GREMLIN Database
Q97V95 - Uncharacterized protein
UniProt: Q97V95 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 250 (231)
Sequences: 5415 (3381)
Seq/√Len: 222.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_S170_R4.3931.00
128_G132_S3.5411.00
141_I164_V3.4931.00
104_D107_V3.1401.00
46_I199_K2.9831.00
81_P109_V2.9481.00
53_V216_L2.8531.00
209_S212_N2.6911.00
86_N90_R2.6541.00
234_V238_T2.5901.00
11_V17_E2.5561.00
83_D87_H2.5401.00
145_N149_D2.4591.00
50_R54_A2.4561.00
81_P131_D2.3161.00
142_G145_N2.3131.00
129_L132_S2.2761.00
215_K219_E2.2481.00
79_V102_V2.2391.00
143_E172_V2.1831.00
79_V130_V2.1161.00
142_G167_K2.0721.00
79_V88_V2.0141.00
190_I195_D1.9371.00
34_R70_D1.9211.00
192_K195_D1.9171.00
39_K42_K1.8961.00
86_N127_S1.8641.00
9_P17_E1.8401.00
195_D198_T1.8321.00
202_I205_N1.8061.00
124_S128_G1.7971.00
52_V55_S1.7751.00
80_S83_D1.7501.00
238_T241_D1.7371.00
190_I193_V1.6721.00
210_I239_E1.6511.00
55_S58_E1.6441.00
214_A243_M1.6381.00
191_G195_D1.6231.00
86_N126_F1.5621.00
107_V170_R1.5471.00
59_Y62_N1.5321.00
68_V150_A1.5311.00
141_I145_N1.5301.00
191_G194_L1.5171.00
84_D87_H1.4921.00
149_D152_K1.4841.00
194_L198_T1.4781.00
51_D54_A1.4681.00
158_N182_K1.4621.00
82_N131_D1.4551.00
102_V130_V1.4551.00
193_V196_A1.4311.00
192_K198_T1.4261.00
79_V83_D1.4241.00
203_T206_R1.4111.00
192_K197_G1.4041.00
155_V185_A1.3951.00
191_G196_A1.3881.00
153_L162_L1.3661.00
190_I194_L1.3551.00
87_H90_R1.3531.00
106_N170_R1.3511.00
177_A181_V1.3411.00
107_V169_N1.3021.00
12_I224_T1.3011.00
214_A225_L1.2981.00
12_I20_L1.2981.00
144_E167_K1.2911.00
150_A162_L1.2871.00
104_D109_V1.2861.00
12_I23_A1.2611.00
89_V93_L1.2311.00
191_G197_G1.2261.00
46_I224_T1.2181.00
66_L69_K1.2181.00
146_T149_D1.2171.00
68_V175_I1.2011.00
140_S169_N1.1941.00
89_V126_F1.1911.00
114_E118_L1.1871.00
208_Y212_N1.1851.00
145_N153_L1.1811.00
147_I151_A1.1611.00
165_F169_N1.1551.00
152_K156_M1.1511.00
90_R94_M1.1461.00
216_L223_G1.1431.00
46_I226_L1.1281.00
66_L70_D1.1261.00
72_M164_V1.1201.00
212_N215_K1.1131.00
50_R55_S1.1131.00
191_G198_T1.1001.00
125_M128_G1.0981.00
230_N234_V1.0961.00
208_Y211_L1.0931.00
44_I224_T1.0931.00
239_E242_L1.0881.00
169_N172_V1.0811.00
203_T207_Y1.0761.00
30_N45_G1.0761.00
141_I162_L1.0751.00
32_S59_Y1.0661.00
88_V92_M1.0561.00
216_L219_E1.0541.00
9_P19_S1.0521.00
80_S104_D1.0461.00
147_I187_N1.0451.00
217_M223_G1.0271.00
194_L197_G1.0271.00
192_K196_A1.0251.00
237_V241_D1.0201.00
227_V240_R1.0091.00
16_P19_S1.0081.00
152_K155_V0.9981.00
