GREMLIN Database
Q97VB6 - N-carbamoyl-L-amino acid amidohydrolase (AmaB)
UniProt: Q97VB6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 401 (385)
Sequences: 4192 (3087)
Seq/√Len: 157.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_G307_L4.4001.00
331_E343_F3.9101.00
43_L60_G3.6261.00
61_E112_K3.6001.00
243_R305_E3.2571.00
193_E342_K3.1821.00
368_S380_S3.1791.00
38_E42_I3.1611.00
332_R398_L3.0901.00
336_E394_K3.0811.00
72_I94_G3.0571.00
213_F238_F2.9111.00
72_I396_V2.9051.00
152_I157_A2.8371.00
89_Y385_M2.8001.00
337_L394_K2.7141.00
66_L108_N2.4841.00
62_L102_K2.4531.00
336_E398_L2.3971.00
40_I44_S2.3491.00
40_I58_I2.2281.00
237_K304_D2.2121.00
216_Q229_R2.2081.00
330_I395_A2.1901.00
153_S156_E2.1781.00
65_K108_N2.1741.00
46_I95_L2.1611.00
369_H379_Y2.1401.00
201_L343_F2.1281.00
98_L113_L2.0981.00
366_I380_S2.0421.00
252_L290_T2.0381.00
100_S104_R2.0281.00
262_K272_E2.0271.00
380_S385_M2.0121.00
212_T272_E2.0071.00
241_S297_I1.9861.00
38_E41_K1.9781.00
97_V396_V1.9691.00
109_H177_N1.9551.00
372_I375_A1.9241.00
300_S304_D1.9061.00
323_S360_K1.8941.00
237_K305_E1.8671.00
331_E335_K1.8591.00
379_Y382_D1.8501.00
326_V362_G1.8421.00
58_I115_D1.8351.00
22_G25_R1.8341.00
100_S393_E1.8261.00
42_I45_S1.8131.00
210_E312_R1.8061.00
49_H63_G1.8031.00
157_A160_V1.7611.00
85_Y379_Y1.7551.00
30_E160_V1.7451.00
69_A110_S1.7401.00
214_K272_E1.7201.00
260_N274_R1.6871.00
297_I300_S1.6871.00
172_M175_K1.6771.00
39_L76_M1.6581.00
284_R319_P1.6561.00
101_I106_I1.6501.00
37_E163_F1.6471.00
291_I295_V1.6371.00
48_V62_L1.6261.00
71_A114_I1.6091.00
330_I364_I1.5951.00
238_F298_A1.5881.00
41_K44_S1.5791.00
213_F275_L1.5771.00
333_A391_V1.5591.00
41_K45_S1.5531.00
214_K308_E1.5391.00
72_I97_V1.5361.00
180_L395_A1.5311.00
76_M115_D1.5291.00
197_I391_V1.5241.00
329_V398_L1.4981.00
327_I343_F1.4851.00
218_S223_T1.4851.00
100_S390_R1.4821.00
33_I37_E1.4791.00
196_Q340_R1.4731.00
292_N296_N1.4681.00
74_S91_V1.4651.00
93_A389_L1.4651.00
43_L95_L1.4611.00
232_L259_L1.4521.00
71_A176_P1.4301.00
129_L154_F1.4281.00
63_G110_S1.4141.00
295_V299_K1.4121.00
296_N300_S1.4061.00
40_I50_I1.3981.00
72_I180_L1.3931.00
368_S384_D1.3921.00
196_Q384_D1.3861.00
31_Y34_K1.3851.00
248_K293_E1.3841.00
241_S244_D1.3821.00
394_K398_L1.3631.00
137_I357_K1.3621.00
39_L60_G1.3611.00
231_A273_V1.3571.00
78_S88_F1.3541.00
192_E227_R1.3511.00
220_T255_T1.3511.00
64_G67_S1.3461.00
333_A398_L1.3451.00
