GREMLIN Database
Q97V92 - Uncharacterized protein
UniProt: Q97V92 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (371)
Sequences: 208 (174)
Seq/√Len: 9.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
243_E320_R5.7661.00
245_Y316_F4.8101.00
46_V202_I4.4560.99
316_F320_R4.0070.98
223_K227_D3.6350.97
312_G350_K3.5470.96
296_R300_P3.4080.95
183_I224_A3.3880.95
251_K335_G3.3480.95
17_C22_C3.3060.94
171_V177_M3.2680.94
317_L324_A3.2580.94
165_L195_K3.1520.93
254_F344_F3.1100.92
232_N318_A3.0790.92
360_F366_A3.0670.92
183_I200_L2.9630.90
17_C23_P2.8920.89
168_V199_I2.8330.88
94_V388_S2.8020.87
18_G22_C2.7700.87
237_D321_K2.6030.83
162_P165_L2.5020.80
18_G23_P2.4290.78
176_D209_R2.4030.77
340_V344_F2.3960.77
62_A129_L2.2840.73
261_R325_T2.2430.72
245_Y320_R2.2330.72
299_Y307_Y2.2110.71
302_I305_C2.1910.70
263_W312_G2.1320.68
242_V363_I2.1240.68
336_F352_M2.0950.66
336_F344_F2.0770.66
257_I370_V1.9870.62
41_S69_T1.9390.60
183_I367_L1.8780.58
191_I195_K1.8530.57
226_S314_T1.8190.55
267_W302_I1.8140.55
128_D161_L1.7760.53
116_Q289_D1.7600.53
225_I229_L1.7580.52
51_F210_K1.7430.52
167_V189_A1.7020.50
63_P149_P1.6690.49
56_I102_K1.6600.48
204_G279_K1.6470.48
234_K293_Y1.6470.48
40_G149_P1.6210.46
222_D347_E1.6140.46
299_Y306_Y1.6050.46
271_W332_I1.6050.46
273_P277_W1.5830.45
47_F307_Y1.5740.44
161_L226_S1.5640.44
273_P278_N1.5370.43
59_Y117_S1.5300.43
60_P69_T1.4970.41
47_F342_V1.4960.41
64_P67_G1.4930.41
307_Y342_V1.4740.40
47_F60_P1.4600.40
305_C344_F1.4390.39
63_P340_V1.4300.38
267_W305_C1.4300.38
47_F50_R1.4070.37
278_N296_R1.4040.37
19_L27_N1.4040.37
131_L151_A1.4000.37
305_C345_V1.3870.37
303_G345_V1.3800.36
47_F59_Y1.3750.36
63_P124_P1.3630.36
256_A336_F1.3610.36
193_V273_P1.3610.36
222_D346_R1.3470.35
75_S270_A1.3470.35
74_D327_I1.3460.35
141_D316_F1.3430.35
61_S223_K1.3410.35
250_N328_L1.3370.35
137_G332_I1.3340.34
70_S233_I1.3230.34
357_P381_W1.3150.34
177_M185_K1.3150.34
63_P273_P1.3110.34
48_V52_S1.3060.33
303_G348_N1.3060.33
248_K253_L1.3010.33
132_K154_E1.3000.33
342_V345_V1.2970.33
245_Y290_N1.2940.33
236_Y318_A1.2930.33
76_K200_L1.2930.33
93_L149_P1.2910.33
200_L224_A1.2860.33
233_I268_G1.2720.32
299_Y310_R1.2710.32
315_E350_K1.2710.32
209_R257_I1.2680.32
256_A352_M1.2660.32
289_D342_V1.2580.32
361_D368_N1.2580.32
328_L336_F1.2540.31
237_D257_I1.2530.31
251_K333_Y1.2530.31
225_I318_A1.2510.31
60_P95_R1.2510.31
145_P289_D1.2450.31
200_L205_I1.2380.31
19_L302_I1.2380.31
135_P151_A1.2340.31
19_L300_P1.2330.31
243_E357_P1.2330.31
108_P361_D1.2310.31
221_V332_I1.2270.30
230_I234_K1.2250.30
236_Y321_K1.2220.30
200_L310_R1.2190.30
161_L164_P1.2180.30
41_S64_P1.2140.30
215_R322_R1.2100.30
303_G335_G1.2070.30
267_W336_F1.2040.30
56_I236_Y1.2040.30
170_K387_L1.2040.30
328_L352_M1.1980.29
37_E51_F1.1920.29
236_Y327_I1.1850.29
142_E335_G1.1850.29
270_A345_V1.1830.29
226_S298_D1.1830.29
233_I377_D1.1790.29
278_N305_C1.1690.28
169_E172_Y1.1670.28
