GREMLIN Database
Q97V96 - 4-hydroxybutyryl-CoA dehydratase (AbfD-2)
UniProt: Q97V96 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 502 (467)
Sequences: 818 (514)
Seq/√Len: 23.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_S262_N7.8601.00
139_Y143_N5.4591.00
10_V41_V5.3821.00
406_K410_E4.8831.00
26_K34_H4.5161.00
182_V217_F4.4861.00
12_A196_E4.3581.00
349_A358_W4.1901.00
30_D33_E4.1261.00
180_I270_V3.7811.00
14_R30_D3.5481.00
400_L425_L3.5391.00
172_V273_L3.5301.00
267_M270_V3.4281.00
197_E269_R3.3471.00
6_G49_D3.3391.00
176_T264_F3.3091.00
63_W70_E3.2301.00
176_T181_Y3.2101.00
135_E138_K2.9891.00
15_H19_V2.9741.00
178_D264_F2.9271.00
175_V274_G2.9231.00
57_E70_E2.9131.00
14_R32_T2.9081.00
471_A475_S2.9011.00
229_I259_I2.8900.99
218_S271_F2.8640.99
175_V273_L2.7950.99
180_I215_V2.7930.99
400_L409_I2.7720.99
313_A328_L2.7210.99
314_K468_E2.5450.99
378_E381_K2.5000.99
324_I386_I2.4990.99
309_A331_M2.4900.98
73_R86_A2.4830.98
330_E378_E2.4380.98
170_L182_V2.3850.98
20_E227_K2.3530.98
174_Q178_D2.3520.98
8_E11_N2.3450.98
181_Y264_F2.3390.98
5_T52_H2.2900.97
64_S67_I2.2720.97
64_S71_V2.2630.97
5_T8_E2.1930.97
174_Q262_N2.1910.96
259_I408_Y2.1460.96
4_R12_A2.1440.96
16_R19_V2.1340.96
4_R196_E2.1220.96
26_K398_W2.0900.95
79_R83_D2.0090.94
136_Y197_E1.9670.94
318_V324_I1.9630.94
131_E135_E1.9440.93
69_E142_K1.9220.93
174_Q181_Y1.9090.93
420_S423_D1.9090.93
350_V361_N1.9010.92
7_E11_N1.8900.92
155_K390_I1.8810.92
170_L260_F1.8670.92
212_D274_G1.8550.91
303_D339_Y1.8500.91
65_S71_V1.8460.91
61_R70_E1.8300.91
311_N472_K1.8230.91
98_T102_F1.8230.91
80_S358_W1.8200.91
327_K385_D1.7770.90
63_W67_I1.7640.89
82_E86_A1.7630.89
230_I254_H1.7410.89
308_A434_V1.7100.88
153_D186_K1.6120.84
20_E27_E1.5990.84
122_A286_F1.5790.83
60_A90_L1.5770.83
6_G45_K1.5750.83
96_H300_G1.5710.83
92_R96_H1.5560.82
190_T231_G1.5500.82
267_M273_L1.5290.81
229_I408_Y1.5190.80
173_T181_Y1.5130.80
314_K319_E1.4500.77
56_S93_K1.4430.77
172_V215_V1.4370.77
122_A127_K1.4340.76
136_Y218_S1.4310.76
302_G379_I1.4080.75
402_N405_L1.4040.75
231_G253_N1.4030.75
323_H327_K1.3990.75
88_V346_S1.3980.75
270_V273_L1.3970.74
135_E139_Y1.3970.74
136_Y139_Y1.3900.74
465_E468_E1.3810.74
66_F138_K1.3780.73
180_I264_F1.3760.73
136_Y269_R1.3740.73
128_E131_E1.3740.73
415_G419_Y1.3680.73
275_D278_M1.3360.71
232_R243_G1.3350.71
390_I395_P1.3250.70
173_T183_S1.3240.70
200_V260_F1.3160.70
160_L164_E1.3150.70
