GREMLIN Database
Q97VA3 - Agmatinase (Agmatine ureohydrolase) (SpeB-2)
UniProt: Q97VA3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (270)
Sequences: 5198 (3418)
Seq/√Len: 208.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_I118_A3.7911.00
230_I256_I3.7201.00
105_Y134_K3.7101.00
101_Q130_R3.2661.00
129_L168_A3.2501.00
235_V289_L2.8851.00
101_Q134_K2.8121.00
240_A286_T2.6261.00
232_I243_T2.4291.00
271_F297_G2.3391.00
36_G57_R2.2821.00
98_N102_T2.2531.00
54_M85_D2.1961.00
201_R218_E2.0451.00
235_V256_I2.0411.00
33_A113_L2.0381.00
35_L107_I2.0241.00
179_Q182_I1.9881.00
232_I276_V1.9741.00
253_S289_L1.9651.00
54_M58_Q1.9481.00
101_Q131_T1.9471.00
108_I131_T1.8631.00
201_R222_L1.8441.00
144_F234_V1.8361.00
27_N111_K1.8241.00
37_I117_I1.8181.00
104_L128_I1.8091.00
95_D99_A1.8091.00
104_L117_I1.8041.00
144_F259_I1.7661.00
228_V268_L1.7621.00
40_D50_R1.7611.00
126_L171_E1.7551.00
166_R170_E1.7551.00
37_I100_I1.7511.00
105_Y109_S1.7431.00
109_S135_K1.7331.00
178_V201_R1.7251.00
212_L216_I1.7241.00
209_K254_F1.7211.00
118_A294_I1.7141.00
126_L130_R1.7051.00
210_Y218_E1.7031.00
234_V251_L1.6861.00
56_I290_A1.6791.00
273_V294_I1.6581.00
182_I202_S1.6521.00
116_F271_F1.5961.00
117_I128_I1.5931.00
214_T218_E1.5861.00
239_F253_S1.5531.00
37_I96_T1.5351.00
227_H270_G1.5231.00
261_R296_E1.5001.00
92_Y95_D1.5001.00
33_A107_I1.4861.00
214_T217_R1.4831.00
209_K255_E1.4811.00
32_A298_M1.4641.00
138_K176_E1.4561.00
210_Y214_T1.4461.00
252_T255_E1.4431.00
225_P267_K1.4411.00
276_V290_A1.4361.00
276_V286_T1.4231.00
108_I135_K1.4211.00
232_I240_A1.4151.00
124_I274_V1.4091.00
56_I276_V1.4061.00
132_L139_I1.4011.00
234_V256_I1.3791.00
217_R221_S1.3571.00
31_K79_N1.3561.00
103_S106_E1.3491.00
82_D85_D1.3451.00
143_H179_Q1.3341.00
232_I273_V1.3281.00
97_M123_S1.3261.00
108_I132_L1.3211.00
242_G286_T1.3081.00
101_Q105_Y1.3081.00
228_V271_F1.3031.00
232_I290_A1.2951.00
35_L117_I1.2911.00
161_H245_T1.2681.00
107_I115_P1.2541.00
216_I262_K1.2511.00
122_H229_S1.2511.00
204_T207_D1.2411.00
257_I296_E1.2361.00
51_F279_P1.2351.00
46_R280_Y1.2341.00
142_V263_L1.2311.00
167_R170_E1.2301.00
55_G287_A1.2261.00
161_H244_G1.2241.00
116_F294_I1.2071.00
211_N215_V1.2001.00
131_T135_K1.1881.00
148_Y185_S1.1871.00
152_D167_R1.1871.00
220_N262_K1.1841.00
55_G58_Q1.1821.00
165_L179_Q1.1801.00
242_G281_D1.1791.00
43_V49_A1.1791.00
136_F269_V1.1771.00
128_I272_D1.1731.00
217_R262_K1.1721.00
97_M127_P1.1671.00
141_I165_L1.1641.00
105_Y135_K1.1491.00
147_H233_D1.1471.00
213_D217_R1.1371.00
35_L104_L1.1361.00
100_I117_I1.1151.00
205_I209_K1.1141.00
114_V271_F1.1101.00
40_D48_G1.0911.00
102_T106_E1.0891.00
47_P51_F1.0891.00
128_I227_H1.0841.00
138_K224_G1.0791.00
219_I222_L1.0791.00
145_D149_D1.0771.00
33_A83_M1.0771.00
215_V219_I1.0741.00
277_A280_Y1.0731.00
125_T129_L1.0661.00
32_A114_V1.0571.00
129_L141_I1.0471.00
66_Y71_D1.0471.00
178_V222_L1.0461.00
286_T290_A1.0391.00
