GREMLIN Database
Q97VB2 - Second ORF in transposon ISC1229
UniProt: Q97VB2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (236)
Sequences: 3962 (2920)
Seq/√Len: 190.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_R121_M3.2801.00
50_Q112_R2.9961.00
217_H220_K2.9581.00
103_V114_E2.7631.00
166_C192_L2.6681.00
150_V162_F2.6411.00
162_F235_A2.5721.00
134_T247_P2.4881.00
106_R114_E2.3351.00
49_V52_K2.3201.00
157_P161_S2.3171.00
49_V56_R2.2511.00
57_L108_L2.1351.00
211_L215_E2.0981.00
158_R161_S2.0801.00
131_V247_P2.0701.00
110_Q114_E2.0611.00
43_Y119_R2.0371.00
146_I238_V2.0371.00
49_V107_T1.9671.00
41_S149_I1.9391.00
47_N115_L1.9341.00
184_I228_T1.9271.00
126_V133_L1.9161.00
138_I143_A1.9161.00
222_K225_K1.8911.00
232_R236_R1.8881.00
50_Q115_L1.8741.00
168_L231_A1.8691.00
121_M124_G1.8321.00
107_T114_E1.8131.00
132_L238_V1.8011.00
44_L194_S1.7671.00
13_T172_V1.7351.00
174_R179_E1.7341.00
51_T55_N1.7091.00
105_A109_L1.7001.00
131_V134_T1.6811.00
142_A195_L1.6771.00
194_S198_F1.6711.00
23_N27_K1.6611.00
78_F82_D1.6421.00
239_W243_Y1.6381.00
241_V247_P1.6161.00
116_K119_R1.6151.00
156_F165_Y1.6141.00
198_F201_E1.6051.00
166_C235_A1.5891.00
135_I241_V1.5811.00
240_S244_N1.5791.00
43_Y47_N1.5741.00
106_R113_E1.5691.00
46_M115_L1.5631.00
107_T110_Q1.5591.00
221_L225_K1.5541.00
145_I195_L1.5411.00
216_A220_K1.5351.00
75_L78_F1.5211.00
132_L143_A1.5041.00
135_I238_V1.5011.00
103_V117_E1.4701.00
57_L101_I1.4681.00
214_H230_L1.4561.00
82_D85_D1.4501.00
47_N50_Q1.4331.00
200_A234_L1.4311.00
204_Y214_H1.4181.00
78_F81_G1.4091.00
199_L234_L1.4061.00
54_E72_E1.3991.00
50_Q108_L1.3901.00
163_V232_R1.3741.00
200_A231_A1.3431.00
106_R110_Q1.3261.00
70_L74_R1.3141.00
119_R123_E1.3131.00
175_S179_E1.2931.00
197_Y231_A1.2861.00
131_V241_V1.2831.00
133_L140_K1.2751.00
45_F56_R1.2731.00
153_I242_W1.2631.00
72_E76_E1.2621.00
110_Q113_E1.2591.00
218_K223_G1.2421.00
108_L112_R1.2401.00
149_I189_N1.2331.00
53_Q57_L1.2301.00
142_A199_L1.2251.00
40_V191_Y1.2231.00
48_D52_K1.2231.00
42_L46_M1.2211.00
213_F233_K1.2111.00
218_K224_R1.2101.00
240_S243_Y1.2041.00
80_K83_F1.2031.00
210_L230_L1.1991.00
74_R77_K1.1961.00
123_E140_K1.1881.00
78_F83_F1.1851.00
19_E23_N1.1721.00
210_L237_I1.1611.00
73_E77_K1.1381.00
135_I234_L1.1381.00
49_V53_Q1.1251.00
213_F217_H1.1191.00
71_S74_R1.1061.00
241_V246_K1.1011.00
217_H222_K1.1001.00
163_V169_D1.1001.00
43_Y115_L1.0941.00
79_S82_D1.0871.00
40_V122_I1.0681.00
95_G121_M1.0661.00
44_L191_Y1.0641.00
197_Y228_T1.0601.00
132_L242_W1.0591.00
75_L82_D1.0521.00
