Q97VA3 - SULSO - GREMLIN Contacts

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Q97VA3 - Agmatinase (Agmatine ureohydrolase) (SpeB-2)

UniProt:	Q97VA3	Sequences: MRQLDALKSPRFTQISTFGRLPICEKNEEIKAAFLGIPFDDAVTYRPGARFGPMGIRQGSRLLRPYNQFLDTYPFDKLNACDMGDINVIPGYIEDTMNAIQTSLYEIISSKNLVPFIAGGDHSITLPILRTLYKKFGKINIVHFDSHYDFWDSYWGKKYTHGTWLRRAIEEGLIKEAVQGGIRASTFSKEDLRDKERLGIRSFTIRDLKYNLDTVIREINSLSGPTHVSIDIDVVDPAFAPGTGTPEVGGLTSFEIIEIVRKLRFDKLVGFDVVEVAPPYDMSEITAMLAANIIYEGMSVLSLNL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	305 (270)
Sequences:	5198 (3418)
Seq/√Len:	208.0

ECOLI - SPEB
BACSU - SPEB HUTG ARGI
HALSA - HUTG Q9HP79
SULSO - Q97VA3 Q97ZX8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
56_I	118_A	3.791	1.00
230_I	256_I	3.720	1.00
105_Y	134_K	3.710	1.00
101_Q	130_R	3.266	1.00
129_L	168_A	3.250	1.00
235_V	289_L	2.885	1.00
101_Q	134_K	2.812	1.00
240_A	286_T	2.626	1.00
232_I	243_T	2.429	1.00
271_F	297_G	2.339	1.00
36_G	57_R	2.282	1.00
98_N	102_T	2.253	1.00
54_M	85_D	2.196	1.00
201_R	218_E	2.045	1.00
235_V	256_I	2.041	1.00
33_A	113_L	2.038	1.00
35_L	107_I	2.024	1.00
179_Q	182_I	1.988	1.00
232_I	276_V	1.974	1.00
253_S	289_L	1.965	1.00
54_M	58_Q	1.948	1.00
101_Q	131_T	1.947	1.00
108_I	131_T	1.863	1.00
201_R	222_L	1.844	1.00
144_F	234_V	1.836	1.00
27_N	111_K	1.824	1.00
37_I	117_I	1.818	1.00
104_L	128_I	1.809	1.00
95_D	99_A	1.809	1.00
104_L	117_I	1.804	1.00
144_F	259_I	1.766	1.00
228_V	268_L	1.762	1.00
40_D	50_R	1.761	1.00
126_L	171_E	1.755	1.00
166_R	170_E	1.755	1.00
37_I	100_I	1.751	1.00
105_Y	109_S	1.743	1.00
109_S	135_K	1.733	1.00
178_V	201_R	1.725	1.00
212_L	216_I	1.724	1.00
209_K	254_F	1.721	1.00
118_A	294_I	1.714	1.00
126_L	130_R	1.705	1.00
210_Y	218_E	1.703	1.00
234_V	251_L	1.686	1.00
56_I	290_A	1.679	1.00
273_V	294_I	1.658	1.00
182_I	202_S	1.652	1.00
116_F	271_F	1.596	1.00
117_I	128_I	1.593	1.00
214_T	218_E	1.586	1.00
239_F	253_S	1.553	1.00
37_I	96_T	1.535	1.00
227_H	270_G	1.523	1.00
261_R	296_E	1.500	1.00
92_Y	95_D	1.500	1.00
33_A	107_I	1.486	1.00
214_T	217_R	1.483	1.00
209_K	255_E	1.481	1.00
32_A	298_M	1.464	1.00
138_K	176_E	1.456	1.00
210_Y	214_T	1.446	1.00
252_T	255_E	1.443	1.00
225_P	267_K	1.441	1.00
276_V	290_A	1.436	1.00
276_V	286_T	1.423	1.00
108_I	135_K	1.421	1.00
232_I	240_A	1.415	1.00
124_I	274_V	1.409	1.00
56_I	276_V	1.406	1.00
132_L	139_I	1.401	1.00
234_V	256_I	1.379	1.00
217_R	221_S	1.357	1.00
31_K	79_N	1.356	1.00
103_S	106_E	1.349	1.00
82_D	85_D	1.345	1.00
143_H	179_Q	1.334	1.00
232_I	273_V	1.328	1.00
97_M	123_S	1.326	1.00
108_I	132_L	1.321	1.00
242_G	286_T	1.308	1.00
101_Q	105_Y	1.308	1.00
228_V	271_F	1.303	1.00
