GREMLIN Database
Q97VA7 - 4-aminobutyrate aminotransferase (GabT-1)
UniProt: Q97VA7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 440 (384)
Sequences: 20953 (12357)
Seq/√Len: 630.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_Q93_E4.4621.00
399_R435_I4.0061.00
247_K251_E4.0001.00
56_T64_V3.6311.00
350_K427_D3.3151.00
204_L245_G3.2261.00
112_K333_E3.1221.00
51_K58_T3.1191.00
350_K423_E2.9121.00
271_K277_W2.8811.00
339_N342_S2.8591.00
360_N434_K2.7301.00
343_R347_L2.6991.00
83_F337_S2.6481.00
422_P425_L2.6361.00
86_K90_E2.5791.00
68_L429_A2.4441.00
112_K336_E2.4331.00
330_A333_E2.3781.00
245_G248_E2.3491.00
83_F334_F2.3271.00
56_T425_L2.3021.00
354_L430_I2.2821.00
50_D60_V2.2451.00
248_E252_K2.2311.00
81_N334_F2.2191.00
58_T64_V2.1681.00
83_F330_A2.1651.00
346_R423_E2.1441.00
395_R398_K2.1151.00
354_L427_D2.0971.00
112_K329_L2.0531.00
148_T220_D2.0491.00
208_D252_K2.0401.00
109_F328_G1.9611.00
85_R89_Q1.9281.00
428_R432_I1.9251.00
352_L356_K1.8881.00
122_K304_E1.8771.00
395_R399_R1.8681.00
401_L432_I1.8671.00
349_R353_E1.8481.00
59_D63_N1.8361.00
334_F338_H1.8231.00
63_N400_G1.8231.00
225_L258_I1.8161.00
208_D212_S1.8131.00
121_A304_E1.7961.00
304_E307_D1.7861.00
104_E108_N1.7771.00
50_D94_K1.7751.00
354_L357_E1.7731.00
56_T428_R1.7591.00
352_L368_G1.7211.00
111_K115_S1.7071.00
207_L246_L1.6911.00
116_T336_E1.6821.00
88_V327_A1.6711.00
126_T298_S1.6691.00
364_G378_V1.6611.00
133_V286_T1.6461.00
295_I324_G1.6271.00
88_V92_L1.6221.00
271_K345_E1.6101.00
112_K115_S1.5911.00
226_V246_L1.5871.00
53_Q82_P1.5861.00
224_I250_A1.5861.00
108_N329_L1.5691.00
352_L373_I1.5641.00
395_R436_I1.5501.00
287_I299_M1.5441.00
292_G297_V1.5421.00
55_S425_L1.5371.00
347_L350_K1.5361.00
90_E94_K1.5141.00
211_M255_V1.5051.00
259_V275_Y1.5051.00
241_G244_K1.4911.00
347_L426_L1.4881.00
64_V428_R1.4761.00
143_I306_F1.4751.00
205_S209_Y1.4721.00
55_S420_T1.4581.00
150_I221_V1.4541.00
208_D245_G1.4451.00
287_I301_A1.4341.00
396_A403_V1.4291.00
343_R346_R1.4261.00
135_A300_V1.4221.00
117_L301_A1.4191.00
247_K250_A1.4131.00
149_I223_G1.4111.00
399_R436_I1.4101.00
82_P86_K1.4071.00
110_S125_F1.4061.00
358_V434_K1.4031.00
187_P206_L1.3951.00
247_K257_L1.3861.00
434_K438_N1.3861.00
152_F242_F1.3851.00
123_L301_A1.3831.00
114_L123_L1.3791.00
329_L333_E1.3751.00
354_L431_E1.3721.00
137_V149_I1.3661.00
212_S253_Y1.3641.00
272_M276_Q1.3631.00
330_A334_F1.3621.00
148_T184_V1.3601.00
350_K354_L1.3511.00