234_V241_D0.9951.00
80_S105_N0.9941.00
240_R244_Y0.9891.00
112_F133_V0.9751.00
230_N233_L0.9721.00
103_V106_N0.9691.00
202_I206_R0.9691.00
83_D91_I0.9661.00
193_V197_G0.9491.00
233_L243_M0.9391.00
113_T116_E0.9331.00
222_I225_L0.9331.00
85_V133_V0.9301.00
216_L220_K0.9291.00
79_V100_I0.9281.00
151_A184_L0.9241.00
147_I183_Y0.9200.99
99_G111_I0.9180.99
211_L242_L0.9130.99
229_E236_I0.9120.99
151_A183_Y0.9110.99
233_L240_R0.9060.99
139_I157_N0.8920.99
238_T244_Y0.8900.99
82_N129_L0.8870.99
85_V128_G0.8870.99
217_M226_L0.8850.99
101_P171_L0.8850.99
239_E244_Y0.8820.99
196_A199_K0.8820.99
206_R209_S0.8760.99
142_G169_N0.8690.99
11_V15_F0.8680.99
202_I207_Y0.8650.99
233_L237_V0.8590.99
220_K223_G0.8560.99
227_V243_M0.8520.99
227_V241_D0.8470.99
154_M162_L0.8470.99
190_I196_A0.8430.99
212_N216_L0.8420.99
7_A10_I0.8420.99
11_V14_I0.8310.99
40_E44_I0.8290.99
231_Q235_G0.8190.99
99_G161_R0.8140.99
77_V100_I0.8120.99
15_F192_K0.8100.99
71_I183_Y0.8070.99
91_I95_N0.8070.99
218_I223_G0.8070.99
219_E222_I0.8060.99
88_V130_V0.8010.99
217_M220_K0.7950.98
219_E223_G0.7920.98
241_D244_Y0.7890.98
211_L215_K0.7860.98
17_E45_G0.7860.98
181_V185_A0.7830.98
213_A216_L0.7820.98
217_M222_I0.7820.98
217_M221_R0.7810.98
195_D199_K0.7780.98
32_S57_S0.7750.98
154_M177_A0.7720.98
104_D170_R0.7710.98
199_K224_T0.7710.98
102_V134_M0.7700.98
213_A217_M0.7700.98
238_T242_L0.7700.98
150_A175_I0.7670.98
210_I214_A0.7660.98
101_P108_I0.7630.98
211_L214_A0.7610.98
143_E167_K0.7550.98
66_L71_I0.7540.98
58_E61_T0.7540.98
233_L244_Y0.7530.98
218_I222_I0.7530.98
217_M228_M0.7530.98
206_R210_I0.7480.98
97_I100_I0.7480.98
116_E135_S0.7440.98
32_S62_N0.7410.98
110_G134_M0.7400.98
230_N236_I0.7360.98
234_V237_V0.7340.97
103_V171_L0.7320.97
155_V158_N0.7280.97
68_V71_I0.7230.97
141_I153_L0.7190.97
204_I214_A0.7180.97
24_I50_R0.7180.97
166_S172_V0.7120.97
141_I150_A0.7100.97
92_M100_I0.7090.97
124_S133_V0.7090.97
232_K235_G0.7080.97
71_I175_I0.7070.97
237_V240_R0.7070.97
220_K226_L0.7050.97
223_G226_L0.7040.97
236_I240_R0.7030.97
85_V124_S0.7010.97
78_I103_V0.6960.97
88_V112_F0.6960.97
91_I94_M0.6920.96
147_I180_I0.6880.96
231_Q234_V0.6870.96
77_V92_M0.6830.96
190_I198_T0.6780.96
232_K236_I0.6770.96
33_G60_G0.6760.96
215_K218_I0.6760.96
55_S59_Y0.6710.96
191_G199_K0.6700.96
90_R126_F0.6630.95
235_G239_E0.6600.95
81_P104_D0.6600.95
89_V117_I0.6580.95
68_V147_I0.6570.95
180_I184_L0.6560.95
108_I140_S0.6560.95
151_A180_I0.6550.95
78_I106_N0.6540.95
207_Y212_N0.6530.95
12_I35_I0.6530.95
