GREMLIN Database
Q97VA9 - Uncharacterized protein
UniProt: Q97VA9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (243)
Sequences: 189 (107)
Seq/√Len: 6.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
269_Q289_K5.4180.99
193_T196_E4.3260.97
182_T222_N4.0740.96
269_Q288_N3.7700.94
146_N168_C3.4610.91
190_P199_E3.1650.86
192_N196_E3.0750.84
207_K267_E3.0320.84
25_L31_A2.8100.78
262_R266_E2.7270.76
186_V196_E2.7150.76
120_V259_M2.6680.74
186_V225_A2.5240.70
206_L264_L2.3070.63
200_D204_S2.1750.58
24_D51_G2.1050.55
26_H51_G2.1050.55
25_L53_L2.0370.53
104_T300_N2.0180.52
189_T196_E1.9790.51
198_T201_Q1.9780.50
106_L109_N1.9510.49
197_M205_N1.9280.49
175_I201_Q1.8490.46
136_L143_I1.8460.45
18_K141_L1.8160.44
22_T44_A1.7900.43
24_D52_D1.7760.43
26_H52_D1.7760.43
183_F223_L1.7190.41
183_F206_L1.7140.41
93_V186_V1.7000.40
188_P196_E1.6870.40
136_L163_E1.6480.38
191_W195_R1.6100.37
170_G176_N1.5790.36
255_H292_I1.5690.35
174_N177_G1.5620.35
22_T35_F1.5500.35
46_T126_Q1.5490.35
142_K155_M1.5400.34
265_E268_F1.5350.34
63_D170_G1.5300.34
159_I162_S1.4920.33
189_T193_T1.4810.32
48_I269_Q1.4780.32
191_W196_E1.4680.32
183_F232_L1.4660.32
165_M299_Y1.4650.32
89_K175_I1.4600.32
218_K300_N1.4480.31
53_L66_N1.4410.31
187_N225_A1.4360.31
23_S175_I1.4330.31
197_M201_Q1.4080.30
25_L45_D1.4010.30
208_R260_S1.3990.30
170_G286_K1.3920.29
227_P296_G1.3870.29
86_K90_S1.3860.29
66_N137_K1.3830.29
49_I147_L1.3800.29
142_K176_N1.3680.29
175_I180_M1.3630.29
258_S302_G1.3570.28
108_E114_D1.3350.28
52_D148_G1.3340.28
83_E86_K1.3240.27
92_G293_I1.3230.27
90_S283_A1.3220.27
163_E178_Y1.3200.27
106_L110_R1.3200.27
109_N278_I1.2930.26
63_D220_I1.2910.26
150_D297_S1.2910.26
145_T160_T1.2860.26
128_W222_N1.2860.26
203_Y264_L1.2800.26
186_V197_M1.2650.26
258_S277_H1.2650.26
63_D77_G1.2580.25
20_L54_A1.2480.25
187_N193_T1.2380.25
48_I91_S1.2350.25
68_K190_P1.2320.25
75_I225_A1.2300.25
105_E109_N1.2030.24
62_I84_I1.2000.24
18_K44_A1.1820.23
264_L268_F1.1790.23
201_Q205_N1.1750.23
263_K266_E1.1710.23
92_G302_G1.1670.23
104_T107_N1.1650.23
69_F159_I1.1610.23
265_E287_I1.1600.23
106_L113_L1.1500.22
68_K78_K1.1460.22
75_I120_V1.1300.22
36_L295_P1.1150.22
75_I130_R1.1120.21
233_D276_G1.1090.21
224_H276_G1.1090.21
226_P276_G1.1090.21
226_P233_D1.1090.21
224_H233_D1.1090.21
62_I72_E1.1060.21
210_I264_L1.1030.21
199_E302_G1.0920.21
46_T155_M1.0890.21
117_F299_Y1.0870.21
192_N195_R1.0780.21
157_D207_K1.0710.20
211_E285_D1.0610.20
105_E112_S1.0570.20
50_G136_L1.0540.20
125_L176_N1.0520.20
91_S120_V1.0370.20
126_Q155_M1.0360.20
62_I85_I1.0310.19
30_T119_R1.0230.19
191_W199_E1.0220.19
202_I260_S1.0190.19