232_I	290_A	1.295	1.00
35_L	117_I	1.291	1.00
161_H	245_T	1.268	1.00
107_I	115_P	1.254	1.00
216_I	262_K	1.251	1.00
122_H	229_S	1.251	1.00
204_T	207_D	1.241	1.00
257_I	296_E	1.236	1.00
51_F	279_P	1.235	1.00
46_R	280_Y	1.234	1.00
142_V	263_L	1.231	1.00
167_R	170_E	1.230	1.00
55_G	287_A	1.226	1.00
161_H	244_G	1.224	1.00
116_F	294_I	1.207	1.00
211_N	215_V	1.200	1.00
131_T	135_K	1.188	1.00
148_Y	185_S	1.187	1.00
152_D	167_R	1.187	1.00
220_N	262_K	1.184	1.00
55_G	58_Q	1.182	1.00
165_L	179_Q	1.180	1.00
242_G	281_D	1.179	1.00
43_V	49_A	1.179	1.00
136_F	269_V	1.177	1.00
128_I	272_D	1.173	1.00
217_R	262_K	1.172	1.00
97_M	127_P	1.167	1.00
141_I	165_L	1.164	1.00
105_Y	135_K	1.149	1.00
147_H	233_D	1.147	1.00
213_D	217_R	1.137	1.00
35_L	104_L	1.136	1.00
100_I	117_I	1.115	1.00
205_I	209_K	1.114	1.00
114_V	271_F	1.110	1.00
40_D	48_G	1.091	1.00
102_T	106_E	1.089	1.00
47_P	51_F	1.089	1.00
128_I	227_H	1.084	1.00
138_K	224_G	1.079	1.00
219_I	222_L	1.079	1.00
145_D	149_D	1.077	1.00
33_A	83_M	1.077	1.00
215_V	219_I	1.074	1.00
277_A	280_Y	1.073	1.00
125_T	129_L	1.066	1.00
32_A	114_V	1.057	1.00
129_L	141_I	1.047	1.00
66_Y	71_D	1.047	1.00
178_V	222_L	1.046	1.00
286_T	290_A	1.039	1.00
213_D	262_K	1.031	1.00
105_Y	131_T	1.031	1.00
96_T	100_I	1.027	1.00
161_H	243_T	1.021	1.00
225_P	269_V	1.016	1.00
37_I	124_I	1.007	1.00
251_L	259_I	1.007	1.00
130_R	171_E	1.003	1.00
191_D	197_R	1.002	1.00
35_L	103_S	1.001	1.00
104_L	115_P	0.989	1.00
95_D	98_N	0.987	1.00
160_T	163_T	0.983	1.00
282_M	285_I	0.981	1.00
132_L	270_G	0.980	1.00
47_P	50_R	0.976	1.00
136_F	225_P	0.975	1.00
216_I	219_I	0.975	1.00
256_I	293_I	0.974	1.00
34_F	118_A	0.972	1.00
165_L	177_A	0.967	1.00
228_V	260_V	0.967	1.00
203_F	222_L	0.962	1.00
57_R	85_D	0.962	1.00
183_R	237_P	0.957	1.00
152_D	166_R	0.953	0.99
150_F	195_K	0.948	0.99
140_N	176_E	0.948	0.99
57_R	84_G	0.936	0.99
240_A	289_L	0.936	0.99
150_F	169_I	0.933	0.99
143_H	229_S	0.931	0.99
55_G	59_G	0.925	0.99
148_Y	179_Q	0.924	0.99
125_T	272_D	0.923	0.99
226_T	267_K	0.923	0.99
36_G	84_G	0.920	0.99
107_I	113_L	0.918	0.99
210_Y	215_V	0.918	0.99
161_H	275_E	0.915	0.99
148_Y	182_I	0.909	0.99
106_E	109_S	0.909	0.99
74_P	77_K	0.907	0.99
31_K	113_L	0.904	0.99
140_N	178_V	0.903	0.99
207_D	210_Y	0.898	0.99
144_F	251_L	0.896	0.99
122_H	161_H	0.894	0.99
235_V	253_S	0.884	0.99
148_Y	202_S	0.884	0.99
40_D	46_R	0.882	0.99
183_R	236_D	0.876	0.99
243_T	246_P	0.873	0.99
36_G	85_D	0.870	0.99
209_K	258_E	0.868	0.99
284_E	287_A	0.857	0.99
203_F	218_E	0.855	0.99
211_N	214_T	0.852	0.99
262_K	265_F	0.849	0.99
128_I	270_G	0.849	0.99
139_I	269_V	0.848	0.99
49_A	277_A	0.848	0.99
32_A	78_L	0.845	0.99
