Q97VA4 - SULSO - GREMLIN Contacts

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Q97VA4 - Uncharacterized protein

UniProt:	Q97VA4	Sequences: MWFIYGRPTNNPFGREKEIESLLGLYKLGQPVGLIGPRRIGKTSLLLASLEHSSFPYSLISAEEFVRGEKGFDFAEFLSAYITSVTSTIYSKANYKIILEKGKSYLKQLRDLLGQVKVTFNIPELYSTIELTLDKAEKKKYLEKEFRDALDLPQILSEKFGLQRVVIAIDEFQYLRLAKQSIPGIFHIMRSKWQFHKNVTYVISGSLIGMMMELLSSRNQPFYQFFYLMKVNPFDRKTSIEFLRKGFEVNNLDVKSEEIELIVDQVDGFPAWLNLVGIKIVTEKRSANEVINSLVKDINLVTALENDLKRLSPTARAVLKNLASLGGAGSPKDLGLDLLTVTRGLKQLMNYGLVEKEGRGIYRIVDPILIKYLVSQP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	377 (309)
Sequences:	9974 (8626)
Seq/√Len:	490.7

ECOLI - MALT
BACSU - GUTR
SULSO - Q97VA4 Q7LX62 Q7LX94 Q97X15 Q97Y08 Q97X37

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
239_S	273_L	4.379	1.00
23_L	52_H	4.140	1.00
235_D	238_T	3.761	1.00
315_A	347_Q	3.628	1.00
330_S	333_D	3.581	1.00
312_S	347_Q	3.445	1.00
46_L	204_S	2.885	1.00
22_L	49_S	2.857	1.00
200_T	206_S	2.853	1.00
331_P	334_L	2.646	1.00
236_R	260_E	2.498	1.00
46_L	168_A	2.493	1.00
172_F	203_I	2.457	1.00
35_I	228_L	2.394	1.00
36_G	40_I	2.390	1.00
44_S	48_A	2.338	1.00
240_I	259_I	2.322	1.00
200_T	204_S	2.305	1.00
312_S	315_A	2.298	1.00
243_L	277_G	2.289	1.00
315_A	348_L	2.278	1.00
324_S	374_V	2.271	1.00
322_L	329_G	2.241	1.00
50_L	168_A	2.221	1.00
239_S	263_V	2.150	1.00
16_E	238_T	2.141	1.00
21_S	227_Y	2.114	1.00
19_I	48_A	2.062	1.00
22_L	32_V	2.061	1.00
170_D	204_S	2.013	1.00
48_A	51_E	1.989	1.00
27_K	56_P	1.968	1.00
176_R	179_K	1.961	1.00
12_P	48_A	1.936	1.00
47_L	62_A	1.934	1.00
59_L	163_Q	1.918	1.00
14_G	238_T	1.861	1.00
35_I	230_K	1.833	1.00
238_T	241_E	1.823	1.00
48_A	52_H	1.820	1.00
20_E	24_G	1.782	1.00
316_R	320_K	1.753	1.00
355_E	363_R	1.747	1.00
319_L	348_L	1.740	1.00
318_V	344_G	1.703	1.00
261_L	265_Q	1.655	1.00
18_E	229_M	1.644	1.00
236_R	263_V	1.614	1.00
236_R	240_I	1.597	1.00
34_L	231_V	1.592	1.00
34_L	46_L	1.571	1.00
326_G	329_G	1.564	1.00
12_P	44_S	1.563	1.00
275_L	278_I	1.530	1.00
262_I	273_L	1.506	1.00
244_R	259_I	1.497	1.00
146_F	149_A	1.489	1.00
145_E	148_D	1.487	1.00
305_E	309_K	1.486	1.00
44_S	274_N	1.482	1.00
322_L	364_I	1.481	1.00
13_F	245_K	1.479	1.00
236_R	264_D	1.453	1.00
23_L	49_S	1.449	1.00
241_E	245_K	1.436	1.00
17_K	20_E	1.432	1.00
261_L	264_D	1.429	1.00
336_L	341_V	1.410	1.00
191_S	195_F	1.401	1.00
40_I	270_P	1.398	1.00
