GREMLIN Database
Q97VA8 - Amino acid transporter, putative
UniProt: Q97VA8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 529 (426)
Sequences: 24308 (16147)
Seq/√Len: 782.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
378_R391_I4.1801.00
164_A397_V4.0701.00
61_L281_G3.0921.00
435_L439_V3.0301.00
381_D391_I2.9911.00
267_Y271_L2.8181.00
21_S263_K2.8091.00
311_L315_V2.7631.00
264_K267_Y2.5871.00
383_N390_L2.5631.00
370_A380_A2.4901.00
262_M268_N2.4791.00
85_Y372_D2.4421.00
101_Y369_W2.4121.00
378_R381_D2.3891.00
195_L290_L2.3621.00
327_P331_L2.3211.00
26_F275_I2.2931.00
326_T330_A2.2831.00
157_I401_L2.2711.00
22_P275_I2.2081.00
459_V463_G2.1171.00
470_L473_A2.1001.00
89_A97_A2.0951.00
367_F371_F2.0851.00
260_G371_F2.0701.00
165_I169_I2.0641.00
193_V197_L2.0501.00
157_I404_V2.0401.00
73_L437_P2.0261.00
25_S262_M2.0151.00
22_P268_N2.0081.00
171_K175_S1.9941.00
261_E364_R1.9911.00
327_P330_A1.9711.00
394_I398_I1.9231.00
168_S390_L1.9221.00
164_A393_T1.9161.00
22_P26_F1.9151.00
467_F470_L1.8931.00
271_L275_I1.8921.00
92_S435_L1.8911.00
182_I186_L1.8831.00
460_S464_F1.8691.00
463_G467_F1.8681.00
161_I401_L1.8641.00
503_M507_I1.8451.00
326_T329_F1.8451.00
89_A94_P1.8301.00
105_W396_T1.8251.00
62_L66_G1.8181.00
16_L382_V1.8101.00
44_W53_W1.8061.00
156_G404_V1.8061.00
497_I501_G1.8051.00
373_R377_E1.7941.00
21_S24_A1.7881.00
379_L395_I1.7791.00
326_T332_L1.7691.00
92_S431_L1.7341.00
461_L465_P1.7171.00
88_Q100_N1.7121.00
463_G470_L1.6791.00
296_G299_F1.6781.00
470_L474_L1.6571.00
456_I459_V1.6561.00
231_F234_P1.6411.00
264_K268_N1.6361.00
70_L430_A1.6241.00
161_I397_V1.6201.00
338_L342_V1.6101.00
460_S463_G1.6091.00
329_F332_L1.6081.00
24_A178_F1.5971.00
274_I278_L1.5941.00
186_L190_V1.5791.00
472_F476_Q1.5781.00
495_V499_T1.5731.00
100_N428_I1.5651.00
455_G459_V1.5641.00
487_N490_T1.5531.00
26_F279_F1.5421.00
435_L438_F1.5361.00
210_F213_V1.5241.00
116_S355_N1.5201.00
168_S394_I1.5201.00
167_A356_P1.5161.00
29_T276_A1.5041.00
112_L400_G1.4961.00
102_W501_G1.4961.00
278_L282_V1.4951.00
160_L400_G1.4951.00
199_T202_Q1.4911.00
123_F155_I1.4811.00
463_G466_E1.4751.00
383_N388_I1.4651.00
453_I456_I1.4641.00
151_G154_I1.4481.00
56_S241_A1.4421.00
199_T203_F1.4421.00
440_K443_F1.4191.00
52_N231_F1.4131.00
474_L477_T1.4121.00
20_V24_A1.4111.00
377_E380_A1.4111.00
310_S314_T1.4041.00
366_L392_S1.4031.00
391_I395_I1.4011.00
458_L462_I1.3971.00
466_E470_L1.3911.00
506_A510_I1.3871.00
460_S474_L1.3761.00
362_L396_T1.3701.00
17_V387_H1.3651.00
258_W360_I1.3601.00
471_L474_L1.3581.00
119_G159_I1.3581.00
93_H96_V1.3561.00
460_S477_T1.3431.00
427_G464_F1.3391.00
95_L508_S1.3381.00
203_F206_A1.3321.00
465_P469_F1.3251.00