58_V340_V1.1650.28
215_R330_R1.1640.28
241_K359_V1.1600.28
245_Y254_F1.1460.28
64_P69_T1.1390.27
199_I223_K1.1350.27
48_V366_A1.1330.27
131_L340_V1.1270.27
125_V162_P1.1160.26
182_G363_I1.1150.26
270_A305_C1.1130.26
165_L169_E1.1130.26
96_G129_L1.1090.26
123_R332_I1.1080.26
39_Y42_S1.1070.26
313_V326_A1.0990.26
322_R362_D1.0970.26
265_F289_D1.0970.26
59_Y223_K1.0970.26
126_E210_K1.0950.26
309_S370_V1.0910.26
115_I275_S1.0890.26
39_Y126_E1.0860.25
237_D356_K1.0820.25
17_C27_N1.0800.25
287_E303_G1.0760.25
240_D359_V1.0740.25
164_P169_E1.0600.25
76_K194_E1.0550.24
70_S98_V1.0500.24
264_S325_T1.0450.24
149_P211_L1.0440.24
55_K210_K1.0420.24
305_C348_N1.0340.24
200_L338_L1.0330.24
28_T46_V1.0330.24
155_K233_I1.0290.24
117_S223_K1.0280.24
60_P118_I1.0260.24
302_I381_W1.0260.24
207_K239_I1.0260.24
303_G342_V1.0250.24
56_I103_D1.0240.23
242_V359_V1.0240.23
210_K322_R1.0080.23
38_V198_R1.0060.23
85_E182_G1.0020.23
144_L150_S0.9940.23
266_E346_R0.9920.22
224_A308_A0.9920.22
362_D373_L0.9910.22
185_K198_R0.9910.22
41_S332_I0.9890.22
154_E228_T0.9810.22
209_R347_E0.9780.22
271_W334_E0.9750.22
22_C27_N0.9730.22
271_W343_W0.9730.22
28_T139_I0.9710.22
360_F369_F0.9710.22
226_S267_W0.9670.22
117_S160_T0.9650.22
17_C271_W0.9640.22
258_L353_F0.9630.22
274_G328_L0.9610.22
148_G220_A0.9610.22
300_P307_Y0.9580.21
209_R222_D0.9540.21
226_S302_I0.9530.21
63_P295_G0.9480.21
210_K239_I0.9450.21
263_W305_C0.9450.21
98_V240_D0.9420.21
47_F289_D0.9350.21
30_T227_D0.9330.21
99_K383_S0.9320.21
118_I284_V0.9250.21
222_D277_W0.9230.20
234_K296_R0.9170.20
114_D117_S0.9160.20
47_F95_R0.9150.20
273_P296_R0.9150.20
244_V258_L0.9140.20
267_W303_G0.9120.20
305_C335_G0.9110.20
287_E336_F0.9080.20
140_L338_L0.9060.20
90_R174_D0.9040.20
73_E197_S0.9030.20
191_I209_R0.8990.20
300_P303_G0.8940.20
102_K321_K0.8930.20
227_D254_F0.8930.20
35_F227_D0.8900.20
226_S366_A0.8820.19
267_W344_F0.8760.19
77_Y208_E0.8750.19
19_L22_C0.8730.19
222_D312_G0.8690.19
330_R336_F0.8670.19
242_V257_I0.8550.19
102_K166_A0.8520.19
339_P352_M0.8520.19
94_V250_N0.8500.18
73_E76_K0.8470.18
22_C271_W0.8470.18
267_W333_Y0.8430.18
200_L358_V0.8420.18
153_L156_L0.8410.18
112_L158_I0.8390.18
93_L342_V0.8360.18
200_L374_L0.8360.18
257_I367_L0.8350.18
191_I275_S0.8350.18
141_D332_I0.8340.18
169_E199_I0.8330.18
89_M194_E0.8320.18
166_A365_T0.8320.18
18_G25_I0.8260.18
321_K371_K0.8260.18
25_I205_I0.8230.18
308_A343_W0.8230.18
91_L172_Y0.8170.18
47_F265_F0.8170.18
58_V114_D0.8090.17
61_S333_Y0.8040.17
166_A208_E0.8040.17
19_L267_W0.8020.17
33_V378_L0.7940.17
145_P336_F0.7930.17
32_R239_I0.7920.17
165_L226_S0.7920.17
134_I332_I0.7920.17
276_T336_F0.7910.17
128_D275_S0.7900.17
289_D303_G0.7890.17
121_S162_P0.7880.17
265_F309_S0.7820.17
215_R299_Y0.7810.17
73_E200_L0.7800.17
278_N303_G0.7790.17
222_D263_W0.7780.17
85_E286_I0.7770.17
156_L163_P0.7760.17
83_L267_W0.7750.17
207_K320_R0.7740.17
78_W90_R0.7740.17
315_E322_R0.7730.17
