GREMLIN Database
Q97VA5 - Uncharacterized protein
UniProt: Q97VA5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 302 (243)
Sequences: 203 (106)
Seq/√Len: 6.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_N148_K4.6280.98
239_Q259_K4.1330.96
179_A187_K3.3990.90
164_N204_N3.2480.87
239_Q258_G3.2380.87
168_T178_V3.0180.83
175_S178_V2.8070.78
11_T157_S2.5610.71
47_V179_A2.5110.69
188_G234_L2.4110.66
168_T207_A2.3930.65
174_K178_V2.3850.65
234_L238_F2.3390.63
13_I19_V2.2770.61
189_H237_K2.2610.61
157_S183_I2.2120.59
87_G239_Q2.0830.54
232_R236_E2.0770.54
185_Y234_L2.0760.54
80_Y263_I2.0480.53
180_P183_I2.0100.51
181_E272_G1.9220.48
127_N147_I1.8860.47
126_W141_K1.8620.46
36_V87_G1.8280.44
146_E151_I1.7970.43
172_P177_R1.7750.42
98_R233_E1.7610.42
173_Y177_R1.7600.42
171_T178_V1.7100.40
23_A115_V1.7060.40
170_E178_V1.7040.40
145_I269_Y1.6920.39
62_K106_Q1.6850.39
110_S183_I1.6710.39
40_D129_G1.6240.37
13_I41_L1.5860.36
225_H262_V1.5830.36
182_Y186_N1.5410.34
36_V42_V1.5210.33
205_F231_V1.5150.33
56_Y65_T1.5020.33
63_L207_A1.4940.33
169_N207_A1.4870.32
77_Y102_D1.4830.32
174_K177_R1.4620.32
55_E90_D1.4440.31
183_I186_N1.4430.31
123_K158_S1.4370.31
30_F231_V1.4360.31
57_L179_A1.4260.30
94_V191_M1.4200.30
73_K126_W1.4050.30
171_T175_S1.4050.30
228_S272_G1.4040.30
171_T174_K1.4030.30
101_V135_F1.3950.29
13_I33_N1.3730.29
123_K136_V1.3350.28
78_Y181_E1.3320.27
71_E151_I1.3280.27
68_E87_G1.3110.27
21_R102_D1.3070.27
171_T181_E1.3050.27
113_K230_S1.3040.27
146_E254_I1.2960.26
38_G108_L1.2950.26
88_M270_S1.2830.26
190_E230_S1.2770.26
55_E150_I1.2700.26
52_K125_I1.2620.25
148_K239_Q1.2600.25
10_V32_V1.2560.25
66_K152_E1.2490.25
35_L261_L1.2360.25
10_V23_A1.2350.25
98_R183_I1.2270.24
191_M207_A1.2270.24
165_Y205_F1.2180.24
186_N200_N1.2100.24
171_T226_V1.2090.24
21_R54_D1.1970.24
47_V90_D1.1950.23
178_V181_E1.1860.23
165_Y243_G1.1720.23
168_T253_A1.1660.23
24_I265_P1.1640.23
53_V234_L1.1620.23
95_T256_K1.1600.23
47_V57_L1.1500.22
54_D88_M1.1450.22
99_I181_E1.1400.22
217_A267_S1.1400.22
94_V183_I1.1390.22
79_I181_E1.1390.22
32_V163_L1.1340.22
184_I230_S1.1230.22
63_L101_V1.1120.21
200_N270_S1.1110.21
233_E236_E1.1090.21
51_K123_K1.1070.21
115_V140_F1.0990.21
40_D130_N1.0880.21
153_I238_F1.0840.21
47_V187_K1.0780.20
34_Y136_V1.0530.20
131_D267_S1.0500.20
209_P266_G1.0500.20
183_I187_K1.0500.20
165_Y188_G1.0490.20
63_L99_I1.0480.20
172_P175_S1.0470.20
228_S247_H1.0370.19
99_I229_R1.0360.19
231_V271_E1.0290.19
91_F96_I1.0270.19
36_V92_N1.0220.19
103_L123_K1.0180.19
11_T188_G1.0180.19
6_K153_I1.0170.19
67_E169_N1.0160.19
37_F128_L1.0090.19
36_V261_L1.0040.19