92_S96_V1.3161.00
377_E381_D1.3141.00
328_F331_L1.3131.00
455_G460_S1.3081.00
78_T90_R1.3061.00
202_Q205_D1.3061.00
502_I506_A1.3061.00
191_T195_L1.3021.00
381_D390_L1.2941.00
68_A277_V1.2931.00
363_T393_T1.2891.00
441_K445_N1.2851.00
469_F473_A1.2811.00
431_L435_L1.2791.00
326_T331_L1.2781.00
200_P203_F1.2771.00
60_S245_V1.2771.00
39_I118_L1.2751.00
187_S346_A1.2741.00
164_A394_I1.2741.00
160_L397_V1.2741.00
116_S160_L1.2711.00
192_F286_L1.2711.00
264_K271_L1.2691.00
24_A174_W1.2581.00
150_L154_I1.2571.00
157_I161_I1.2471.00
312_N316_Y1.2461.00
367_F382_V1.2451.00
460_S466_E1.2441.00
464_F468_G1.2421.00
441_K444_F1.2391.00
22_P271_L1.2311.00
185_I189_I1.2301.00
456_I463_G1.2301.00
463_G476_Q1.2251.00
54_T289_S1.2231.00
119_G348_W1.2211.00
434_A438_F1.2071.00
454_S459_V1.2061.00
91_S432_T1.2031.00
297_E300_L1.2001.00
196_A290_L1.2001.00
312_N315_V1.1941.00
20_V174_W1.1891.00
507_I510_I1.1851.00
163_G355_N1.1831.00
454_S457_P1.1821.00
202_Q206_A1.1801.00
52_N238_A1.1791.00
268_N271_L1.1751.00
69_F274_I1.1751.00
81_S260_G1.1751.00
496_I500_S1.1701.00
341_I345_I1.1681.00
68_A273_I1.1661.00
488_F492_L1.1641.00
16_L367_F1.1621.00
115_Y354_S1.1591.00
466_E469_F1.1571.00
488_F491_I1.1561.00
468_G472_F1.1561.00
462_I465_P1.1541.00
366_L375_M1.1501.00
195_L294_A1.1501.00
499_T503_M1.1411.00
30_F279_F1.1361.00
457_P460_S1.1351.00
20_V25_S1.1341.00
32_L280_I1.1281.00
198_I201_S1.1281.00
265_V270_L1.1261.00
45_L53_W1.1231.00
148_T151_G1.1161.00
153_V157_I1.1151.00
371_F380_A1.1131.00
463_G477_T1.1131.00
311_L314_T1.1111.00
504_I507_I1.1101.00
466_E475_Y1.1101.00
29_T255_P1.1061.00
462_I476_Q1.1021.00
391_I394_I1.1001.00
442_N446_K1.0971.00
86_V90_R1.0971.00
23_W27_F1.0961.00
67_M430_A1.0961.00
263_K268_N1.0861.00
507_I511_I1.0831.00
460_S476_Q1.0831.00
442_N445_N1.0821.00
461_L464_F1.0791.00
501_G504_I1.0711.00
282_V286_L1.0701.00
473_A476_Q1.0671.00
71_F84_D1.0641.00
75_S87_F1.0631.00
25_S272_G1.0541.00
463_G469_F1.0511.00
198_I203_F1.0491.00
504_I508_S1.0451.00
88_Q428_I1.0431.00
166_I176_F1.0391.00
88_Q96_V1.0381.00
154_I158_I1.0301.00
491_I494_L1.0301.00
28_A258_W1.0271.00
492_L496_I1.0211.00
459_V466_E1.0211.00
190_V194_A1.0201.00
466_E477_T1.0201.00
201_S204_S1.0191.00
177_V356_P1.0171.00
80_R86_V1.0171.00
176_F180_T1.0151.00
201_S205_D1.0081.00
123_F127_F1.0061.00
98_F102_W1.0061.00
19_E263_K1.0051.00
58_L285_I1.0041.00
467_F471_L1.0021.00
189_I193_V1.0011.00
200_P204_S0.9951.00
459_V462_I0.9841.00
465_P476_Q0.9841.00
175_S179_I0.9801.00
444_F447_V0.9791.00
164_A168_S0.9781.00
382_V387_H0.9751.00
464_F474_L0.9731.00
73_L76_V0.9711.00
494_L498_Y0.9681.00
466_E474_L0.9651.00
508_S511_I0.9621.00
487_N491_I0.9621.00
85_Y368_A0.9601.00
