GREMLIN Database
Q97VA6 - Amino acid transporter, putative
UniProt: Q97VA6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 520 (426)
Sequences: 24550 (16149)
Seq/√Len: 782.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
379_F392_K4.3461.00
168_S398_M4.2661.00
422_S425_V3.7581.00
62_I288_G3.1491.00
382_D392_K3.1331.00
274_R278_I2.9681.00
384_S387_R2.9141.00
22_G270_R2.9121.00
425_V428_L2.9101.00
433_M437_S2.8741.00
271_N274_R2.7271.00
86_Y373_D2.7051.00
488_S492_L2.6951.00
269_V275_S2.6221.00
371_A381_G2.6161.00
384_S391_I2.5851.00
102_N370_Y2.5661.00
200_E297_L2.5081.00
379_F382_D2.4941.00
27_L282_G2.4831.00
161_A402_L2.4371.00
23_I282_G2.3971.00
339_V343_L2.3381.00
430_L434_A2.3351.00
198_I202_S2.3291.00
267_G372_M2.2961.00
431_F435_I2.2721.00
23_I275_S2.1811.00
268_E365_R2.1751.00
90_S98_G2.1621.00
26_A269_V2.1541.00
169_L173_F2.1301.00
395_I399_I2.1021.00
168_S394_I2.0951.00
455_A459_I2.0841.00
23_I27_L2.0801.00
368_F372_M2.0641.00
161_A405_L2.0601.00
172_I391_I2.0211.00
165_V402_L2.0061.00
160_G405_L1.9821.00
176_K180_A1.9781.00
422_S428_L1.9751.00
409_T412_V1.9561.00
106_F397_S1.9171.00
90_S95_P1.9111.00
187_P191_I1.9001.00
278_I282_G1.8831.00
374_R378_D1.8751.00
452_I456_L1.8681.00
380_V396_L1.8681.00
432_P435_I1.8541.00
17_L383_V1.8511.00
63_V67_L1.8361.00
22_G25_D1.8241.00
420_L425_V1.8231.00
303_G306_F1.7991.00
45_S54_P1.7801.00
53_N245_I1.7641.00
238_A241_N1.7621.00
318_G321_P1.7331.00
89_V101_G1.7291.00
281_L285_I1.7121.00
459_I463_Y1.6961.00
171_P357_S1.6851.00
25_D183_W1.6801.00
165_V398_M1.6771.00
384_S389_V1.6641.00
271_N275_S1.6591.00
438_I441_L1.6431.00
429_M432_P1.6371.00
64_G460_Y1.6351.00
114_M401_G1.6251.00
387_R391_I1.6241.00
118_G356_L1.6161.00
21_F25_D1.6161.00
486_A490_V1.6061.00
155_L158_V1.5901.00
164_I401_G1.5851.00
429_M433_M1.5821.00
30_N283_T1.5811.00
191_I195_G1.5801.00
57_G248_L1.5721.00
172_I395_I1.5681.00
285_I289_F1.5501.00
27_L286_I1.5441.00
421_S424_A1.5361.00
125_G159_I1.5321.00
103_A492_L1.5151.00
367_L393_A1.5081.00
492_L495_I1.4971.00
412_V415_A1.4961.00
63_V456_L1.4951.00
94_H97_L1.4941.00
431_F434_A1.4881.00
392_K396_L1.4821.00
18_V388_H1.4811.00
212_L215_F1.4811.00
494_I498_V1.4771.00
424_A428_L1.4681.00
192_A347_A1.4621.00
61_P252_Y1.4581.00
425_V430_L1.4561.00
173_F387_R1.4441.00
449_K453_I1.4281.00
363_G397_S1.4161.00
265_V361_F1.4141.00
67_L456_L1.4131.00
154_Y158_V1.4111.00
118_G164_I1.4031.00
378_D382_D1.4031.00
426_A458_I1.3981.00
71_I454_A1.3861.00
25_D179_R1.3811.00
498_V502_I1.3791.00
368_F383_V1.3681.00
364_S394_I1.3671.00
79_V91_R1.3571.00
378_D381_G1.3561.00
201_A297_L1.3541.00
96_A499_A1.3531.00
164_I398_M1.3511.00
485_L488_S1.3491.00