131_D248_I0.9990.19
254_I263_I0.9960.19
211_N234_L0.9940.18
71_E230_S0.9900.18
94_V104_V0.9880.18
156_S159_P0.9870.18
63_L239_Q0.9870.18
208_P215_D0.9850.18
206_H246_G0.9850.18
215_D246_G0.9850.18
208_P264_N0.9850.18
206_H264_N0.9850.18
246_G264_N0.9850.18
208_P246_G0.9850.18
50_N69_V0.9850.18
12_D208_P0.9850.18
12_D206_H0.9850.18
12_D246_G0.9850.18
12_D39_G0.9850.18
39_G246_G0.9850.18
39_G206_H0.9850.18
12_D264_N0.9850.18
39_G208_P0.9850.18
206_H215_D0.9850.18
39_G215_D0.9850.18
39_G264_N0.9850.18
215_D264_N0.9850.18
12_D215_D0.9850.18
7_L32_V0.9800.18
171_T177_R0.9780.18
53_V145_I0.9690.18
52_K227_G0.9690.18
100_Y115_V0.9600.18
146_E184_I0.9570.18
6_K11_T0.9560.18
66_K210_Y0.9460.17
256_K261_L0.9450.17
110_S273_V0.9450.17
74_R78_Y0.9440.17
148_K152_E0.9400.17
50_N269_Y0.9390.17
46_V50_N0.9370.17
230_S271_E0.9260.17
131_D266_G0.9260.17
106_Q238_F0.9130.17
168_T179_A0.9070.17
74_R175_S0.8980.16
146_E150_I0.8950.16
172_P178_V0.8920.16
124_V144_D0.8890.16
6_K32_V0.8840.16
87_G171_T0.8760.16
177_R187_K0.8750.16
188_G225_H0.8740.16
106_Q136_V0.8730.16
191_M231_V0.8660.16
9_F35_L0.8540.15
54_D182_Y0.8540.15
116_R143_N0.8520.15
21_R107_Q0.8510.15
67_E235_E0.8390.15
243_G262_V0.8380.15
86_K173_Y0.8360.15
175_S272_G0.8300.15
239_Q260_T0.8270.15
177_R184_I0.8270.15
32_V114_I0.8260.15
36_V95_T0.8250.15
131_D217_A0.8240.15
235_E257_I0.8140.15
65_T158_S0.8140.15
163_L245_H0.8080.15
53_V70_E0.8080.15
152_E180_P0.8030.15
106_Q150_I0.7960.14
172_P236_E0.7940.14
199_K233_E0.7890.14
159_P183_I0.7890.14
13_I158_S0.7870.14
63_L153_I0.7840.14
178_V242_L0.7840.14
99_I126_W0.7810.14
33_N211_N0.7800.14
160_L263_I0.7780.14
86_K151_I0.7680.14
96_I109_N0.7660.14
45_G77_Y0.7650.14
15_G266_G0.7620.14
134_F202_I0.7580.14
233_E255_D0.7560.14
8_M42_V0.7560.14
21_R198_T0.7530.14
47_V99_I0.7520.14
74_R159_P0.7510.14
53_V230_S0.7500.14
22_K171_T0.7490.14
204_N251_S0.7470.13
35_L209_P0.7440.13
87_G164_N0.7410.13
11_T149_E0.7380.13
55_E65_T0.7330.13
72_I96_I0.7310.13
165_Y214_L0.7300.13
38_G41_L0.7220.13
81_I254_I0.7200.13
258_G261_L0.7190.13
36_V146_E0.7190.13
62_K237_K0.7180.13
71_E74_R0.7160.13
68_E81_I0.7140.13
109_N259_K0.7060.13
153_I186_N0.7050.13
66_K180_P0.7040.13
87_G141_K0.7030.13
55_E123_K0.7020.13
18_I102_D0.7000.13
157_S162_M0.7000.13
108_L126_W0.7000.13
172_P272_G0.6990.13
31_K134_F0.6990.13
168_T226_V0.6890.12
17_D142_N0.6880.12
215_D249_H0.6880.12
46_V103_L0.6880.12
249_H264_N0.6880.12
39_G249_H0.6880.12
208_P249_H0.6880.12
206_H249_H0.6880.12
246_G249_H0.6880.12
12_D249_H0.6880.12
185_Y263_I0.6860.12
54_D72_I0.6830.12
85_R233_E0.6810.12
62_K81_I0.6760.12
