GREMLIN Database
Q97VB5 - Aminotransferase
UniProt: Q97VB5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 444 (383)
Sequences: 20881 (12385)
Seq/√Len: 632.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_K73_D4.3881.00
230_R234_K3.9891.00
394_R433_D3.8941.00
36_Y44_K3.5731.00
337_Y425_D3.3231.00
93_A320_E3.1451.00
31_S38_Y3.0781.00
254_E260_L2.8721.00
326_N329_S2.8641.00
337_Y421_K2.8311.00
63_R324_R2.7111.00
330_H334_M2.6491.00
66_N70_E2.6451.00
348_R432_D2.6411.00
420_N423_E2.6071.00
48_F427_G2.3961.00
93_A323_E2.3801.00
186_C228_L2.3701.00
228_L231_K2.3591.00
317_A320_E2.3391.00
341_R428_V2.2721.00
63_R321_E2.2541.00
394_R437_E2.2411.00
36_Y423_E2.2401.00
231_K235_E2.2271.00
30_S40_V2.2071.00
63_R317_A2.1971.00
61_N321_E2.1941.00
390_D393_A2.1481.00
333_V421_K2.1451.00
390_D437_E2.1221.00
195_D235_E2.1091.00
38_Y44_K2.0761.00
131_K203_N2.0091.00
93_A316_P2.0041.00
341_R425_D2.0011.00
349_H432_D1.9861.00
90_A315_I1.9341.00
170_P193_Y1.8971.00
396_L430_A1.8921.00
339_G343_Q1.8761.00
65_I69_K1.8681.00
426_E430_A1.8511.00
336_D340_K1.8501.00
208_I241_I1.8341.00
390_D394_R1.8211.00
104_K288_K1.8181.00
103_S288_K1.7861.00
85_D89_K1.7841.00
39_D43_K1.7811.00
288_K292_E1.7791.00
321_E325_L1.7711.00
30_S74_R1.7541.00
108_S282_G1.7431.00
92_K96_K1.7231.00
194_V229_I1.6991.00
353_G367_V1.6921.00
36_Y426_E1.6821.00
195_D199_R1.6811.00
339_G357_G1.6671.00
68_I314_A1.6611.00
341_R344_E1.6611.00
43_K395_R1.6541.00
349_H436_K1.6461.00
207_M233_A1.6421.00
131_K167_V1.6241.00
115_N269_T1.6171.00
68_I72_L1.6171.00
209_I229_I1.6141.00
97_V323_E1.6001.00
33_K62_E1.5911.00
254_E332_K1.5881.00
279_V311_S1.5801.00
198_I238_V1.5591.00
270_T283_I1.5291.00
334_M337_Y1.5251.00
275_S281_I1.5131.00
44_K426_E1.4991.00
136_Y170_P1.4971.00
35_V423_E1.4971.00
339_G362_W1.4841.00
70_E74_R1.4831.00
93_A96_K1.4831.00
125_Y290_I1.4811.00
334_M424_I1.4801.00
89_K316_P1.4671.00
224_E227_P1.4611.00
135_R225_Y1.4511.00
242_A258_V1.4431.00
341_R429_D1.4411.00
343_Q346_K1.4361.00
184_P222_P1.4291.00
91_T107_Y1.4281.00
35_V418_I1.4251.00
390_D434_I1.4241.00
98_M285_G1.4181.00
133_L204_V1.4111.00
270_T285_G1.4021.00
132_I206_A1.3991.00
117_A284_T1.3941.00
230_R240_F1.3901.00
330_H333_V1.3791.00
105_F285_G1.3741.00
230_R233_A1.3721.00
62_E66_N1.3691.00
317_A321_E1.3631.00
432_D436_K1.3621.00
196_Y200_Q1.3621.00
134_A168_R1.3611.00
316_P320_E1.3551.00
394_R434_I1.3491.00