175_L	186_F	1.397	1.00
188_I	192_K	1.397	1.00
314_T	340_T	1.393	1.00
260_E	264_D	1.392	1.00
74_F	77_F	1.382	1.00
53_S	58_S	1.378	1.00
58_S	166_V	1.373	1.00
37_P	40_I	1.370	1.00
314_T	344_G	1.370	1.00
26_Y	53_S	1.370	1.00
275_L	307_D	1.343	1.00
266_V	276_V	1.338	1.00
19_I	49_S	1.331	1.00
25_L	32_V	1.329	1.00
16_E	20_E	1.323	1.00
240_I	256_S	1.322	1.00
38_R	206_S	1.305	1.00
357_E	363_R	1.298	1.00
315_A	351_Y	1.293	1.00
304_L	369_L	1.289	1.00
255_K	258_E	1.283	1.00
146_F	150_L	1.266	1.00
295_V	299_N	1.263	1.00
22_L	45_L	1.256	1.00
337_D	340_T	1.255	1.00
308_L	316_R	1.252	1.00
59_L	62_A	1.243	1.00
170_D	173_Q	1.237	1.00
286_S	289_E	1.237	1.00
308_L	373_L	1.235	1.00
33_G	203_I	1.232	1.00
191_S	194_Q	1.231	1.00
240_I	260_E	1.225	1.00
240_I	244_R	1.222	1.00
18_E	232_N	1.220	1.00
318_V	341_V	1.203	1.00
246_G	274_N	1.199	1.00
63_E	80_A	1.199	1.00
353_L	369_L	1.195	1.00
314_T	317_A	1.182	1.00
142_L	146_F	1.181	1.00
26_Y	58_S	1.169	1.00
256_S	260_E	1.162	1.00
346_K	350_N	1.153	1.00
35_I	205_G	1.139	1.00
239_S	268_G	1.137	1.00
142_L	145_E	1.135	1.00
330_S	334_L	1.133	1.00
143_E	147_R	1.125	1.00
349_M	356_K	1.121	1.00
296_K	299_N	1.114	1.00
57_Y	60_I	1.113	1.00
367_P	371_K	1.112	1.00
17_K	21_S	1.107	1.00
349_M	354_V	1.104	1.00
329_G	362_Y	1.102	1.00
336_L	340_T	1.101	1.00
78_L	81_Y	1.093	1.00
234_F	242_F	1.091	1.00
11_N	44_S	1.087	1.00
354_V	364_I	1.086	1.00
203_I	206_S	1.085	1.00
235_D	239_S	1.077	1.00
21_S	24_G	1.066	1.00
62_A	65_F	1.061	1.00
23_L	27_K	1.057	1.00
25_L	227_Y	1.056	1.00
367_P	370_I	1.056	1.00
40_I	269_F	1.054	1.00
75_A	80_A	1.052	1.00
46_L	50_L	1.051	1.00
265_Q	371_K	1.049	1.00
24_G	28_L	1.045	1.00
294_L	299_N	1.032	1.00
152_L	157_S	1.028	1.00
49_S	53_S	1.026	1.00
151_D	155_I	1.019	1.00
76_E	80_A	1.018	1.00
65_F	175_L	1.016	1.00
43_T	47_L	1.015	1.00
295_V	298_I	1.013	1.00
271_A	366_D	1.010	1.00
143_E	146_F	1.003	1.00
38_R	171_E	1.001	1.00
345_L	362_Y	1.000	1.00
18_E	21_S	0.998	1.00
174_Y	179_K	0.997	1.00
241_E	244_R	0.990	1.00
242_F	273_L	0.986	1.00
34_L	229_M	0.983	1.00
266_V	273_L	0.982	1.00
325_L	328_A	0.981	1.00
16_E	241_E	0.980	1.00
64_E	67_R	0.976	1.00
45_L	231_V	0.976	1.00
212_M	216_S	0.971	1.00
40_I	231_V	0.969	1.00
157_S	165_V	0.964	1.00
347_Q	351_Y	0.963	1.00
325_L	329_G	0.963	1.00
58_S	61_S	0.960	1.00
65_F	76_E	0.955	1.00
318_V	345_L	0.953	1.00
60_I	63_E	0.953	1.00
73_D	76_E	0.952	1.00