198_T232_R0.6740.12
235_E238_F0.6720.12
167_H268_M0.6720.12
15_G247_H0.6710.12
53_V67_E0.6590.12
12_D40_D0.6520.12
40_D208_P0.6520.12
40_D206_H0.6520.12
40_D215_D0.6520.12
40_D246_G0.6520.12
40_D264_N0.6520.12
54_D162_M0.6470.12
128_L145_I0.6460.12
153_I239_Q0.6450.12
54_D63_L0.6450.12
179_A183_I0.6440.12
104_V116_R0.6410.12
70_E255_D0.6370.12
84_N181_E0.6330.12
10_V20_F0.6250.11
173_Y178_V0.6240.11
13_I103_L0.6240.11
181_E263_I0.6200.11
42_V137_D0.6180.11
174_K231_V0.6180.11
20_F162_M0.6170.11
231_V257_I0.6160.11
63_L81_I0.6150.11
51_K186_N0.6150.11
69_V179_A0.6140.11
133_P169_N0.6130.11
83_E86_K0.6130.11
169_N226_V0.6090.11
23_A107_Q0.6080.11
18_I242_L0.6010.11
70_E141_K0.5990.11
125_I162_M0.5920.11
111_W204_N0.5920.11
33_N103_L0.5910.11
64_I108_L0.5900.11
67_E253_A0.5900.11
105_S115_V0.5900.11
184_I248_I0.5840.11
148_K263_I0.5840.11
88_M255_D0.5790.11
153_I157_S0.5780.11
169_N245_H0.5770.11
14_H264_N0.5750.11
14_H246_G0.5750.11
14_H39_G0.5750.11
14_H206_H0.5750.11
14_H208_P0.5750.11
14_H215_D0.5750.11
87_G258_G0.5750.11
36_V80_Y0.5750.11
229_R257_I0.5730.11
171_T236_E0.5710.11
14_H132_D0.5700.11
42_V128_L0.5680.11
189_H253_A0.5670.11
129_G206_H0.5630.11
129_G246_G0.5630.11
129_G264_N0.5630.11
129_G215_D0.5630.11
129_G208_P0.5630.11
12_D129_G0.5630.11
39_G129_G0.5630.11
36_V239_Q0.5620.11
88_M243_G0.5610.11
141_K191_M0.5600.11
256_K265_P0.5600.11
69_V243_G0.5580.10
142_N147_I0.5580.10
30_F244_L0.5570.10
168_T242_L0.5570.10
79_I188_G0.5560.10
78_Y81_I0.5500.10
41_L54_D0.5490.10
16_S267_S0.5490.10
8_M238_F0.5440.10
20_F251_S0.5440.10
151_I186_N0.5430.10
31_K167_H0.5420.10
30_F68_E0.5420.10
169_N243_G0.5410.10
177_R272_G0.5400.10
105_S109_N0.5380.10
36_V172_P0.5370.10
123_K134_F0.5360.10
161_F170_E0.5350.10
57_L104_V0.5350.10
9_F265_P0.5350.10
216_N225_H0.5260.10
169_N175_S0.5240.10
114_I148_K0.5230.10
180_P187_K0.5170.10
136_V146_E0.5170.10
10_V107_Q0.5150.10
105_S159_P0.5130.10
76_G251_S0.5130.10
186_N190_E0.5090.10
103_L125_I0.5040.10
176_Y239_Q0.5030.10
82_L239_Q0.5020.10
188_G205_F0.5020.10
81_I141_K0.5020.10
108_L158_S0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uf3A 6 0.6954 100 0.74 Contact Map
2yvtA 1 0.8046 100 0.742 Contact Map
4peiA 2 0.8179 100 0.752 Contact Map
3rl5A 1 0.6755 99.9 0.781 Contact Map
3qfmA 2 0.7086 99.9 0.806 Contact Map
3d03A 5 0.7417 99.9 0.808 Contact Map
3ib7A 2 0.7781 99.8 0.813 Contact Map
1nnwA 2 0.7285 99.8 0.816 Contact Map
4ykeA 2 0.8642 99.8 0.817 Contact Map
1s3lA 1 0.5364 99.8 0.817 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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