382_D391_I1.3481.00
93_L97_L1.3481.00
271_N278_I1.3461.00
69_G284_L1.3451.00
53_N238_A1.3451.00
168_S395_I1.3271.00
190_L194_I1.3261.00
40_T120_T1.3261.00
487_G491_I1.3201.00
342_V346_L1.3201.00
78_K443_T1.3141.00
161_A165_V1.3071.00
17_L368_F1.2971.00
23_I278_I1.2921.00
425_V431_F1.2861.00
121_L163_E1.2851.00
82_V267_G1.2841.00
55_L296_A1.2841.00
167_M356_L1.2781.00
121_L349_I1.2701.00
275_S278_I1.2671.00
46_T54_P1.2621.00
197_I293_A1.2611.00
411_P414_S1.2601.00
196_M200_E1.2531.00
69_G280_I1.2511.00
492_L496_F1.2381.00
418_F421_S1.2291.00
21_F179_R1.2201.00
117_T355_Y1.2201.00
419_L422_S1.2191.00
21_F26_A1.2181.00
410_L414_S1.2171.00
367_L376_M1.2151.00
87_V91_R1.2081.00
70_I281_L1.2071.00
202_S207_L1.2031.00
272_P277_P1.2001.00
304_Y307_T1.1931.00
421_S425_V1.1901.00
418_F425_V1.1851.00
417_A425_V1.1831.00
200_E301_Q1.1811.00
439_A442_K1.1791.00
433_M436_L1.1791.00
289_F293_A1.1731.00
418_F422_S1.1611.00
26_A279_S1.1601.00
429_M434_A1.1581.00
31_I286_I1.1551.00
422_S426_A1.1511.00
24_L28_W1.1501.00
157_M161_A1.1501.00
437_S440_V1.1371.00
452_I455_A1.1341.00
463_Y467_Q1.1331.00
422_S430_L1.1291.00
72_F85_D1.1281.00
181_F185_A1.1261.00
99_F103_A1.1241.00
436_L439_A1.1211.00
499_A502_I1.1201.00
270_R275_S1.1141.00
497_Y501_F1.1131.00
490_V494_I1.1101.00
430_L435_I1.1101.00
462_I466_Y1.1051.00
485_L489_I1.1001.00
392_K395_I1.1001.00
30_N262_T1.0991.00
170_I181_F1.0971.00
439_A443_T1.0911.00
81_R87_V1.0911.00
410_L425_V1.0901.00
418_F428_L1.0851.00
182_Q357_S1.0841.00
422_S431_F1.0841.00
415_A418_F1.0791.00
451_R455_A1.0781.00
89_V97_L1.0771.00
106_F367_L1.0721.00
76_G88_Y1.0721.00
450_I454_A1.0641.00
211_R215_F1.0591.00
162_V166_I1.0561.00
91_R438_I1.0561.00
372_M381_G1.0561.00
195_G199_V1.0521.00
246_I463_Y1.0501.00
469_L473_A1.0491.00
86_Y369_S1.0461.00
469_L472_P1.0411.00
29_F265_V1.0381.00
152_N155_L1.0331.00
320_L323_P1.0241.00
488_S495_I1.0231.00
383_V388_H1.0161.00
495_I499_A1.0101.00
168_S172_I1.0051.00
158_V162_V1.0041.00
194_I198_I1.0031.00
241_N244_N1.0031.00
449_K452_I1.0011.00
180_A184_I1.0001.00
498_V501_F0.9961.00
438_I442_K0.9941.00
493_F497_Y0.9911.00
426_A430_L0.9861.00
420_L424_A0.9831.00
212_L216_A0.9801.00
495_I498_V0.9761.00
211_R214_N0.9761.00
399_I403_I0.9751.00
67_L453_I0.9731.00
20_E270_R0.9721.00
59_L292_T0.9701.00
424_A427_I0.9651.00
413_T416_G0.9631.00
421_S428_L0.9591.00
74_Y77_S0.9581.00
437_S441_L0.9531.00
94_H500_K0.9511.00
172_I384_S0.9511.00
172_I389_V0.9501.00
489_I492_L0.9481.00
416_G419_L0.9481.00
81_R91_R0.9481.00
185_A354_M0.9461.00
175_N361_F0.9451.00
213_N216_A0.9371.00
266_A276_M0.9301.00
430_L433_M0.9291.00
207_L300_N0.9291.00
31_I287_T0.9211.00
457_S461_L0.9181.00