271_K276_Q1.3511.00
358_V430_I1.3321.00
342_S346_R1.3291.00
297_V325_L1.3281.00
347_L423_E1.3261.00
86_K89_Q1.3181.00
354_L434_K1.3171.00
59_D65_Y1.3171.00
143_I308_K1.3141.00
53_Q80_N1.3101.00
277_W369_L1.3021.00
115_S336_E1.3011.00
421_I426_L1.2991.00
226_V243_L1.2971.00
275_Y285_V1.2941.00
133_V225_L1.2901.00
136_A286_T1.2841.00
81_N338_H1.2831.00
224_I246_L1.2731.00
291_I297_V1.2711.00
140_A258_I1.2691.00
284_I302_Y1.2601.00
195_P206_L1.2561.00
51_K94_K1.2551.00
49_I57_V1.2511.00
281_E303_R1.2501.00
205_S208_D1.2441.00
197_K239_P1.2431.00
85_R93_E1.2411.00
77_L334_F1.2381.00
126_T300_V1.2301.00
208_D249_L1.2271.00
108_N333_E1.2241.00
80_N85_R1.2241.00
87_R330_A1.2231.00
122_K307_D1.2201.00
244_K248_E1.2151.00
425_L428_R1.2131.00
204_L249_L1.2041.00
431_E435_I1.1981.00
297_V328_G1.1951.00
88_V323_L1.1871.00
278_E369_L1.1871.00
345_E349_R1.1861.00
85_R92_L1.1841.00
333_E337_S1.1831.00
291_I299_M1.1691.00
191_P194_C1.1591.00
267_G341_L1.1561.00
396_A432_I1.1551.00
89_Q92_L1.1511.00
125_F325_L1.1501.00
166_L225_L1.1491.00
360_N438_N1.1381.00
256_P306_F1.1371.00
396_A436_I1.1321.00
195_P198_D1.1321.00
399_R432_I1.1261.00
259_V280_I1.1211.00
241_G278_E1.1201.00
284_I300_V1.1071.00
244_K279_N1.1011.00
401_L429_A1.1001.00
273_W287_I1.0991.00
334_F337_S1.0951.00
50_D104_E1.0941.00
56_T66_I1.0921.00
428_R431_E1.0881.00
192_Y364_G1.0871.00
55_S66_I1.0841.00
423_E427_D1.0691.00
353_E357_E1.0671.00
146_K254_S1.0661.00
53_Q64_V1.0541.00
396_A401_L1.0421.00
208_D248_E1.0371.00
130_A163_T1.0361.00
109_F329_L1.0271.00
427_D431_E1.0271.00
166_L183_V1.0171.00
132_A286_T1.0151.00
250_A255_V1.0151.00
206_L209_Y1.0141.00
50_D62_G1.0111.00
53_Q58_T1.0101.00
48_A60_V1.0101.00
50_D58_T1.0081.00
139_I300_V1.0031.00
293_E331_S1.0021.00
83_F333_E0.9941.00
112_K116_T0.9931.00
240_K244_K0.9891.00
248_E251_E0.9861.00
223_G258_I0.9831.00
394_E398_K0.9721.00
116_T272_M0.9721.00
208_D253_Y0.9721.00
391_V395_R0.9711.00
356_K359_Q0.9711.00
342_S345_E0.9701.00
137_V166_L0.9651.00
119_M285_V0.9641.00
341_L344_V0.9641.00
147_K220_D0.9621.00
151_A225_L0.9591.00
270_G276_Q0.9571.00
86_K93_E0.9531.00
228_P259_V0.9501.00
194_C210_A0.9461.00
77_L331_S0.9441.00
152_F238_P0.9431.00
266_V335_I0.9401.00
76_N290_A0.9401.00
90_E326_A0.9351.00
83_F86_K0.9341.00
66_I425_L0.9331.00
237_V369_L0.9331.00
364_G376_E0.9321.00
243_L278_E0.9311.00
424_S427_D0.9291.00
376_E411_N0.9241.00
139_I302_Y0.9161.00
209_Y216_Y0.9141.00
