GREMLIN Database
Q97V97 - Deacetylase, putative
UniProt: Q97V97 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 437 (406)
Sequences: 6834 (4832)
Seq/√Len: 239.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
364_K370_E4.7201.00
84_K412_N4.4921.00
96_R414_N3.9911.00
361_E433_L3.4781.00
32_K36_E3.3201.00
365_K429_E3.2931.00
23_G26_E3.2641.00
86_A89_S3.0681.00
326_K330_Q2.7991.00
10_E30_Y2.7791.00
95_D418_D2.7721.00
12_L99_A2.7081.00
33_E37_K2.6691.00
365_K433_L2.6651.00
44_N154_K2.6461.00
85_R93_E2.6431.00
29_N33_E2.6381.00
323_E327_K2.6201.00
89_S100_R2.6091.00
186_E339_L2.5461.00
9_I13_K2.4491.00
10_E13_K2.3261.00
57_E130_K2.2861.00
178_G376_N2.2821.00
42_K57_E2.2391.00
190_D303_R2.2331.00
70_N109_L2.2081.00
67_L157_A2.1971.00
186_E305_F2.1921.00
30_Y34_T2.1461.00
32_K45_L2.1321.00
11_F27_T2.0731.00
92_I417_I2.0501.00
320_K324_L2.0441.00
233_D320_K1.9771.00
6_Y10_E1.9751.00
211_L304_A1.9611.00
39_L117_K1.9521.00
362_S433_L1.9341.00
65_T128_N1.9211.00
31_L72_Y1.9151.00
208_C289_C1.9101.00
366_V429_E1.8971.00
288_E305_F1.8961.00
33_E36_E1.8921.00
14_K30_Y1.8841.00
13_K89_S1.8771.00
323_E326_K1.8761.00
118_H122_K1.8681.00
12_L102_A1.8591.00
319_Y323_E1.8511.00
352_N357_K1.8431.00
92_I95_D1.8291.00
215_I284_V1.8231.00
91_T100_R1.8191.00
151_N154_K1.8131.00
9_I90_A1.8031.00
15_P23_G1.7921.00
74_V88_F1.7861.00
6_Y9_I1.7491.00
359_M430_F1.7471.00
415_I420_Y1.7381.00
35_V56_A1.7381.00
116_I131_L1.7361.00
217_T328_H1.7311.00
190_D335_N1.7201.00
64_K158_D1.7091.00
189_L211_L1.6701.00
32_K43_A1.6681.00
429_E432_K1.6551.00
22_E26_E1.6441.00
84_K93_E1.6301.00
361_E365_K1.6281.00
188_V305_F1.6281.00
322_F326_K1.6251.00
185_V325_L1.6251.00
118_H428_E1.6211.00
421_Y425_K1.6181.00
211_L215_I1.6151.00
369_T373_V1.5891.00
212_A215_I1.5851.00
16_S27_T1.5771.00
25_D29_N1.5761.00
29_N32_K1.5641.00
418_D422_K1.5601.00
146_D150_K1.5421.00
220_D224_R1.5411.00
77_V88_F1.5401.00
211_L306_A1.5351.00
30_Y33_E1.5241.00
72_Y133_Y1.5211.00
125_L432_K1.5181.00
112_R131_L1.5171.00
357_K360_I1.5141.00
188_V303_R1.5051.00
188_V339_L1.4771.00
235_R315_N1.4741.00
327_K331_K1.4661.00
366_V425_K1.4501.00
59_N128_N1.4441.00
358_A362_S1.4381.00
322_F340_A1.4371.00
188_V337_E1.4371.00
12_L16_S1.4321.00
7_T114_F1.4251.00
17_I88_F1.4201.00
226_L231_Y1.4111.00
12_L90_A1.4101.00
55_Y154_K1.4081.00
95_D416_K1.4011.00
429_E433_L1.3951.00
57_E128_N1.3941.00
27_T72_Y1.3801.00
159_S355_V1.3651.00
239_E243_E1.3621.00
400_G403_G1.3611.00
9_I92_I1.3551.00
10_E34_T1.3491.00
236_E239_E1.3491.00
7_T117_K1.3481.00
