Q97VA9 - SULSO - GREMLIN Contacts

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Q97VA9 - Uncharacterized protein

UniProt:	Q97VA9	Sequences: MGLFKRNNPDSNKIGGLKILFTSDLHGSETAFRKFLNAALMTKADTLIIGGDLAGKSLVPIIDIGNSKFKIEDKIVGKEGVDEIIKKYKSSGVYYTIVDQKGLTELNENRKSLDEEFKRVILERLQEWDRIAEEKLKGTNLKIYTNLGNDDPLYMFDVITKSERMVKCEGEIVNINGYEMITFGYVNPTPWNTPREMTEDQIYSNLKRIIEKVGNPAKTIFNLHAPPYGTNLDNAPLLDKTLKPVVKNGEIVMTHVGSMSIRKLEEEFQPLLGIHGHIHESRAFDKINKTIIINPGSEYNLGMLHAAYIILEDNKVKTHQFVIG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	324 (243)
Sequences:	189 (107)
Seq/√Len:	6.9

SULSO - Q97VA9 Q97WI0 Q97VA5 Q97WP7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
269_Q	289_K	5.418	0.99
193_T	196_E	4.326	0.97
182_T	222_N	4.074	0.96
269_Q	288_N	3.770	0.94
146_N	168_C	3.461	0.91
190_P	199_E	3.165	0.86
192_N	196_E	3.075	0.84
207_K	267_E	3.032	0.84
25_L	31_A	2.810	0.78
262_R	266_E	2.727	0.76
186_V	196_E	2.715	0.76
120_V	259_M	2.668	0.74
186_V	225_A	2.524	0.70
206_L	264_L	2.307	0.63
200_D	204_S	2.175	0.58
24_D	51_G	2.105	0.55
26_H	51_G	2.105	0.55
25_L	53_L	2.037	0.53
104_T	300_N	2.018	0.52
189_T	196_E	1.979	0.51
198_T	201_Q	1.978	0.50
106_L	109_N	1.951	0.49
197_M	205_N	1.928	0.49
175_I	201_Q	1.849	0.46
136_L	143_I	1.846	0.45
18_K	141_L	1.816	0.44
22_T	44_A	1.790	0.43
24_D	52_D	1.776	0.43
26_H	52_D	1.776	0.43
183_F	223_L	1.719	0.41
183_F	206_L	1.714	0.41
93_V	186_V	1.700	0.40
188_P	196_E	1.687	0.40
136_L	163_E	1.648	0.38
191_W	195_R	1.610	0.37
170_G	176_N	1.579	0.36
255_H	292_I	1.569	0.35
174_N	177_G	1.562	0.35
22_T	35_F	1.550	0.35
46_T	126_Q	1.549	0.35
142_K	155_M	1.540	0.34
265_E	268_F	1.535	0.34
63_D	170_G	1.530	0.34
159_I	162_S	1.492	0.33
189_T	193_T	1.481	0.32
48_I	269_Q	1.478	0.32
191_W	196_E	1.468	0.32
183_F	232_L	1.466	0.32
165_M	299_Y	1.465	0.32
89_K	175_I	1.460	0.32
218_K	300_N	1.448	0.31
53_L	66_N	1.441	0.31
187_N	225_A	1.436	0.31
23_S	175_I	1.433	0.31
197_M	201_Q	1.408	0.30
25_L	45_D	1.401	0.30
208_R	260_S	1.399	0.30
170_G	286_K	1.392	0.29
227_P	296_G	1.387	0.29
86_K	90_S	1.386	0.29
66_N	137_K	1.383	0.29
49_I	147_L	1.380	0.29
142_K	176_N	1.368	0.29
175_I	180_M	1.363	0.29
258_S	302_G	1.357	0.28
108_E	114_D	1.335	0.28
52_D	148_G	1.334	0.28
83_E	86_K	1.324	0.27
92_G	293_I	1.323	0.27
90_S	283_A	1.322	0.27
163_E	178_Y	1.320	0.27
106_L	110_R	1.320	0.27
109_N	278_I	1.293	0.26
63_D	220_I	1.291	0.26