246_L257_L0.9121.00
343_R423_E0.9081.00
143_I256_P0.9081.00
374_G412_V0.9031.00
326_A330_A0.9021.00
77_L84_V0.9001.00
153_E195_P0.8991.00
229_I369_L0.8971.00
84_V327_A0.8971.00
335_I340_I0.8951.00
148_T221_V0.8931.00
136_A258_I0.8911.00
48_A107_V0.8891.00
241_G245_G0.8881.00
335_I341_L0.8841.00
66_I428_R0.8821.00
277_W345_E0.8741.00
75_V293_E0.8721.00
68_L421_I0.8681.00
118_G275_Y0.8681.00
251_E281_E0.8671.00
60_V104_E0.8661.00
357_E360_N0.8661.00
130_A160_T0.8661.00
348_G352_L0.8631.00
116_T332_L0.8621.00
353_E356_K0.8621.00
218_G253_Y0.8601.00
148_T212_S0.8581.00
249_L253_Y0.8581.00
120_R301_A0.8491.00
55_S422_P0.8491.00
90_E93_E0.8481.00
108_N112_K0.8471.00
357_E434_K0.8411.00
140_A223_G0.8411.00
229_I372_M0.8411.00
264_T372_M0.8411.00
211_M221_V0.8381.00
105_I326_A0.8381.00
272_M341_L0.8351.00
151_A185_K0.8341.00
140_A256_P0.8251.00
340_I344_V0.8251.00
365_D376_E0.8221.00
341_L345_E0.8221.00
371_F421_I0.8171.00
83_F87_R0.8151.00
421_I429_A0.8121.00
142_F313_F0.8071.00
206_L210_A0.8021.00
295_I323_L0.7991.00
113_L301_A0.7981.00
367_R376_E0.7971.00
354_L426_L0.7951.00
231_G263_Q0.7941.00
350_K353_E0.7921.00
66_I429_A0.7921.00
145_G220_D0.7911.00
165_G179_F0.7871.00
372_M416_M0.7851.00
346_R350_K0.7841.00
266_V332_L0.7811.00
250_A257_L0.7811.00
186_F189_P0.7801.00
105_I329_L0.7781.00
254_S305_D0.7781.00
109_F325_L0.7761.00
390_K394_E0.7751.00
217_L220_D0.7711.00
275_Y280_I0.7631.00
247_K280_I0.7621.00
273_W285_V0.7611.00
366_I373_I0.7611.00
245_G249_L0.7601.00
228_P243_L0.7571.00
73_S416_M0.7571.00
393_I405_K0.7561.00
316_G319_R0.7511.00
123_L299_M0.7491.00
415_L433_L0.7481.00
266_V272_M0.7471.00
103_T106_R0.7471.00
87_R327_A0.7471.00
119_M281_E0.7441.00
54_G420_T0.7411.00
105_I325_L0.7391.00
392_V433_L0.7381.00
347_L371_F0.7381.00
368_G373_I0.7371.00
266_V287_I0.7371.00
127_T131_D0.7361.00
68_L401_L0.7351.00
55_S418_P0.7331.00
140_A284_I0.7321.00
224_I255_V0.7301.00
211_M249_L0.7281.00
221_V255_V0.7281.00
126_T132_A0.7271.00
204_L208_D0.7271.00
269_T277_W0.7231.00
272_M336_E0.7221.00
105_I108_N0.7221.00
226_V257_L0.7201.00
207_L224_I0.7181.00
94_K104_E0.7171.00
102_P107_V0.7171.00
84_V293_E0.7151.00
196_F238_P0.7081.00
267_G335_I0.7081.00
186_F190_Y0.7081.00
303_R306_F0.7081.00
137_V225_L0.7071.00
133_V163_T0.7071.00
244_K278_E0.7071.00
106_R110_S0.7041.00
147_K182_R0.7031.00
136_A284_I0.6991.00
346_R349_R0.6991.00
66_I401_L0.6971.00
69_V404_Y0.6971.00
162_G179_F0.6941.00
