GREMLIN Database
Q97VA2 - Uncharacterized protein
UniProt: Q97VA2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 219 (173)
Sequences: 3078 (2116)
Seq/√Len: 160.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_N60_R4.4321.00
42_E136_K3.7661.00
44_V129_V2.8261.00
45_I139_I2.7521.00
8_L32_P2.5041.00
49_A104_V2.4311.00
122_S126_E2.4241.00
44_V132_L2.3041.00
170_L184_V2.1911.00
127_E130_R2.1631.00
18_T21_R2.1141.00
170_L210_T2.0811.00
74_A204_L2.0721.00
52_G57_R2.0431.00
21_R106_C1.9931.00
193_N196_T1.9771.00
108_P117_E1.9561.00
12_D18_T1.8651.00
77_A205_I1.8291.00
143_K147_D1.8201.00
172_K182_W1.8031.00
74_A200_T1.7771.00
8_L34_P1.7671.00
5_I9_I1.7571.00
77_A201_I1.7031.00
72_A82_N1.7001.00
36_N82_N1.6881.00
14_C121_C1.6541.00
170_L182_W1.6381.00
15_P116_D1.6141.00
45_I71_L1.6001.00
140_A185_G1.5461.00
44_V101_T1.5081.00
164_R187_Y1.4761.00
75_L98_V1.4641.00
172_K180_I1.4531.00
15_P19_Q1.4471.00
7_R127_E1.4441.00
138_Y181_I1.4371.00
197_G201_I1.4291.00
196_T199_L1.3911.00
99_Y128_E1.3881.00
140_A183_L1.3741.00
201_I205_I1.3671.00
133_K181_I1.3631.00
4_F131_I1.3591.00
22_K31_K1.3541.00
78_V208_F1.3531.00
22_K57_R1.3351.00
162_N165_F1.3241.00
118_I148_S1.3111.00
11_C121_C1.3101.00
129_V138_Y1.2931.00
11_C106_C1.2741.00
140_A146_W1.2621.00
173_V183_L1.2621.00
42_E97_N1.2561.00
137_V184_V1.2431.00
13_K123_V1.2411.00
197_G200_T1.2401.00
139_I211_A1.2271.00
53_N58_T1.2171.00
191_P196_T1.2161.00
105_K128_E1.2121.00
53_N57_R1.2041.00
106_C121_C1.2041.00
81_S97_N1.1941.00
11_C14_C1.1851.00
55_G63_T1.1701.00
203_M206_E1.1551.00
139_I207_I1.1411.00
204_L207_I1.1281.00
3_N6_S1.1241.00
141_L186_S1.1201.00
101_T128_E1.1031.00
146_W185_G1.1011.00
184_V207_I1.0880.99
139_I186_S1.0860.99
45_I75_L1.0700.99
6_S10_A1.0680.99
9_I32_P1.0600.99
150_I183_L1.0590.99
51_A55_G1.0570.99
206_E209_N1.0540.99
43_I207_I1.0510.99
43_I139_I1.0400.99
49_A108_P1.0300.99
118_I144_I1.0170.99
45_I141_L1.0160.99
208_F212_K1.0070.99
140_A149_L1.0040.99
146_W161_P1.0030.99
38_Q97_N0.9930.99
166_Y169_A0.9910.99
207_I211_A0.9880.99
33_V61_M0.9830.99
101_T125_L0.9800.99
103_A148_S0.9790.99
198_R202_N0.9690.99
206_E210_T0.9580.99
146_W166_Y0.9390.99
74_A78_V0.9380.98
112_K117_E0.9300.98
13_K124_F0.9280.98
53_N66_E0.9200.98
161_P166_Y0.9110.98
5_I34_P0.9040.98
115_K119_I0.9000.98
208_F211_A0.8940.98
12_D19_Q0.8940.98
207_I210_T0.8920.98
73_N77_A0.8890.98
144_I147_D0.8880.98
140_A145_A0.8880.98
63_T102_S0.8820.98
209_N212_K0.8800.98
43_I211_A0.8800.98
46_V125_L0.8790.98
15_P114_N0.8760.98
46_V149_L0.8750.98
69_N73_N0.8720.98
35_P99_Y0.8700.98
3_N7_R0.8700.98
38_Q41_A0.8700.98
6_S9_I0.8690.98
127_E131_I0.8630.97
46_V140_A0.8620.97
122_S148_S0.8610.97
47_G62_F0.8550.97
184_V210_T0.8530.97
182_W210_T0.8510.97
123_V127_E0.8510.97
15_P18_T0.8490.97
44_V138_Y0.8460.97
126_E130_R0.8450.97
173_V179_S0.8420.97
52_G107_A0.8350.97
137_V182_W0.8260.97