150_D	297_S	1.291	0.26
145_T	160_T	1.286	0.26
128_W	222_N	1.286	0.26
203_Y	264_L	1.280	0.26
186_V	197_M	1.265	0.26
258_S	277_H	1.265	0.26
63_D	77_G	1.258	0.25
20_L	54_A	1.248	0.25
187_N	193_T	1.238	0.25
48_I	91_S	1.235	0.25
68_K	190_P	1.232	0.25
75_I	225_A	1.230	0.25
105_E	109_N	1.203	0.24
62_I	84_I	1.200	0.24
18_K	44_A	1.182	0.23
264_L	268_F	1.179	0.23
201_Q	205_N	1.175	0.23
263_K	266_E	1.171	0.23
92_G	302_G	1.167	0.23
104_T	107_N	1.165	0.23
69_F	159_I	1.161	0.23
265_E	287_I	1.160	0.23
106_L	113_L	1.150	0.22
68_K	78_K	1.146	0.22
75_I	120_V	1.130	0.22
36_L	295_P	1.115	0.22
75_I	130_R	1.112	0.21
233_D	276_G	1.109	0.21
224_H	276_G	1.109	0.21
226_P	276_G	1.109	0.21
226_P	233_D	1.109	0.21
224_H	233_D	1.109	0.21
62_I	72_E	1.106	0.21
210_I	264_L	1.103	0.21
199_E	302_G	1.092	0.21
46_T	155_M	1.089	0.21
117_F	299_Y	1.087	0.21
192_N	195_R	1.078	0.21
157_D	207_K	1.071	0.20
211_E	285_D	1.061	0.20
105_E	112_S	1.057	0.20
50_G	136_L	1.054	0.20
125_L	176_N	1.052	0.20
91_S	120_V	1.037	0.20
126_Q	155_M	1.036	0.20
62_I	85_I	1.031	0.19
30_T	119_R	1.023	0.19
191_W	199_E	1.022	0.19
202_I	260_S	1.019	0.19
150_D	235_A	1.017	0.19
202_I	278_I	1.011	0.19
269_Q	290_T	1.008	0.19
199_E	287_I	0.987	0.18
191_W	299_Y	0.981	0.18
166_V	204_S	0.971	0.18
48_I	112_S	0.969	0.18
42_T	283_A	0.962	0.18
83_E	278_I	0.962	0.18
235_A	297_S	0.960	0.18
150_D	278_I	0.954	0.18
33_R	124_R	0.953	0.18
206_L	223_L	0.949	0.18
146_N	167_K	0.946	0.18
64_I	129_D	0.941	0.17
172_I	282_R	0.940	0.17
142_K	170_G	0.937	0.17
48_I	190_P	0.936	0.17
47_L	291_I	0.925	0.17
127_E	144_Y	0.921	0.17
263_K	285_D	0.920	0.17
204_S	218_K	0.918	0.17
71_I	170_G	0.916	0.17
81_V	84_I	0.911	0.17
90_S	177_G	0.911	0.17
120_V	175_I	0.908	0.17
147_L	169_E	0.906	0.17
127_E	198_T	0.889	0.16
204_S	208_R	0.883	0.16
63_D	144_Y	0.882	0.16
62_I	73_D	0.882	0.16
78_K	198_T	0.882	0.16
165_M	267_E	0.880	0.16
124_R	153_L	0.879	0.16
86_K	119_R	0.878	0.16
201_Q	204_S	0.869	0.16
223_L	283_A	0.867	0.16
151_D	258_S	0.855	0.16
168_C	173_V	0.851	0.16
286_K	291_I	0.843	0.15
196_E	302_G	0.840	0.15
120_V	293_I	0.839	0.15
130_R	201_Q	0.836	0.15
42_T	80_G	0.835	0.15
115_E	199_E	0.835	0.15
89_K	123_E	0.834	0.15
209_I	225_A	0.832	0.15
71_I	76_V	0.830	0.15
168_C	293_I	0.830	0.15
64_I	158_V	0.829	0.15
198_T	234_N	0.829	0.15
144_Y	257_G	0.829	0.15
65_G	73_D	0.827	0.15
28_S	271_L	0.819	0.15
183_F	273_G	0.816	0.15