287_I291_I0.6921.00
150_I207_L0.6911.00
424_S428_R0.6891.00
229_I269_T0.6881.00
310_P313_F0.6861.00
288_S298_S0.6841.00
116_T273_W0.6821.00
429_A432_I0.6821.00
139_I309_L0.6821.00
238_P241_G0.6821.00
128_T131_D0.6811.00
88_V96_W0.6791.00
209_Y212_S0.6791.00
344_V348_G0.6781.00
237_V368_G0.6771.00
91_Q95_V0.6751.00
257_L280_I0.6751.00
376_E412_V0.6711.00
266_V291_I0.6691.00
105_I109_F0.6681.00
70_T416_M0.6681.00
57_V402_L0.6681.00
251_E257_L0.6661.00
138_K314_H0.6661.00
49_I52_A0.6631.00
377_L392_V0.6621.00
186_F210_A0.6621.00
117_L285_V0.6621.00
258_I284_I0.6611.00
396_A433_L0.6601.00
362_H378_V0.6591.00
184_V210_A0.6581.00
107_V111_K0.6571.00
240_K278_E0.6571.00
275_Y282_P0.6551.00
366_I375_I0.6541.00
153_E187_P0.6541.00
348_G368_G0.6541.00
350_K426_L0.6521.00
343_R422_P0.6511.00
119_M275_Y0.6491.00
194_C198_D0.6491.00
401_L428_R0.6491.00
91_Q94_K0.6481.00
112_K332_L0.6481.00
63_N398_K0.6471.00
392_V436_I0.6471.00
430_I434_K0.6461.00
231_G372_M0.6461.00
92_L323_L0.6451.00
117_L273_W0.6441.00
240_K369_L0.6431.00
344_V419_L0.6421.00
55_S421_I0.6421.00
190_Y193_R0.6411.00
349_R352_L0.6401.00
421_I425_L0.6401.00
230_Q236_V0.6391.00
91_Q105_I0.6391.00
262_V286_T0.6391.00
64_V432_I0.6391.00
388_G391_V0.6371.00
377_L437_L0.6371.00
391_V394_E0.6361.00
139_I284_I0.6361.00
432_I436_I0.6351.00
211_M253_Y0.6341.00
70_T418_P0.6331.00
143_I305_D0.6321.00
207_L249_L0.6321.00
243_L259_V0.6281.00
249_L252_K0.6281.00
375_I433_L0.6271.00
94_K105_I0.6251.00
77_L340_I0.6231.00
114_L120_R0.6211.00
135_A314_H0.6211.00
52_A95_V0.6211.00
413_I433_L0.6201.00
129_G262_V0.6191.00
48_A102_P0.6171.00
392_V396_A0.6161.00
87_R90_E0.6151.00
194_C197_K0.6151.00
114_L121_A0.6141.00
327_A330_A0.6121.00
415_L429_A0.6121.00
146_K255_V0.6111.00
69_V402_L0.6101.00
116_T271_K0.6091.00
141_R161_A0.6081.00
351_A430_I0.6071.00
80_N92_L0.6061.00
228_P264_T0.6061.00
118_G276_Q0.6041.00
146_K220_D0.6041.00
82_P93_E0.6021.00
347_L421_I0.6021.00
151_A193_R0.6011.00
230_Q233_G0.5991.00
87_R333_E0.5991.00
76_N419_L0.5961.00
148_T217_L0.5961.00
92_L327_A0.5951.00
109_F297_V0.5931.00
363_V437_L0.5921.00
354_L358_V0.5911.00
156_Y159_I0.5901.00
392_V413_I0.5901.00
52_A57_V0.5891.00
344_V371_F0.5891.00
387_E391_V0.5891.00
432_I435_I0.5891.00
205_S245_G0.5891.00
393_I397_L0.5881.00
194_C206_L0.5871.00
394_E397_L0.5861.00
251_E305_D0.5841.00
198_D206_L0.5821.00
351_A373_I0.5811.00
336_E339_N0.5801.00
148_T216_Y0.5791.00
148_T192_Y0.5781.00