338_I342_V0.9141.00
122_Q159_I0.9061.00
165_V169_L0.9061.00
306_F334_A0.9041.00
125_G349_I0.8991.00
296_A300_N0.8961.00
20_E176_K0.8951.00
78_K441_L0.8931.00
166_I353_L0.8891.00
458_I462_I0.8861.00
197_I201_A0.8851.00
391_I395_I0.8841.00
360_S398_M0.8841.00
90_S373_D0.8831.00
189_A351_Q0.8811.00
260_I264_Y0.8811.00
93_L433_M0.8791.00
62_I256_F0.8791.00
380_V392_K0.8781.00
167_M357_S0.8751.00
25_D180_A0.8751.00
423_V458_I0.8711.00
28_W183_W0.8701.00
282_G286_I0.8641.00
103_A376_M0.8581.00
238_A245_I0.8571.00
414_S417_A0.8561.00
484_I487_G0.8551.00
121_L352_L0.8531.00
197_I297_L0.8521.00
23_I279_S0.8511.00
461_L464_T0.8501.00
229_V232_S0.8481.00
426_A457_S0.8471.00
410_L413_T0.8451.00
288_G292_T0.8431.00
443_T446_N0.8431.00
487_G490_V0.8421.00
121_L353_L0.8411.00
208_A211_R0.8401.00
96_A100_V0.8381.00
167_M360_S0.8361.00
242_I245_I0.8351.00
67_L71_I0.8331.00
17_L365_R0.8291.00
306_F309_K0.8281.00
261_N362_V0.8271.00
24_L183_W0.8271.00
38_F294_A0.8261.00
77_S444_E0.8241.00
466_Y470_T0.8231.00
116_I254_V0.8231.00
190_L290_I0.8191.00
83_A87_V0.8181.00
472_P475_G0.8181.00
417_A420_L0.8181.00
464_T468_Y0.8181.00
411_P425_V0.8151.00
164_I405_L0.8111.00
398_M402_L0.8091.00
17_L268_E0.8081.00
55_L299_Y0.8051.00
68_V461_L0.8051.00
59_L63_V0.8041.00
66_F70_I0.8041.00
485_L490_V0.7951.00
411_P422_S0.7911.00
169_L172_I0.7911.00
332_G338_I0.7871.00
484_I488_S0.7861.00
336_G340_L0.7831.00
417_A421_S0.7831.00
78_K444_E0.7831.00
74_Y435_I0.7811.00
157_M405_L0.7801.00
436_L440_V0.7801.00
122_Q160_G0.7771.00
465_F468_Y0.7691.00
483_G486_A0.7681.00
483_G488_S0.7611.00
83_A86_Y0.7591.00
409_T415_A0.7571.00
420_L434_A0.7571.00
486_A489_I0.7571.00
463_Y466_Y0.7561.00
384_S388_H0.7551.00
432_P436_L0.7541.00
409_T414_S0.7531.00
54_P295_L0.7531.00
113_F116_I0.7531.00
50_V53_N0.7501.00
418_F424_A0.7491.00
105_Y109_T0.7491.00
450_I453_I0.7481.00
24_L180_A0.7471.00
35_G38_F0.7461.00
435_I439_A0.7461.00
332_G341_G0.7451.00
180_A183_W0.7441.00
399_I402_L0.7431.00
247_S251_V0.7421.00
93_L429_M0.7401.00
51_G299_Y0.7371.00
416_G420_L0.7371.00
201_A293_A0.7361.00
277_P280_I0.7361.00
159_I162_V0.7361.00
420_L430_L0.7351.00
422_S434_A0.7351.00
66_F281_L0.7341.00
319_T323_P0.7331.00
411_P415_A0.7281.00
32_A186_I0.7281.00
34_L189_A0.7261.00
429_M435_I0.7241.00
425_V434_A0.7241.00
339_V342_V0.7241.00
173_F177_V0.7211.00
376_M380_V0.7211.00
34_L37_L0.7211.00
179_R183_W0.7191.00
488_S493_F0.7181.00
483_G487_G0.7131.00
161_A406_T0.7131.00
488_S491_I0.7101.00
211_R216_A0.7081.00
417_A422_S0.7081.00
492_L499_A0.7081.00
457_S460_Y0.7051.00
412_V416_G0.7031.00
491_I495_I0.7021.00
273_K444_E0.7021.00
489_I493_F0.7021.00
96_A493_F0.7001.00
485_L492_L0.7001.00