192_R195_K0.8220.97
159_N166_Y0.8190.96
83_Q97_N0.8180.96
203_M207_I0.8170.96
74_A201_I0.8170.96
163_V185_G0.8120.96
200_T207_I0.8110.96
159_N162_N0.8100.96
69_N72_A0.8020.96
11_C105_K0.7720.95
35_P128_E0.7630.95
199_L202_N0.7600.95
132_L135_T0.7510.94
70_N201_I0.7510.94
45_I98_V0.7480.94
51_A102_S0.7460.94
115_K147_D0.7430.94
8_L124_F0.7380.94
14_C106_C0.7360.94
5_I39_I0.7360.94
18_T32_P0.7350.94
51_A67_S0.7340.94
194_M197_G0.7300.93
43_I80_L0.7300.93
200_T203_M0.7280.93
167_H186_S0.7250.93
58_T63_T0.7210.93
138_Y149_L0.7190.93
202_N205_I0.7180.93
73_N76_Y0.7170.93
119_I151_Y0.7160.93
143_K162_N0.7100.92
133_K136_K0.7050.92
43_I98_V0.7030.92
13_K120_N0.6980.92
47_G188_H0.6960.92
200_T204_L0.6930.92
150_I171_V0.6910.91
35_P132_L0.6870.91
187_Y199_L0.6840.91
108_P111_N0.6820.91
123_V126_E0.6820.91
73_N201_I0.6810.91
103_A118_I0.6770.91
18_T106_C0.6740.90
116_D119_I0.6730.90
166_Y185_G0.6720.90
11_C21_R0.6720.90
51_A61_M0.6710.90
129_V149_L0.6660.90
38_Q99_Y0.6600.89
9_I31_K0.6530.89
80_L98_V0.6480.89
102_S188_H0.6440.88
72_A100_I0.6420.88
51_A111_N0.6420.88
62_F109_P0.6390.88
76_Y81_S0.6360.88
187_Y191_P0.6360.88
49_A111_N0.6340.87
129_V181_I0.6310.87
170_L206_E0.6310.87
166_Y171_V0.6270.87
5_I32_P0.6250.87
173_V181_I0.6240.87
184_V211_A0.6230.87
140_A171_V0.6220.86
192_R196_T0.6140.86
52_G66_E0.6140.86
61_M102_S0.6140.86
102_S111_N0.6130.86
126_E173_V0.6030.85
205_I209_N0.5930.84
31_K59_G0.5920.84
72_A75_L0.5920.84
56_N63_T0.5900.83
130_R179_S0.5870.83
34_P99_Y0.5840.83
31_K56_N0.5830.83
186_S200_T0.5810.83
78_V205_I0.5780.82
104_V114_N0.5780.82
135_T138_Y0.5770.82
41_A101_T0.5710.81
171_V185_G0.5660.81
200_T205_I0.5650.81
167_H203_M0.5640.81
111_N117_E0.5590.80
197_G208_F0.5580.80
48_L113_P0.5580.80
101_T105_K0.5580.80
107_A112_K0.5570.80
76_Y83_Q0.5550.80
102_S190_S0.5490.79
192_R200_T0.5490.79
151_Y160_V0.5450.78
44_V135_T0.5370.77
37_G41_A0.5360.77
80_L212_K0.5340.77
122_S151_Y0.5330.77
33_V55_G0.5320.77
71_L75_L0.5310.77
103_A122_S0.5240.76
80_L211_A0.5230.76
32_P106_C0.5220.75
146_W159_N0.5220.75
205_I208_F0.5210.75
125_L129_V0.5210.75
197_G203_M0.5200.75
196_T200_T0.5200.75
50_P59_G0.5180.75
171_V183_L0.5180.75
48_L63_T0.5170.75
43_I137_V0.5140.74
75_L80_L0.5120.74
140_A144_I0.5110.74
116_D120_N0.5070.73
41_A132_L0.5060.73
109_P117_E0.5040.73
68_S102_S0.5020.73
161_P185_G0.5010.72
78_V204_L0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d3yA 1 0.9498 100 0.265 Contact Map
1vk2A 1 0.8037 100 0.288 Contact Map
1ui0A 1 0.8311 100 0.295 Contact Map
3ikbA 1 0.7763 100 0.374 Contact Map
1wywA 1 0.8447 100 0.487 Contact Map
1oe4A 2 0.7945 100 0.544 Contact Map
1mugA 1 0.7397 100 0.547 Contact Map
2c2qA 1 0.8265 100 0.597 Contact Map
2l3fA 1 0.7169 99.1 0.811 Contact Map
1yc5A 1 0.3562 29 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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