23_L	56_P	0.952	1.00
294_L	298_I	0.950	1.00
200_T	203_I	0.949	1.00
11_N	245_K	0.948	1.00
166_V	200_T	0.945	1.00
286_S	290_V	0.945	1.00
54_S	57_Y	0.944	1.00
148_D	152_L	0.936	1.00
18_E	231_V	0.936	1.00
50_L	166_V	0.933	1.00
18_E	45_L	0.927	1.00
146_F	151_D	0.921	1.00
211_M	215_L	0.919	1.00
57_Y	61_S	0.914	1.00
234_F	238_T	0.911	1.00
323_A	374_V	0.910	1.00
21_S	229_M	0.908	1.00
59_L	165_V	0.905	1.00
370_I	374_V	0.905	1.00
288_N	292_N	0.904	1.00
77_F	80_A	0.903	1.00
263_V	268_G	0.900	1.00
50_L	62_A	0.898	1.00
190_R	217_S	0.898	1.00
145_E	149_A	0.896	1.00
145_E	150_L	0.889	1.00
243_L	262_I	0.883	1.00
26_Y	166_V	0.878	1.00
26_Y	49_S	0.872	1.00
90_Y	93_A	0.870	1.00
145_E	157_S	0.868	1.00
77_F	179_K	0.867	1.00
42_K	271_A	0.865	1.00
147_R	151_D	0.860	1.00
294_L	297_D	0.857	1.00
59_L	65_F	0.856	1.00
246_G	277_G	0.853	1.00
322_L	354_V	0.852	1.00
61_S	165_V	0.852	1.00
209_G	212_M	0.847	1.00
148_D	151_D	0.846	1.00
37_P	233_P	0.840	1.00
69_E	72_F	0.839	1.00
144_K	148_D	0.839	1.00
21_S	25_L	0.838	1.00
349_M	362_Y	0.837	1.00
74_F	80_A	0.835	1.00
202_V	206_S	0.834	1.00
329_G	354_V	0.834	1.00
149_A	154_Q	0.834	1.00
289_E	293_S	0.830	1.00
190_R	194_Q	0.829	1.00
141_Y	144_K	0.825	1.00
288_N	291_I	0.823	1.00
53_S	56_P	0.822	1.00
267_D	367_P	0.821	1.00
58_S	62_A	0.820	1.00
20_E	23_L	0.812	1.00
50_L	54_S	0.811	1.00
243_L	273_L	0.810	1.00
168_A	204_S	0.806	1.00
214_L	218_R	0.804	1.00
236_R	266_V	0.800	1.00
60_I	64_E	0.797	1.00
63_E	169_I	0.796	1.00
154_Q	157_S	0.796	1.00
263_V	266_V	0.795	1.00
33_G	205_G	0.795	1.00
153_P	156_L	0.794	1.00
356_K	362_Y	0.793	1.00
336_L	344_G	0.792	1.00
76_E	79_S	0.792	1.00
283_E	286_S	0.791	1.00
141_Y	146_F	0.790	1.00
13_F	238_T	0.788	1.00
172_F	175_L	0.785	1.00
337_D	341_V	0.784	1.00
46_L	202_V	0.781	1.00
167_I	201_Y	0.776	1.00
328_A	361_I	0.774	1.00
215_L	218_R	0.772	1.00
317_A	320_K	0.772	1.00
187_H	191_S	0.771	1.00
340_T	344_G	0.771	1.00
315_A	344_G	0.769	1.00
309_K	316_R	0.769	1.00
287_A	290_V	0.768	1.00
259_I	263_V	0.767	1.00
338_L	341_V	0.766	1.00
147_R	150_L	0.764	1.00
243_L	246_G	0.762	1.00
199_V	206_S	0.762	1.00
129_I	132_T	0.757	1.00
282_T	285_R	0.756	1.00
177_L	187_H	0.752	1.00
237_K	240_I	0.748	1.00
157_S	199_V	0.748	1.00
243_L	259_I	0.744	1.00
249_V	255_K	0.744	1.00
233_P	266_V	0.742	1.00
283_E	287_A	0.741	1.00
75_A	78_L	0.739	1.00
46_L	170_D	0.736	1.00
34_L	45_L	0.736	1.00
