GREMLIN Database
Q97VA4 - Uncharacterized protein
UniProt: Q97VA4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 377 (309)
Sequences: 9974 (8626)
Seq/√Len: 490.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
239_S273_L4.3791.00
23_L52_H4.1401.00
235_D238_T3.7611.00
315_A347_Q3.6281.00
330_S333_D3.5811.00
312_S347_Q3.4451.00
46_L204_S2.8851.00
22_L49_S2.8571.00
200_T206_S2.8531.00
331_P334_L2.6461.00
236_R260_E2.4981.00
46_L168_A2.4931.00
172_F203_I2.4571.00
35_I228_L2.3941.00
36_G40_I2.3901.00
44_S48_A2.3381.00
240_I259_I2.3221.00
200_T204_S2.3051.00
312_S315_A2.2981.00
243_L277_G2.2891.00
315_A348_L2.2781.00
324_S374_V2.2711.00
322_L329_G2.2411.00
50_L168_A2.2211.00
239_S263_V2.1501.00
16_E238_T2.1411.00
21_S227_Y2.1141.00
19_I48_A2.0621.00
22_L32_V2.0611.00
170_D204_S2.0131.00
48_A51_E1.9891.00
27_K56_P1.9681.00
176_R179_K1.9611.00
12_P48_A1.9361.00
47_L62_A1.9341.00
59_L163_Q1.9181.00
14_G238_T1.8611.00
35_I230_K1.8331.00
238_T241_E1.8231.00
48_A52_H1.8201.00
20_E24_G1.7821.00
316_R320_K1.7531.00
355_E363_R1.7471.00
319_L348_L1.7401.00
318_V344_G1.7031.00
261_L265_Q1.6551.00
18_E229_M1.6441.00
236_R263_V1.6141.00
236_R240_I1.5971.00
34_L231_V1.5921.00
34_L46_L1.5711.00
326_G329_G1.5641.00
12_P44_S1.5631.00
275_L278_I1.5301.00
262_I273_L1.5061.00
244_R259_I1.4971.00
146_F149_A1.4891.00
145_E148_D1.4871.00
305_E309_K1.4861.00
44_S274_N1.4821.00
322_L364_I1.4811.00
13_F245_K1.4791.00
236_R264_D1.4531.00
23_L49_S1.4491.00
241_E245_K1.4361.00
17_K20_E1.4321.00
261_L264_D1.4291.00
336_L341_V1.4101.00
191_S195_F1.4011.00
40_I270_P1.3981.00
175_L186_F1.3971.00
188_I192_K1.3971.00
314_T340_T1.3931.00
260_E264_D1.3921.00
74_F77_F1.3821.00
53_S58_S1.3781.00
58_S166_V1.3731.00
37_P40_I1.3701.00
314_T344_G1.3701.00
26_Y53_S1.3701.00
275_L307_D1.3431.00
266_V276_V1.3381.00
19_I49_S1.3311.00
25_L32_V1.3291.00
16_E20_E1.3231.00
240_I256_S1.3221.00
38_R206_S1.3051.00
357_E363_R1.2981.00
315_A351_Y1.2931.00
304_L369_L1.2891.00
255_K258_E1.2831.00
146_F150_L1.2661.00
295_V299_N1.2631.00
22_L45_L1.2561.00
337_D340_T1.2551.00
308_L316_R1.2521.00
59_L62_A1.2431.00
170_D173_Q1.2371.00
286_S289_E1.2371.00
308_L373_L1.2351.00
33_G203_I1.2321.00
191_S194_Q1.2311.00
240_I260_E1.2251.00
240_I244_R1.2221.00
18_E232_N1.2201.00
318_V341_V1.2031.00
246_G274_N1.1991.00
63_E80_A1.1991.00
353_L369_L1.1951.00
314_T317_A1.1821.00
142_L146_F1.1811.00
26_Y58_S1.1691.00
256_S260_E1.1621.00
346_K350_N1.1531.00