32_D36_R1.3431.00
232_L273_V1.3411.00
233_V243_R1.3361.00
352_A361_V1.3341.00
48_V98_L1.3331.00
65_K107_S1.3321.00
386_L390_R1.3231.00
246_A254_A1.3201.00
63_G67_S1.3171.00
237_K244_D1.3071.00
212_T310_E1.3071.00
179_Y352_A1.2981.00
39_L43_L1.2981.00
212_T274_R1.2891.00
118_N121_G1.2881.00
235_A239_V1.2871.00
210_E274_R1.2831.00
289_H293_E1.2811.00
98_L111_I1.2771.00
239_V259_L1.2731.00
335_K341_Y1.2701.00
214_K310_E1.2671.00
238_F275_L1.2631.00
68_D109_H1.2591.00
252_L281_S1.2581.00
242_V254_A1.2571.00
40_I52_V1.2541.00
156_E159_R1.2521.00
313_H316_T1.2441.00
123_R148_D1.2391.00
237_K240_V1.2371.00
55_A133_L1.2341.00
233_V239_V1.2181.00
232_L261_V1.2021.00
23_V81_Y1.1961.00
195_Y342_K1.1811.00
330_I362_G1.1751.00
196_Q387_N1.1711.00
180_L399_L1.1701.00
99_R103_E1.1631.00
128_L132_G1.1571.00
235_A259_L1.1561.00
148_D152_I1.1441.00
139_D142_Y1.1411.00
143_V388_G1.1401.00
95_L113_L1.1361.00
213_F235_A1.1331.00
369_H381_S1.1321.00
176_P180_L1.1311.00
70_I109_H1.1301.00
189_I224_P1.1261.00
21_D25_R1.1231.00
224_P227_R1.1231.00
25_R28_L1.1201.00
37_E40_I1.1201.00
59_I71_A1.1081.00
70_I178_Y1.1051.00
284_R318_N1.1041.00
59_I114_I1.1021.00
140_K144_Y1.0980.99
390_R394_K1.0940.99
46_I99_R1.0870.99
177_N180_L1.0850.99
202_G282_I1.0840.99
261_V273_V1.0830.99
98_L102_K1.0810.99
164_M167_E1.0790.99
302_A309_V1.0780.99
174_M177_N1.0780.99
298_A309_V1.0760.99
16_I38_E1.0540.99
239_V256_V1.0520.99
64_G110_S1.0480.99
335_K340_R1.0430.99
34_K37_E1.0390.99
216_Q372_I1.0360.99
22_G27_A1.0260.99
89_Y182_L1.0260.99
155_E159_R1.0210.99
15_N18_W1.0200.99
30_E34_K1.0190.99
60_G63_G1.0170.99
25_R29_N1.0150.99
327_I362_G1.0090.99
128_L354_Y1.0050.99
339_M387_N0.9990.99
213_F309_V0.9890.99
147_R153_S0.9870.99
333_A394_K0.9870.99
223_T269_I0.9860.99
297_I301_I0.9850.99
366_I388_G0.9830.99
368_S381_S0.9790.99
174_M180_L0.9750.99
381_S384_D0.9730.99
332_R336_E0.9720.99
389_L393_E0.9700.99
106_I397_E0.9660.99
334_C391_V0.9620.99
39_L115_D0.9570.99
288_D316_T0.9550.99
17_G21_D0.9520.99
129_L132_G0.9520.99
93_A182_L0.9480.98
235_A275_L0.9440.98
159_R165_G0.9430.98
97_V393_E0.9380.98
229_R308_E0.9310.98
19_T22_G0.9280.98
26_L29_N0.9270.98
62_L107_S0.9250.98
199_I330_I0.9220.98
337_L390_R0.9170.98
80_P265_V0.9170.98
23_V27_A0.9130.98
37_E41_K0.9130.98
324_D328_S0.9120.98
176_P359_S0.9110.98
57_N130_G0.9100.98
172_M176_P0.9090.98
209_Y291_I0.9020.98
363_M373_S0.8960.98
123_R354_Y0.8870.98