213_D262_K1.0311.00
105_Y131_T1.0311.00
96_T100_I1.0271.00
161_H243_T1.0211.00
225_P269_V1.0161.00
37_I124_I1.0071.00
251_L259_I1.0071.00
130_R171_E1.0031.00
191_D197_R1.0021.00
35_L103_S1.0011.00
104_L115_P0.9891.00
95_D98_N0.9871.00
160_T163_T0.9831.00
282_M285_I0.9811.00
132_L270_G0.9801.00
47_P50_R0.9761.00
136_F225_P0.9751.00
216_I219_I0.9751.00
256_I293_I0.9741.00
34_F118_A0.9721.00
165_L177_A0.9671.00
228_V260_V0.9671.00
203_F222_L0.9621.00
57_R85_D0.9621.00
183_R237_P0.9571.00
152_D166_R0.9530.99
150_F195_K0.9480.99
140_N176_E0.9480.99
57_R84_G0.9360.99
240_A289_L0.9360.99
150_F169_I0.9330.99
143_H229_S0.9310.99
55_G59_G0.9250.99
148_Y179_Q0.9240.99
125_T272_D0.9230.99
226_T267_K0.9230.99
36_G84_G0.9200.99
107_I113_L0.9180.99
210_Y215_V0.9180.99
161_H275_E0.9150.99
148_Y182_I0.9090.99
106_E109_S0.9090.99
74_P77_K0.9070.99
31_K113_L0.9040.99
140_N178_V0.9030.99
207_D210_Y0.8980.99
144_F251_L0.8960.99
122_H161_H0.8940.99
235_V253_S0.8840.99
148_Y202_S0.8840.99
40_D46_R0.8820.99
183_R236_D0.8760.99
243_T246_P0.8730.99
36_G85_D0.8700.99
209_K258_E0.8680.99
284_E287_A0.8570.99
203_F218_E0.8550.99
211_N214_T0.8520.99
262_K265_F0.8490.99
128_I270_G0.8490.99
139_I269_V0.8480.99
49_A277_A0.8480.99
32_A78_L0.8450.99
122_H272_D0.8420.99
251_L256_I0.8410.99
73_Y76_D0.8360.99
102_T105_Y0.8320.99
104_L131_T0.8320.99
162_G245_T0.8310.99
196_E202_S0.8290.99
195_K200_I0.8290.99
177_A200_I0.8260.99
174_I177_A0.8250.99
141_I168_A0.8230.99
35_L115_P0.8180.98
235_V239_F0.8150.98
253_S257_I0.8150.98
146_S183_R0.8140.98
132_L269_V0.8120.98
98_N101_Q0.8110.98
230_I293_I0.8100.98
216_I220_N0.8020.98
40_D49_A0.8010.98
184_A247_E0.7970.98
125_T164_W0.7960.98
203_F208_L0.7940.98
140_N223_S0.7930.98
178_V219_I0.7890.98
40_D47_P0.7870.98
153_S156_G0.7870.98
153_S167_R0.7850.98
206_R261_R0.7840.98
129_L139_I0.7840.98
122_H275_E0.7830.98
52_G244_G0.7820.98
278_P281_D0.7740.98
115_P132_L0.7710.98
206_R258_E0.7710.98
27_N113_L0.7700.98
180_G219_I0.7650.98
57_R82_D0.7530.97
213_D258_E0.7520.97
39_F93_I0.7500.97
52_G278_P0.7480.97
82_D86_I0.7450.97
183_R247_E0.7400.97
218_E221_S0.7380.97
187_F191_D0.7360.97
123_S159_Y0.7350.97
142_V178_V0.7310.97
42_A121_D0.7310.97
67_N296_E0.7300.97
276_V287_A0.7300.97
259_I262_K0.7280.97
144_F180_G0.7260.97
257_I293_I0.7240.97
117_I124_I0.7220.97
220_N265_F0.7200.97
52_G55_G0.7180.96
41_D96_T0.7170.96
220_N223_S0.7140.96
285_I289_L0.7130.96
39_F96_T0.7130.96
294_I297_G0.7120.96
88_V96_T0.7100.96
144_F228_V0.7080.96
203_F215_V0.7050.96
145_D233_D0.7050.96
106_E111_K0.7030.96
216_I259_I0.7000.96
180_G251_L0.7000.96
103_S107_I0.6990.96
240_A276_V0.6970.96
239_F252_T0.6960.96
92_Y157_K0.6950.96
127_P131_T0.6930.96
243_T277_A0.6920.96
125_T165_L0.6920.96
139_I225_P0.6880.96
228_V297_G0.6860.95
169_I200_I0.6840.95
59_G291_A0.6780.95
238_A253_S0.6780.95
229_S274_V0.6740.95
142_V180_G0.6740.95
52_G277_A0.6740.95
100_I127_P0.6730.95
57_R74_P0.6720.95