98_T373_T1.3140.70
47_T94_I1.3130.70
123_E354_E1.3120.70
100_A231_G1.3100.70
16_R222_D1.3090.69
208_E276_W1.3080.69
227_K408_Y1.3080.69
465_E469_K1.2910.68
51_A72_N1.2880.68
378_E382_F1.2820.68
99_G474_L1.2780.68
392_G395_P1.2650.67
81_P358_W1.2590.66
76_H294_Y1.2460.66
472_K475_S1.2450.65
175_V267_M1.2420.65
361_N364_F1.2410.65
202_P213_F1.2400.65
219_I265_V1.2320.65
313_A318_V1.2300.65
472_K476_Q1.2300.65
119_R134_V1.2190.64
132_R268_E1.2180.64
381_K445_V1.2130.63
219_I223_T1.2110.63
471_A476_Q1.2040.63
422_E426_R1.2030.63
409_I425_L1.1980.62
139_Y145_V1.1960.62
306_I331_M1.1960.62
106_V149_G1.1940.62
131_E134_V1.1910.62
132_R270_V1.1860.62
49_D52_H1.1760.61
315_Q419_Y1.1750.61
316_I388_G1.1730.61
66_F71_V1.1690.60
305_I431_L1.1690.60
388_G391_I1.1680.60
25_G399_D1.1620.60
384_T445_V1.1400.59
81_P347_L1.1320.58
255_E301_L1.1290.58
265_V269_R1.1280.58
220_P265_V1.1240.57
312_L431_L1.1150.57
259_I412_Y1.1150.57
127_K130_Y1.1110.57
54_E61_R1.1050.56
470_I473_Y1.1040.56
145_V197_E1.1020.56
439_A443_E1.1020.56
171_R212_D1.1000.56
3_L69_E1.0950.55
301_L444_S1.0860.55
181_Y215_V1.0800.54
39_P42_L1.0770.54
167_H411_K1.0750.54
43_A99_G1.0740.54
199_V335_N1.0690.54
108_W149_G1.0690.54
198_I221_L1.0690.54
200_V217_F1.0680.54
100_A253_N1.0680.54
327_K382_F1.0660.53
157_I160_L1.0650.53
312_L386_I1.0640.53
183_S200_V1.0580.53
337_N371_L1.0580.53
217_F265_V1.0560.53
167_H183_S1.0540.53
71_V141_Q1.0460.52
407_P410_E1.0460.52
429_R447_G1.0410.52
295_G299_S1.0380.51
150_A189_I1.0380.51
181_Y262_N1.0360.51
164_E209_K1.0360.51
11_N14_R1.0330.51
463_D466_Y1.0320.51
153_D286_F1.0320.51
121_M125_G1.0300.51
136_Y147_L1.0290.51
253_N439_A1.0260.51
257_L413_L1.0250.50
388_G450_S1.0220.50
377_Y381_K1.0160.50
470_I475_S1.0160.50
450_S453_A1.0130.50
192_I228_V1.0050.49
139_Y197_E1.0040.49
388_G392_G0.9980.49
113_A140_V0.9930.48
146_A191_G0.9850.48
133_F137_L0.9840.48
138_K180_I0.9800.47
21_I177_K0.9780.47
139_Y147_L0.9620.46
302_G372_V0.9610.46
330_E382_F0.9530.45
377_Y445_V0.9520.45
14_R31_V0.9500.45
45_K403_P0.9490.45
200_V223_T0.9470.45
40_S194_A0.9450.45
186_K372_V0.9440.45
62_A76_H0.9410.45
226_I263_V0.9390.44
10_V409_I0.9340.44
192_I221_L0.9330.44
470_I474_L0.9320.44
68_N314_K0.9320.44
211_M276_W0.9310.44
231_G255_E0.9300.44
178_D268_E0.9290.44
178_D181_Y0.9280.44
140_V147_L0.9270.44
27_E403_P0.9250.43
161_R164_E0.9200.43
14_R222_D0.9200.43
131_E270_V0.9190.43
11_N21_I0.9140.43