224_R227_Y1.0501.00
35_P94_T1.0461.00
43_Y141_L1.0401.00
213_F230_L1.0381.00
112_R116_K1.0311.00
213_F229_A1.0301.00
50_Q54_E1.0271.00
196_F235_A1.0271.00
11_K172_V1.0221.00
75_L83_F1.0181.00
79_S83_F1.0151.00
80_K84_S1.0071.00
121_M125_N1.0031.00
200_A230_L1.0031.00
54_E108_L0.9980.99
129_D147_I0.9940.99
24_M28_A0.9780.99
146_I192_L0.9780.99
217_H226_L0.9760.99
217_H221_L0.9720.99
47_N51_T0.9710.99
201_E204_Y0.9710.99
103_V121_M0.9700.99
186_K193_G0.9690.99
184_I193_G0.9690.99
44_L48_D0.9670.99
201_E224_R0.9660.99
98_L102_Q0.9620.99
96_T121_M0.9580.99
158_R239_W0.9530.99
237_I241_V0.9460.99
208_P212_K0.9330.99
124_G128_Q0.9330.99
138_I238_V0.9250.99
79_S85_D0.9230.99
53_Q104_L0.9210.99
215_E219_D0.9200.99
208_P211_L0.9170.99
37_K149_I0.9140.99
53_Q107_T0.9130.99
210_L234_L0.9060.99
12_K17_D0.9000.99
40_V144_G0.8870.99
68_E78_F0.8760.99
39_L118_V0.8720.99
99_R103_V0.8710.99
53_Q108_L0.8700.99
200_A227_Y0.8700.99
126_V144_G0.8690.99
201_E227_Y0.8670.99
135_I138_I0.8500.98
138_I142_A0.8480.98
161_S164_A0.8460.98
138_I234_L0.8430.98
75_L81_G0.8350.98
14_D175_S0.8310.98
196_F231_A0.8250.98
222_K226_L0.8240.98
46_M118_V0.8230.98
150_V153_I0.8200.98
197_Y201_E0.8150.98
202_T206_R0.8140.98
169_D185_S0.8100.98
52_K55_N0.8070.98
76_E80_K0.8050.98
99_R102_Q0.7970.98
114_E117_E0.7910.97
164_A169_D0.7880.97
212_K216_A0.7870.97
22_E26_N0.7870.97
109_L113_E0.7860.97
40_V145_I0.7820.97
149_I191_Y0.7790.97
213_F216_A0.7680.97
42_L118_V0.7670.97
117_E121_M0.7650.97
184_I229_A0.7630.97
75_L79_S0.7630.97
172_V179_E0.7620.97
68_E82_D0.7620.97
123_E133_L0.7600.97
21_L24_M0.7590.97
152_D155_R0.7550.97
216_A219_D0.7400.96
77_K81_G0.7400.96
70_L73_E0.7360.96
68_E84_S0.7330.96
68_E74_R0.7300.96
70_L81_G0.7290.96
16_Y20_K0.7270.96
38_E100_E0.7220.96
113_E117_E0.7170.95
32_V128_Q0.7170.95
77_K80_K0.7110.95
46_M114_E0.7080.95
201_E231_A0.7070.95
62_F67_E0.7060.95
70_L79_S0.7050.95
30_E33_N0.7050.95
159_P239_W0.7050.95
75_L80_K0.6980.95
200_A203_Q0.6970.95
34_N38_E0.6950.95
125_N128_Q0.6940.95
55_N59_R0.6900.94
81_G85_D0.6860.94
59_R63_L0.6840.94
115_L119_R0.6830.94
47_N119_R0.6820.94
109_L112_R0.6810.94
96_T99_R0.6800.94
107_T111_T0.6790.94
100_E103_V0.6750.94
42_L100_E0.6730.94
169_D172_V0.6650.93
188_G193_G0.6640.93
217_H229_A0.6590.93
8_V11_K0.6580.93
71_S75_L0.6530.93
69_K78_F0.6530.93
212_K215_E0.6500.92
71_S78_F0.6480.92
119_R141_L0.6470.92
70_L82_D0.6450.92
41_S191_Y0.6440.92
11_K16_Y0.6410.92
45_F49_V0.6390.92
236_R239_W0.6350.91
163_V236_R0.6330.91
41_S189_N0.6320.91
145_I149_I0.6300.91