117_K121_D1.3441.00
317_D345_Y1.3411.00
26_E29_N1.3311.00
190_D337_E1.3201.00
208_C287_F1.3181.00
238_T241_E1.3111.00
13_K90_A1.3061.00
41_V56_A1.3041.00
289_C304_A1.3011.00
136_E142_V1.2791.00
360_I364_K1.2761.00
85_R91_T1.2761.00
34_T37_K1.2761.00
317_D320_K1.2671.00
28_A54_V1.2631.00
66_L431_L1.2541.00
82_E85_R1.2511.00
186_E307_K1.2501.00
55_Y59_N1.2401.00
360_I373_V1.2401.00
111_A423_A1.2381.00
99_A102_A1.2361.00
286_G307_K1.2341.00
213_K216_S1.2321.00
327_K330_Q1.2291.00
28_A72_Y1.2241.00
97_I417_I1.2231.00
14_K27_T1.2191.00
249_D252_V1.2141.00
96_R416_K1.1861.00
44_N151_N1.1801.00
362_S429_E1.1801.00
146_D149_E1.1761.00
384_G387_V1.1641.00
186_E341_H1.1571.00
32_K54_V1.1561.00
11_F110_M1.1551.00
72_Y135_G1.1521.00
360_I370_E1.1511.00
136_E143_N1.1461.00
368_G374_I1.1351.00
189_L210_D1.1341.00
205_R210_D1.1321.00
46_E55_Y1.1301.00
362_S366_V1.1291.00
316_Q320_K1.1251.00
357_K361_E1.1201.00
145_E149_E1.1191.00
41_V131_L1.1191.00
392_I395_A1.1111.00
226_L229_G1.1101.00
310_F325_L1.1081.00
209_I219_V1.1071.00
282_C310_F1.1031.00
92_I97_I1.0981.00
215_I306_A1.0901.00
46_E154_K1.0891.00
187_L214_I1.0881.00
22_E29_N1.0881.00
93_E98_Y1.0841.00
70_N105_N1.0781.00
319_Y322_F1.0761.00
14_K26_E1.0731.00
145_E386_F1.0711.00
242_R246_K1.0681.00
318_P345_Y1.0651.00
243_E247_K1.0631.00
28_A45_L1.0611.00
370_E374_I1.0601.00
7_T34_T1.0551.00
324_L328_H1.0531.00
41_V58_I1.0521.00
282_C308_L1.0511.00
227_I231_Y1.0501.00
184_Y309_D1.0491.00
244_L247_K1.0491.00
68_I112_R1.0481.00
228_E328_H1.0461.00
245_I248_Y1.0441.00
238_T242_R1.0441.00
396_V400_G1.0411.00
320_K323_E1.0401.00
353_S395_A1.0391.00
70_N108_T1.0251.00
253_E256_K1.0231.00
253_E257_K1.0191.00
189_L214_I1.0131.00
46_E151_N1.0131.00
8_L12_L1.0081.00
324_L327_K1.0071.00
240_E243_E1.0031.00
404_Y416_K0.9851.00
5_L92_I0.9761.00
18_S139_I0.9761.00
361_E364_K0.9751.00
65_T130_K0.9741.00
11_F30_Y0.9711.00
4_E424_I0.9701.00
9_I89_S0.9651.00
39_L113_L0.9651.00
35_V113_L0.9641.00
189_L336_G0.9571.00
91_T98_Y0.9531.00
36_E43_A0.9521.00
277_L376_N0.9501.00
213_K220_D0.9481.00
25_D47_K0.9441.00
383_M387_V0.9441.00
212_A216_S0.9441.00
243_E246_K0.9381.00
60_V128_N0.9371.00
225_V229_G0.9371.00
10_E33_E0.9351.00
160_V394_D0.9341.00
90_A97_I0.9281.00
326_K338_I0.9281.00
81_S87_P0.9241.00
366_V426_H0.9201.00
4_E420_Y0.9201.00
191_Y207_P0.9121.00
5_L9_I0.9111.00
68_I431_L0.9081.00
369_T374_I0.9081.00
368_G373_V0.9061.00
110_M114_F0.9051.00
55_Y130_K0.9041.00
19_A139_I0.8971.00
358_A433_L0.8951.00
34_T39_L0.8911.00
47_K148_I0.8901.00
