Q97VB8 - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q97VB8 - Alcohol dehydrogenase (Zn containing) (Adh-11)

UniProt:	Q97VB8	Sequences: MWKVFFINGNFVKENVRDELPKPNEVKVFPKYIGICGTDKNIYLGKKPVKEPLVLGHEISGITEKGEKVAIFPNYWCGYCNNCRRGFYNSCKNKISIGVNADGGMAEYINVPKDFVFRIPYTLDLKLGALVEPTAVAVAALNKIDKEIEKVIIIGGGSTGTLVSIVAEINGLETFVIEKDSRKEEILKEKGFRTTKELKFDDRVAVIDTINNQESMVLAQSILKNSIARSELIITGLDNEQISLNRDIIVRNEVIIRGSIIYSKDDFLNSIKIVSENQEKFNKIVDKVGYIDNINEWFRKYVIELPNIKVLIKMDSI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	317 (286)
Sequences:	52717 (36934)
Seq/√Len:	2184.0

ECOLI - RSPB GATD YBDR TDH YPHC ADHP YDJJ YDJL AHR YAHK YJJN IDND FRMA YGGP YCJQ QOR1 ACUI CURA
BACSU - TDH ADHA YJMD ADHB DHSO YYCR BDHA YOGA YHFP YFMJ
HALSA - Q9HP38 Q9HMB6 Q9HQS8 Q9HR85 GLCDH
SULSO - Q97VB8 Q7LXK1 Q97YT7 ADH Q97ZV3 Q97XR4 GLCD1 GLCD2 Q97VV5 Q97TZ4 Q97YM2 Q97WA1 Q97VW0 Q97V32 Q97W06 Q97UW5 GLCD3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
31_K	125_L	3.371	1.00
293_N	296_E	3.120	1.00
150_K	173_E	2.850	1.00
124_D	127_L	2.630	1.00
26_V	116_V	2.599	1.00
146_K	149_E	2.529	1.00
168_E	193_R	2.526	1.00
18_D	108_Y	2.500	1.00
289_G	300_K	2.498	1.00
126_K	288_V	2.487	1.00
156_G	176_V	2.432	1.00
151_V	167_A	2.422	1.00
29_F	108_Y	2.410	1.00
29_F	63_T	2.397	1.00
27_K	63_T	2.336	1.00
287_K	300_K	2.324	1.00
59_I	104_G	2.312	1.00
206_V	209_T	2.286	1.00
185_E	189_E	2.258	1.00
288_V	313_K	2.245	1.00
184_E	188_K	2.245	1.00
142_N	170_N	2.218	1.00
173_E	194_T	2.216	1.00
95_I	119_I	2.209	1.00
22_K	25_E	2.201	1.00
272_K	276_E	2.179	1.00
164_S	192_F	2.171	1.00
122_T	275_S	2.118	1.00
60_S	125_L	2.093	1.00
27_K	110_N	2.087	1.00
134_T	162_L	2.020	1.00
169_I	278_Q	1.954	1.00
299_R	303_I	1.952	1.00
290_Y	293_N	1.947	1.00
185_E	188_K	1.942	1.00
152_I	177_I	1.942	1.00
142_N	269_N	1.898	1.00
231_E	255_I	1.887	1.00
119_I	125_L	1.871	1.00
184_E	195_T	1.832	1.00
296_E	299_R	1.828	1.00
178_E	184_E	1.817	1.00
27_K	64_E	1.799	1.00
44_L	302_V	1.791	1.00
231_E	257_R	1.764	1.00
300_K	305_L	1.755	1.00
289_G	297_W	1.749	1.00
296_E	300_K	1.743	1.00
181_S	185_E	1.719	1.00
186_I	189_E	1.703	1.00
154_I	222_I	1.686	1.00
127_L	282_N	1.680	1.00
173_E	193_R	1.666	1.00
149_E	231_E	1.666	1.00
105_M	298_F	1.654	1.00
27_K	108_Y	1.631	1.00
