Q97VA2 - SULSO - GREMLIN Contacts

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Q97VA2 - Uncharacterized protein

UniProt:	Q97VA2	Sequences: MENFISRLIACDKCPRLTQYRKSFPDNYWKKPVPPNGQIDAEIVIVGLAPAGNGGNRTGRMFTGDESSNNLANALYAVGLSNQPFSVSKDDGLKLFNVYITSAVKCAPPQNKPNKDEIINCSVFLEEEVRILKNTKVYIALGKIAWDSLIYVFKKIGYNVPNVRFYHGALVKVVKPDMSIIWLVGSYHPSPRNMKTGRLTINMLIEIFNTAKMLVNTKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	219 (173)
Sequences:	3078 (2116)
Seq/√Len:	160.9

HALSA - Q9HQC4 Q9HNJ0 Q9HRG7
SULSO - Q97VA2 Q97WF1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
36_N	60_R	4.432	1.00
42_E	136_K	3.766	1.00
44_V	129_V	2.826	1.00
45_I	139_I	2.752	1.00
8_L	32_P	2.504	1.00
49_A	104_V	2.431	1.00
122_S	126_E	2.424	1.00
44_V	132_L	2.304	1.00
170_L	184_V	2.191	1.00
127_E	130_R	2.163	1.00
18_T	21_R	2.114	1.00
170_L	210_T	2.081	1.00
74_A	204_L	2.072	1.00
52_G	57_R	2.043	1.00
21_R	106_C	1.993	1.00
193_N	196_T	1.977	1.00
108_P	117_E	1.956	1.00
12_D	18_T	1.865	1.00
77_A	205_I	1.829	1.00
143_K	147_D	1.820	1.00
172_K	182_W	1.803	1.00
74_A	200_T	1.777	1.00
8_L	34_P	1.767	1.00
5_I	9_I	1.757	1.00
77_A	201_I	1.703	1.00
72_A	82_N	1.700	1.00
36_N	82_N	1.688	1.00
14_C	121_C	1.654	1.00
170_L	182_W	1.638	1.00
15_P	116_D	1.614	1.00
45_I	71_L	1.600	1.00
140_A	185_G	1.546	1.00
44_V	101_T	1.508	1.00
164_R	187_Y	1.476	1.00
75_L	98_V	1.464	1.00
172_K	180_I	1.453	1.00
15_P	19_Q	1.447	1.00
7_R	127_E	1.444	1.00
138_Y	181_I	1.437	1.00
197_G	201_I	1.429	1.00
196_T	199_L	1.391	1.00
99_Y	128_E	1.388	1.00
140_A	183_L	1.374	1.00
201_I	205_I	1.367	1.00
133_K	181_I	1.363	1.00
4_F	131_I	1.359	1.00
22_K	31_K	1.354	1.00
78_V	208_F	1.353	1.00
22_K	57_R	1.335	1.00
162_N	165_F	1.324	1.00
118_I	148_S	1.311	1.00
11_C	121_C	1.310	1.00
129_V	138_Y	1.293	1.00
11_C	106_C	1.274	1.00
140_A	146_W	1.262	1.00
173_V	183_L	1.262	1.00
42_E	97_N	1.256	1.00
137_V	184_V	1.243	1.00
13_K	123_V	1.241	1.00
197_G	200_T	1.240	1.00
139_I	211_A	1.227	1.00
53_N	58_T	1.217	1.00
191_P	196_T	1.216	1.00
105_K	128_E	1.212	1.00
53_N	57_R	1.204	1.00
106_C	121_C	1.204	1.00
81_S	97_N	1.194	1.00
11_C	14_C	1.185	1.00
55_G	63_T	1.170	1.00
203_M	206_E	1.155	1.00
139_I	207_I	1.141	1.00
204_L	207_I	1.128	1.00
3_N	6_S	1.124	1.00
141_L	186_S	1.120	1.00
101_T	128_E	1.103	1.00
146_W	185_G	1.101	1.00
184_V	207_I	1.088	0.99