69_K72_E0.6280.91
78_F85_D0.6280.91
74_R82_D0.6270.91
160_E232_R0.6240.91
75_L84_S0.6220.91
233_K236_R0.6220.91
171_V185_S0.6210.91
76_E79_S0.6190.90
111_T115_L0.6190.90
16_Y21_L0.6190.90
112_R115_L0.6180.90
218_K226_L0.6180.90
74_R85_D0.6110.90
169_D193_G0.6100.90
53_Q111_T0.6060.89
74_R78_F0.6060.89
191_Y194_S0.6050.89
38_E60_A0.6050.89
119_R122_I0.6040.89
9_R169_D0.6040.89
10_G187_R0.6040.89
146_I162_F0.6030.89
74_R81_G0.6020.89
42_L103_V0.6010.89
50_Q111_T0.6010.89
79_S84_S0.6000.89
99_R117_E0.6000.89
103_V107_T0.5980.89
38_E97_V0.5940.89
196_F238_V0.5940.89
76_E83_F0.5890.88
102_Q106_R0.5880.88
138_I146_I0.5870.88
36_L125_N0.5840.88
46_M111_T0.5840.88
145_I191_Y0.5790.87
131_V245_N0.5770.87
76_E82_D0.5770.87
70_L80_K0.5760.87
168_L196_F0.5760.87
35_P95_G0.5760.87
138_I199_L0.5740.87
23_N26_N0.5730.87
182_K185_S0.5710.87
85_D93_Y0.5710.87
77_K83_F0.5670.86
195_L199_L0.5670.86
69_K76_E0.5660.86
103_V106_R0.5650.86
225_K229_A0.5650.86
154_K243_Y0.5610.86
207_N211_L0.5610.86
69_K74_R0.5610.86
81_G84_S0.5600.85
72_E75_L0.5590.85
134_T241_V0.5590.85
29_R34_N0.5580.85
30_E34_N0.5560.85
172_V181_R0.5560.85
215_E218_K0.5530.85
203_Q207_N0.5520.85
70_L75_L0.5510.85
69_K84_S0.5500.84
68_E93_Y0.5500.84
185_S193_G0.5500.84
53_Q56_R0.5500.84
167_G176_G0.5500.84
174_R178_I0.5490.84
204_Y227_Y0.5480.84
104_L107_T0.5460.84
204_Y218_K0.5460.84
193_G228_T0.5440.84
168_L232_R0.5440.84
243_Y246_K0.5410.83
73_E124_G0.5400.83
34_N37_K0.5380.83
134_T147_I0.5370.83
56_R104_L0.5370.83
199_L203_Q0.5350.83
40_V148_G0.5330.83
76_E84_S0.5320.82
22_E28_A0.5280.82
45_F52_K0.5270.82
7_D23_N0.5270.82
45_F48_D0.5240.82
167_G193_G0.5220.81
42_L45_F0.5220.81
56_R59_R0.5200.81
9_R164_A0.5190.81
106_R117_E0.5180.81
68_E71_S0.5170.81
39_L121_M0.5170.81
131_V135_I0.5160.81
32_V35_P0.5140.80
66_D82_D0.5100.80
7_D16_Y0.5100.80
113_E116_K0.5090.80
99_R110_Q0.5080.80
42_L104_L0.5060.79
229_A232_R0.5050.79
132_L138_I0.5030.79
201_E205_S0.5030.79
218_K221_L0.5030.79
77_K82_D0.5000.78
203_Q234_L0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1keaA 2 0.7888 92.8 0.911 Contact Map
2a1jB 2 0.3068 80.9 0.927 Contact Map
4glxA 1 0.5339 80.4 0.927 Contact Map
3fhfA 1 0.741 77.9 0.929 Contact Map
1pu6A 1 0.7769 77.4 0.93 Contact Map
2a1jA 1 0.2351 76.4 0.93 Contact Map
1z00A 1 0.3267 75.7 0.931 Contact Map
1z00B 1 0.2829 75.2 0.931 Contact Map
2duyA 1 0.255 75.1 0.931 Contact Map
2abkA 1 0.7769 73.8 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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