122_H	272_D	0.842	0.99
251_L	256_I	0.841	0.99
73_Y	76_D	0.836	0.99
102_T	105_Y	0.832	0.99
104_L	131_T	0.832	0.99
162_G	245_T	0.831	0.99
196_E	202_S	0.829	0.99
195_K	200_I	0.829	0.99
177_A	200_I	0.826	0.99
174_I	177_A	0.825	0.99
141_I	168_A	0.823	0.99
35_L	115_P	0.818	0.98
235_V	239_F	0.815	0.98
253_S	257_I	0.815	0.98
146_S	183_R	0.814	0.98
132_L	269_V	0.812	0.98
98_N	101_Q	0.811	0.98
230_I	293_I	0.810	0.98
216_I	220_N	0.802	0.98
40_D	49_A	0.801	0.98
184_A	247_E	0.797	0.98
125_T	164_W	0.796	0.98
203_F	208_L	0.794	0.98
140_N	223_S	0.793	0.98
178_V	219_I	0.789	0.98
40_D	47_P	0.787	0.98
153_S	156_G	0.787	0.98
153_S	167_R	0.785	0.98
206_R	261_R	0.784	0.98
129_L	139_I	0.784	0.98
122_H	275_E	0.783	0.98
52_G	244_G	0.782	0.98
278_P	281_D	0.774	0.98
115_P	132_L	0.771	0.98
206_R	258_E	0.771	0.98
27_N	113_L	0.770	0.98
180_G	219_I	0.765	0.98
57_R	82_D	0.753	0.97
213_D	258_E	0.752	0.97
39_F	93_I	0.750	0.97
52_G	278_P	0.748	0.97
82_D	86_I	0.745	0.97
183_R	247_E	0.740	0.97
218_E	221_S	0.738	0.97
187_F	191_D	0.736	0.97
123_S	159_Y	0.735	0.97
142_V	178_V	0.731	0.97
42_A	121_D	0.731	0.97
67_N	296_E	0.730	0.97
276_V	287_A	0.730	0.97
259_I	262_K	0.728	0.97
144_F	180_G	0.726	0.97
257_I	293_I	0.724	0.97
117_I	124_I	0.722	0.97
220_N	265_F	0.720	0.97
52_G	55_G	0.718	0.96
41_D	96_T	0.717	0.96
220_N	223_S	0.714	0.96
285_I	289_L	0.713	0.96
39_F	96_T	0.713	0.96
294_I	297_G	0.712	0.96
88_V	96_T	0.710	0.96
144_F	228_V	0.708	0.96
203_F	215_V	0.705	0.96
145_D	233_D	0.705	0.96
106_E	111_K	0.703	0.96
216_I	259_I	0.700	0.96
180_G	251_L	0.700	0.96
103_S	107_I	0.699	0.96
240_A	276_V	0.697	0.96
239_F	252_T	0.696	0.96
92_Y	157_K	0.695	0.96
127_P	131_T	0.693	0.96
243_T	277_A	0.692	0.96
125_T	165_L	0.692	0.96
139_I	225_P	0.688	0.96
228_V	297_G	0.686	0.95
169_I	200_I	0.684	0.95
59_G	291_A	0.678	0.95
238_A	253_S	0.678	0.95
229_S	274_V	0.674	0.95
142_V	180_G	0.674	0.95
52_G	277_A	0.674	0.95
100_I	127_P	0.673	0.95
57_R	74_P	0.672	0.95
38_P	85_D	0.672	0.95
133_Y	137_G	0.670	0.95
149_D	233_D	0.668	0.95
208_L	259_I	0.666	0.95
169_I	177_A	0.666	0.95
281_D	284_E	0.665	0.95
208_L	255_E	0.665	0.95
93_I	97_M	0.665	0.95
69_F	72_T	0.664	0.95
149_D	275_E	0.662	0.94
116_F	298_M	0.654	0.94
30_I	113_L	0.653	0.94
27_N	30_I	0.651	0.94
46_R	246_P	0.650	0.94
242_G	276_V	0.650	0.94
254_F	258_E	0.645	0.94
42_A	93_I	0.644	0.94
178_V	203_F	0.642	0.94
34_F	116_F	0.641	0.93
211_N	255_E	0.638	0.93
142_V	226_T	0.633	0.93
296_E	299_S	0.631	0.93
258_E	262_K	0.631	0.93
152_D	158_K	0.626	0.93
112_N	115_P	0.625	0.93
226_T	268_L	0.624	0.93
128_I	132_L	0.623	0.93
99_A	102_T	0.623	0.93
130_R	168_A	0.622	0.92