195_D228_L1.3491.00
39_D45_Y1.3481.00
254_E259_N1.3361.00
119_I132_I1.3321.00
281_I312_L1.3261.00
329_S333_V1.3241.00
337_Y341_R1.3201.00
95_L105_F1.3131.00
341_R432_D1.3121.00
391_V398_I1.3061.00
255_W259_N1.3031.00
334_M421_K1.2931.00
89_K320_E1.2921.00
419_I424_I1.2911.00
345_L428_V1.2891.00
118_A269_T1.2851.00
345_L432_D1.2851.00
96_K323_E1.2781.00
61_N325_L1.2771.00
66_N69_K1.2761.00
209_I226_M1.2751.00
31_S74_R1.2711.00
125_Y293_F1.2711.00
199_R236_N1.2701.00
29_V37_F1.2661.00
33_K60_G1.2661.00
122_S241_I1.2661.00
207_M229_I1.2551.00
115_N208_I1.2491.00
267_I286_V1.2481.00
258_V268_L1.2471.00
131_K201_E1.2451.00
274_A281_I1.2441.00
261_W358_V1.2331.00
260_L358_V1.2301.00
224_E261_W1.2281.00
57_L321_E1.2141.00
281_I315_I1.2091.00
67_S317_A1.2051.00
264_H287_S1.1931.00
274_A283_I1.1901.00
423_E426_E1.1901.00
104_K292_E1.1841.00
149_L166_V1.1811.00
60_G65_I1.1801.00
68_I310_V1.1781.00
320_E324_R1.1751.00
227_P231_K1.1721.00
65_I73_D1.1591.00
182_K185_D1.1521.00
65_I72_L1.1501.00
108_S284_T1.1471.00
391_V430_A1.1451.00
429_D433_D1.1401.00
242_A263_I1.1401.00
195_D232_I1.1391.00
69_K72_L1.1351.00
101_N264_H1.1291.00
239_L290_I1.1281.00
107_Y312_L1.1201.00
169_I197_V1.1181.00
332_K336_D1.1091.00
227_P262_D1.1061.00
267_I284_T1.1041.00
391_V434_I1.1011.00
149_L208_I1.1001.00
250_G328_L1.0901.00
36_Y46_L1.0871.00
129_R237_D1.0861.00
340_K344_E1.0811.00
256_F270_T1.0781.00
421_K425_D1.0651.00
35_V46_L1.0641.00
33_K44_K1.0521.00
426_E429_D1.0511.00
112_T146_S1.0461.00
321_E324_R1.0361.00
425_D429_D1.0351.00
30_S85_D1.0301.00
391_V396_L1.0291.00
195_D236_N1.0241.00
394_R430_A1.0221.00
396_L427_G1.0201.00
90_A316_P1.0181.00
233_A238_V1.0181.00
195_D231_K1.0161.00
30_S42_G1.0091.00
187_G195_D1.0071.00
276_A318_V0.9991.00
121_I284_T0.9991.00
253_G259_N0.9931.00
328_L331_V0.9921.00
33_K38_Y0.9871.00
193_Y196_Y0.9841.00
114_A269_T0.9821.00
119_I149_L0.9791.00
212_I358_V0.9781.00
134_A208_I0.9761.00
97_V255_W0.9701.00
93_A97_V0.9681.00
102_I285_G0.9591.00
389_V393_A0.9581.00
231_K234_K0.9551.00
223_K227_P0.9451.00
330_H421_K0.9431.00
28_I40_V0.9431.00
198_I204_V0.9351.00
56_N273_G0.9331.00
211_P242_A0.9331.00
66_N73_D0.9331.00
64_V314_A0.9321.00
57_L318_V0.9311.00
249_W322_Y0.9281.00
353_G365_E0.9271.00
148_S163_M0.9261.00
422_E425_D0.9261.00
329_S332_K0.9251.00
130_Y203_N0.9231.00
63_R320_E0.9211.00
229_I240_F0.9211.00
30_S38_Y0.9191.00
46_L423_E0.9171.00