492_L495_V0.9601.00
77_S443_F0.9571.00
462_I466_E0.9511.00
489_P493_S0.9481.00
433_T436_S0.9481.00
234_P237_G0.9451.00
464_F467_F0.9441.00
460_S467_F0.9401.00
472_F475_Y0.9351.00
27_F178_F0.9351.00
427_G431_L0.9331.00
314_T327_P0.9301.00
463_G473_A0.9291.00
491_I495_V0.9281.00
161_I165_I0.9281.00
460_S475_Y0.9261.00
458_L463_G0.9241.00
454_S460_S0.9221.00
466_E473_A0.9131.00
341_I344_W0.9131.00
168_S383_N0.9081.00
180_T353_Y0.9031.00
473_A477_T0.9021.00
456_I460_S0.9021.00
49_P52_N0.9001.00
158_I162_I0.9001.00
123_F348_W0.8981.00
95_L99_V0.8971.00
33_V184_S0.8951.00
466_E476_Q0.8941.00
168_S388_I0.8931.00
425_S428_I0.8921.00
432_T436_S0.8911.00
454_S458_L0.8891.00
259_S269_S0.8891.00
105_W366_L0.8861.00
89_A372_D0.8851.00
398_I402_I0.8851.00
192_F196_A0.8821.00
381_D384_E0.8821.00
231_F238_A0.8821.00
66_G462_I0.8791.00
359_V397_V0.8791.00
453_I457_P0.8771.00
281_G285_I0.8751.00
160_L404_V0.8741.00
433_T437_P0.8741.00
454_S463_G0.8721.00
120_A155_I0.8711.00
61_L249_Y0.8701.00
490_T494_L0.8671.00
424_I428_I0.8631.00
253_N257_S0.8631.00
90_R440_K0.8621.00
501_G505_Y0.8611.00
19_E171_K0.8601.00
456_I462_I0.8591.00
460_S465_P0.8581.00
114_L247_Y0.8571.00
458_L461_L0.8501.00
338_L341_I0.8501.00
120_A156_G0.8481.00
162_I352_F0.8461.00
463_G474_L0.8461.00
442_N447_V0.8451.00
197_L202_Q0.8421.00
198_I202_Q0.8411.00
489_P492_L0.8401.00
95_L502_I0.8401.00
24_A175_S0.8351.00
80_R90_R0.8331.00
192_F290_L0.8321.00
397_V401_L0.8311.00
339_L343_M0.8311.00
390_L394_I0.8291.00
93_H509_Y0.8241.00
310_S313_S0.8211.00
184_S350_P0.8201.00
447_V454_S0.8161.00
165_I168_S0.8141.00
463_G472_F0.8131.00
30_F280_I0.8101.00
119_G351_N0.8091.00
470_L475_Y0.8091.00
66_G70_L0.8081.00
453_I458_L0.8071.00
460_S470_L0.7991.00
201_S206_A0.7931.00
240_L244_V0.7931.00
16_L364_R0.7911.00
37_I287_F0.7901.00
467_F474_L0.7891.00
185_I283_Y0.7881.00
289_S293_H0.7861.00
54_T292_L0.7841.00
379_L391_I0.7841.00
490_T493_S0.7811.00
254_L361_S0.7771.00
163_G356_P0.7751.00
155_I158_I0.7751.00
77_S445_N0.7721.00
53_W288_T0.7711.00
470_L477_T0.7711.00
22_P272_G0.7691.00
465_P468_G0.7691.00
235_F238_A0.7671.00
328_F332_L0.7651.00
82_G86_V0.7631.00
455_G458_L0.7601.00
102_W375_M0.7601.00
124_A152_S0.7601.00
200_P210_F0.7591.00
487_N494_L0.7591.00
469_F476_Q0.7581.00
443_F446_K0.7581.00
51_A292_L0.7571.00
163_G359_V0.7561.00
16_L261_E0.7561.00
459_V477_T0.7561.00
23_W178_F0.7551.00
467_F473_A0.7521.00
440_K445_N0.7511.00
459_V476_Q0.7431.00
175_S178_F0.7431.00
426_Y433_T0.7421.00
500_S504_I0.7411.00
459_V465_P0.7401.00
117_Y412_V0.7381.00
488_F501_G0.7381.00
197_L200_P0.7371.00
496_I499_T0.7371.00
65_L274_I0.7351.00
58_L62_L0.7341.00
270_L273_I0.7341.00
457_P477_T0.7331.00