367_R374_G0.5781.00
152_F226_V0.5771.00
266_V273_W0.5771.00
389_T405_K0.5761.00
49_I95_V0.5751.00
137_V162_G0.5741.00
109_F125_F0.5731.00
120_R285_V0.5721.00
244_K247_K0.5721.00
38_A41_Y0.5711.00
351_A426_L0.5711.00
118_G281_E0.5701.00
53_Q56_T0.5691.00
358_V431_E0.5691.00
347_L422_P0.5691.00
150_I210_A0.5691.00
284_I306_F0.5661.00
108_N111_K0.5631.00
367_R412_V0.5611.00
47_I50_D0.5591.00
84_V331_S0.5581.00
126_T131_D0.5571.00
185_K189_P0.5561.00
76_N335_I0.5561.00
170_N173_K0.5551.00
272_M335_I0.5551.00
345_E348_G0.5541.00
66_I421_I0.5531.00
433_L437_L0.5521.00
212_S220_D0.5501.00
50_D53_Q0.5491.00
212_S252_K0.5491.00
350_K430_I0.5451.00
47_I397_L0.5451.00
307_D310_P0.5441.00
426_L430_I0.5441.00
429_A433_L0.5420.99
90_E330_A0.5410.99
272_M332_L0.5410.99
152_F246_L0.5410.99
427_D430_I0.5400.99
192_Y378_V0.5390.99
154_G233_G0.5370.99
343_R426_L0.5360.99
114_L119_M0.5350.99
186_F207_L0.5340.99
207_L245_G0.5340.99
377_L388_G0.5330.99
338_H343_R0.5330.99
263_Q372_M0.5330.99
117_L287_I0.5320.99
285_V301_A0.5320.99
170_N174_E0.5300.99
363_V375_I0.5290.99
176_Q179_F0.5290.99
84_V330_A0.5290.99
144_T222_A0.5290.99
246_L255_V0.5280.99
88_V295_I0.5270.99
85_R293_E0.5260.99
228_P275_Y0.5260.99
375_I415_L0.5260.99
177_P180_D0.5260.99
256_P284_I0.5250.99
52_A75_V0.5230.99
401_L436_I0.5220.99
400_G432_I0.5220.99
141_R177_P0.5210.99
397_L402_L0.5200.99
418_P421_I0.5200.99
426_L429_A0.5200.99
114_L117_L0.5190.99
321_N324_G0.5190.99
332_L336_E0.5190.99
307_D311_T0.5170.99
282_P285_V0.5160.99
240_K279_N0.5150.99
358_V437_L0.5140.99
237_V278_E0.5140.99
83_F338_H0.5130.99
387_E390_K0.5100.99
114_L301_A0.5090.99
204_L246_L0.5090.99
113_L123_L0.5080.99
261_E274_A0.5080.99
362_H437_L0.5080.99
356_K366_I0.5080.99
51_K64_V0.5040.99
191_P198_D0.5040.99
96_W99_L0.5040.99
117_L123_L0.5040.99
48_A104_E0.5030.99
238_P243_L0.5030.99
247_K259_V0.5020.99
244_K280_I0.5010.99
329_L336_E0.5010.99
113_L299_M0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4atqA 7 0.9818 100 0.381 Contact Map
3oksA 2 0.9818 100 0.394 Contact Map
4ffcA 4 0.975 100 0.399 Contact Map
2epjA 2 0.9068 100 0.399 Contact Map
4uoxA 3 0.9455 100 0.409 Contact Map
2ykyA 4 0.9182 100 0.414 Contact Map
4a0gA 2 0.9659 100 0.416 Contact Map
4e3qA 3 0.9386 100 0.417 Contact Map
1z7dA 2 0.8318 100 0.42 Contact Map
4ao9A 2 0.9227 100 0.425 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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