439_A444_S0.9120.43
156_G414_Q0.9110.42
81_P349_A0.9110.42
22_Y445_V0.9100.42
58_S70_E0.9090.42
198_I258_V0.9090.42
132_R182_V0.9040.42
22_Y424_R0.9010.42
63_W68_N0.9000.42
78_H87_K0.8990.42
163_H210_D0.8980.42
7_E58_S0.8900.41
14_R33_E0.8880.41
9_Y139_Y0.8850.41
37_L230_I0.8830.41
182_V356_G0.8820.40
43_A251_R0.8790.40
343_I348_D0.8780.40
310_Y328_L0.8770.40
322_P452_E0.8770.40
388_G395_P0.8770.40
348_D361_N0.8760.40
386_I396_S0.8750.40
20_E404_K0.8680.40
466_Y472_K0.8680.40
340_G364_F0.8670.39
64_S142_K0.8670.39
53_E56_S0.8660.39
272_M275_D0.8650.39
139_Y142_K0.8650.39
231_G443_E0.8650.39
21_I172_V0.8610.39
144_D217_F0.8610.39
312_L428_V0.8560.39
231_G439_A0.8560.39
467_A470_I0.8540.39
261_D345_A0.8510.38
152_T169_Y0.8490.38
76_H86_A0.8480.38
92_R300_G0.8460.38
39_P235_N0.8450.38
430_L471_A0.8410.38
272_M279_S0.8400.38
281_I285_I0.8380.38
294_Y346_S0.8380.38
253_N444_S0.8330.37
147_L218_S0.8330.37
466_Y475_S0.8300.37
253_N443_E0.8270.37
21_I53_E0.8270.37
124_R277_Q0.8260.37
67_I138_K0.8210.36
390_I394_A0.8200.36
446_H450_S0.8170.36
332_V462_Y0.8160.36
469_K473_Y0.8110.36
308_A431_L0.8100.36
340_G344_A0.8090.36
165_Q213_F0.8090.36
7_E319_E0.8050.35
255_E439_A0.8040.35
258_V271_F0.8040.35
67_I142_K0.8030.35
123_E134_V0.8020.35
327_K451_P0.8020.35
190_T253_N0.7970.35
162_P165_Q0.7940.35
440_F447_G0.7930.35
103_Q255_E0.7920.35
118_S130_Y0.7900.34
242_E423_D0.7890.34
38_K42_L0.7890.34
152_T194_A0.7880.34
342_G346_S0.7850.34
321_A450_S0.7810.34
80_S334_L0.7810.34
67_I71_V0.7800.34
128_E176_T0.7800.34
223_T405_L0.7800.34
473_Y476_Q0.7790.34
100_A244_E0.7780.34
244_E433_N0.7780.34
79_R135_E0.7780.34
173_T262_N0.7770.34
158_R317_G0.7770.34
332_V464_Y0.7760.34
471_A474_L0.7730.33
103_Q149_G0.7710.33
43_A46_A0.7700.33
72_N144_D0.7700.33
264_F267_M0.7700.33
10_V32_T0.7690.33
277_Q465_E0.7690.33
403_P407_P0.7660.33
254_H434_V0.7650.33
99_G476_Q0.7650.33
71_V142_K0.7640.33
121_M272_M0.7640.33
160_L167_H0.7630.33
326_N374_R0.7620.33
172_V465_E0.7610.33
223_T263_V0.7600.33
34_H45_K0.7600.33
29_K55_D0.7590.32
9_Y143_N0.7580.32
142_K259_I0.7580.32
294_Y301_L0.7550.32
386_I431_L0.7510.32
75_T412_Y0.7490.32
54_E277_Q0.7490.32
397_E401_K0.7480.32
26_K29_K0.7480.32
259_I427_M0.7460.32
73_R76_H0.7460.32
250_Y426_R0.7440.32
13_I19_V0.7440.32
308_A317_G0.7410.31
255_E443_E0.7400.31
95_S301_L0.7390.31
64_S141_Q0.7390.31
185_A412_Y0.7380.31
303_D467_A0.7380.31
123_E224_E0.7370.31