316_Q321_V0.8901.00
67_L394_D0.8880.99
78_D81_S0.8840.99
256_K259_L0.8820.99
236_E240_E0.8760.99
149_E389_K0.8750.99
420_Y424_I0.8730.99
422_K425_K0.8720.99
179_V381_Q0.8690.99
310_F321_V0.8690.99
245_I249_D0.8680.99
102_A415_I0.8540.99
16_S106_K0.8530.99
70_N112_R0.8530.99
290_G301_P0.8490.99
239_E242_R0.8450.99
138_E409_H0.8440.99
214_I329_L0.8410.99
248_Y251_D0.8400.99
326_K340_A0.8390.99
237_L242_R0.8370.99
63_K127_V0.8370.99
72_Y109_L0.8360.99
358_A361_E0.8350.99
58_I116_I0.8340.99
337_E340_A0.8330.99
428_E432_K0.8300.99
246_K250_I0.8280.99
5_L97_I0.8280.99
211_L214_I0.8270.99
35_V41_V0.8260.99
78_D82_E0.8230.99
109_L133_Y0.8220.99
94_N98_Y0.8220.99
318_P343_F0.8200.99
387_V390_L0.8160.99
9_I97_I0.8160.99
57_E60_V0.8150.99
396_V399_I0.8140.99
399_I403_G0.8130.99
6_Y13_K0.8110.99
112_R163_E0.8110.99
160_V396_V0.8110.99
150_K154_K0.8090.99
98_Y414_N0.8090.99
65_T158_D0.8080.99
48_T135_G0.8070.99
192_G207_P0.8070.99
238_T243_E0.8060.99
256_K260_G0.8030.99
416_K419_D0.8010.99
48_T52_P0.7950.99
71_H104_D0.7950.99
19_A136_E0.7940.99
79_P82_E0.7920.99
240_E244_L0.7910.99
139_I142_V0.7900.99
151_N155_L0.7900.99
377_S381_Q0.7890.99
246_K249_D0.7840.99
370_E373_V0.7810.99
396_V401_A0.7810.99
231_Y234_V0.7800.99
239_E246_K0.7790.99
35_V43_A0.7780.99
290_G302_H0.7770.99
175_I371_P0.7760.99
56_A59_N0.7730.99
29_N45_L0.7710.99
17_I77_V0.7690.99
149_E390_L0.7690.99
405_Y408_A0.7690.99
419_D422_K0.7620.98
354_T357_K0.7610.98
364_K371_P0.7590.98
8_L99_A0.7580.98
252_V256_K0.7580.98
231_Y235_R0.7560.98
229_G232_D0.7540.98
152_T156_K0.7490.98
122_K428_E0.7440.98
354_T358_A0.7430.98
7_T10_E0.7430.98
383_M386_F0.7380.98
55_Y147_Y0.7370.98
183_L322_F0.7370.98
125_L129_V0.7360.98
176_V377_S0.7350.98
26_E33_E0.7330.98
363_A426_H0.7330.98
56_A60_V0.7320.98
165_A176_V0.7320.98
7_T39_L0.7320.98
7_T30_Y0.7310.98
210_D335_N0.7300.98
61_N126_N0.7280.98
7_T110_M0.7270.98
111_A427_T0.7250.98
57_E154_K0.7250.98
364_K369_T0.7250.98
114_F117_K0.7210.98
400_G405_Y0.7200.98
344_E347_V0.7190.98
46_E147_Y0.7190.98
228_E231_Y0.7170.98
235_R239_E0.7170.98
116_I129_V0.7150.98
206_N283_N0.7140.98
212_A284_V0.7120.98
362_S365_K0.7120.98
253_E260_G0.7100.98
388_Y395_A0.7090.98
137_E409_H0.7080.98
161_I165_A0.7050.97
176_V374_I0.7050.97
110_M420_Y0.7020.97
376_N381_Q0.7000.97
75_Q409_H0.6990.97
334_F340_A0.6980.97
37_K117_K0.6970.97
31_L109_L0.6960.97
137_E197_H0.6950.97
104_D138_E0.6940.97
226_L230_F0.6940.97
360_I371_P0.6940.97
358_A430_F0.6940.97
271_K274_E0.6930.97
39_L120_L0.6920.97
105_N108_T0.6910.97
