GREMLIN Database
Q97VB8 - Alcohol dehydrogenase (Zn containing) (Adh-11)
UniProt: Q97VB8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (286)
Sequences: 52717 (36934)
Seq/√Len: 2184.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_K125_L3.3711.00
293_N296_E3.1201.00
150_K173_E2.8501.00
124_D127_L2.6301.00
26_V116_V2.5991.00
146_K149_E2.5291.00
168_E193_R2.5261.00
18_D108_Y2.5001.00
289_G300_K2.4981.00
126_K288_V2.4871.00
156_G176_V2.4321.00
151_V167_A2.4221.00
29_F108_Y2.4101.00
29_F63_T2.3971.00
27_K63_T2.3361.00
287_K300_K2.3241.00
59_I104_G2.3121.00
206_V209_T2.2861.00
185_E189_E2.2581.00
288_V313_K2.2451.00
184_E188_K2.2451.00
142_N170_N2.2181.00
173_E194_T2.2161.00
95_I119_I2.2091.00
22_K25_E2.2011.00
272_K276_E2.1791.00
164_S192_F2.1711.00
122_T275_S2.1181.00
60_S125_L2.0931.00
27_K110_N2.0871.00
134_T162_L2.0201.00
169_I278_Q1.9541.00
299_R303_I1.9521.00
290_Y293_N1.9471.00
185_E188_K1.9421.00
152_I177_I1.9421.00
142_N269_N1.8981.00
231_E255_I1.8871.00
119_I125_L1.8711.00
184_E195_T1.8321.00
296_E299_R1.8281.00
178_E184_E1.8171.00
27_K64_E1.7991.00
44_L302_V1.7911.00
231_E257_R1.7641.00
300_K305_L1.7551.00
289_G297_W1.7491.00
296_E300_K1.7431.00
181_S185_E1.7191.00
186_I189_E1.7031.00
154_I222_I1.6861.00
127_L282_N1.6801.00
173_E193_R1.6661.00
149_E231_E1.6661.00
105_M298_F1.6541.00
27_K108_Y1.6311.00
126_K313_K1.6281.00
119_I128_G1.5931.00
226_S254_V1.5821.00
63_T108_Y1.5761.00
181_S197_E1.5691.00
181_S200_F1.5571.00
30_P59_I1.5571.00
175_F207_I1.5541.00
24_N112_P1.5501.00
197_E200_F1.5491.00
25_E112_P1.5401.00
226_S232_L1.5201.00
208_D211_N1.5181.00
21_P110_N1.5131.00
226_S230_S1.5051.00
295_N299_R1.5011.00
21_P27_K1.5011.00
25_E110_N1.4841.00
286_D300_K1.4771.00
24_N68_K1.4671.00
43_Y298_F1.4631.00
71_I113_K1.4451.00
150_K175_F1.4391.00
202_D205_A1.4301.00
91_C94_K1.4201.00
32_Y126_K1.4061.00
169_I273_I1.3961.00
272_K275_S1.3901.00
164_S176_V1.3821.00
154_I177_I1.3731.00
32_Y313_K1.3691.00
138_V142_N1.3681.00
20_L64_E1.3591.00
179_K198_L1.3561.00
194_T210_I1.3481.00
94_K118_R1.3021.00
181_S184_E1.2841.00
179_K184_E1.2811.00
30_P109_I1.2521.00
23_P67_E1.2511.00
18_D27_K1.2501.00
131_V274_V1.2421.00
290_Y313_K1.2371.00
209_T213_Q1.2341.00
24_N113_K1.2311.00
111_V116_V1.2241.00
67_E118_R1.2091.00
209_T212_N1.1921.00
269_N272_K1.1801.00
184_E197_E1.1741.00
188_K195_T1.1691.00
23_P68_K1.1641.00
208_D213_Q1.1581.00
264_K268_L1.1561.00
139_A266_D1.1561.00
186_I307_N1.1521.00
59_I98_G1.1431.00
212_N215_S1.1311.00
43_Y302_V1.1241.00
273_I278_Q1.1241.00
35_I297_W1.1231.00
294_I312_I1.1201.00
224_K248_I1.1081.00
189_E283_K1.1061.00
73_P91_C1.1041.00
211_N214_E1.1021.00
137_A163_V1.0991.00
13_K292_D1.0981.00
201_D206_V1.0881.00
142_N266_D1.0841.00
175_F194_T1.0801.00
144_I233_I1.0761.00
33_I105_M1.0721.00
21_P25_E1.0701.00
221_S224_K1.0641.00
167_A172_L1.0591.00
176_V192_F1.0591.00
208_D212_N1.0501.00
156_G178_E1.0391.00
137_A166_V1.0391.00
32_Y125_L1.0331.00
268_L272_K1.0271.00
138_V269_N1.0181.00
140_A235_T1.0161.00
188_K194_T1.0141.00
156_G187_L1.0121.00
105_M294_I1.0101.00