125_G279_S0.7370.31
20_E138_K0.7360.31
59_L89_K0.7310.31
7_E226_I0.7310.31
27_E48_Y0.7300.31
315_Q427_M0.7300.31
187_A429_R0.7290.31
255_E444_S0.7290.31
180_I274_G0.7270.30
429_R440_F0.7230.30
10_V42_L0.7220.30
183_S213_F0.7210.30
227_K259_I0.7210.30
117_T312_L0.7200.30
96_H470_I0.7200.30
55_D58_S0.7190.30
8_E274_G0.7180.30
372_V440_F0.7140.30
28_V38_K0.7140.30
187_A409_I0.7130.30
82_E85_A0.7110.30
129_Y132_R0.7100.29
384_T441_L0.7100.29
180_I273_L0.7090.29
373_T454_Q0.7080.29
144_D197_E0.7080.29
187_A190_T0.7070.29
231_G444_S0.7070.29
253_N301_L0.7060.29
337_N341_S0.7060.29
85_A347_L0.6990.29
33_E181_Y0.6970.29
77_I114_I0.6970.29
21_I279_S0.6970.29
314_K416_M0.6970.29
426_R475_S0.6960.29
402_N406_K0.6960.29
12_A15_H0.6960.29
224_E357_C0.6950.29
415_G424_R0.6950.29
117_T353_C0.6950.29
364_F381_K0.6950.29
369_K373_T0.6940.29
80_S320_K0.6930.28
410_E420_S0.6920.28
210_D226_I0.6920.28
33_E410_E0.6910.28
355_D361_N0.6900.28
178_D412_Y0.6890.28
191_G440_F0.6890.28
136_Y193_G0.6890.28
103_Q443_E0.6880.28
66_F268_E0.6870.28
23_V43_A0.6860.28
37_L299_S0.6790.28
385_D388_G0.6770.28
28_V33_E0.6770.28
394_A425_L0.6770.28
15_H30_D0.6770.28
312_L387_A0.6760.28
197_E265_V0.6760.28
226_I258_V0.6750.27
227_K402_N0.6750.27
466_Y474_L0.6720.27
187_A257_L0.6710.27
142_K383_S0.6710.27
28_V469_K0.6710.27
15_H222_D0.6700.27
399_D430_L0.6700.27
27_E178_D0.6680.27
100_A255_E0.6680.27
180_I262_N0.6680.27
226_I260_F0.6670.27
198_I288_S0.6660.27
397_E426_R0.6650.27
310_Y464_Y0.6650.27
83_D214_A0.6640.27
329_N333_L0.6640.27
228_V256_G0.6610.27
20_E31_V0.6610.27
327_K388_G0.6610.27
83_D420_S0.6600.27
443_E447_G0.6590.27
219_I263_V0.6580.27
160_L165_Q0.6580.27
223_T250_Y0.6570.26
131_E222_D0.6560.26
147_L199_V0.6560.26
312_L427_M0.6560.26
139_Y269_R0.6550.26
347_L407_P0.6540.26
236_D246_D0.6540.26
24_M399_D0.6530.26
200_V428_V0.6520.26
301_L439_A0.6510.26
186_K474_L0.6500.26
331_M379_I0.6500.26
467_A474_L0.6500.26
21_I31_V0.6490.26
148_A189_I0.6490.26
37_L204_R0.6480.26
152_T454_Q0.6470.26
432_E439_A0.6470.26
288_S360_V0.6460.26
46_A97_K0.6460.26
318_V379_I0.6450.26
406_K421_T0.6450.26
259_I421_T0.6440.26
174_Q264_F0.6430.26
156_G162_P0.6420.26
159_T317_G0.6410.26
316_I428_V0.6410.26
154_V185_A0.6410.26
103_Q432_E0.6390.25
325_Q456_I0.6390.25
309_A340_G0.6370.25
45_K230_I0.6370.25
408_Y412_Y0.6370.25
100_A444_S0.6360.25
5_T12_A0.6360.25
220_P271_F0.6360.25
305_I469_K0.6350.25