456_I466_E0.7321.00
462_I477_T0.7311.00
427_G467_F0.7291.00
41_I288_T0.7271.00
469_F472_F0.7241.00
264_K270_L0.7231.00
31_G181_G0.7231.00
199_T204_S0.7211.00
65_L69_F0.7211.00
428_I431_L0.7211.00
275_I279_F0.7201.00
74_A433_T0.7191.00
198_I205_D0.7181.00
82_G85_Y0.7111.00
198_I206_A0.7101.00
96_V428_I0.7071.00
423_E426_Y0.7071.00
153_V404_V0.7051.00
411_T414_S0.7041.00
459_V472_F0.7001.00
119_G352_F0.6971.00
489_P494_L0.6971.00
497_I504_I0.6971.00
120_A152_S0.6971.00
299_F302_S0.6961.00
55_L238_A0.6961.00
398_I401_L0.6951.00
467_F475_Y0.6931.00
493_S496_I0.6931.00
459_V474_L0.6921.00
286_L290_L0.6921.00
81_S367_F0.6921.00
200_P206_A0.6901.00
459_V464_F0.6891.00
453_I460_S0.6891.00
169_I172_Y0.6861.00
375_M379_L0.6851.00
23_W175_S0.6821.00
343_M346_A0.6821.00
113_G403_G0.6791.00
413_I416_V0.6751.00
412_V416_V0.6731.00
199_T293_H0.6701.00
74_A87_F0.6701.00
26_F272_G0.6691.00
379_L392_S0.6691.00
366_L395_I0.6691.00
359_V363_T0.6681.00
108_F358_L0.6671.00
85_Y89_A0.6671.00
459_V470_L0.6661.00
109_A399_V0.6651.00
309_N312_N0.6651.00
500_S503_M0.6641.00
503_M506_A0.6631.00
256_A273_I0.6621.00
198_I204_S0.6561.00
423_E428_I0.6551.00
505_Y508_S0.6541.00
313_S316_Y0.6531.00
459_V475_Y0.6491.00
468_G476_Q0.6491.00
92_S432_T0.6481.00
439_V443_F0.6471.00
457_P474_L0.6461.00
55_L58_L0.6451.00
363_T392_S0.6421.00
157_I405_L0.6421.00
54_T285_I0.6411.00
453_I459_V0.6361.00
279_F283_Y0.6361.00
470_L476_Q0.6351.00
159_I355_N0.6331.00
235_F239_L0.6331.00
127_F148_T0.6321.00
104_L108_F0.6311.00
167_A393_T0.6281.00
250_V422_F0.6271.00
199_T205_D0.6271.00
339_L344_W0.6261.00
196_A286_L0.6261.00
122_W347_F0.6251.00
456_I473_A0.6231.00
458_L477_T0.6211.00
64_T252_Y0.6211.00
168_S393_T0.6201.00
487_N496_I0.6201.00
384_E390_L0.6201.00
231_F235_F0.6181.00
123_F159_I0.6181.00
68_A252_Y0.6181.00
88_Q432_T0.6171.00
487_N493_S0.6171.00
493_S497_I0.6171.00
174_W178_F0.6171.00
370_A379_L0.6161.00
75_S256_A0.6141.00
167_A360_I0.6141.00
299_F331_L0.6131.00
488_F494_L0.6131.00
464_F470_L0.6121.00
415_I420_V0.6111.00
441_K447_V0.6071.00
30_F181_G0.6071.00
465_P477_T0.6061.00
464_F477_T0.6051.00
125_Y344_W0.6051.00
383_N387_H0.6031.00
389_P392_S0.6001.00
19_E23_W0.5991.00
464_F475_Y0.5981.00
430_A466_E0.5981.00
60_S246_W0.5971.00
200_P205_D0.5961.00
183_V187_S0.5941.00
39_I42_V0.5941.00
111_S114_L0.5921.00
492_L497_I0.5911.00
506_A509_Y0.5881.00
257_S361_S0.5871.00
455_G474_L0.5871.00
174_W356_P0.5861.00
26_F29_T0.5851.00
172_Y175_S0.5851.00
51_A297_E0.5841.00
340_Y343_M0.5841.00
490_T497_I0.5841.00
378_R395_I0.5791.00
407_Y410_V0.5791.00
250_V426_Y0.5781.00
327_P332_L0.5761.00
198_I293_H0.5731.00
91_S435_L0.5731.00
120_A123_F0.5731.00