135_R221_P0.9171.00
322_Y327_I0.9161.00
63_R66_N0.9141.00
322_Y328_L0.9111.00
131_K204_V0.9101.00
346_K352_I0.9091.00
206_A241_I0.9091.00
226_M261_W0.9091.00
365_E409_S0.9051.00
28_I88_V0.9051.00
313_S317_A0.9001.00
363_A410_W0.8881.00
260_L332_K0.8831.00
112_T143_T0.8821.00
121_I286_V0.8811.00
201_E236_N0.8791.00
220_V358_V0.8741.00
35_V420_N0.8731.00
55_V276_A0.8681.00
57_L64_V0.8651.00
46_L426_E0.8651.00
70_E73_D0.8631.00
48_F419_I0.8611.00
232_I236_N0.8591.00
335_G339_G0.8591.00
118_A241_I0.8521.00
70_E313_S0.8501.00
40_V85_D0.8481.00
97_V319_I0.8471.00
343_Q347_E0.8451.00
125_Y239_L0.8441.00
224_E228_L0.8421.00
386_T390_D0.8401.00
354_D365_E0.8391.00
369_D372_N0.8321.00
327_I331_V0.8301.00
135_R171_E0.8281.00
234_K264_H0.8271.00
228_L232_I0.8251.00
340_K343_Q0.8231.00
344_E348_R0.8121.00
348_R436_K0.8121.00
94_L285_G0.8111.00
419_I427_G0.8101.00
63_R67_S0.8071.00
360_L419_I0.8061.00
122_S206_A0.8061.00
247_T361_F0.8031.00
122_S239_L0.8031.00
279_V310_V0.8031.00
341_R424_I0.8021.00
255_W328_L0.7991.00
197_V200_Q0.7991.00
89_K93_A0.7961.00
237_D289_E0.7941.00
86_I313_S0.7911.00
95_L102_I0.7911.00
361_F414_S0.7871.00
124_F300_A0.7871.00
182_K193_Y0.7861.00
99_P258_V0.7841.00
249_W319_I0.7821.00
130_Y165_G0.7771.00
230_R263_I0.7751.00
34_G418_I0.7731.00
108_S114_A0.7711.00
328_L332_K0.7701.00
344_E347_E0.7671.00
433_D437_E0.7671.00
258_V263_I0.7661.00
128_P203_N0.7641.00
126_K129_R0.7631.00
101_N268_L0.7621.00
233_A240_F0.7621.00
413_I431_I0.7611.00
169_I194_V0.7611.00
337_Y340_K0.7601.00
344_E432_D0.7571.00
46_L427_G0.7561.00
366_L387_T0.7551.00
198_I232_I0.7521.00
35_V416_P0.7521.00
167_V197_V0.7511.00
105_F283_I0.7491.00
207_M238_V0.7471.00
53_V414_S0.7471.00
109_T113_E0.7461.00
356_R365_E0.7421.00
221_P224_E0.7421.00
86_I316_P0.7411.00
211_P226_M0.7401.00
171_E221_P0.7401.00
187_G196_Y0.7361.00
256_F268_L0.7351.00
48_F396_L0.7331.00
90_A312_L0.7301.00
333_V337_Y0.7271.00
249_W274_A0.7271.00
119_I208_I0.7261.00
249_W270_T0.7261.00
67_S314_A0.7251.00
204_V238_V0.7241.00
289_E292_E0.7211.00
214_G246_M0.7191.00
355_V362_W0.7191.00
220_V357_G0.7181.00
122_S267_I0.7171.00
255_W323_E0.7171.00
387_T431_I0.7161.00
303_H306_E0.7161.00
194_V207_M0.7151.00
252_V260_L0.7131.00
249_W255_W0.7091.00
333_V336_D0.7081.00
227_P261_W0.7051.00
102_I268_L0.7041.00
209_I240_F0.7021.00
86_I312_L0.6981.00
234_K240_F0.6971.00
193_Y197_V0.6971.00
83_G88_V0.6961.00