35_F	50_G	0.816	0.15
104_T	114_D	0.813	0.15
197_M	236_P	0.812	0.15
236_P	256_V	0.809	0.15
190_P	264_L	0.796	0.14
255_H	285_D	0.795	0.14
109_N	273_G	0.793	0.14
18_K	23_S	0.792	0.14
107_N	119_R	0.792	0.14
136_L	140_N	0.791	0.14
178_Y	293_I	0.789	0.14
165_M	264_L	0.785	0.14
80_G	259_M	0.785	0.14
60_P	192_N	0.783	0.14
117_F	173_V	0.783	0.14
62_I	82_D	0.782	0.14
276_G	279_H	0.780	0.14
224_H	279_H	0.780	0.14
233_D	279_H	0.780	0.14
226_P	279_H	0.780	0.14
79_E	125_L	0.778	0.14
54_A	147_L	0.777	0.14
54_A	156_F	0.774	0.14
128_W	182_T	0.773	0.14
60_P	191_W	0.770	0.14
34_K	248_N	0.758	0.14
169_E	184_G	0.751	0.14
60_P	196_E	0.750	0.14
42_T	261_I	0.743	0.13
22_T	32_F	0.738	0.13
19_I	81_V	0.737	0.13
89_K	141_L	0.735	0.13
21_F	47_L	0.734	0.13
48_I	54_A	0.732	0.13
254_T	293_I	0.731	0.13
29_E	289_K	0.730	0.13
45_D	229_G	0.729	0.13
75_I	81_V	0.728	0.13
25_L	176_N	0.727	0.13
52_D	149_N	0.725	0.13
36_L	68_K	0.718	0.13
19_I	33_R	0.718	0.13
75_I	173_V	0.715	0.13
61_I	248_N	0.715	0.13
119_R	263_K	0.710	0.13
262_R	283_A	0.708	0.13
170_G	282_R	0.707	0.13
170_G	181_I	0.698	0.13
19_I	44_A	0.698	0.13
134_E	141_L	0.696	0.13
53_L	76_V	0.695	0.13
171_E	260_S	0.693	0.13
189_T	199_E	0.693	0.13
108_E	161_K	0.689	0.13
85_I	145_T	0.684	0.12
32_F	129_D	0.682	0.12
115_E	204_S	0.682	0.12
168_C	172_I	0.681	0.12
223_L	232_L	0.678	0.12
77_G	176_N	0.675	0.12
110_R	113_L	0.675	0.12
123_E	147_L	0.667	0.12
148_G	226_P	0.667	0.12
148_G	276_G	0.667	0.12
148_G	233_D	0.667	0.12
148_G	224_H	0.667	0.12
150_D	296_G	0.666	0.12
86_K	259_M	0.664	0.12
276_G	294_N	0.664	0.12
224_H	294_N	0.664	0.12
226_P	294_N	0.664	0.12
233_D	294_N	0.664	0.12
47_L	286_K	0.661	0.12
175_I	194_P	0.661	0.12
284_F	291_I	0.655	0.12
48_I	291_I	0.655	0.12
48_I	139_T	0.655	0.12
70_K	116_E	0.653	0.12
112_S	171_E	0.652	0.12
200_D	264_L	0.652	0.12
178_Y	271_L	0.648	0.12
45_D	136_L	0.645	0.12
185_Y	298_E	0.645	0.12
94_Y	293_I	0.643	0.12
74_K	267_E	0.642	0.12
196_E	272_L	0.640	0.12
80_G	208_R	0.638	0.12
75_I	199_E	0.638	0.12
186_V	193_T	0.638	0.12
261_I	273_G	0.636	0.12
166_V	171_E	0.633	0.12
147_L	165_M	0.632	0.12
249_G	298_E	0.631	0.12
196_E	199_E	0.629	0.12
74_K	127_E	0.628	0.12
45_D	163_E	0.627	0.12
209_I	260_S	0.627	0.12
25_L	50_G	0.627	0.12
134_E	302_G	0.625	0.12
93_V	106_L	0.624	0.12
27_G	296_G	0.623	0.11
25_L	49_I	0.623	0.11
62_I	81_V	0.622	0.11
192_N	197_M	0.621	0.11