83_W86_A0.6910.97
26_E30_Y0.6900.97
157_A394_D0.6880.97
238_T246_K0.6880.97
175_I359_M0.6880.97
53_V57_E0.6880.97
401_A427_T0.6870.97
268_E271_K0.6870.97
237_L241_E0.6860.97
200_N377_S0.6860.97
390_L393_R0.6840.97
11_F31_L0.6840.97
53_V147_Y0.6830.97
119_L432_K0.6790.97
417_I421_Y0.6760.97
169_P172_R0.6760.97
218_L329_L0.6760.97
330_Q337_E0.6760.97
418_D421_Y0.6740.97
116_I120_L0.6730.97
24_I51_H0.6720.97
31_L113_L0.6720.97
187_L211_L0.6710.97
40_G45_L0.6690.97
9_I12_L0.6680.96
70_N133_Y0.6640.96
105_N109_L0.6620.96
396_V402_G0.6620.96
280_P313_V0.6590.96
63_K128_N0.6580.96
319_Y343_F0.6580.96
237_L240_E0.6570.96
28_A32_K0.6570.96
407_N412_N0.6570.96
425_K429_E0.6570.96
232_D235_R0.6560.96
399_I402_G0.6550.96
312_L343_F0.6550.96
267_N270_E0.6550.96
214_I218_L0.6540.96
236_E244_L0.6510.96
185_V340_A0.6480.96
228_E331_K0.6460.96
53_V59_N0.6430.96
348_R351_V0.6430.96
144_L148_I0.6420.96
257_K260_G0.6410.96
17_I20_T0.6410.96
44_N57_E0.6400.96
175_I360_I0.6400.96
185_V310_F0.6390.95
118_H424_I0.6390.95
275_A279_Y0.6380.95
331_K334_F0.6380.95
401_A404_Y0.6380.95
206_N301_P0.6380.95
400_G404_Y0.6370.95
282_C325_L0.6370.95
328_H331_K0.6370.95
115_A427_T0.6340.95
224_R231_Y0.6320.95
111_A115_A0.6290.95
115_A428_E0.6290.95
345_Y389_K0.6290.95
236_E242_R0.6280.95
55_Y132_L0.6270.95
185_V322_F0.6270.95
96_R406_S0.6260.95
15_P88_F0.6260.95
401_A405_Y0.6250.95
238_T244_L0.6250.95
384_G388_Y0.6250.95
386_F390_L0.6240.95
191_Y205_R0.6240.95
246_K252_V0.6230.95
421_Y424_I0.6210.95
103_S402_G0.6190.95
79_P101_G0.6160.95
28_A43_A0.6160.95
235_R241_E0.6160.95
244_L252_V0.6150.94
245_I251_D0.6140.94
67_L132_L0.6120.94
385_L389_K0.6120.94
4_E110_M0.6100.94
162_M165_A0.6090.94
232_D239_E0.6070.94
115_A119_L0.6070.94
376_N382_P0.6070.94
36_E42_K0.6060.94
53_V58_I0.6060.94
377_S380_T0.6060.94
53_V56_A0.6060.94
406_S414_N0.6060.94
108_T112_R0.6020.94
259_L265_K0.6000.94
407_N414_N0.5960.94
243_E248_Y0.5940.93
297_K307_K0.5940.93
247_K252_V0.5940.93
27_T31_L0.5930.93
83_W87_P0.5920.93
14_K23_G0.5900.93
25_D45_L0.5890.93
185_V338_I0.5890.93
159_S165_A0.5880.93
158_D164_G0.5880.93
236_E246_K0.5870.93
232_D238_T0.5850.93
87_P90_A0.5850.93
216_S220_D0.5830.93
90_A99_A0.5830.93
52_P135_G0.5830.93
405_Y414_N0.5810.93
104_D409_H0.5810.93
350_S395_A0.5800.93
227_I230_F0.5790.93
137_E311_R0.5790.93
31_L133_Y0.5790.93
104_D113_L0.5780.92
354_T360_I0.5770.92
94_N418_D0.5770.92
147_Y151_N0.5760.92
325_L328_H0.5750.92
203_L272_I0.5730.92
218_L325_L0.5720.92
45_L52_P0.5710.92
213_K221_M0.5690.92