387_T434_I0.6961.00
334_M360_L0.6931.00
50_S414_S0.6931.00
64_V276_A0.6921.00
270_T274_A0.6921.00
43_K393_A0.6901.00
365_E410_W0.6901.00
357_G362_W0.6901.00
46_L396_L0.6861.00
427_G430_A0.6831.00
115_N146_S0.6801.00
84_A87_R0.6801.00
331_V335_G0.6791.00
86_I89_K0.6791.00
74_R85_D0.6781.00
120_K301_H0.6761.00
185_D193_Y0.6751.00
170_P185_D0.6741.00
145_G163_M0.6741.00
87_R91_T0.6711.00
214_G361_F0.6701.00
110_S113_E0.6701.00
93_A319_I0.6691.00
126_K237_D0.6691.00
422_E426_E0.6661.00
86_I90_A0.6661.00
121_I294_F0.6651.00
330_H420_N0.6651.00
337_Y424_I0.6631.00
29_V32_A0.6631.00
345_L349_H0.6601.00
32_A75_L0.6591.00
212_I252_V0.6591.00
198_I236_N0.6591.00
118_A267_I0.6591.00
287_S290_I0.6561.00
196_Y199_R0.6551.00
290_I293_F0.6551.00
349_H435_L0.6541.00
250_G322_Y0.6531.00
125_Y289_E0.6531.00
72_L310_V0.6511.00
391_V431_I0.6501.00
133_L194_V0.6501.00
226_M242_A0.6491.00
355_V364_I0.6491.00
335_G357_G0.6481.00
60_G72_L0.6481.00
76_Q279_V0.6481.00
97_V256_F0.6471.00
240_F263_I0.6461.00
99_P259_N0.6441.00
90_A281_I0.6411.00
367_V370_K0.6401.00
88_V92_K0.6381.00
366_L435_L0.6381.00
99_P102_I0.6381.00
345_L348_R0.6371.00
364_I431_I0.6351.00
434_I437_E0.6341.00
98_M268_L0.6331.00
71_Q74_R0.6331.00
346_K354_D0.6331.00
387_T391_V0.6321.00
169_I193_Y0.6301.00
295_E300_A0.6301.00
57_L327_I0.6291.00
411_F431_I0.6261.00
245_V269_T0.6241.00
258_V265_P0.6241.00
223_K358_V0.6231.00
28_I83_G0.6221.00
241_I267_I0.6211.00
223_K261_W0.6211.00
67_S70_E0.6201.00
428_V432_D0.6201.00
71_Q86_I0.6201.00
98_M256_F0.6181.00
334_M419_I0.6181.00
271_A282_G0.6181.00
129_R238_V0.6181.00
121_I267_I0.6171.00
385_Y389_V0.6171.00
338_L428_V0.6131.00
346_K355_V0.6121.00
413_I427_G0.6121.00
35_V419_I0.6121.00
183_Y187_G0.6111.00
44_K430_A0.6091.00
213_T216_N0.6081.00
286_V291_G0.6081.00
338_L362_W0.6071.00
117_A301_H0.6071.00
213_T219_I0.6061.00
50_S416_P0.6061.00
336_D339_G0.6031.00
111_G245_V0.6031.00
184_P187_G0.6021.00
123_R161_N0.5981.00
108_S113_E0.5971.00
97_V254_E0.5961.00
133_L197_V0.5951.00
32_A37_F0.5951.00
331_V417_L0.5941.00
419_I423_E0.5941.00
157_F160_P0.5931.00
334_M420_N0.5931.00
249_W256_F0.5891.00
139_Y142_S0.5891.00
131_K165_G0.5881.00
314_A317_A0.5871.00
330_H424_I0.5861.00
232_I235_E0.5851.00
135_R229_I0.5841.00
67_S320_E0.5821.00
234_K289_E0.5821.00
194_V232_I0.5821.00
430_A434_I0.5811.00
90_A107_Y0.5791.00
71_Q75_L0.5791.00
323_E326_N0.5781.00
136_Y168_R0.5781.00