38_P85_D0.6720.95
133_Y137_G0.6700.95
149_D233_D0.6680.95
208_L259_I0.6660.95
169_I177_A0.6660.95
281_D284_E0.6650.95
208_L255_E0.6650.95
93_I97_M0.6650.95
69_F72_T0.6640.95
149_D275_E0.6620.94
116_F298_M0.6540.94
30_I113_L0.6530.94
27_N30_I0.6510.94
46_R246_P0.6500.94
242_G276_V0.6500.94
254_F258_E0.6450.94
42_A93_I0.6440.94
178_V203_F0.6420.94
34_F116_F0.6410.93
211_N255_E0.6380.93
142_V226_T0.6330.93
296_E299_S0.6310.93
258_E262_K0.6310.93
152_D158_K0.6260.93
112_N115_P0.6250.93
226_T268_L0.6240.93
128_I132_L0.6230.93
99_A102_T0.6230.93
130_R168_A0.6220.92
37_I128_I0.6190.92
58_Q284_E0.6170.92
226_T266_D0.6130.92
122_H147_H0.6100.92
32_A116_F0.6090.92
273_V293_I0.6080.92
227_H272_D0.6070.92
43_V47_P0.6070.92
239_F289_L0.6060.91
104_L127_P0.6060.91
59_G287_A0.6030.91
205_I251_L0.6030.91
93_I160_T0.6020.91
203_F207_D0.6010.91
122_H227_H0.6010.91
249_G257_I0.5990.91
55_G278_P0.5990.91
181_G234_V0.5900.90
99_A103_S0.5900.90
109_S112_N0.5900.90
153_S158_K0.5900.90
143_H165_L0.5890.90
150_F198_L0.5890.90
41_D44_T0.5880.90
148_Y151_W0.5860.90
138_K225_P0.5840.90
212_L259_I0.5840.90
132_L136_F0.5840.90
229_S272_D0.5840.90
36_G82_D0.5830.90
44_T161_H0.5820.90
284_E288_M0.5820.90
241_P286_T0.5810.90
143_H245_T0.5800.90
126_L167_R0.5790.90
125_T274_V0.5780.89
140_N219_I0.5760.89
59_G284_E0.5760.89
237_P240_A0.5740.89
55_G284_E0.5730.89
141_I177_A0.5730.89
133_Y139_I0.5710.89
144_F256_I0.5710.89
108_I112_N0.5710.89
227_H269_V0.5680.89
86_I99_A0.5660.88
169_I172_G0.5650.88
148_Y184_A0.5650.88
140_N225_P0.5630.88
32_A115_P0.5630.88
96_T99_A0.5630.88
83_M107_I0.5590.88
112_N135_K0.5580.88
122_H274_V0.5560.88
195_K202_S0.5550.87
89_I99_A0.5530.87
218_E222_L0.5510.87
151_W162_G0.5510.87
271_F294_I0.5490.87
67_N70_L0.5470.87
56_I294_I0.5470.87
143_H164_W0.5430.86
163_T167_R0.5430.86
36_G74_P0.5420.86
60_S63_L0.5420.86
168_A171_E0.5420.86
221_S224_G0.5390.86
148_Y195_K0.5360.86
119_G124_I0.5360.86
54_M284_E0.5350.86
133_Y171_E0.5320.85
240_A243_T0.5300.85
151_W245_T0.5250.84
291_A294_I0.5250.84
212_L258_E0.5250.84
210_Y217_R0.5230.84
41_D93_I0.5220.84
281_D286_T0.5190.84
183_R249_G0.5180.84
126_L159_Y0.5150.83
40_D52_G0.5130.83
33_A75_F0.5120.83
51_F54_M0.5110.83
75_F80_A0.5090.83
108_I136_F0.5080.83
180_G208_L0.5060.82
104_L108_I0.5060.82
125_T227_H0.5060.82
263_L266_D0.5050.82
100_I124_I0.5020.82
185_S295_Y0.5020.82
133_Y176_E0.5010.82
288_M292_N0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gq6A 5 0.9705 100 0.1 Contact Map
3niqA 5 0.9934 100 0.112 Contact Map
3nioA 5 0.9738 100 0.114 Contact Map
1wohA 5 0.9738 100 0.114 Contact Map
4dz4A 5 0.9639 100 0.134 Contact Map
3m1rA 5 0.9869 100 0.137 Contact Map
4mykA 3 0.9115 100 0.151 Contact Map
1xfkA 1 0.9607 100 0.181 Contact Map
3pzlA 5 0.9344 100 0.182 Contact Map
3lhlA 3 0.8918 100 0.19 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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