150_D235_A1.0170.19
202_I278_I1.0110.19
269_Q290_T1.0080.19
199_E287_I0.9870.18
191_W299_Y0.9810.18
166_V204_S0.9710.18
48_I112_S0.9690.18
42_T283_A0.9620.18
83_E278_I0.9620.18
235_A297_S0.9600.18
150_D278_I0.9540.18
33_R124_R0.9530.18
206_L223_L0.9490.18
146_N167_K0.9460.18
64_I129_D0.9410.17
172_I282_R0.9400.17
142_K170_G0.9370.17
48_I190_P0.9360.17
47_L291_I0.9250.17
127_E144_Y0.9210.17
263_K285_D0.9200.17
204_S218_K0.9180.17
71_I170_G0.9160.17
81_V84_I0.9110.17
90_S177_G0.9110.17
120_V175_I0.9080.17
147_L169_E0.9060.17
127_E198_T0.8890.16
204_S208_R0.8830.16
63_D144_Y0.8820.16
62_I73_D0.8820.16
78_K198_T0.8820.16
165_M267_E0.8800.16
124_R153_L0.8790.16
86_K119_R0.8780.16
201_Q204_S0.8690.16
223_L283_A0.8670.16
151_D258_S0.8550.16
168_C173_V0.8510.16
286_K291_I0.8430.15
196_E302_G0.8400.15
120_V293_I0.8390.15
130_R201_Q0.8360.15
42_T80_G0.8350.15
115_E199_E0.8350.15
89_K123_E0.8340.15
209_I225_A0.8320.15
71_I76_V0.8300.15
168_C293_I0.8300.15
64_I158_V0.8290.15
198_T234_N0.8290.15
144_Y257_G0.8290.15
65_G73_D0.8270.15
28_S271_L0.8190.15
183_F273_G0.8160.15
35_F50_G0.8160.15
104_T114_D0.8130.15
197_M236_P0.8120.15
236_P256_V0.8090.15
190_P264_L0.7960.14
255_H285_D0.7950.14
109_N273_G0.7930.14
18_K23_S0.7920.14
107_N119_R0.7920.14
136_L140_N0.7910.14
178_Y293_I0.7890.14
165_M264_L0.7850.14
80_G259_M0.7850.14
60_P192_N0.7830.14
117_F173_V0.7830.14
62_I82_D0.7820.14
276_G279_H0.7800.14
224_H279_H0.7800.14
233_D279_H0.7800.14
226_P279_H0.7800.14
79_E125_L0.7780.14
54_A147_L0.7770.14
54_A156_F0.7740.14
128_W182_T0.7730.14
60_P191_W0.7700.14
34_K248_N0.7580.14
169_E184_G0.7510.14
60_P196_E0.7500.14
42_T261_I0.7430.13
22_T32_F0.7380.13
19_I81_V0.7370.13
89_K141_L0.7350.13
21_F47_L0.7340.13
48_I54_A0.7320.13
254_T293_I0.7310.13
29_E289_K0.7300.13
45_D229_G0.7290.13
75_I81_V0.7280.13
25_L176_N0.7270.13
52_D149_N0.7250.13
36_L68_K0.7180.13
19_I33_R0.7180.13
75_I173_V0.7150.13
61_I248_N0.7150.13
119_R263_K0.7100.13
262_R283_A0.7080.13
170_G282_R0.7070.13
170_G181_I0.6980.13
19_I44_A0.6980.13
134_E141_L0.6960.13
53_L76_V0.6950.13
171_E260_S0.6930.13
189_T199_E0.6930.13
108_E161_K0.6890.13
85_I145_T0.6840.12
32_F129_D0.6820.12
115_E204_S0.6820.12
168_C172_I0.6810.12
223_L232_L0.6780.12
77_G176_N0.6750.12
110_R113_L0.6750.12
123_E147_L0.6670.12
148_G226_P0.6670.12
148_G276_G0.6670.12
148_G233_D0.6670.12
148_G224_H0.6670.12
150_D296_G0.6660.12
86_K259_M0.6640.12
276_G294_N0.6640.12
224_H294_N0.6640.12
226_P294_N0.6640.12
233_D294_N0.6640.12
47_L286_K0.6610.12
175_I194_P0.6610.12
284_F291_I0.6550.12
48_I291_I0.6550.12
48_I139_T0.6550.12
70_K116_E0.6530.12