35_I205_G1.1391.00
239_S268_G1.1371.00
142_L145_E1.1351.00
330_S334_L1.1331.00
143_E147_R1.1251.00
349_M356_K1.1211.00
296_K299_N1.1141.00
57_Y60_I1.1131.00
367_P371_K1.1121.00
17_K21_S1.1071.00
349_M354_V1.1041.00
329_G362_Y1.1021.00
336_L340_T1.1011.00
78_L81_Y1.0931.00
234_F242_F1.0911.00
11_N44_S1.0871.00
354_V364_I1.0861.00
203_I206_S1.0851.00
235_D239_S1.0771.00
21_S24_G1.0661.00
62_A65_F1.0611.00
23_L27_K1.0571.00
25_L227_Y1.0561.00
367_P370_I1.0561.00
40_I269_F1.0541.00
75_A80_A1.0521.00
46_L50_L1.0511.00
265_Q371_K1.0491.00
24_G28_L1.0451.00
294_L299_N1.0321.00
152_L157_S1.0281.00
49_S53_S1.0261.00
151_D155_I1.0191.00
76_E80_A1.0181.00
65_F175_L1.0161.00
43_T47_L1.0151.00
295_V298_I1.0131.00
271_A366_D1.0101.00
143_E146_F1.0031.00
38_R171_E1.0011.00
345_L362_Y1.0001.00
18_E21_S0.9981.00
174_Y179_K0.9971.00
241_E244_R0.9901.00
242_F273_L0.9861.00
34_L229_M0.9831.00
266_V273_L0.9821.00
325_L328_A0.9811.00
16_E241_E0.9801.00
64_E67_R0.9761.00
45_L231_V0.9761.00
212_M216_S0.9711.00
40_I231_V0.9691.00
157_S165_V0.9641.00
347_Q351_Y0.9631.00
325_L329_G0.9631.00
58_S61_S0.9601.00
65_F76_E0.9551.00
318_V345_L0.9531.00
60_I63_E0.9531.00
73_D76_E0.9521.00
23_L56_P0.9521.00
294_L298_I0.9501.00
200_T203_I0.9491.00
11_N245_K0.9481.00
166_V200_T0.9451.00
286_S290_V0.9451.00
54_S57_Y0.9441.00
148_D152_L0.9361.00
18_E231_V0.9361.00
50_L166_V0.9331.00
18_E45_L0.9271.00
146_F151_D0.9211.00
211_M215_L0.9191.00
57_Y61_S0.9141.00
234_F238_T0.9111.00
323_A374_V0.9101.00
21_S229_M0.9081.00
59_L165_V0.9051.00
370_I374_V0.9051.00
288_N292_N0.9041.00
77_F80_A0.9031.00
263_V268_G0.9001.00
50_L62_A0.8981.00
190_R217_S0.8981.00
145_E149_A0.8961.00
145_E150_L0.8891.00
243_L262_I0.8831.00
26_Y166_V0.8781.00
26_Y49_S0.8721.00
90_Y93_A0.8701.00
145_E157_S0.8681.00
77_F179_K0.8671.00
42_K271_A0.8651.00
147_R151_D0.8601.00
294_L297_D0.8571.00
59_L65_F0.8561.00
246_G277_G0.8531.00
322_L354_V0.8521.00
61_S165_V0.8521.00
209_G212_M0.8471.00
148_D151_D0.8461.00
37_P233_P0.8401.00
69_E72_F0.8391.00
144_K148_D0.8391.00
21_S25_L0.8381.00
349_M362_Y0.8371.00
74_F80_A0.8351.00
202_V206_S0.8341.00
329_G354_V0.8341.00
149_A154_Q0.8341.00
289_E293_S0.8301.00
190_R194_Q0.8291.00
141_Y144_K0.8251.00
288_N291_I0.8231.00
53_S56_P0.8221.00
267_D367_P0.8211.00
58_S62_A0.8201.00
20_E23_L0.8121.00
50_L54_S0.8111.00
243_L273_L0.8101.00
168_A204_S0.8061.00
214_L218_R0.8041.00
236_R266_V0.8001.00
60_I64_E0.7971.00
63_E169_I0.7961.00