142_Y146_R0.8820.98
244_D248_K0.8810.98
30_E33_I0.8760.97
333_A337_L0.8710.97
327_I331_E0.8710.97
93_A392_L0.8700.97
76_M88_F0.8680.97
322_F361_V0.8680.97
387_N390_R0.8650.97
30_E157_A0.8650.97
14_T18_W0.8580.97
62_L98_L0.8570.97
42_I46_I0.8570.97
39_L113_L0.8570.97
62_L101_I0.8560.97
281_S286_R0.8550.97
189_I193_E0.8540.97
148_D345_Y0.8530.97
132_G138_F0.8530.97
218_S269_I0.8480.97
383_E387_N0.8430.97
284_R288_D0.8410.97
23_V84_K0.8330.97
245_H293_E0.8320.97
156_E160_V0.8260.96
277_V294_F0.8250.96
57_N60_G0.8240.96
372_I377_E0.8230.96
355_M359_S0.8230.96
245_H248_K0.8220.96
235_A256_V0.8220.96
171_L176_P0.8200.96
93_A388_G0.8190.96
128_L131_S0.8170.96
245_H297_I0.8150.96
173_H176_P0.8150.96
171_L175_K0.8130.96
170_R174_M0.8130.96
180_L392_L0.8120.96
68_D177_N0.8120.96
36_R58_I0.8090.96
182_L388_G0.8070.96
367_P371_G0.8050.96
19_T23_V0.8030.96
141_N144_Y0.8030.96
242_V275_L0.7980.96
158_L162_G0.7960.96
195_Y340_R0.7950.96
61_E69_A0.7950.96
154_F157_A0.7930.95
129_L143_V0.7920.95
329_V333_A0.7910.95
262_K274_R0.7890.95
79_V116_F0.7860.95
261_V264_N0.7850.95
145_S153_S0.7850.95
33_I161_S0.7850.95
212_T312_R0.7830.95
27_A32_D0.7820.95
61_E110_S0.7820.95
286_R289_H0.7810.95
211_F311_Y0.7770.95
48_V95_L0.7750.95
211_F277_V0.7750.95
14_T23_V0.7730.95
96_E100_S0.7730.95
199_I327_I0.7730.95
18_W96_E0.7720.95
334_C341_Y0.7710.95
245_H290_T0.7700.95
104_R393_E0.7690.95
112_K171_L0.7670.95
16_I19_T0.7670.95
211_F298_A0.7660.95
67_S110_S0.7640.94
328_S332_R0.7630.94
58_I61_E0.7610.94
135_T358_I0.7600.94
133_L143_V0.7570.94
51_M112_K0.7540.94
53_D56_G0.7490.94
367_P384_D0.7490.94
50_I58_I0.7480.94
22_G28_L0.7480.94
244_D297_I0.7470.94
101_I107_S0.7470.94
192_E226_D0.7460.94
104_R397_E0.7440.94
213_F307_L0.7440.94
327_I330_I0.7430.94
48_V102_K0.7410.94
39_L91_V0.7390.93
238_F302_A0.7370.93
292_N295_V0.7360.93
171_L178_Y0.7350.93
116_F179_Y0.7340.93
279_V290_T0.7340.93
36_R117_T0.7330.93
183_H186_Q0.7320.93
288_D292_N0.7280.93
29_N124_F0.7270.93
213_F234_G0.7260.93
302_A307_L0.7250.93
209_Y311_Y0.7250.93
211_F275_L0.7240.93
252_L286_R0.7240.93
43_L98_L0.7210.93
217_S231_A0.7200.93
76_M91_V0.7190.92
299_K302_A0.7180.92
19_T24_L0.7150.92
355_M358_I0.7110.92
17_G20_E0.7080.92
258_I276_T0.7070.92
200_P205_G0.7070.92
197_I367_P0.7040.92
46_I102_K0.7040.92
135_T355_M0.7040.92
54_D140_K0.7030.92
285_N288_D0.7020.92
116_F355_M0.7010.92
329_V399_L0.7010.92
73_G351_D0.7000.91