139_I	186_S	1.086	0.99
45_I	75_L	1.070	0.99
6_S	10_A	1.068	0.99
9_I	32_P	1.060	0.99
150_I	183_L	1.059	0.99
51_A	55_G	1.057	0.99
206_E	209_N	1.054	0.99
43_I	207_I	1.051	0.99
43_I	139_I	1.040	0.99
49_A	108_P	1.030	0.99
118_I	144_I	1.017	0.99
45_I	141_L	1.016	0.99
208_F	212_K	1.007	0.99
140_A	149_L	1.004	0.99
146_W	161_P	1.003	0.99
38_Q	97_N	0.993	0.99
166_Y	169_A	0.991	0.99
207_I	211_A	0.988	0.99
33_V	61_M	0.983	0.99
101_T	125_L	0.980	0.99
103_A	148_S	0.979	0.99
198_R	202_N	0.969	0.99
206_E	210_T	0.958	0.99
146_W	166_Y	0.939	0.99
74_A	78_V	0.938	0.98
112_K	117_E	0.930	0.98
13_K	124_F	0.928	0.98
53_N	66_E	0.920	0.98
161_P	166_Y	0.911	0.98
5_I	34_P	0.904	0.98
115_K	119_I	0.900	0.98
208_F	211_A	0.894	0.98
12_D	19_Q	0.894	0.98
207_I	210_T	0.892	0.98
73_N	77_A	0.889	0.98
144_I	147_D	0.888	0.98
140_A	145_A	0.888	0.98
63_T	102_S	0.882	0.98
209_N	212_K	0.880	0.98
43_I	211_A	0.880	0.98
46_V	125_L	0.879	0.98
15_P	114_N	0.876	0.98
46_V	149_L	0.875	0.98
69_N	73_N	0.872	0.98
35_P	99_Y	0.870	0.98
3_N	7_R	0.870	0.98
38_Q	41_A	0.870	0.98
6_S	9_I	0.869	0.98
127_E	131_I	0.863	0.97
46_V	140_A	0.862	0.97
122_S	148_S	0.861	0.97
47_G	62_F	0.855	0.97
184_V	210_T	0.853	0.97
182_W	210_T	0.851	0.97
123_V	127_E	0.851	0.97
15_P	18_T	0.849	0.97
44_V	138_Y	0.846	0.97
126_E	130_R	0.845	0.97
173_V	179_S	0.842	0.97
52_G	107_A	0.835	0.97
137_V	182_W	0.826	0.97
192_R	195_K	0.822	0.97
159_N	166_Y	0.819	0.96
83_Q	97_N	0.818	0.96
203_M	207_I	0.817	0.96
74_A	201_I	0.817	0.96
163_V	185_G	0.812	0.96
200_T	207_I	0.811	0.96
159_N	162_N	0.810	0.96
69_N	72_A	0.802	0.96
11_C	105_K	0.772	0.95
35_P	128_E	0.763	0.95
199_L	202_N	0.760	0.95
132_L	135_T	0.751	0.94
70_N	201_I	0.751	0.94
45_I	98_V	0.748	0.94
51_A	102_S	0.746	0.94
115_K	147_D	0.743	0.94
8_L	124_F	0.738	0.94
14_C	106_C	0.736	0.94
5_I	39_I	0.736	0.94
18_T	32_P	0.735	0.94
51_A	67_S	0.734	0.94
194_M	197_G	0.730	0.93
43_I	80_L	0.730	0.93
200_T	203_M	0.728	0.93
167_H	186_S	0.725	0.93
58_T	63_T	0.721	0.93
138_Y	149_L	0.719	0.93
202_N	205_I	0.718	0.93
73_N	76_Y	0.717	0.93
119_I	151_Y	0.716	0.93
143_K	162_N	0.710	0.92
133_K	136_K	0.705	0.92
43_I	98_V	0.703	0.92
13_K	120_N	0.698	0.92
47_G	188_H	0.696	0.92
200_T	204_L	0.693	0.92
150_I	171_V	0.691	0.91
35_P	132_L	0.687	0.91
187_Y	199_L	0.684	0.91
108_P	111_N	0.682	0.91
123_V	126_E	0.682	0.91