84_D129_L0.6530.95
225_L229_E0.6520.95
18_S22_E0.6440.95
230_N240_R0.6430.95
199_K203_T0.6430.95
233_L239_E0.6420.95
209_S213_A0.6420.95
220_K228_M0.6400.94
228_M232_K0.6380.94
217_M232_K0.6380.94
51_D55_S0.6370.94
71_I147_I0.6370.94
181_V184_L0.6370.94
222_I227_V0.6360.94
214_A218_I0.6340.94
21_K25_D0.6330.94
29_N73_S0.6320.94
108_I163_P0.6320.94
111_I138_I0.6300.94
222_I226_L0.6300.94
240_R243_M0.6280.94
219_E224_T0.6260.94
93_L126_F0.6250.94
56_F59_Y0.6250.94
160_R177_A0.6210.94
8_N37_V0.6210.94
229_E235_G0.6200.94
228_M231_Q0.6190.93
107_V168_D0.6180.93
45_G48_S0.6170.93
146_T187_N0.6170.93
42_K45_G0.6170.93
140_S165_F0.6140.93
223_G227_V0.6110.93
39_K43_P0.6100.93
193_V198_T0.6080.93
229_E232_K0.6070.93
147_I177_A0.6060.93
90_R93_L0.6050.93
92_M117_I0.6030.93
218_I225_L0.5970.92
82_N105_N0.5910.92
78_I100_I0.5900.92
223_G243_M0.5830.91
111_I135_S0.5820.91
73_S174_I0.5820.91
213_A219_E0.5800.91
209_S239_E0.5790.91
86_N94_M0.5690.90
85_V112_F0.5680.90
228_M233_L0.5660.90
221_R225_L0.5650.90
96_N114_E0.5640.90
204_I207_Y0.5640.90
85_V130_V0.5630.90
77_V97_I0.5620.90
34_R38_L0.5580.89
103_V170_R0.5540.89
216_L242_L0.5530.89
49_T235_G0.5510.89
215_K222_I0.5510.89
205_N208_Y0.5500.89
72_M78_I0.5470.88
223_G228_M0.5470.88
213_A220_K0.5460.88
219_E243_M0.5450.88
213_A223_G0.5430.88
8_N20_L0.5410.88
85_V89_V0.5410.88
58_E62_N0.5380.88
217_M229_E0.5370.88
21_K32_S0.5360.87
204_I208_Y0.5360.87
41_E186_K0.5340.87
143_E166_S0.5320.87
13_T42_K0.5320.87
16_P22_E0.5300.87
126_F129_L0.5290.87
225_L228_M0.5280.87
235_G238_T0.5280.87
227_V236_I0.5270.87
101_P161_R0.5270.87
74_K172_V0.5260.86
219_E242_L0.5250.86
99_G160_R0.5250.86
67_K71_I0.5250.86
233_L236_I0.5210.86
229_E233_L0.5200.86
89_V164_V0.5200.86
221_R226_L0.5180.86
220_K229_E0.5150.85
185_A189_N0.5140.85
99_G113_T0.5130.85
146_T183_Y0.5120.85
23_A44_I0.5100.85
67_K147_I0.5080.85
223_G229_E0.5070.84
76_L171_L0.5050.84
68_V145_N0.5030.84
217_M227_V0.5010.84
80_S86_N0.5000.84
150_A154_M0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zy9A 2 0.984 100 0.341 Contact Map
2ouxA 2 0.74 100 0.425 Contact Map
3kxrA 3 0.66 100 0.483 Contact Map
2yvyA 2 0.72 100 0.5 Contact Map
3l2bA 2 0.464 99.9 0.572 Contact Map
1vr9A 1 0.48 99.9 0.582 Contact Map
3ddjA 1 0.992 99.9 0.583 Contact Map
4af0A 3 0.532 99.9 0.59 Contact Map
2yzqA 2 0.716 99.9 0.591 Contact Map
3usbA 4 0.968 99.9 0.592 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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