48_A51_A0.5721.00
85_Y97_A0.5721.00
275_I278_L0.5721.00
21_S171_K0.5711.00
25_S258_W0.5711.00
456_I474_L0.5701.00
181_G184_S0.5701.00
153_V156_G0.5701.00
428_I434_A0.5691.00
431_L464_F0.5691.00
384_E387_H0.5691.00
62_L462_I0.5671.00
414_S418_V0.5651.00
364_R367_F0.5651.00
428_I432_T0.5631.00
362_L366_L0.5621.00
290_L293_H0.5601.00
459_V467_F0.5591.00
163_G352_F0.5581.00
77_S441_K0.5581.00
260_G367_F0.5581.00
471_L475_Y0.5571.00
57_Y248_Y0.5551.00
497_I500_S0.5551.00
415_I419_T0.5551.00
55_L59_I0.5541.00
298_R302_S0.5541.00
239_L243_P0.5531.00
426_Y429_F0.5521.00
459_V469_F0.5511.00
85_Y101_Y0.5491.00
173_G360_I0.5481.00
60_S249_Y0.5471.00
432_T435_L0.5471.00
488_F495_V0.5451.00
48_A241_A0.5451.00
54_T58_L0.5451.00
34_T39_I0.5451.00
279_F282_V0.5431.00
118_L122_W0.5431.00
454_S477_T0.5431.00
417_D420_V0.5421.00
71_F429_F0.5411.00
74_A91_S0.5411.00
430_A433_T0.5411.00
33_V283_Y0.5391.00
38_P188_T0.5391.00
466_E472_F0.5391.00
84_D253_N0.5381.00
504_I510_I0.5371.00
59_I242_I0.5371.00
439_V442_N0.5361.00
75_S269_S0.5351.00
237_G240_L0.5351.00
309_N315_V0.5341.00
51_A54_T0.5341.00
126_L344_W0.5341.00
498_Y502_I0.5331.00
455_G463_G0.5331.00
192_F287_F0.5311.00
164_A359_V0.5311.00
428_I435_L0.5311.00
23_W26_F0.5301.00
338_L343_M0.5281.00
412_V419_T0.5281.00
496_I503_M0.5271.00
287_F291_N0.5261.00
115_Y355_N0.5261.00
183_V349_L0.5251.00
467_F476_Q0.5251.00
433_T438_F0.5241.00
490_T501_G0.5221.00
103_A425_S0.5221.00
422_F426_Y0.5211.00
159_I352_F0.5201.00
56_S245_V0.5201.00
41_I291_N0.5201.00
178_F182_I0.5181.00
489_P504_I0.5181.00
161_I164_A0.5181.00
460_S469_F0.5171.00
416_V420_V0.5161.00
414_S417_D0.5161.00
342_V346_A0.5161.00
159_I163_G0.5151.00
456_I477_T0.5151.00
109_A403_G0.5151.00
115_Y118_L0.5131.00
34_T38_P0.5121.00
456_I476_Q0.5111.00
160_L401_L0.5111.00
172_Y176_F0.5111.00
469_F477_T0.5111.00
465_P474_L0.5101.00
68_A72_Y0.5091.00
65_L277_V0.5091.00
84_D257_S0.5091.00
29_T272_G0.5081.00
104_L425_S0.5081.00
455_G464_F0.5071.00
229_L232_V0.5061.00
72_Y273_I0.5051.00
426_Y430_A0.5051.00
161_I394_I0.5051.00
402_I405_L0.5031.00
113_G116_S0.5021.00
70_L463_G0.5011.00
38_P184_S0.5011.00
113_G400_G0.5011.00
297_E301_T0.5001.00
364_R389_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.7864 100 0.419 Contact Map
4djkA 2 0.8223 100 0.439 Contact Map
3giaA 1 0.8053 100 0.454 Contact Map
2jlnA 1 0.8147 98.7 0.881 Contact Map
3dh4A 3 0.8393 98.3 0.896 Contact Map
2a65A 2 0.879 97.9 0.905 Contact Map
2xq2A 2 0.8412 97.8 0.907 Contact Map
4wgvA 2 0.7127 97.5 0.913 Contact Map
4xp4A 1 0.9036 97 0.92 Contact Map
4us3A 1 0.7864 97 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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