393_E397_E0.7000.91
177_N182_L0.6980.91
222_P253_R0.6970.91
152_I160_V0.6970.91
170_R180_L0.6960.91
140_K143_V0.6960.91
380_S384_D0.6940.91
17_G22_G0.6930.91
231_A271_R0.6910.91
72_I111_I0.6910.91
216_Q269_I0.6900.91
328_S331_E0.6880.91
232_L236_S0.6880.91
222_P348_A0.6870.91
118_N126_P0.6870.91
14_T17_G0.6850.91
51_M133_L0.6840.91
210_E314_L0.6810.90
216_Q370_L0.6800.90
381_S385_M0.6780.90
37_E52_V0.6780.90
141_N145_S0.6770.90
335_K338_S0.6750.90
42_I95_L0.6750.90
390_R393_E0.6750.90
332_R335_K0.6740.90
51_M61_E0.6720.90
328_S343_F0.6720.90
51_M59_I0.6690.90
258_I264_N0.6690.90
44_S49_H0.6680.89
296_N299_K0.6650.89
89_Y366_I0.6640.89
36_R39_L0.6630.89
193_E196_Q0.6620.89
128_L206_L0.6590.89
122_S268_A0.6580.89
170_R176_P0.6570.89
329_V332_R0.6570.89
159_R164_M0.6560.89
368_S371_G0.6550.89
96_E99_R0.6550.89
64_G98_L0.6540.88
155_E158_L0.6540.88
14_T84_K0.6530.88
366_I385_M0.6520.88
62_L106_I0.6520.88
158_L163_F0.6520.88
139_D143_V0.6520.88
185_E198_G0.6510.88
224_P347_W0.6490.88
29_N32_D0.6490.88
240_V243_R0.6480.88
236_S240_V0.6480.88
43_L50_I0.6460.88
176_P182_L0.6450.88
145_S343_F0.6450.88
233_V305_E0.6450.88
16_I35_V0.6430.88
191_E195_Y0.6400.87
172_M180_L0.6380.87
349_G353_Q0.6380.87
172_M178_Y0.6370.87
118_N220_T0.6370.87
144_Y155_E0.6360.87
44_S50_I0.6340.87
191_E370_L0.6310.87
134_T355_M0.6310.87
172_M177_N0.6310.87
19_T31_Y0.6300.87
232_L235_A0.6300.87
388_G392_L0.6290.86
205_G208_V0.6280.86
242_V256_V0.6270.86
237_K241_S0.6270.86
213_F298_A0.6230.86
15_N19_T0.6230.86
141_N146_R0.6220.86
75_H86_D0.6220.86
234_G301_I0.6200.86
190_L198_G0.6170.85
382_D386_L0.6160.85
207_S287_I0.6150.85
379_Y385_M0.6140.85
203_I206_L0.6120.85
19_T27_A0.6120.85
229_R306_K0.6120.85
55_A140_K0.6120.85
196_Q367_P0.6110.85
173_H178_Y0.6100.85
188_P192_E0.6100.85
14_T25_R0.6090.85
254_A279_V0.6080.85
333_A395_A0.6080.85
25_R30_E0.6080.85
59_I134_T0.6080.85
53_D57_N0.6070.84
28_L117_T0.6060.84
364_I388_G0.6060.84
204_A282_I0.6040.84
101_I397_E0.6020.84
186_Q200_P0.6020.84
39_L95_L0.6010.84
153_S157_A0.6010.84
100_S103_E0.6000.84
20_E24_L0.5980.84
221_G257_G0.5980.84
213_F302_A0.5960.83
15_N27_A0.5950.83
58_I63_G0.5950.83
236_S239_V0.5950.83
166_D170_R0.5950.83
118_N129_L0.5940.83
289_H292_N0.5930.83
325_E329_V0.5920.83
154_F158_L0.5900.83
62_L65_K0.5900.83
22_G26_L0.5880.83
181_E198_G0.5870.82
23_V88_F0.5850.82
194_G197_I0.5850.82
49_H61_E0.5850.82
189_I197_I0.5840.82