126_K	313_K	1.628	1.00
119_I	128_G	1.593	1.00
226_S	254_V	1.582	1.00
63_T	108_Y	1.576	1.00
181_S	197_E	1.569	1.00
181_S	200_F	1.557	1.00
30_P	59_I	1.557	1.00
175_F	207_I	1.554	1.00
24_N	112_P	1.550	1.00
197_E	200_F	1.549	1.00
25_E	112_P	1.540	1.00
226_S	232_L	1.520	1.00
208_D	211_N	1.518	1.00
21_P	110_N	1.513	1.00
226_S	230_S	1.505	1.00
295_N	299_R	1.501	1.00
21_P	27_K	1.501	1.00
25_E	110_N	1.484	1.00
286_D	300_K	1.477	1.00
24_N	68_K	1.467	1.00
43_Y	298_F	1.463	1.00
71_I	113_K	1.445	1.00
150_K	175_F	1.439	1.00
202_D	205_A	1.430	1.00
91_C	94_K	1.420	1.00
32_Y	126_K	1.406	1.00
169_I	273_I	1.396	1.00
272_K	275_S	1.390	1.00
164_S	176_V	1.382	1.00
154_I	177_I	1.373	1.00
32_Y	313_K	1.369	1.00
138_V	142_N	1.368	1.00
20_L	64_E	1.359	1.00
179_K	198_L	1.356	1.00
194_T	210_I	1.348	1.00
94_K	118_R	1.302	1.00
181_S	184_E	1.284	1.00
179_K	184_E	1.281	1.00
30_P	109_I	1.252	1.00
23_P	67_E	1.251	1.00
18_D	27_K	1.250	1.00
131_V	274_V	1.242	1.00
290_Y	313_K	1.237	1.00
209_T	213_Q	1.234	1.00
24_N	113_K	1.231	1.00
111_V	116_V	1.224	1.00
67_E	118_R	1.209	1.00
209_T	212_N	1.192	1.00
269_N	272_K	1.180	1.00
184_E	197_E	1.174	1.00
188_K	195_T	1.169	1.00
23_P	68_K	1.164	1.00
208_D	213_Q	1.158	1.00
264_K	268_L	1.156	1.00
139_A	266_D	1.156	1.00
186_I	307_N	1.152	1.00
59_I	98_G	1.143	1.00
212_N	215_S	1.131	1.00
43_Y	302_V	1.124	1.00
273_I	278_Q	1.124	1.00
35_I	297_W	1.123	1.00
294_I	312_I	1.120	1.00
224_K	248_I	1.108	1.00
189_E	283_K	1.106	1.00
73_P	91_C	1.104	1.00
211_N	214_E	1.102	1.00
137_A	163_V	1.099	1.00
13_K	292_D	1.098	1.00
201_D	206_V	1.088	1.00
142_N	266_D	1.084	1.00
175_F	194_T	1.080	1.00
144_I	233_I	1.076	1.00
33_I	105_M	1.072	1.00
21_P	25_E	1.070	1.00
221_S	224_K	1.064	1.00
167_A	172_L	1.059	1.00
176_V	192_F	1.059	1.00
208_D	212_N	1.050	1.00
156_G	178_E	1.039	1.00
137_A	166_V	1.039	1.00
32_Y	125_L	1.033	1.00
268_L	272_K	1.027	1.00
138_V	269_N	1.018	1.00
140_A	235_T	1.016	1.00
188_K	194_T	1.014	1.00
156_G	187_L	1.012	1.00
105_M	294_I	1.010	1.00
66_G	69_V	1.007	1.00
206_V	210_I	1.006	1.00
204_V	224_K	1.004	1.00
205_A	209_T	1.002	1.00
68_K	125_L	0.996	1.00
300_K	310_V	0.995	1.00
152_I	207_I	0.995	1.00
31_K	60_S	0.990	1.00
36_C	58_E	0.987	1.00
28_V	61_G	0.981	1.00
299_R	302_V	0.978	1.00
175_F	196_K	0.978	1.00