154_Q157_S0.7961.00
263_V266_V0.7951.00
33_G205_G0.7951.00
153_P156_L0.7941.00
356_K362_Y0.7931.00
336_L344_G0.7921.00
76_E79_S0.7921.00
283_E286_S0.7911.00
141_Y146_F0.7901.00
13_F238_T0.7881.00
172_F175_L0.7851.00
337_D341_V0.7841.00
46_L202_V0.7811.00
167_I201_Y0.7761.00
328_A361_I0.7741.00
215_L218_R0.7721.00
317_A320_K0.7721.00
187_H191_S0.7711.00
340_T344_G0.7711.00
315_A344_G0.7691.00
309_K316_R0.7691.00
287_A290_V0.7681.00
259_I263_V0.7671.00
338_L341_V0.7661.00
147_R150_L0.7641.00
243_L246_G0.7621.00
199_V206_S0.7621.00
129_I132_T0.7571.00
282_T285_R0.7561.00
177_L187_H0.7521.00
237_K240_I0.7481.00
157_S199_V0.7481.00
243_L259_I0.7441.00
249_V255_K0.7441.00
233_P266_V0.7421.00
283_E287_A0.7411.00
75_A78_L0.7391.00
46_L170_D0.7361.00
34_L45_L0.7361.00
323_A364_I0.7351.00
243_L247_F0.7351.00
59_L63_E0.7341.00
26_Y200_T0.7331.00
25_L229_M0.7311.00
313_P316_R0.7301.00
365_V369_L0.7291.00
42_K206_S0.7271.00
293_S296_K0.7231.00
308_L319_L0.7221.00
158_E161_G0.7201.00
239_S277_G0.7191.00
319_L353_L0.7191.00
322_L326_G0.7171.00
49_S200_T0.7151.00
23_L26_Y0.7151.00
282_T286_S0.7081.00
39_R171_E0.7061.00
340_T343_R0.7061.00
355_E365_V0.7041.00
206_S366_D0.7031.00
346_K349_M0.7021.00
151_D154_Q0.7011.00
240_I263_V0.6981.00
50_L60_I0.6981.00
22_L34_L0.6981.00
271_A275_L0.6971.00
287_A291_I0.6961.00
152_L155_I0.6961.00
19_I23_L0.6931.00
317_A321_N0.6911.00
247_F254_V0.6901.00
79_S83_T0.6901.00
345_L354_V0.6881.00
289_E292_N0.6881.00
58_S164_R0.6871.00
170_D367_P0.6861.00
43_T170_D0.6851.00
187_H190_R0.6841.00
64_E170_D0.6821.00
210_M214_L0.6801.00
18_E49_S0.6781.00
269_F272_W0.6761.00
213_E216_S0.6761.00
161_G164_R0.6711.00
213_E217_S0.6701.00
32_V227_Y0.6691.00
242_F274_N0.6641.00
77_F188_I0.6631.00
338_L342_T0.6611.00
284_K287_A0.6601.00
179_K188_I0.6581.00
274_N278_I0.6581.00
74_F81_Y0.6561.00
318_V334_L0.6541.00
285_R290_V0.6511.00
199_V205_G0.6511.00
304_L372_Y0.6431.00
314_T336_L0.6401.00
290_V293_S0.6401.00
77_F81_Y0.6391.00
62_A168_A0.6381.00
24_G27_K0.6351.00
369_L372_Y0.6351.00
207_L210_M0.6351.00
38_R173_Q0.6331.00
143_E148_D0.6331.00
319_L323_A0.6331.00
74_F178_A0.6331.00
57_Y62_A0.6311.00
271_A274_N0.6241.00
212_M215_L0.6211.00
254_V258_E0.6191.00
58_S63_E0.6191.00
40_I232_N0.6181.00
59_L64_E0.6171.00
86_T90_Y0.6171.00
150_L154_Q0.6171.00
234_F270_P0.6160.99
44_S47_L0.6150.99
143_E150_L0.6150.99
61_S64_E0.6120.99
171_E174_Y0.6120.99
32_V200_T0.6110.99
155_I158_E0.6100.99
57_Y63_E0.6100.99