66_G69_V1.0071.00
206_V210_I1.0061.00
204_V224_K1.0041.00
205_A209_T1.0021.00
68_K125_L0.9961.00
300_K310_V0.9951.00
152_I207_I0.9951.00
31_K60_S0.9901.00
36_C58_E0.9871.00
28_V61_G0.9811.00
299_R302_V0.9781.00
175_F196_K0.9781.00
95_I125_L0.9781.00
134_T270_S0.9731.00
40_K301_Y0.9721.00
179_K199_K0.9651.00
248_I252_N0.9631.00
289_G293_N0.9601.00
123_L128_G0.9521.00
164_S174_T0.9501.00
176_V187_L0.9491.00
269_N273_I0.9471.00
53_L102_D0.9461.00
153_I163_V0.9451.00
220_Q224_K0.9381.00
161_T186_I0.9361.00
180_D183_K0.9361.00
29_F107_E0.9331.00
156_G164_S0.9191.00
32_Y311_L0.9181.00
153_I167_A0.9161.00
59_I109_I0.9141.00
183_K307_N0.9131.00
33_I104_G0.9051.00
206_V211_N0.9011.00
152_I225_N0.8981.00
211_N216_M0.8931.00
182_R185_E0.8921.00
209_T216_M0.8891.00
105_M312_I0.8821.00
177_I198_L0.8801.00
166_V270_S0.8741.00
222_I232_L0.8721.00
135_A266_D0.8711.00
152_I216_M0.8701.00
36_C57_H0.8701.00
16_V102_D0.8671.00
207_I216_M0.8581.00
20_L27_K0.8561.00
265_D269_N0.8551.00
26_V113_K0.8511.00
36_C39_D0.8511.00
18_D64_E0.8481.00
204_V221_S0.8401.00
179_K187_L0.8371.00
229_R253_E0.8361.00
35_I301_Y0.8321.00
178_E195_T0.8311.00
249_I256_I0.8281.00
170_N269_N0.8251.00
208_D227_I0.8221.00
141_L167_A0.8221.00
137_A162_L0.8211.00
167_A174_T0.8201.00
13_K291_I0.8161.00
180_D197_E0.8131.00
144_I209_T0.8111.00
140_A163_V0.8091.00
151_V172_L0.8061.00
209_T214_E0.8031.00
166_V273_I0.8031.00
207_I211_N0.7991.00
38_T57_H0.7991.00
117_F268_L0.7981.00
92_K228_A0.7961.00
265_D268_L0.7951.00
104_G109_I0.7941.00
34_G58_E0.7931.00
287_K296_E0.7891.00
65_K92_K0.7861.00
22_K110_N0.7851.00
212_N216_M0.7841.00
187_L192_F0.7691.00
121_Y275_S0.7661.00
68_K71_I0.7641.00
273_I276_E0.7621.00
207_I210_I0.7621.00
210_I213_Q0.7611.00
73_P94_K0.7611.00
301_Y310_V0.7571.00
62_I65_K0.7551.00
142_N166_V0.7531.00
16_V54_V0.7521.00
213_Q216_M0.7491.00
220_Q241_Q0.7481.00
174_T193_R0.7481.00
289_G312_I0.7481.00
217_V227_I0.7401.00
204_V208_D0.7391.00
153_I176_V0.7381.00
120_P275_S0.7361.00
137_A159_T0.7321.00
204_V225_N0.7311.00
285_V288_V0.7261.00
139_A253_E0.7241.00
214_E217_V0.7241.00
273_I277_N0.7201.00
289_G310_V0.7181.00
60_S129_A0.7171.00
117_F267_F0.7161.00
123_L274_V0.7161.00
234_I256_I0.7161.00
71_I91_C0.7121.00
241_Q245_N0.7101.00
136_V159_T0.7091.00
271_I275_S0.7061.00
138_V273_I0.7061.00
67_E70_A0.7041.00
145_D231_E0.7031.00
202_D206_V0.7001.00
144_I218_L0.6991.00
18_D63_T0.6991.00
186_I190_K0.6991.00
145_D255_I0.6981.00
245_N248_I0.6971.00
137_A141_L0.6961.00
138_V270_S0.6921.00
207_I213_Q0.6921.00
300_K303_I0.6921.00
24_N114_D0.6911.00
35_I105_M0.6911.00
31_K313_K0.6901.00
249_I258_G0.6891.00
30_P33_I0.6871.00
306_P310_V0.6861.00
200_F206_V0.6861.00
219_A232_L0.6851.00
124_D128_G0.6851.00
249_I254_V0.6831.00
287_K310_V0.6791.00
211_N215_S0.6771.00
60_S119_I0.6761.00
178_E187_L0.6721.00
207_I225_N0.6711.00
19_E110_N0.6711.00
93_N96_S0.6701.00
95_I121_Y0.6701.00
186_I284_I0.6701.00
228_A252_N0.6671.00
57_H133_P0.6661.00
161_T284_I0.6661.00
38_T42_I0.6661.00
240_E243_S0.6631.00
145_D257_R0.6631.00
138_V266_D0.6611.00