95_I	125_L	0.978	1.00
134_T	270_S	0.973	1.00
40_K	301_Y	0.972	1.00
179_K	199_K	0.965	1.00
248_I	252_N	0.963	1.00
289_G	293_N	0.960	1.00
123_L	128_G	0.952	1.00
164_S	174_T	0.950	1.00
176_V	187_L	0.949	1.00
269_N	273_I	0.947	1.00
53_L	102_D	0.946	1.00
153_I	163_V	0.945	1.00
220_Q	224_K	0.938	1.00
161_T	186_I	0.936	1.00
180_D	183_K	0.936	1.00
29_F	107_E	0.933	1.00
156_G	164_S	0.919	1.00
32_Y	311_L	0.918	1.00
153_I	167_A	0.916	1.00
59_I	109_I	0.914	1.00
183_K	307_N	0.913	1.00
33_I	104_G	0.905	1.00
206_V	211_N	0.901	1.00
152_I	225_N	0.898	1.00
211_N	216_M	0.893	1.00
182_R	185_E	0.892	1.00
209_T	216_M	0.889	1.00
105_M	312_I	0.882	1.00
177_I	198_L	0.880	1.00
166_V	270_S	0.874	1.00
222_I	232_L	0.872	1.00
135_A	266_D	0.871	1.00
152_I	216_M	0.870	1.00
36_C	57_H	0.870	1.00
16_V	102_D	0.867	1.00
207_I	216_M	0.858	1.00
20_L	27_K	0.856	1.00
265_D	269_N	0.855	1.00
26_V	113_K	0.851	1.00
36_C	39_D	0.851	1.00
18_D	64_E	0.848	1.00
204_V	221_S	0.840	1.00
179_K	187_L	0.837	1.00
229_R	253_E	0.836	1.00
35_I	301_Y	0.832	1.00
178_E	195_T	0.831	1.00
249_I	256_I	0.828	1.00
170_N	269_N	0.825	1.00
208_D	227_I	0.822	1.00
141_L	167_A	0.822	1.00
137_A	162_L	0.821	1.00
167_A	174_T	0.820	1.00
13_K	291_I	0.816	1.00
180_D	197_E	0.813	1.00
144_I	209_T	0.811	1.00
140_A	163_V	0.809	1.00
151_V	172_L	0.806	1.00
209_T	214_E	0.803	1.00
166_V	273_I	0.803	1.00
207_I	211_N	0.799	1.00
38_T	57_H	0.799	1.00
117_F	268_L	0.798	1.00
92_K	228_A	0.796	1.00
265_D	268_L	0.795	1.00
104_G	109_I	0.794	1.00
34_G	58_E	0.793	1.00
287_K	296_E	0.789	1.00
65_K	92_K	0.786	1.00
22_K	110_N	0.785	1.00
212_N	216_M	0.784	1.00
187_L	192_F	0.769	1.00
121_Y	275_S	0.766	1.00
68_K	71_I	0.764	1.00
273_I	276_E	0.762	1.00
207_I	210_I	0.762	1.00
210_I	213_Q	0.761	1.00
73_P	94_K	0.761	1.00
301_Y	310_V	0.757	1.00
62_I	65_K	0.755	1.00
142_N	166_V	0.753	1.00
16_V	54_V	0.752	1.00
213_Q	216_M	0.749	1.00
220_Q	241_Q	0.748	1.00
174_T	193_R	0.748	1.00
289_G	312_I	0.748	1.00
217_V	227_I	0.740	1.00
204_V	208_D	0.739	1.00
153_I	176_V	0.738	1.00
120_P	275_S	0.736	1.00
137_A	159_T	0.732	1.00
204_V	225_N	0.731	1.00
285_V	288_V	0.726	1.00
139_A	253_E	0.724	1.00
214_E	217_V	0.724	1.00
273_I	277_N	0.720	1.00
289_G	310_V	0.718	1.00
60_S	129_A	0.717	1.00
117_F	267_F	0.716	1.00