412_V422_S0.6971.00
491_I494_I0.6961.00
420_L423_V0.6931.00
273_K442_K0.6931.00
71_I457_S0.6901.00
417_A428_L0.6901.00
56_L245_I0.6891.00
163_E356_L0.6871.00
293_A297_L0.6861.00
364_S393_A0.6851.00
75_V88_Y0.6841.00
412_V425_V0.6821.00
423_V427_I0.6821.00
367_L396_L0.6811.00
56_L59_L0.6811.00
67_L457_S0.6801.00
20_E175_N0.6791.00
122_Q156_I0.6781.00
179_R357_S0.6771.00
410_L421_S0.6771.00
360_S364_S0.6771.00
390_P393_A0.6771.00
118_G122_Q0.6751.00
465_F473_A0.6751.00
27_L279_S0.6751.00
115_G118_G0.6741.00
371_A380_V0.6741.00
171_P394_I0.6711.00
33_L358_A0.6711.00
172_I387_R0.6701.00
27_L30_N0.6671.00
437_S442_K0.6661.00
451_R454_A0.6661.00
380_V393_A0.6641.00
35_G39_S0.6631.00
409_T413_T0.6631.00
447_E453_I0.6601.00
82_V368_F0.6591.00
332_G337_N0.6581.00
422_S429_M0.6561.00
113_F117_T0.6541.00
109_T359_A0.6531.00
468_Y472_P0.6531.00
238_A242_I0.6521.00
420_L426_A0.6511.00
244_N247_S0.6501.00
435_I438_I0.6501.00
86_Y90_S0.6501.00
417_A424_A0.6491.00
86_Y98_G0.6481.00
209_I213_N0.6471.00
69_G259_I0.6471.00
207_L212_L0.6451.00
31_I186_I0.6441.00
419_L423_V0.6431.00
42_Y295_L0.6411.00
496_F500_K0.6411.00
20_E24_L0.6401.00
425_V432_P0.6391.00
122_Q125_G0.6381.00
414_S422_S0.6381.00
86_Y102_N0.6371.00
413_T417_A0.6361.00
74_Y445_K0.6351.00
172_I394_I0.6351.00
441_L444_E0.6341.00
153_P156_I0.6341.00
379_F396_L0.6331.00
75_V92_N0.6311.00
65_F259_I0.6301.00
471_V475_G0.6291.00
76_G263_I0.6291.00
434_A439_A0.6291.00
365_R368_F0.6281.00
171_P361_F0.6251.00
119_I410_L0.6251.00
409_T425_V0.6241.00
415_A422_S0.6241.00
242_I246_I0.6241.00
60_L249_N0.6231.00
128_P131_T0.6231.00
197_I294_A0.6231.00
496_F499_A0.6221.00
263_I280_I0.6221.00
40_T43_V0.6201.00
297_L300_N0.6191.00
454_A458_I0.6181.00
76_G276_M0.6141.00
167_M353_L0.6131.00
461_L465_F0.6121.00
294_A298_E0.6111.00
286_I290_I0.6101.00
157_M160_G0.6101.00
101_G424_A0.6091.00
70_I453_I0.6081.00
304_Y308_T0.6081.00
74_Y448_N0.6071.00
488_S496_F0.6071.00
70_I448_N0.6071.00
188_L192_A0.6061.00
264_Y362_V0.6061.00
363_G367_L0.6061.00
267_G368_F0.6051.00
117_T120_T0.6051.00
425_V429_M0.6041.00
412_V428_L0.6011.00
428_L431_F0.6001.00
199_V203_V0.5991.00
164_I402_L0.5991.00
282_G285_I0.5981.00
489_I495_I0.5971.00
414_S418_F0.5971.00
115_G404_G0.5961.00
188_L347_A0.5951.00
207_L211_R0.5941.00
482_Y485_L0.5931.00
434_A438_I0.5931.00
52_G56_L0.5921.00
416_G421_S0.5911.00
35_G291_F0.5911.00
305_D309_K0.5891.00
482_Y486_A0.5881.00
466_Y469_L0.5871.00
34_L39_S0.5871.00
35_G40_T0.5871.00
432_P455_A0.5871.00
85_D260_I0.5861.00
24_L27_L0.5851.00
271_N277_P0.5851.00
486_A492_L0.5841.00
343_L347_A0.5841.00
485_L496_F0.5841.00
269_V276_M0.5831.00
35_G42_Y0.5831.00
178_Y361_F0.5821.00
257_S260_I0.5811.00