43_A409_I0.6340.25
335_N437_S0.6330.25
23_V307_G0.6320.25
160_L209_K0.6320.25
213_F388_G0.6310.25
102_F180_I0.6300.25
92_R303_D0.6300.25
106_V432_E0.6300.25
155_K158_R0.6300.25
103_Q253_N0.6300.25
22_Y227_K0.6290.25
302_G335_N0.6290.25
64_S69_E0.6280.25
37_L40_S0.6280.25
176_T267_M0.6270.25
9_Y265_V0.6240.25
22_Y115_Y0.6240.25
40_S274_G0.6230.25
6_G52_H0.6230.25
224_E262_N0.6220.25
58_S319_E0.6210.25
63_W66_F0.6210.25
183_S227_K0.6190.24
20_E405_L0.6180.24
57_E86_A0.6180.24
94_I382_F0.6180.24
227_K404_K0.6170.24
103_Q188_N0.6150.24
376_P384_T0.6130.24
65_S70_E0.6130.24
10_V45_K0.6110.24
106_V295_G0.6110.24
337_N340_G0.6100.24
231_G433_N0.6100.24
8_E82_E0.6100.24
182_V265_V0.6090.24
343_I400_L0.6090.24
301_L443_E0.6080.24
212_D377_Y0.6080.24
311_N329_N0.6080.24
72_N90_L0.6060.24
213_F262_N0.6060.24
85_A346_S0.6030.24
118_S127_K0.6030.24
255_E433_N0.6010.24
30_D465_E0.6010.24
163_H176_T0.6000.23
19_V221_L0.6000.23
241_E406_K0.5990.23
23_V28_V0.5980.23
75_T137_L0.5980.23
138_K142_K0.5970.23
72_N271_F0.5970.23
198_I228_V0.5950.23
26_K262_N0.5950.23
4_R140_V0.5940.23
150_A200_V0.5930.23
436_F440_F0.5920.23
27_E172_V0.5920.23
401_K422_E0.5920.23
296_G342_G0.5920.23
190_T251_R0.5900.23
140_V218_S0.5890.23
21_I409_I0.5890.23
410_E473_Y0.5870.23
311_N427_M0.5870.23
58_S86_A0.5860.23
9_Y52_H0.5860.23
104_R190_T0.5840.23
432_E444_S0.5840.23
175_V212_D0.5830.23
170_L215_V0.5830.23
95_S98_T0.5830.23
371_L375_F0.5810.23
122_A126_K0.5800.22
148_A193_G0.5790.22
50_A93_K0.5780.22
154_V253_N0.5770.22
87_K144_D0.5770.22
31_V41_V0.5750.22
231_G244_E0.5750.22
155_K159_T0.5740.22
101_C434_V0.5730.22
48_Y146_A0.5720.22
3_L8_E0.5720.22
176_T183_S0.5710.22
391_I395_P0.5710.22
154_V439_A0.5710.22
343_I347_L0.5700.22
169_Y204_R0.5700.22
119_R123_E0.5690.22
145_V269_R0.5690.22
466_Y476_Q0.5690.22
270_V467_A0.5680.22
128_E132_R0.5660.22
63_W142_K0.5660.22
260_F271_F0.5650.22
311_N468_E0.5650.22
134_V466_Y0.5650.22
177_K267_M0.5640.22
226_I403_P0.5640.22
12_A191_G0.5640.22
75_T78_H0.5640.22
332_V391_I0.5630.22
162_P167_H0.5630.22
328_L361_N0.5630.22
58_S405_L0.5610.22
242_E398_W0.5600.21
219_I269_R0.5590.21
302_G447_G0.5580.21
26_K82_E0.5580.21
8_E182_V0.5570.21
14_R38_K0.5570.21
453_A457_A0.5570.21
286_F290_H0.5570.21
367_V456_I0.5570.21
186_K447_G0.5570.21
22_Y27_E0.5570.21
339_Y342_G0.5560.21
252_T444_S0.5560.21
44_F425_L0.5550.21
322_P450_S0.5550.21
171_R420_S0.5540.21
154_V299_S0.5540.21