37_I	128_I	0.619	0.92
58_Q	284_E	0.617	0.92
226_T	266_D	0.613	0.92
122_H	147_H	0.610	0.92
32_A	116_F	0.609	0.92
273_V	293_I	0.608	0.92
227_H	272_D	0.607	0.92
43_V	47_P	0.607	0.92
239_F	289_L	0.606	0.91
104_L	127_P	0.606	0.91
59_G	287_A	0.603	0.91
205_I	251_L	0.603	0.91
93_I	160_T	0.602	0.91
203_F	207_D	0.601	0.91
122_H	227_H	0.601	0.91
249_G	257_I	0.599	0.91
55_G	278_P	0.599	0.91
181_G	234_V	0.590	0.90
99_A	103_S	0.590	0.90
109_S	112_N	0.590	0.90
153_S	158_K	0.590	0.90
143_H	165_L	0.589	0.90
150_F	198_L	0.589	0.90
41_D	44_T	0.588	0.90
148_Y	151_W	0.586	0.90
138_K	225_P	0.584	0.90
212_L	259_I	0.584	0.90
132_L	136_F	0.584	0.90
229_S	272_D	0.584	0.90
36_G	82_D	0.583	0.90
44_T	161_H	0.582	0.90
284_E	288_M	0.582	0.90
241_P	286_T	0.581	0.90
143_H	245_T	0.580	0.90
126_L	167_R	0.579	0.90
125_T	274_V	0.578	0.89
140_N	219_I	0.576	0.89
59_G	284_E	0.576	0.89
237_P	240_A	0.574	0.89
55_G	284_E	0.573	0.89
141_I	177_A	0.573	0.89
133_Y	139_I	0.571	0.89
144_F	256_I	0.571	0.89
108_I	112_N	0.571	0.89
227_H	269_V	0.568	0.89
86_I	99_A	0.566	0.88
169_I	172_G	0.565	0.88
148_Y	184_A	0.565	0.88
140_N	225_P	0.563	0.88
32_A	115_P	0.563	0.88
96_T	99_A	0.563	0.88
83_M	107_I	0.559	0.88
112_N	135_K	0.558	0.88
122_H	274_V	0.556	0.88
195_K	202_S	0.555	0.87
89_I	99_A	0.553	0.87
218_E	222_L	0.551	0.87
151_W	162_G	0.551	0.87
271_F	294_I	0.549	0.87
67_N	70_L	0.547	0.87
56_I	294_I	0.547	0.87
143_H	164_W	0.543	0.86
163_T	167_R	0.543	0.86
36_G	74_P	0.542	0.86
60_S	63_L	0.542	0.86
168_A	171_E	0.542	0.86
221_S	224_G	0.539	0.86
148_Y	195_K	0.536	0.86
119_G	124_I	0.536	0.86
54_M	284_E	0.535	0.86
133_Y	171_E	0.532	0.85
240_A	243_T	0.530	0.85
151_W	245_T	0.525	0.84
291_A	294_I	0.525	0.84
212_L	258_E	0.525	0.84
210_Y	217_R	0.523	0.84
41_D	93_I	0.522	0.84
281_D	286_T	0.519	0.84
183_R	249_G	0.518	0.84
126_L	159_Y	0.515	0.83
40_D	52_G	0.513	0.83
33_A	75_F	0.512	0.83
51_F	54_M	0.511	0.83
75_F	80_A	0.509	0.83
108_I	136_F	0.508	0.83
180_G	208_L	0.506	0.82
104_L	108_I	0.506	0.82
125_T	227_H	0.506	0.82
263_L	266_D	0.505	0.82
100_I	124_I	0.502	0.82
185_S	295_Y	0.502	0.82
133_Y	176_E	0.501	0.82
288_M	292_N	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1gq6A	5	0.9705	100	0.1	Contact Map
3niqA	5	0.9934	100	0.112	Contact Map
3nioA	5	0.9738	100	0.114	Contact Map
1wohA	5	0.9738	100	0.114	Contact Map
4dz4A	5	0.9639	100	0.134	Contact Map
3m1rA	5	0.9869	100	0.137	Contact Map
4mykA	3	0.9115	100	0.151	Contact Map
1xfkA	1	0.9607	100	0.181	Contact Map
3pzlA	5	0.9344	100	0.182	Contact Map
3lhlA	3	0.8918	100	0.19	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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