199_V335_S0.5811.00
445_K448_N0.5811.00
42_Y298_E0.5801.00
183_W187_P0.5801.00
61_P253_V0.5801.00
440_V443_T0.5791.00
85_D264_Y0.5791.00
84_A263_I0.5791.00
58_L255_G0.5781.00
177_V181_F0.5771.00
61_P256_F0.5771.00
488_S500_K0.5761.00
199_V337_N0.5761.00
127_I131_T0.5741.00
276_M280_I0.5741.00
386_K391_I0.5731.00
229_V233_N0.5721.00
421_S430_L0.5721.00
246_I467_Q0.5711.00
410_L422_S0.5701.00
175_N265_V0.5661.00
493_F496_F0.5621.00
330_L334_A0.5621.00
410_L417_A0.5611.00
424_A430_L0.5611.00
428_L434_A0.5611.00
174_G177_V0.5611.00
115_G401_G0.5601.00
30_N279_S0.5591.00
39_S189_A0.5581.00
447_E450_I0.5581.00
418_F426_A0.5571.00
44_A47_G0.5561.00
29_F32_A0.5551.00
421_S426_A0.5551.00
426_A461_L0.5541.00
36_L254_V0.5541.00
38_F42_Y0.5521.00
104_G108_A0.5521.00
33_L359_A0.5501.00
351_Q354_M0.5501.00
268_E390_P0.5491.00
411_P416_G0.5491.00
168_S360_S0.5481.00
230_T233_N0.5471.00
396_L400_A0.5451.00
162_V165_V0.5451.00
203_V208_A0.5441.00
124_F348_S0.5431.00
45_S252_Y0.5421.00
55_L59_L0.5411.00
346_L350_V0.5411.00
38_F193_A0.5391.00
239_Y242_I0.5391.00
482_Y488_S0.5391.00
470_T474_I0.5391.00
305_D308_T0.5381.00
450_I455_A0.5371.00
428_L432_P0.5361.00
494_I497_Y0.5361.00
177_V180_A0.5361.00
125_G163_E0.5351.00
434_A437_S0.5341.00
26_A265_V0.5311.00
165_V168_S0.5301.00
45_S49_L0.5301.00
427_I458_I0.5301.00
68_V260_I0.5291.00
335_S340_L0.5251.00
81_R267_G0.5251.00
93_L431_F0.5241.00
487_G492_L0.5231.00
57_G252_Y0.5221.00
449_K454_A0.5221.00
490_V493_F0.5221.00
120_T124_F0.5211.00
488_S494_I0.5211.00
39_S43_V0.5211.00
33_L261_N0.5211.00
117_T122_Q0.5201.00
431_F436_L0.5191.00
483_G492_L0.5191.00
73_S280_I0.5191.00
443_T447_E0.5181.00
365_R390_P0.5181.00
17_L82_V0.5181.00
269_V279_S0.5161.00
49_L248_L0.5141.00
342_V345_A0.5131.00
486_A493_F0.5131.00
403_I406_T0.5131.00
286_I289_F0.5111.00
460_Y464_T0.5091.00
437_S443_T0.5081.00
118_G121_L0.5071.00
418_F423_V0.5061.00
203_V335_S0.5051.00
41_Y44_A0.5051.00
264_Y366_L0.5051.00
188_L350_V0.5051.00
207_L297_L0.5051.00
268_E383_V0.5051.00
455_A458_I0.5041.00
469_L474_I0.5041.00
49_L52_G0.5041.00
402_L405_L0.5041.00
482_Y496_F0.5021.00
470_T473_A0.5021.00
436_L442_K0.5011.00
21_F175_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.7962 100 0.377 Contact Map
4djkA 2 0.8173 100 0.409 Contact Map
3giaA 1 0.8192 100 0.413 Contact Map
2jlnA 1 0.8019 99 0.86 Contact Map
3dh4A 3 0.8538 98.4 0.888 Contact Map
2xq2A 2 0.8558 98.2 0.894 Contact Map
4xp4A 1 0.8942 97.4 0.911 Contact Map
4wgvA 2 0.7173 97.3 0.913 Contact Map
2a65A 2 0.8827 97 0.917 Contact Map
4us3A 1 0.8019 96.8 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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