123_L	274_V	0.716	1.00
234_I	256_I	0.716	1.00
71_I	91_C	0.712	1.00
241_Q	245_N	0.710	1.00
136_V	159_T	0.709	1.00
271_I	275_S	0.706	1.00
138_V	273_I	0.706	1.00
67_E	70_A	0.704	1.00
145_D	231_E	0.703	1.00
202_D	206_V	0.700	1.00
144_I	218_L	0.699	1.00
18_D	63_T	0.699	1.00
186_I	190_K	0.699	1.00
145_D	255_I	0.698	1.00
245_N	248_I	0.697	1.00
137_A	141_L	0.696	1.00
138_V	270_S	0.692	1.00
207_I	213_Q	0.692	1.00
300_K	303_I	0.692	1.00
24_N	114_D	0.691	1.00
35_I	105_M	0.691	1.00
31_K	313_K	0.690	1.00
249_I	258_G	0.689	1.00
30_P	33_I	0.687	1.00
306_P	310_V	0.686	1.00
200_F	206_V	0.686	1.00
219_A	232_L	0.685	1.00
124_D	128_G	0.685	1.00
249_I	254_V	0.683	1.00
287_K	310_V	0.679	1.00
211_N	215_S	0.677	1.00
60_S	119_I	0.676	1.00
178_E	187_L	0.672	1.00
207_I	225_N	0.671	1.00
19_E	110_N	0.671	1.00
93_N	96_S	0.670	1.00
95_I	121_Y	0.670	1.00
186_I	284_I	0.670	1.00
228_A	252_N	0.667	1.00
57_H	133_P	0.666	1.00
161_T	284_I	0.666	1.00
38_T	42_I	0.666	1.00
240_E	243_S	0.663	1.00
145_D	257_R	0.663	1.00
138_V	266_D	0.661	1.00
165_I	190_K	0.659	1.00
163_V	235_T	0.658	1.00
29_F	64_E	0.658	1.00
70_A	73_P	0.657	1.00
64_E	92_K	0.657	1.00
117_F	271_I	0.656	1.00
9_G	299_R	0.655	1.00
36_C	133_P	0.653	1.00
213_Q	218_L	0.652	1.00
56_G	105_M	0.652	1.00
32_Y	60_S	0.646	1.00
68_K	121_Y	0.646	1.00
175_F	210_I	0.645	1.00
202_D	221_S	0.642	1.00
220_Q	248_I	0.639	1.00
164_S	190_K	0.638	1.00
178_E	198_L	0.633	1.00
144_I	231_E	0.633	1.00
37_G	41_N	0.630	1.00
132_E	136_V	0.630	1.00
208_D	214_E	0.627	1.00
143_K	266_D	0.626	1.00
300_K	306_P	0.622	1.00
203_R	221_S	0.621	1.00
178_E	197_E	0.620	1.00
253_E	263_S	0.618	1.00
206_V	213_Q	0.617	1.00
184_E	187_L	0.617	1.00
40_K	302_V	0.616	1.00
41_N	46_K	0.616	1.00
32_Y	288_V	0.615	1.00
38_T	41_N	0.613	1.00
206_V	212_N	0.612	1.00
150_K	208_D	0.611	1.00
139_A	143_K	0.611	1.00
298_F	302_V	0.609	1.00
8_N	299_R	0.609	1.00
168_E	174_T	0.608	1.00
136_V	235_T	0.607	1.00
59_I	71_I	0.607	1.00
13_K	294_I	0.603	1.00
20_L	65_K	0.602	1.00
209_T	218_L	0.597	1.00
33_I	312_I	0.595	1.00
175_F	216_M	0.594	1.00
21_P	24_N	0.589	1.00
113_K	116_V	0.589	1.00
211_N	218_L	0.588	1.00
131_V	270_S	0.587	1.00
35_I	312_I	0.587	1.00
143_K	255_I	0.585	1.00
147_E	171_G	0.584	1.00
67_E	71_I	0.584	1.00