73_N	201_I	0.681	0.91
103_A	118_I	0.677	0.91
18_T	106_C	0.674	0.90
116_D	119_I	0.673	0.90
166_Y	185_G	0.672	0.90
11_C	21_R	0.672	0.90
51_A	61_M	0.671	0.90
129_V	149_L	0.666	0.90
38_Q	99_Y	0.660	0.89
9_I	31_K	0.653	0.89
80_L	98_V	0.648	0.89
102_S	188_H	0.644	0.88
72_A	100_I	0.642	0.88
51_A	111_N	0.642	0.88
62_F	109_P	0.639	0.88
76_Y	81_S	0.636	0.88
187_Y	191_P	0.636	0.88
49_A	111_N	0.634	0.87
129_V	181_I	0.631	0.87
170_L	206_E	0.631	0.87
166_Y	171_V	0.627	0.87
5_I	32_P	0.625	0.87
173_V	181_I	0.624	0.87
184_V	211_A	0.623	0.87
140_A	171_V	0.622	0.86
192_R	196_T	0.614	0.86
52_G	66_E	0.614	0.86
61_M	102_S	0.614	0.86
102_S	111_N	0.613	0.86
126_E	173_V	0.603	0.85
205_I	209_N	0.593	0.84
31_K	59_G	0.592	0.84
72_A	75_L	0.592	0.84
56_N	63_T	0.590	0.83
130_R	179_S	0.587	0.83
34_P	99_Y	0.584	0.83
31_K	56_N	0.583	0.83
186_S	200_T	0.581	0.83
78_V	205_I	0.578	0.82
104_V	114_N	0.578	0.82
135_T	138_Y	0.577	0.82
41_A	101_T	0.571	0.81
171_V	185_G	0.566	0.81
200_T	205_I	0.565	0.81
167_H	203_M	0.564	0.81
111_N	117_E	0.559	0.80
197_G	208_F	0.558	0.80
48_L	113_P	0.558	0.80
101_T	105_K	0.558	0.80
107_A	112_K	0.557	0.80
76_Y	83_Q	0.555	0.80
102_S	190_S	0.549	0.79
192_R	200_T	0.549	0.79
151_Y	160_V	0.545	0.78
44_V	135_T	0.537	0.77
37_G	41_A	0.536	0.77
80_L	212_K	0.534	0.77
122_S	151_Y	0.533	0.77
33_V	55_G	0.532	0.77
71_L	75_L	0.531	0.77
103_A	122_S	0.524	0.76
80_L	211_A	0.523	0.76
32_P	106_C	0.522	0.75
146_W	159_N	0.522	0.75
205_I	208_F	0.521	0.75
125_L	129_V	0.521	0.75
197_G	203_M	0.520	0.75
196_T	200_T	0.520	0.75
50_P	59_G	0.518	0.75
171_V	183_L	0.518	0.75
48_L	63_T	0.517	0.75
43_I	137_V	0.514	0.74
75_L	80_L	0.512	0.74
140_A	144_I	0.511	0.74
116_D	120_N	0.507	0.73
41_A	132_L	0.506	0.73
109_P	117_E	0.504	0.73
68_S	102_S	0.502	0.73
161_P	185_G	0.501	0.72
78_V	204_L	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2d3yA	1	0.9498	100	0.265	Contact Map
1vk2A	1	0.8037	100	0.288	Contact Map
1ui0A	1	0.8311	100	0.295	Contact Map
3ikbA	1	0.7763	100	0.374	Contact Map
1wywA	1	0.8447	100	0.487	Contact Map
1oe4A	2	0.7945	100	0.544	Contact Map
1mugA	1	0.7397	100	0.547	Contact Map
2c2qA	1	0.8265	100	0.597	Contact Map
2l3fA	1	0.7169	99.1	0.811	Contact Map
1yc5A	1	0.3562	29	0.952	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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