66_V69_E0.6090.99
258_E280_I0.6090.99
12_P16_E0.6070.99
305_E372_Y0.6070.99
236_R259_I0.6060.99
311_L315_A0.6060.99
38_R366_D0.6060.99
76_E179_K0.6050.99
214_L222_F0.6040.99
244_R256_S0.6040.99
328_A363_R0.6040.99
275_L279_K0.6040.99
15_R18_E0.6030.99
145_E152_L0.6020.99
319_L373_L0.6010.99
139_K142_L0.6000.99
49_S202_V0.5990.99
306_N309_K0.5990.99
267_D327_G0.5960.99
19_I52_H0.5960.99
57_Y65_F0.5950.99
303_A307_D0.5930.99
18_E34_L0.5910.99
59_L88_T0.5910.99
211_M214_L0.5910.99
260_E263_V0.5910.99
269_F273_L0.5900.99
47_L50_L0.5890.99
36_G39_R0.5880.99
80_A85_V0.5880.99
277_G281_V0.5850.99
146_F188_I0.5840.99
40_I233_P0.5820.99
53_S166_V0.5820.99
72_F77_F0.5800.99
286_S291_I0.5780.99
14_G235_D0.5720.99
150_L153_P0.5690.99
252_L259_I0.5670.99
233_P267_D0.5670.99
88_T92_K0.5620.99
239_S266_V0.5620.99
194_Q223_Y0.5610.99
38_R271_A0.5600.99
85_V88_T0.5590.99
58_S65_F0.5580.99
174_Y178_A0.5560.99
23_L53_S0.5540.99
285_R288_N0.5540.99
342_T346_K0.5530.99
310_R351_Y0.5510.99
269_F274_N0.5510.99
344_G347_Q0.5510.99
262_I276_V0.5490.99
12_P238_T0.5490.99
47_L51_E0.5480.99
303_A306_N0.5480.99
357_E361_I0.5460.99
42_K366_D0.5460.99
257_E260_E0.5460.99
319_L364_I0.5450.99
258_E262_I0.5450.99
285_R289_E0.5430.99
144_K147_R0.5420.99
60_I65_F0.5410.99
72_F75_A0.5410.99
264_D268_G0.5410.99
32_V229_M0.5410.99
308_L320_K0.5370.99
62_A66_V0.5360.99
236_R268_G0.5360.99
326_G370_I0.5360.99
151_D191_S0.5320.99
139_K145_E0.5320.99
326_G374_V0.5300.98
130_E133_L0.5290.98
145_E154_Q0.5290.98
199_V204_S0.5280.98
33_G226_F0.5280.98
13_F242_F0.5280.98
193_W226_F0.5270.98
175_L179_K0.5250.98
83_T87_S0.5230.98
67_R174_Y0.5230.98
143_E149_A0.5230.98
198_N206_S0.5200.98
244_R253_D0.5160.98
53_S57_Y0.5140.98
348_L354_V0.5140.98
146_F153_P0.5130.98
13_F241_E0.5110.98
149_A153_P0.5080.98
283_E291_I0.5070.98
262_I277_G0.5040.98
186_F192_K0.5030.98
266_V280_I0.5020.98
65_F68_G0.5000.98
72_F78_L0.5000.98
302_T306_N0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qenA 1 0.8727 100 0.464 Contact Map
2fnaA 1 0.8727 100 0.468 Contact Map
1z6tA 1 0.8064 100 0.511 Contact Map
2a5yB 2 0.8143 100 0.548 Contact Map
3sfzA 1 0.8064 99.9 0.583 Contact Map
1w5sA 1 0.8488 99.9 0.591 Contact Map
1fnnA 1 0.8276 99.9 0.597 Contact Map
1vt4I 4 0.7958 99.9 0.607 Contact Map
2qbyA 1 0.8329 99.9 0.613 Contact Map
2v1uA 1 0.817 99.9 0.633 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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