296_R307_Y0.7720.17
125_V161_L0.7720.17
267_W353_F0.7710.16
83_L261_R0.7670.16
289_D307_Y0.7660.16
176_D222_D0.7660.16
108_P112_L0.7660.16
271_W302_I0.7610.16
268_G273_P0.7600.16
254_F381_W0.7600.16
50_R342_V0.7590.16
15_Y169_E0.7580.16
233_I316_F0.7580.16
272_Y376_S0.7580.16
91_L240_D0.7570.16
86_F329_W0.7560.16
350_K381_W0.7560.16
162_P314_T0.7560.16
18_G43_P0.7560.16
41_S229_L0.7560.16
40_G54_P0.7550.16
323_Q331_E0.7540.16
198_R345_V0.7540.16
277_W347_E0.7520.16
100_Y309_S0.7510.16
232_N321_K0.7510.16
178_R371_K0.7510.16
174_D225_I0.7500.16
230_I344_F0.7450.16
98_V217_S0.7430.16
239_I356_K0.7430.16
52_S354_K0.7400.16
215_R277_W0.7400.16
211_L254_F0.7390.16
61_S221_V0.7370.16
163_P322_R0.7370.16
309_S371_K0.7360.16
49_G54_P0.7340.16
303_G307_Y0.7330.16
333_Y336_F0.7330.16
170_K386_L0.7330.16
59_Y86_F0.7310.16
59_Y329_W0.7300.16
305_C336_F0.7300.16
192_D225_I0.7300.16
323_Q363_I0.7300.16
151_A353_F0.7280.15
52_S362_D0.7270.15
253_L302_I0.7260.15
250_N336_F0.7250.15
129_L140_L0.7240.15
231_E356_K0.7240.15
250_N276_T0.7230.15
318_A321_K0.7160.15
47_F303_G0.7150.15
289_D299_Y0.7140.15
237_D322_R0.7130.15
135_P388_S0.7130.15
340_V376_S0.7120.15
193_V296_R0.7120.15
198_R308_A0.7100.15
251_K344_F0.7100.15
250_N313_V0.7090.15
307_Y323_Q0.7060.15
311_L343_W0.7060.15
164_P332_I0.7030.15
154_E211_L0.7010.15
93_L211_L0.7000.15
262_D321_K0.7000.15
64_P295_G0.6990.15
118_I337_N0.6980.15
351_E354_K0.6980.15
140_L376_S0.6970.15
167_V185_K0.6970.15
240_D361_D0.6960.15
141_D144_L0.6960.15
20_S92_S0.6960.15
163_P355_G0.6960.15
223_K303_G0.6960.15
271_W276_T0.6940.15
92_S254_F0.6940.15
31_V123_R0.6930.15
116_Q204_G0.6920.15
233_I241_K0.6920.15
265_F303_G0.6910.15
92_S125_V0.6910.15
155_K259_L0.6870.15
299_Y322_R0.6860.15
256_A328_L0.6850.15
101_H134_I0.6840.15
289_D305_C0.6810.14
162_P194_E0.6810.14
202_I316_F0.6780.14
121_S229_L0.6770.14
162_P323_Q0.6770.14
99_K139_I0.6760.14
50_R345_V0.6730.14
188_N318_A0.6720.14
25_I257_I0.6710.14
322_R364_S0.6700.14
84_S126_E0.6680.14
165_L191_I0.6600.14
298_D348_N0.6600.14
371_K377_D0.6590.14
250_N348_N0.6580.14
35_F182_G0.6560.14
166_A210_K0.6540.14
87_L331_E0.6530.14
261_R264_S0.6520.14
61_S202_I0.6500.14
267_W327_I0.6500.14
42_S70_S0.6490.14
195_K272_Y0.6480.14
50_R194_E0.6460.14
88_S168_V0.6450.14
55_K232_N0.6440.14
68_D196_I0.6440.14
187_Y193_V0.6430.14
183_I352_M0.6410.14
195_K236_Y0.6350.13
233_I245_Y0.6330.13
200_L217_S0.6330.13
116_Q307_Y0.6320.13
47_F299_Y0.6310.13
18_G27_N0.6300.13
362_D384_K0.6300.13
126_E179_A0.6300.13
119_T128_D0.6280.13
164_P198_R0.6280.13
47_F263_W0.6270.13
297_S370_V0.6260.13
36_K368_N0.6250.13
230_I233_I0.6230.13
86_F223_K0.6200.13
124_P308_A0.6160.13
63_P196_I0.6160.13
124_P162_P0.6150.13
160_T226_S0.6100.13
84_S309_S0.6090.13
303_G337_N0.6080.13
166_A283_Y0.6070.13
258_L326_A0.6060.13
87_L376_S0.6060.13
21_Y82_D0.6060.13
58_V70_S0.6050.13
183_I233_I0.6040.13
131_L135_P0.6040.13
326_A357_P0.6030.13