112_S171_E0.6520.12
200_D264_L0.6520.12
178_Y271_L0.6480.12
45_D136_L0.6450.12
185_Y298_E0.6450.12
94_Y293_I0.6430.12
74_K267_E0.6420.12
196_E272_L0.6400.12
80_G208_R0.6380.12
75_I199_E0.6380.12
186_V193_T0.6380.12
261_I273_G0.6360.12
166_V171_E0.6330.12
147_L165_M0.6320.12
249_G298_E0.6310.12
196_E199_E0.6290.12
74_K127_E0.6280.12
45_D163_E0.6270.12
209_I260_S0.6270.12
25_L50_G0.6270.12
134_E302_G0.6250.12
93_V106_L0.6240.12
27_G296_G0.6230.11
25_L49_I0.6230.11
62_I81_V0.6220.11
192_N197_M0.6210.11
119_R223_L0.6190.11
115_E263_K0.6150.11
172_I201_Q0.6150.11
71_I181_I0.6100.11
136_L162_S0.6090.11
187_N195_R0.6040.11
73_D159_I0.6040.11
152_P190_P0.6010.11
190_P265_E0.5920.11
30_T272_L0.5920.11
285_D292_I0.5920.11
34_K189_T0.5900.11
47_L227_P0.5850.11
84_I180_M0.5850.11
79_E139_T0.5850.11
180_M222_N0.5810.11
184_G203_Y0.5790.11
76_V126_Q0.5780.11
190_P296_G0.5760.11
160_T269_Q0.5750.11
86_K174_N0.5740.11
34_K42_T0.5740.11
209_I264_L0.5710.11
273_G292_I0.5660.11
159_I230_T0.5620.11
25_L264_L0.5620.11
275_H280_E0.5610.11
21_F36_L0.5600.11
68_K80_G0.5560.10
106_L177_G0.5550.10
181_I223_L0.5520.10
109_N112_S0.5520.10
91_S168_C0.5500.10
28_S235_A0.5500.10
32_F50_G0.5480.10
222_N281_S0.5470.10
202_I283_A0.5460.10
35_F61_I0.5440.10
107_N120_V0.5390.10
169_E295_P0.5380.10
20_L268_F0.5380.10
48_I137_K0.5370.10
61_I291_I0.5360.10
63_D142_K0.5340.10
27_G258_S0.5330.10
166_V299_Y0.5290.10
67_S142_K0.5280.10
120_V199_E0.5250.10
95_Y187_N0.5250.10
94_Y120_V0.5250.10
50_G129_D0.5250.10
127_E201_Q0.5240.10
73_D78_K0.5230.10
43_K185_Y0.5180.10
190_P206_L0.5170.10
116_E158_V0.5150.10
128_W295_P0.5140.10
261_I301_L0.5110.10
259_M287_I0.5110.10
134_E199_E0.5100.10
137_K194_P0.5100.10
187_N254_T0.5090.10
130_R177_G0.5070.10
166_V283_A0.5060.10
201_Q293_I0.5050.10
50_G222_N0.5050.10
82_D285_D0.5040.10
64_I144_Y0.5030.10
83_E171_E0.5030.10
288_N291_I0.5010.10
24_D276_G0.5000.10
24_D224_H0.5000.10
24_D226_P0.5000.10
24_D233_D0.5000.10
26_H276_G0.5000.10
26_H233_D0.5000.10
26_H226_P0.5000.10
26_H224_H0.5000.10
230_T273_G0.5000.10
51_G226_P0.5000.10
51_G276_G0.5000.10
51_G233_D0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yvtA 1 0.7531 100 0.759 Contact Map
1uf3A 6 0.6543 100 0.764 Contact Map
4peiA 2 0.7623 99.9 0.79 Contact Map
3rl5A 1 0.6605 99.9 0.808 Contact Map
3d03A 5 0.6852 99.9 0.817 Contact Map
3ib7A 2 0.7222 99.9 0.821 Contact Map
3qfmA 2 0.6389 99.9 0.821 Contact Map
3rqzA 1 0.6049 99.8 0.827 Contact Map
3t1iA 2 0.7315 99.8 0.83 Contact Map
4ykeA 2 0.784 99.8 0.834 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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