353_S357_K0.5680.92
284_V306_A0.5680.92
104_D137_E0.5670.92
31_L34_T0.5670.92
129_V431_L0.5670.92
266_Y271_K0.5650.92
161_I401_A0.5630.91
191_Y210_D0.5630.91
22_E25_D0.5600.91
122_K432_K0.5600.91
43_A46_E0.5600.91
132_L147_Y0.5600.91
43_A54_V0.5590.91
213_K217_T0.5590.91
285_D298_T0.5590.91
64_K159_S0.5580.91
312_L346_P0.5580.91
162_M384_G0.5560.91
248_Y252_V0.5550.91
143_N146_D0.5550.91
240_E248_Y0.5550.91
71_H138_E0.5540.91
177_L351_V0.5520.91
424_I428_E0.5510.91
58_I120_L0.5510.91
220_D226_L0.5500.90
158_D393_R0.5500.90
340_A343_F0.5490.90
236_E241_E0.5460.90
66_L159_S0.5460.90
214_I217_T0.5450.90
235_R238_T0.5440.90
245_I250_I0.5440.90
61_N128_N0.5440.90
196_L204_V0.5440.90
191_Y334_F0.5430.90
104_D109_L0.5430.90
37_K120_L0.5420.90
8_L97_I0.5420.90
104_D107_G0.5410.90
97_I415_I0.5400.90
187_L329_L0.5400.90
53_V143_N0.5390.90
175_I426_H0.5380.90
41_V116_I0.5380.90
119_L122_K0.5380.90
402_G405_Y0.5370.89
362_S430_F0.5360.89
184_Y341_H0.5360.89
199_S202_P0.5350.89
290_G305_F0.5350.89
69_Y132_L0.5350.89
82_E411_P0.5350.89
63_K126_N0.5340.89
176_V179_V0.5330.89
112_R133_Y0.5330.89
217_T331_K0.5330.89
240_E252_V0.5320.89
68_I131_L0.5320.89
187_L308_L0.5310.89
287_F306_A0.5310.89
161_I430_F0.5310.89
174_Q374_I0.5300.89
179_V384_G0.5290.89
118_H121_D0.5280.89
115_A431_L0.5270.89
71_H137_E0.5270.89
234_V238_T0.5250.88
230_F234_V0.5240.88
115_A424_I0.5230.88
138_E197_H0.5230.88
53_V60_V0.5220.88
225_V230_F0.5220.88
179_V380_T0.5210.88
164_G168_D0.5200.88
208_C212_A0.5190.88
90_A417_I0.5190.88
313_V316_Q0.5190.88
393_R396_V0.5190.88
404_Y419_D0.5180.88
118_H124_E0.5170.88
266_Y270_E0.5160.88
35_V39_L0.5150.87
323_E340_A0.5140.87
48_T146_D0.5130.87
243_E251_D0.5120.87
5_L417_I0.5120.87
283_N309_D0.5120.87
359_M399_I0.5100.87
180_K281_T0.5100.87
42_K59_N0.5090.87
239_E244_L0.5070.87
118_H425_K0.5060.87
91_T97_I0.5060.87
56_A131_L0.5060.87
349_T356_V0.5050.86
127_V431_L0.5050.86
237_L245_I0.5050.86
29_N36_E0.5040.86
107_G420_Y0.5000.86
88_F100_R0.5000.86
119_L126_N0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mmoA 2 0.9931 100 0.253 Contact Map
2pokA 2 0.9886 100 0.287 Contact Map
4g1pA 2 0.9908 100 0.294 Contact Map
2zogA 2 0.9863 100 0.296 Contact Map
3dljA 2 0.9863 100 0.297 Contact Map
3pfeA 2 0.9817 100 0.327 Contact Map
3pfoA 2 0.8581 100 0.342 Contact Map
3iszA 2 0.8398 100 0.346 Contact Map
4pqaA 2 0.849 100 0.347 Contact Map
1cg2A 4 0.8352 100 0.372 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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