165_I190_K0.6591.00
163_V235_T0.6581.00
29_F64_E0.6581.00
70_A73_P0.6571.00
64_E92_K0.6571.00
117_F271_I0.6561.00
9_G299_R0.6551.00
36_C133_P0.6531.00
213_Q218_L0.6521.00
56_G105_M0.6521.00
32_Y60_S0.6461.00
68_K121_Y0.6461.00
175_F210_I0.6451.00
202_D221_S0.6421.00
220_Q248_I0.6391.00
164_S190_K0.6381.00
178_E198_L0.6331.00
144_I231_E0.6331.00
37_G41_N0.6301.00
132_E136_V0.6301.00
208_D214_E0.6271.00
143_K266_D0.6261.00
300_K306_P0.6221.00
203_R221_S0.6211.00
178_E197_E0.6201.00
253_E263_S0.6181.00
206_V213_Q0.6171.00
184_E187_L0.6171.00
40_K302_V0.6161.00
41_N46_K0.6161.00
32_Y288_V0.6151.00
38_T41_N0.6131.00
206_V212_N0.6121.00
150_K208_D0.6111.00
139_A143_K0.6111.00
298_F302_V0.6091.00
8_N299_R0.6091.00
168_E174_T0.6081.00
136_V235_T0.6071.00
59_I71_I0.6071.00
13_K294_I0.6031.00
20_L65_K0.6021.00
209_T218_L0.5971.00
33_I312_I0.5951.00
175_F216_M0.5941.00
21_P24_N0.5891.00
113_K116_V0.5891.00
211_N218_L0.5881.00
131_V270_S0.5871.00
35_I312_I0.5871.00
143_K255_I0.5851.00
147_E171_G0.5841.00
67_E71_I0.5841.00
140_A259_S0.5821.00
213_Q217_V0.5811.00
36_C309_K0.5801.00
37_G157_G0.5801.00
178_E183_K0.5781.00
147_E170_N0.5761.00
19_E108_Y0.5761.00
117_F264_K0.5741.00
177_I196_K0.5731.00
40_K44_L0.5731.00
194_T206_V0.5731.00
166_V170_N0.5711.00
297_W312_I0.5691.00
214_E218_L0.5691.00
63_T92_K0.5681.00
127_L131_V0.5631.00
19_E25_E0.5631.00
214_E227_I0.5621.00
220_Q243_S0.5621.00
140_A233_I0.5621.00
164_S187_L0.5621.00
10_N43_Y0.5611.00
70_A113_K0.5571.00
11_F298_F0.5551.00
130_L311_L0.5541.00
150_K194_T0.5531.00
266_D269_N0.5501.00
133_P136_V0.5501.00
247_D250_V0.5481.00
97_I271_I0.5461.00
187_L195_T0.5461.00
192_F195_T0.5441.00
248_I254_V0.5421.00
162_L279_E0.5421.00
60_S128_G0.5411.00
162_L166_V0.5391.00
112_P115_F0.5381.00
141_L166_V0.5371.00
73_P118_R0.5361.00
58_E309_K0.5351.00
31_K95_I0.5341.00
145_D149_E0.5341.00
50_K53_L0.5341.00
124_D288_V0.5331.00
91_C118_R0.5321.00
143_K257_R0.5271.00
163_V211_N0.5271.00
259_S262_Y0.5241.00
10_N295_N0.5241.00
168_E192_F0.5231.00
18_D110_N0.5221.00
9_G43_Y0.5221.00
65_K71_I0.5211.00
165_I279_E0.5191.00
212_N217_V0.5171.00
233_I257_R0.5171.00
251_R260_I0.5161.00
184_E198_L0.5151.00
161_T190_K0.5151.00
17_R20_L0.5151.00
287_K293_N0.5141.00
248_I251_R0.5131.00
71_I94_K0.5121.00
65_K69_V0.5121.00
156_G160_G0.5121.00
268_L271_I0.5121.00
52_P56_G0.5121.00
34_G129_A0.5091.00
247_D251_R0.5081.00
282_N285_V0.5071.00
220_Q245_N0.5071.00
289_G296_E0.5071.00
125_L128_G0.5051.00
233_I259_S0.5031.00
58_E133_P0.5011.00
162_L165_I0.5011.00
222_I226_S0.5001.00
28_V116_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ej6A 1 0.9874 100 0.218 Contact Map
4ilkA 2 0.9842 100 0.22 Contact Map
2dq4A 4 0.9905 100 0.223 Contact Map
4gkvA 4 0.9874 100 0.225 Contact Map
2d8aA 3 0.9495 100 0.236 Contact Map
4uejA 2 0.9905 100 0.236 Contact Map
1vj0A 4 0.9905 100 0.237 Contact Map
1rjwA 4 0.9905 100 0.238 Contact Map
4oh1A 4 0.9716 100 0.239 Contact Map
3m6iA 4 0.9842 100 0.242 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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