72_L314_A0.5771.00
74_R86_I0.5741.00
98_M270_T0.5721.00
123_R144_E0.5711.00
211_P247_T0.5691.00
129_R203_N0.5691.00
64_V318_V0.5661.00
30_S33_K0.5661.00
166_V169_I0.5661.00
72_L76_Q0.5651.00
331_V360_L0.5641.00
386_T389_V0.5641.00
135_R209_I0.5631.00
64_V317_A0.5621.00
183_Y186_C0.5621.00
387_T411_F0.5621.00
101_N258_V0.5621.00
389_V392_L0.5591.00
56_N417_L0.5561.00
396_L426_E0.5541.00
431_I435_L0.5541.00
338_L424_I0.5541.00
367_V372_N0.5531.00
337_Y428_V0.5521.00
267_I290_I0.5521.00
341_R345_L0.5511.00
368_K372_N0.5501.00
356_R363_A0.5501.00
37_F397_L0.5481.00
356_R410_W0.5481.00
62_E73_D0.5471.00
32_A55_V0.5471.00
430_A433_D0.5461.00
33_K36_Y0.5451.00
126_K205_A0.5441.00
27_I30_S0.5441.00
351_S367_V0.5431.00
46_L419_I0.5431.00
135_R169_I0.5431.00
134_A166_V0.5421.00
427_G431_I0.5410.99
352_I435_L0.5400.99
49_S397_L0.5380.99
352_I364_I0.5370.99
364_I413_I0.5360.99
29_V75_L0.5360.99
95_L103_S0.5360.99
194_V225_Y0.5360.99
227_P230_R0.5350.99
211_P258_V0.5350.99
119_I145_G0.5320.99
395_R430_A0.5320.99
346_K435_L0.5320.99
229_I238_V0.5320.99
199_R235_E0.5310.99
95_L285_G0.5300.99
56_N322_Y0.5290.99
29_V82_F0.5290.99
424_I427_G0.5280.99
246_M361_F0.5280.99
271_A305_F0.5270.99
255_W322_Y0.5270.99
368_K371_N0.5250.99
89_K92_K0.5240.99
31_S44_K0.5240.99
151_G168_R0.5240.99
68_I76_Q0.5230.99
388_F392_L0.5230.99
425_D428_V0.5220.99
101_N287_S0.5210.99
338_L341_R0.5180.99
202_K236_N0.5170.99
268_L285_G0.5160.99
418_I423_E0.5150.99
194_V228_L0.5140.99
255_W319_I0.5140.99
186_C232_I0.5140.99
239_L267_I0.5130.99
95_L98_M0.5130.99
345_L435_L0.5120.99
308_H311_S0.5120.99
220_V261_W0.5120.99
396_L434_I0.5110.99
325_L330_H0.5110.99
387_T435_L0.5100.99
345_L429_D0.5090.99
194_V198_I0.5080.99
70_E317_A0.5070.99
319_I323_E0.5070.99
68_I279_V0.5070.99
94_L283_I0.5060.99
292_E295_E0.5050.99
65_I276_A0.5040.99
57_L61_N0.5040.99
426_E433_D0.5040.99
316_P323_E0.5030.99
153_Y157_F0.5020.99
424_I428_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e3qA 3 0.9752 100 0.386 Contact Map
4uoxA 3 0.9279 100 0.387 Contact Map
4a0gA 2 0.9482 100 0.389 Contact Map
3hmuA 2 0.9797 100 0.392 Contact Map
4atqA 7 0.9437 100 0.396 Contact Map
3oksA 2 0.9505 100 0.397 Contact Map
1z7dA 2 0.8401 100 0.403 Contact Map
4ffcA 4 0.9527 100 0.406 Contact Map
3i5tA 2 0.9572 100 0.41 Contact Map
2epjA 2 0.9257 100 0.418 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0125 seconds.