323_A	364_I	0.735	1.00
243_L	247_F	0.735	1.00
59_L	63_E	0.734	1.00
26_Y	200_T	0.733	1.00
25_L	229_M	0.731	1.00
313_P	316_R	0.730	1.00
365_V	369_L	0.729	1.00
42_K	206_S	0.727	1.00
293_S	296_K	0.723	1.00
308_L	319_L	0.722	1.00
158_E	161_G	0.720	1.00
239_S	277_G	0.719	1.00
319_L	353_L	0.719	1.00
322_L	326_G	0.717	1.00
49_S	200_T	0.715	1.00
23_L	26_Y	0.715	1.00
282_T	286_S	0.708	1.00
39_R	171_E	0.706	1.00
340_T	343_R	0.706	1.00
355_E	365_V	0.704	1.00
206_S	366_D	0.703	1.00
346_K	349_M	0.702	1.00
151_D	154_Q	0.701	1.00
240_I	263_V	0.698	1.00
50_L	60_I	0.698	1.00
22_L	34_L	0.698	1.00
271_A	275_L	0.697	1.00
287_A	291_I	0.696	1.00
152_L	155_I	0.696	1.00
19_I	23_L	0.693	1.00
317_A	321_N	0.691	1.00
247_F	254_V	0.690	1.00
79_S	83_T	0.690	1.00
345_L	354_V	0.688	1.00
289_E	292_N	0.688	1.00
58_S	164_R	0.687	1.00
170_D	367_P	0.686	1.00
43_T	170_D	0.685	1.00
187_H	190_R	0.684	1.00
64_E	170_D	0.682	1.00
210_M	214_L	0.680	1.00
18_E	49_S	0.678	1.00
269_F	272_W	0.676	1.00
213_E	216_S	0.676	1.00
161_G	164_R	0.671	1.00
213_E	217_S	0.670	1.00
32_V	227_Y	0.669	1.00
242_F	274_N	0.664	1.00
77_F	188_I	0.663	1.00
338_L	342_T	0.661	1.00
284_K	287_A	0.660	1.00
179_K	188_I	0.658	1.00
274_N	278_I	0.658	1.00
74_F	81_Y	0.656	1.00
318_V	334_L	0.654	1.00
285_R	290_V	0.651	1.00
199_V	205_G	0.651	1.00
304_L	372_Y	0.643	1.00
314_T	336_L	0.640	1.00
290_V	293_S	0.640	1.00
77_F	81_Y	0.639	1.00
62_A	168_A	0.638	1.00
24_G	27_K	0.635	1.00
369_L	372_Y	0.635	1.00
207_L	210_M	0.635	1.00
38_R	173_Q	0.633	1.00
143_E	148_D	0.633	1.00
319_L	323_A	0.633	1.00
74_F	178_A	0.633	1.00
57_Y	62_A	0.631	1.00
271_A	274_N	0.624	1.00
212_M	215_L	0.621	1.00
254_V	258_E	0.619	1.00
58_S	63_E	0.619	1.00
40_I	232_N	0.618	1.00
59_L	64_E	0.617	1.00
86_T	90_Y	0.617	1.00
150_L	154_Q	0.617	1.00
234_F	270_P	0.616	0.99
44_S	47_L	0.615	0.99
143_E	150_L	0.615	0.99
61_S	64_E	0.612	0.99
171_E	174_Y	0.612	0.99
32_V	200_T	0.611	0.99
155_I	158_E	0.610	0.99
57_Y	63_E	0.610	0.99
66_V	69_E	0.609	0.99
258_E	280_I	0.609	0.99
12_P	16_E	0.607	0.99
305_E	372_Y	0.607	0.99
236_R	259_I	0.606	0.99
311_L	315_A	0.606	0.99
38_R	366_D	0.606	0.99
76_E	179_K	0.605	0.99
214_L	222_F	0.604	0.99
244_R	256_S	0.604	0.99
328_A	363_R	0.604	0.99
275_L	279_K	0.604	0.99
15_R	18_E	0.603	0.99
145_E	152_L	0.602	0.99
319_L	373_L	0.601	0.99
139_K	142_L	0.600	0.99
49_S	202_V	0.599	0.99
306_N	309_K	0.599	0.99