114_I199_V0.5530.21
96_H303_D0.5530.21
176_T407_P0.5520.21
59_L93_K0.5520.21
189_I258_V0.5510.21
307_G471_A0.5510.21
309_A313_A0.5500.21
222_D314_K0.5480.21
157_I164_E0.5480.21
155_K202_P0.5460.21
87_K294_Y0.5450.21
350_V362_P0.5450.21
51_A197_E0.5440.21
297_C368_T0.5440.21
218_S269_R0.5430.21
177_K268_E0.5430.21
37_L80_S0.5420.21
21_I85_A0.5410.21
430_L435_G0.5400.21
221_L228_V0.5400.21
54_E79_R0.5390.20
133_F456_I0.5390.20
219_I407_P0.5390.20
7_E402_N0.5380.20
151_M454_Q0.5380.20
465_E471_A0.5370.20
323_H450_S0.5370.20
436_F439_A0.5370.20
329_N337_N0.5350.20
107_G439_A0.5330.20
58_S135_E0.5330.20
197_E218_S0.5310.20
143_N178_D0.5310.20
128_E267_M0.5310.20
231_G301_L0.5310.20
223_T260_F0.5310.20
197_E336_E0.5300.20
172_V406_K0.5300.20
146_A338_M0.5290.20
161_R169_Y0.5280.20
88_V340_G0.5260.20
336_E339_Y0.5250.20
179_G267_M0.5250.20
8_E261_D0.5240.20
4_R148_A0.5230.20
279_S448_A0.5220.20
187_A389_G0.5220.20
265_V315_Q0.5220.20
60_A64_S0.5210.20
167_H186_K0.5210.20
194_A300_G0.5210.20
224_E473_Y0.5210.20
122_A125_G0.5210.20
14_R261_D0.5200.20
243_G246_D0.5200.20
53_E134_V0.5190.20
296_G447_G0.5190.20
265_V323_H0.5190.20
88_V92_R0.5190.20
151_M287_S0.5180.20
12_A16_R0.5180.20
80_S260_F0.5180.20
311_N430_L0.5170.20
185_A259_I0.5170.20
181_Y469_K0.5170.20
253_N433_N0.5160.19
347_L473_Y0.5160.19
122_A316_I0.5130.19
5_T32_T0.5120.19
175_V268_E0.5110.19
155_K316_I0.5110.19
189_I192_I0.5100.19
337_N367_V0.5090.19
309_A383_S0.5090.19
31_V402_N0.5080.19
11_N177_K0.5070.19
8_E20_E0.5070.19
79_R174_Q0.5070.19
43_A97_K0.5070.19
346_S349_A0.5060.19
378_E411_K0.5060.19
229_I261_D0.5060.19
205_A386_I0.5040.19
58_S463_D0.5040.19
317_G345_A0.5030.19
190_T245_I0.5030.19
325_Q329_N0.5030.19
138_K305_I0.5030.19
59_L328_L0.5030.19
24_M328_L0.5020.19
6_G401_K0.5020.19
28_V319_E0.5020.19
54_E70_E0.5020.19
50_A97_K0.5010.19
126_K409_I0.5010.19
395_P424_R0.5010.19
279_S292_Q0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g5eA 4 0.9104 100 0.507 Contact Map
3hwcA 4 0.9303 100 0.509 Contact Map
1u8vA 3 0.9363 100 0.519 Contact Map
4oo2A 4 0.9801 100 0.536 Contact Map
2yykA 3 0.9243 100 0.544 Contact Map
1ukwA 4 0.6992 99.7 0.899 Contact Map
2pg0A 4 0.7171 99.7 0.899 Contact Map
1ivhA 4 0.7171 99.7 0.901 Contact Map
4l1fA 4 0.6972 99.7 0.901 Contact Map
2wbiA 4 0.745 99.7 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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