119_R	223_L	0.619	0.11
115_E	263_K	0.615	0.11
172_I	201_Q	0.615	0.11
71_I	181_I	0.610	0.11
136_L	162_S	0.609	0.11
187_N	195_R	0.604	0.11
73_D	159_I	0.604	0.11
152_P	190_P	0.601	0.11
190_P	265_E	0.592	0.11
30_T	272_L	0.592	0.11
285_D	292_I	0.592	0.11
34_K	189_T	0.590	0.11
47_L	227_P	0.585	0.11
84_I	180_M	0.585	0.11
79_E	139_T	0.585	0.11
180_M	222_N	0.581	0.11
184_G	203_Y	0.579	0.11
76_V	126_Q	0.578	0.11
190_P	296_G	0.576	0.11
160_T	269_Q	0.575	0.11
86_K	174_N	0.574	0.11
34_K	42_T	0.574	0.11
209_I	264_L	0.571	0.11
273_G	292_I	0.566	0.11
159_I	230_T	0.562	0.11
25_L	264_L	0.562	0.11
275_H	280_E	0.561	0.11
21_F	36_L	0.560	0.11
68_K	80_G	0.556	0.10
106_L	177_G	0.555	0.10
181_I	223_L	0.552	0.10
109_N	112_S	0.552	0.10
91_S	168_C	0.550	0.10
28_S	235_A	0.550	0.10
32_F	50_G	0.548	0.10
222_N	281_S	0.547	0.10
202_I	283_A	0.546	0.10
35_F	61_I	0.544	0.10
107_N	120_V	0.539	0.10
169_E	295_P	0.538	0.10
20_L	268_F	0.538	0.10
48_I	137_K	0.537	0.10
61_I	291_I	0.536	0.10
63_D	142_K	0.534	0.10
27_G	258_S	0.533	0.10
166_V	299_Y	0.529	0.10
67_S	142_K	0.528	0.10
120_V	199_E	0.525	0.10
95_Y	187_N	0.525	0.10
94_Y	120_V	0.525	0.10
50_G	129_D	0.525	0.10
127_E	201_Q	0.524	0.10
73_D	78_K	0.523	0.10
43_K	185_Y	0.518	0.10
190_P	206_L	0.517	0.10
116_E	158_V	0.515	0.10
128_W	295_P	0.514	0.10
261_I	301_L	0.511	0.10
259_M	287_I	0.511	0.10
134_E	199_E	0.510	0.10
137_K	194_P	0.510	0.10
187_N	254_T	0.509	0.10
130_R	177_G	0.507	0.10
166_V	283_A	0.506	0.10
201_Q	293_I	0.505	0.10
50_G	222_N	0.505	0.10
82_D	285_D	0.504	0.10
64_I	144_Y	0.503	0.10
83_E	171_E	0.503	0.10
288_N	291_I	0.501	0.10
24_D	276_G	0.500	0.10
24_D	224_H	0.500	0.10
24_D	226_P	0.500	0.10
24_D	233_D	0.500	0.10
26_H	276_G	0.500	0.10
26_H	233_D	0.500	0.10
26_H	226_P	0.500	0.10
26_H	224_H	0.500	0.10
230_T	273_G	0.500	0.10
51_G	226_P	0.500	0.10
51_G	276_G	0.500	0.10
51_G	233_D	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yvtA	1	0.7531	100	0.759	Contact Map
1uf3A	6	0.6543	100	0.764	Contact Map
4peiA	2	0.7623	99.9	0.79	Contact Map
3rl5A	1	0.6605	99.9	0.808	Contact Map
3d03A	5	0.6852	99.9	0.817	Contact Map
3ib7A	2	0.7222	99.9	0.821	Contact Map
3qfmA	2	0.6389	99.9	0.821	Contact Map
3rqzA	1	0.6049	99.8	0.827	Contact Map
3t1iA	2	0.7315	99.8	0.83	Contact Map
4ykeA	2	0.784	99.8	0.834	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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