267_D	327_G	0.596	0.99
19_I	52_H	0.596	0.99
57_Y	65_F	0.595	0.99
303_A	307_D	0.593	0.99
18_E	34_L	0.591	0.99
59_L	88_T	0.591	0.99
211_M	214_L	0.591	0.99
260_E	263_V	0.591	0.99
269_F	273_L	0.590	0.99
47_L	50_L	0.589	0.99
36_G	39_R	0.588	0.99
80_A	85_V	0.588	0.99
277_G	281_V	0.585	0.99
146_F	188_I	0.584	0.99
40_I	233_P	0.582	0.99
53_S	166_V	0.582	0.99
72_F	77_F	0.580	0.99
286_S	291_I	0.578	0.99
14_G	235_D	0.572	0.99
150_L	153_P	0.569	0.99
252_L	259_I	0.567	0.99
233_P	267_D	0.567	0.99
88_T	92_K	0.562	0.99
239_S	266_V	0.562	0.99
194_Q	223_Y	0.561	0.99
38_R	271_A	0.560	0.99
85_V	88_T	0.559	0.99
58_S	65_F	0.558	0.99
174_Y	178_A	0.556	0.99
23_L	53_S	0.554	0.99
285_R	288_N	0.554	0.99
342_T	346_K	0.553	0.99
310_R	351_Y	0.551	0.99
269_F	274_N	0.551	0.99
344_G	347_Q	0.551	0.99
262_I	276_V	0.549	0.99
12_P	238_T	0.549	0.99
47_L	51_E	0.548	0.99
303_A	306_N	0.548	0.99
357_E	361_I	0.546	0.99
42_K	366_D	0.546	0.99
257_E	260_E	0.546	0.99
319_L	364_I	0.545	0.99
258_E	262_I	0.545	0.99
285_R	289_E	0.543	0.99
144_K	147_R	0.542	0.99
60_I	65_F	0.541	0.99
72_F	75_A	0.541	0.99
264_D	268_G	0.541	0.99
32_V	229_M	0.541	0.99
308_L	320_K	0.537	0.99
62_A	66_V	0.536	0.99
236_R	268_G	0.536	0.99
326_G	370_I	0.536	0.99
151_D	191_S	0.532	0.99
139_K	145_E	0.532	0.99
326_G	374_V	0.530	0.98
130_E	133_L	0.529	0.98
145_E	154_Q	0.529	0.98
199_V	204_S	0.528	0.98
33_G	226_F	0.528	0.98
13_F	242_F	0.528	0.98
193_W	226_F	0.527	0.98
175_L	179_K	0.525	0.98
83_T	87_S	0.523	0.98
67_R	174_Y	0.523	0.98
143_E	149_A	0.523	0.98
198_N	206_S	0.520	0.98
244_R	253_D	0.516	0.98
53_S	57_Y	0.514	0.98
348_L	354_V	0.514	0.98
146_F	153_P	0.513	0.98
13_F	241_E	0.511	0.98
149_A	153_P	0.508	0.98
283_E	291_I	0.507	0.98
262_I	277_G	0.504	0.98
186_F	192_K	0.503	0.98
266_V	280_I	0.502	0.98
65_F	68_G	0.500	0.98
72_F	78_L	0.500	0.98
302_T	306_N	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qenA	1	0.8727	100	0.464	Contact Map
2fnaA	1	0.8727	100	0.468	Contact Map
1z6tA	1	0.8064	100	0.511	Contact Map
2a5yB	2	0.8143	100	0.548	Contact Map
3sfzA	1	0.8064	99.9	0.583	Contact Map
1w5sA	1	0.8488	99.9	0.591	Contact Map
1fnnA	1	0.8276	99.9	0.597	Contact Map
1vt4I	4	0.7958	99.9	0.607	Contact Map
2qbyA	1	0.8329	99.9	0.613	Contact Map
2v1uA	1	0.817	99.9	0.633	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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