147_R156_E0.5830.82
18_W25_R0.5830.82
232_L270_P0.5820.82
338_S341_Y0.5810.82
171_L174_M0.5810.82
242_V277_V0.5810.82
384_D387_N0.5800.82
78_S84_K0.5780.82
238_F309_V0.5780.82
229_R234_G0.5780.82
89_Y93_A0.5760.81
144_Y164_M0.5750.81
22_G82_G0.5730.81
52_V58_I0.5730.81
95_L98_L0.5720.81
26_L122_S0.5680.80
124_F148_D0.5670.80
324_D357_K0.5660.80
282_I345_Y0.5650.80
63_G66_L0.5650.80
102_K105_G0.5650.80
121_G128_L0.5630.80
170_R177_N0.5630.80
175_K178_Y0.5620.80
207_S291_I0.5610.80
337_L387_N0.5600.79
60_G65_K0.5600.79
328_S335_K0.5590.79
48_V60_G0.5590.79
218_S228_R0.5580.79
243_R247_K0.5580.79
180_L183_H0.5560.79
132_G354_Y0.5560.79
79_V265_V0.5550.79
85_Y385_M0.5550.79
209_Y313_H0.5530.79
326_V333_A0.5530.79
84_K88_F0.5520.78
24_L81_Y0.5520.78
17_G23_V0.5510.78
295_V311_Y0.5510.78
232_L239_V0.5490.78
15_N25_R0.5460.78
27_A31_Y0.5450.78
233_V240_V0.5440.77
94_G113_L0.5440.77
149_K260_N0.5430.77
341_Y367_P0.5420.77
23_V78_S0.5420.77
21_D38_E0.5420.77
180_L326_V0.5410.77
368_S379_Y0.5400.77
121_G220_T0.5390.77
45_S99_R0.5380.77
69_A109_H0.5370.77
197_I387_N0.5370.77
118_N125_Q0.5360.76
129_L146_R0.5360.76
185_E190_L0.5360.76
353_Q356_T0.5350.76
331_E341_Y0.5330.76
145_S155_E0.5310.76
71_A179_Y0.5300.76
58_I65_K0.5280.75
104_R107_S0.5280.75
127_S132_G0.5270.75
176_P179_Y0.5240.75
364_I392_L0.5210.74
301_I305_E0.5210.74
293_E296_N0.5200.74
88_F115_D0.5200.74
60_G113_L0.5200.74
283_E286_R0.5190.74
339_M391_V0.5190.74
35_V76_M0.5180.74
72_I179_Y0.5180.74
180_L396_V0.5170.74
41_K260_N0.5160.74
317_A353_Q0.5160.74
218_S372_I0.5160.74
64_G69_A0.5160.74
38_E45_S0.5150.74
26_L31_Y0.5150.74
181_E190_L0.5150.74
97_V101_I0.5150.74
204_A208_V0.5140.73
101_I104_R0.5130.73
329_V395_A0.5110.73
199_I341_Y0.5100.73
181_E186_Q0.5080.73
94_G97_V0.5080.73
323_S328_S0.5060.72
69_A112_K0.5060.72
225_M253_R0.5050.72
78_S385_M0.5040.72
36_R76_M0.5020.72
158_L161_S0.5000.71
217_S268_A0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n5fA 2 0.9925 100 0.392 Contact Map
2v8hA 2 0.995 100 0.396 Contact Map
4wjbA 2 0.9925 100 0.404 Contact Map
4pxdA 2 0.9975 100 0.408 Contact Map
4pxeA 2 0.9975 100 0.415 Contact Map
3gb0A 2 0.8504 100 0.47 Contact Map
3khxA 1 0.8653 100 0.474 Contact Map
1lfwA 1 0.9551 100 0.474 Contact Map
3rzaA 2 0.8454 100 0.48 Contact Map
1cg2A 4 0.8778 100 0.488 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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