0.8641.00
4_L43_L0.8601.00
17_I20_I0.8601.00
237_M240_V0.8561.00
9_K42_T0.8501.00
167_R194_E0.8461.00
90_V140_V0.8461.00
46_L51_E0.8421.00
32_I203_G0.8411.00
175_K198_I0.8391.00
78_V145_A0.8351.00
129_P140_V0.8331.00
168_Y172_K0.8321.00
24_V152_V0.8321.00
153_L185_T0.8311.00
120_E176_K0.8281.00
109_E112_I0.8271.00
7_V46_L0.8271.00
155_M174_I0.8271.00
187_Y199_A0.8221.00
24_V184_T0.8161.00
199_A202_I0.8141.00
204_V219_I0.8141.00
29_F175_K0.8141.00
2_I152_V0.8091.00
84_L137_Q0.8091.00
29_F198_I0.8011.00
4_L58_I0.8001.00
225_S228_V0.7991.00
157_E190_H0.7981.00
108_K112_I0.7961.00
73_R101_S0.7961.00
19_S55_S0.7961.00
201_R212_Q0.7931.00
113_I123_H0.7931.00
97_A148_K0.7871.00
172_K175_K0.7871.00
217_E220_Y0.7861.00
101_S111_R0.7841.00
216_P227_E0.7791.00
216_P219_I0.7731.00
187_Y198_I0.7701.00
46_L58_I0.7701.00
89_K93_N0.7651.00
57_K66_T0.7641.00
110_E113_I0.7641.00
115_I119_L0.7571.00
10_F13_S0.7561.00
239_F242_I0.7551.00
204_V223_P0.7541.00
85_Y88_K0.7511.00
97_A144_K0.7481.00
63_E74_D0.7431.00
152_V184_T0.7421.00
17_I43_L0.7421.00
98_L102_E0.7411.00
87_N92_E0.7401.00
99_E105_K0.7391.00
172_K197_A0.7321.00
112_I115_I0.7311.00
230_S234_N0.7301.00
107_D111_R0.7301.00
194_E198_I0.7271.00
105_K109_E0.7261.00
59_L62_N0.7211.00
235_P238_S0.7191.00
219_I223_P0.7181.00
117_K123_H0.7171.00
115_I146_L0.7171.00
20_I210_L0.7151.00
132_L136_Q0.7131.00
33_L195_A0.7131.00
65_V68_L0.7131.00
80_Q134_G0.7081.00
230_S233_G0.7081.00
30_F186_I0.7061.00
9_K17_I0.7031.00
154_L186_I0.7021.00
175_K179_K0.6981.00
206_D209_R0.6941.00
19_S209_R0.6941.00
75_I152_V0.6871.00
16_V42_T0.6851.00
124_L136_Q0.6831.00
109_E126_D0.6821.00
6_E9_K0.6791.00
24_V186_I0.6771.00
103_I111_R0.6761.00
93_N129_P0.6751.00
29_F187_Y0.6741.00
41_T45_R0.6741.00
151_K183_I0.6711.00
219_I228_V0.6681.00
159_L194_E0.6681.00
10_F16_V0.6641.00
84_L93_N0.6621.00
33_L204_V0.6591.00
10_F55_S0.6541.00
86_P130_A0.6421.00
101_S148_K0.6411.00
122_Y125_M0.6411.00
2_I47_I0.6401.00
57_K67_D0.6391.00
50_L79_F0.6371.00
48_A75_I0.6341.00
192_S220_Y0.6331.00
60_I74_D0.6331.00
27_G184_T0.6321.00
46_L54_S0.6321.00
35_K38_S0.6321.00
227_E231_L0.6301.00
94_L112_I0.6291.00
172_K176_K0.6281.00
112_I125_M0.6211.00
60_I65_V0.6211.00
45_R77_M0.6171.00
152_V186_I0.6151.00
159_L170_A0.6141.00
65_V75_I0.6131.00
2_I60_I0.6131.00
133_S136_Q0.6121.00
29_F200_D0.6101.00
199_A216_P0.6061.00
11_F51_E0.6061.00
207_K230_S0.6031.00
206_D225_S0.6011.00
35_K206_D0.6001.00
227_E230_S0.5981.00
98_L103_I0.5981.00
223_P228_V0.5981.00
47_I58_I0.5931.00
53_V66_T0.5911.00
228_V231_L0.5881.00
96_I99_E0.5861.00
98_L101_S0.5851.00
206_D227_E0.5841.00
65_V70_P0.5791.00
78_V138_Q0.5781.00
235_P239_F0.5771.00
76_G148_K0.5771.00
127_K132_L0.5741.00
196_L216_P0.5741.00
53_V58_I0.5731.00
58_I66_T0.5721.00
229_A232_V0.5691.00
195_A202_I0.5671.00
155_M187_Y0.5671.00
110_E117_K0.5661.00
222_N226_K0.5661.00
98_L108_K0.5641.00
84_L129_P0.5641.00
101_S108_K0.5611.00
95_M98_L0.5571.00
146_L183_I0.5561.00
178_Q183_I0.5551.00
3_T62_N0.5531.00
36_S157_E0.5521.00
164_V168_Y0.5491.00
111_R118_Q0.5471.00
27_G182_N0.5461.00
240_V243_D0.5451.00
23_N213_V0.5451.00
62_N65_V0.5431.00
116_S124_L0.5431.00
169_S172_K0.5411.00
121_I136_Q0.5371.00
121_I124_L0.5361.00
68_L71_S0.5361.00
7_V58_I0.5351.00
15_K19_S0.5341.00
66_T69_P0.5331.00
82_Y137_Q0.5321.00
64_D68_L0.5321.00
78_V141_A0.5321.00
14_F207_K0.5301.00
193_N197_A0.5291.00
138_Q161_N0.5281.00
91_F94_L0.5271.00
83_A86_P0.5261.00
212_Q222_N0.5241.00
195_A199_A0.5221.00
171_R187_Y0.5221.00
60_I152_V0.5211.00
224_L229_A0.5161.00
26_K184_T0.5151.00
116_S121_I0.5101.00
120_E123_H0.5091.00
90_V93_N0.5091.00
90_V94_L0.5081.00
32_I205_I0.5061.00
38_S207_K0.5051.00
218_D224_L0.5041.00
195_A216_P0.5041.00
82_Y141_A0.5021.00
189_T194_E0.5021.00
52_K66_T0.5011.00
232_V236_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2it1A 1 0.8949 100 0.213 Contact Map
1v43A 2 0.9459 100 0.213 Contact Map
2yyzA 1 0.965 100 0.213 Contact Map
1z47A 2 0.9968 100 0.215 Contact Map
3tuiC 2 0.914 100 0.216 Contact Map
1g291 4 0.9204 100 0.217 Contact Map
1oxxK 1 0.9586 100 0.217 Contact Map
4u00A 1 0.7516 100 0.218 Contact Map
4ry2A 2 0.7389 100 0.218 Contact Map
3rlfA 2 0.9777 100 0.219 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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