140_A	259_S	0.582	1.00
213_Q	217_V	0.581	1.00
36_C	309_K	0.580	1.00
37_G	157_G	0.580	1.00
178_E	183_K	0.578	1.00
147_E	170_N	0.576	1.00
19_E	108_Y	0.576	1.00
117_F	264_K	0.574	1.00
177_I	196_K	0.573	1.00
40_K	44_L	0.573	1.00
194_T	206_V	0.573	1.00
166_V	170_N	0.571	1.00
297_W	312_I	0.569	1.00
214_E	218_L	0.569	1.00
63_T	92_K	0.568	1.00
127_L	131_V	0.563	1.00
19_E	25_E	0.563	1.00
214_E	227_I	0.562	1.00
220_Q	243_S	0.562	1.00
140_A	233_I	0.562	1.00
164_S	187_L	0.562	1.00
10_N	43_Y	0.561	1.00
70_A	113_K	0.557	1.00
11_F	298_F	0.555	1.00
130_L	311_L	0.554	1.00
150_K	194_T	0.553	1.00
266_D	269_N	0.550	1.00
133_P	136_V	0.550	1.00
247_D	250_V	0.548	1.00
97_I	271_I	0.546	1.00
187_L	195_T	0.546	1.00
192_F	195_T	0.544	1.00
248_I	254_V	0.542	1.00
162_L	279_E	0.542	1.00
60_S	128_G	0.541	1.00
162_L	166_V	0.539	1.00
112_P	115_F	0.538	1.00
141_L	166_V	0.537	1.00
73_P	118_R	0.536	1.00
58_E	309_K	0.535	1.00
31_K	95_I	0.534	1.00
145_D	149_E	0.534	1.00
50_K	53_L	0.534	1.00
124_D	288_V	0.533	1.00
91_C	118_R	0.532	1.00
143_K	257_R	0.527	1.00
163_V	211_N	0.527	1.00
259_S	262_Y	0.524	1.00
10_N	295_N	0.524	1.00
168_E	192_F	0.523	1.00
18_D	110_N	0.522	1.00
9_G	43_Y	0.522	1.00
65_K	71_I	0.521	1.00
165_I	279_E	0.519	1.00
212_N	217_V	0.517	1.00
233_I	257_R	0.517	1.00
251_R	260_I	0.516	1.00
184_E	198_L	0.515	1.00
161_T	190_K	0.515	1.00
17_R	20_L	0.515	1.00
287_K	293_N	0.514	1.00
248_I	251_R	0.513	1.00
71_I	94_K	0.512	1.00
65_K	69_V	0.512	1.00
156_G	160_G	0.512	1.00
268_L	271_I	0.512	1.00
52_P	56_G	0.512	1.00
34_G	129_A	0.509	1.00
247_D	251_R	0.508	1.00
282_N	285_V	0.507	1.00
220_Q	245_N	0.507	1.00
289_G	296_E	0.507	1.00
125_L	128_G	0.505	1.00
233_I	259_S	0.503	1.00
58_E	133_P	0.501	1.00
162_L	165_I	0.501	1.00
222_I	226_S	0.500	1.00
28_V	116_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ej6A	1	0.9874	100	0.218	Contact Map
4ilkA	2	0.9842	100	0.22	Contact Map
2dq4A	4	0.9905	100	0.223	Contact Map
4gkvA	4	0.9874	100	0.225	Contact Map
2d8aA	3	0.9495	100	0.236	Contact Map
4uejA	2	0.9905	100	0.236	Contact Map
1vj0A	4	0.9905	100	0.237	Contact Map
1rjwA	4	0.9905	100	0.238	Contact Map
4oh1A	4	0.9716	100	0.239	Contact Map
3m6iA	4	0.9842	100	0.242	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.011 seconds.