287_E300_P0.6020.13
161_L165_L0.6010.13
52_S65_I0.6000.13
92_S253_L0.6000.13
60_P342_V0.5990.13
323_Q342_V0.5980.13
199_I275_S0.5980.13
379_K389_F0.5970.13
277_W329_W0.5960.13
229_L327_I0.5940.13
336_F345_V0.5940.13
59_Y217_S0.5930.13
170_K185_K0.5920.13
20_S57_T0.5920.13
222_D303_G0.5920.13
150_S283_Y0.5920.13
118_I308_A0.5900.13
165_L205_I0.5880.13
178_R187_Y0.5870.13
296_R385_S0.5860.13
80_N83_L0.5850.13
24_I38_V0.5850.13
209_R319_S0.5850.13
94_V181_D0.5850.13
97_G332_I0.5840.12
279_K296_R0.5830.12
345_V351_E0.5830.12
253_L300_P0.5820.12
311_L350_K0.5810.12
240_D388_S0.5790.12
276_T352_M0.5790.12
121_S169_E0.5790.12
273_P350_K0.5770.12
253_L340_V0.5730.12
256_A326_A0.5730.12
47_F120_I0.5710.12
61_S336_F0.5700.12
112_L121_S0.5690.12
127_L364_S0.5680.12
86_F268_G0.5680.12
70_S368_N0.5660.12
158_I166_A0.5650.12
211_L314_T0.5650.12
210_K321_K0.5640.12
42_S60_P0.5640.12
28_T338_L0.5630.12
141_D271_W0.5630.12
38_V166_A0.5630.12
256_A309_S0.5630.12
173_V306_Y0.5630.12
89_M93_L0.5620.12
51_F326_A0.5590.12
151_A336_F0.5580.12
223_K328_L0.5580.12
53_Y94_V0.5580.12
253_L336_F0.5550.12
84_S379_K0.5540.12
182_G215_R0.5520.12
79_L223_K0.5520.12
197_S279_K0.5510.12
223_K265_F0.5480.12
42_S117_S0.5470.12
52_S107_L0.5460.12
162_P226_S0.5450.12
183_I248_K0.5450.12
362_D365_T0.5440.12
114_D294_H0.5440.12
171_V236_Y0.5430.12
67_G371_K0.5410.12
112_L342_V0.5410.12
47_F266_E0.5400.12
312_G347_E0.5400.12
155_K232_N0.5400.12
85_E131_L0.5400.12
177_M359_V0.5390.12
310_R322_R0.5380.12
21_Y336_F0.5370.12
286_I378_L0.5360.12
270_A303_G0.5360.12
198_R309_S0.5360.12
234_K276_T0.5330.12
300_P305_C0.5320.12
65_I321_K0.5290.11
73_E329_W0.5290.11
59_Y227_D0.5290.11
156_L386_L0.5290.11
24_I235_N0.5290.11
123_R200_L0.5280.11
60_P116_Q0.5280.11
244_V324_A0.5280.11
83_L340_V0.5280.11
165_L275_S0.5260.11
226_S287_E0.5260.11
270_A278_N0.5250.11
86_F91_L0.5220.11
270_A333_Y0.5180.11
50_R303_G0.5170.11
155_K225_I0.5170.11
200_L313_V0.5170.11
44_P49_G0.5160.11
204_G263_W0.5150.11
16_L194_E0.5120.11
153_L158_I0.5110.11
142_E363_I0.5110.11
19_L23_P0.5110.11
174_D317_L0.5110.11
45_S52_S0.5100.11
43_P331_E0.5090.11
159_A169_E0.5090.11
326_A350_K0.5080.11
201_S342_V0.5080.11
79_L305_C0.5070.11
183_I361_D0.5070.11
94_V118_I0.5060.11
61_S300_P0.5060.11
247_R336_F0.5050.11
139_I155_K0.5030.11
236_Y369_F0.5030.11
331_E345_V0.5030.11
261_R292_R0.5020.11
63_P131_L0.5010.11
317_L326_A0.5000.11
200_L364_S0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ssqA 6 0.1411 10.8 0.984 Contact Map
1qhkA 1 0.1083 10.4 0.985 Contact Map
3fblA 1 0.0957 9.1 0.985 Contact Map
1qgpA 1 0.1738 8.5 0.985 Contact Map
3p9aA 4 0.131 8.5 0.985 Contact Map
2fiyA 1 0.1436 8.4 0.985 Contact Map
3zheB 1 0.1562 8.1 0.985 Contact Map
4ijrA 2 0.1889 7.2 0.986 Contact Map
3bkrA 1 0.2393 6.2 0.986 Contact Map
4me7E 2 0.1033 5.7 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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