Q97V91 - SULSO - GREMLIN Contacts

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Q97V91 - Uncharacterized protein

UniProt:	Q97V91	Sequences: MVKMIVKSIRVKSALSKSGLKELNYSLNPYLGCVFSCPYCYAPNFTPDREASENWGKVVAVKENLLEVLEREVKIYKRGVVGISTITDAYQPIEALRKLTRESLKILLKNGFRVSIQTKSPLVLRDIDVLLEYKDRVDVGFTVTSLNNKLEPNAPPAKGRLRALEELSNEGLETWIFLGPIIQGVNDTEVENIIREISNIKARVIFDSFHYYRGLKFKEGSIHWWVNLKNKILENCKRYSIECHEQSEDWIYEKKRYYKTF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	261 (235)
Sequences:	1718 (1116)
Seq/√Len:	72.8

SULSO - Q97V91

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
70_E	109_K	5.134	1.00
14_A	65_L	4.421	1.00
165_E	169_N	3.299	1.00
64_N	67_E	3.294	1.00
108_L	132_E	3.049	1.00
111_G	136_R	2.958	1.00
140_G	175_W	2.759	1.00
131_L	170_E	2.441	1.00
8_S	97_R	2.412	1.00
121_P	155_P	2.398	1.00
124_L	163_A	2.392	1.00
164_L	174_T	2.350	1.00
143_V	164_L	2.324	1.00
101_R	128_D	2.271	1.00
121_P	159_G	2.250	1.00
162_R	165_E	2.225	1.00
141_F	163_A	2.171	1.00
66_L	102_E	2.148	1.00
104_L	114_V	2.096	1.00
178_L	193_I	2.039	1.00
102_E	105_K	2.038	1.00
8_S	63_E	1.989	1.00
161_L	196_E	1.985	1.00
124_L	166_E	1.971	1.00
165_E	199_N	1.939	1.00
141_F	164_L	1.919	1.00
159_G	162_R	1.892	1.00
127_I	172_L	1.890	1.00
176_I	197_I	1.885	1.00
6_V	61_V	1.881	1.00
148_N	158_K	1.835	1.00
66_L	106_I	1.834	1.00
162_R	166_E	1.813	1.00
49_R	60_A	1.800	1.00
24_N	79_G	1.762	1.00
164_L	202_A	1.733	1.00
15_L	69_L	1.723	1.00
127_I	170_E	1.711	1.00
178_L	181_I	1.710	1.00
175_W	204_V	1.695	1.00
59_V	93_I	1.663	1.00
181_I	190_V	1.643	1.00
234_E	238_R	1.640	1.00
210_H	236_C	1.639	1.00
196_E	199_N	1.633	1.00
235_N	238_R	1.628	0.99
74_K	110_N	1.617	0.99
85_T	89_A	1.600	0.99
130_L	137_V	1.592	0.99
108_L	136_R	1.591	0.99
158_K	196_E	1.473	0.99
178_L	190_V	1.468	0.99
15_L	72_E	1.466	0.99
69_L	107_L	1.457	0.99
218_K	233_L	1.445	0.99
123_V	139_V	1.443	0.99
179_G	208_S	1.440	0.99
139_V	172_L	1.417	0.99
14_A	68_V	1.413	0.99
168_S	174_T	1.411	0.99
66_L	103_S	1.403	0.98
39_Y	119_K	1.402	0.98
11_V	64_N	1.394	0.98
124_L	127_I	1.393	0.98
90_Y	126_D	1.390	0.98
123_V	163_A	1.375	0.98
25_Y	79_G	1.370	0.98
47_P	51_A	1.366	0.98
166_E	170_E	1.365	0.98
166_E	169_N	1.354	0.98
168_S	203_R	1.345	0.98
143_V	193_I	1.329	0.98
13_S	68_V	1.305	0.98
185_V	225_W	1.285	0.97
222_I	230_N	1.260	0.97
6_V	93_I	1.257	0.97
148_N	156_P	1.255	0.97
27_L	103_S	1.241	0.97
7_K	58_V	1.241	0.97
17_K	25_Y	1.236	0.97
70_E	110_N	1.236	0.97
11_V	68_V	1.227	0.96
121_P	163_A	1.214	0.96
111_G	132_E	1.206	0.96
9_I	64_N	1.177	0.95
140_G	177_F	1.176	0.95
195_R	199_N	1.166	0.95
222_I	229_K	1.165	0.95
68_V	71_R	1.161	0.95
122_L	125_R	1.157	0.95
6_V	59_V	1.153	0.95
45_F	86_I	1.150	0.95
107_L	133_Y	1.148	0.95
219_E	223_H	1.142	0.95
80_V	115_S	1.137	0.94
82_G	85_T	1.133	0.94
105_K	109_K	1.130	0.94
139_V	167_L	1.118	0.94
155_P	159_G	1.115	0.94
228_L	231_K	1.114	0.94
194_I	205_I	1.103	0.94
13_S	75_I	1.096	0.93
221_S	226_V	1.096	0.93
6_V	97_R	1.095	0.93
30_Y	94_E	1.092	0.93
218_K	237_K	1.085	0.93
132_E	135_D	1.079	0.93
222_I	233_L	1.053	0.92
67_E	102_E	1.051	0.92
165_E	168_S	1.048	0.92
148_N	157_A	1.040	0.91
231_K	234_E	1.040	0.91
29_P	83_I	1.040	0.91
182_I	217_F	1.038	0.91
98_K	102_E	1.033	0.91
108_L	129_V	1.015	0.90
81_V	107_L	1.010	0.90
123_V	137_V	1.010	0.90
98_K	105_K	1.001	0.90
146_L	161_L	0.998	0.90
82_G	117_Q	0.994	0.89
120_S	155_P	0.992	0.89
78_R	112_F	0.982	0.89
83_I	103_S	0.981	0.89
184_G	231_K	0.976	0.89
141_F	167_L	0.967	0.88
234_E	237_K	0.966	0.88
70_E	74_K	0.966	0.88
71_R	75_I	0.965	0.88
33_C	37_C	0.957	0.88
76_Y	112_F	0.955	0.87
61_V	97_R	0.942	0.87
178_L	186_N	0.940	0.87
41_Y	85_T	0.937	0.86
117_Q	140_G	0.937	0.86
121_P	124_L	0.935	0.86
90_Y	125_R	0.931	0.86
65_L	68_V	0.923	0.86
132_E	136_R	0.920	0.85
85_T	155_P	0.916	0.85
95_A	122_L	0.914	0.85
168_S	201_K	0.913	0.85
41_Y	86_I	0.913	0.85
168_S	202_A	0.907	0.85
233_L	237_K	0.905	0.84
179_G	207_D	0.903	0.84
60_A	120_S	0.901	0.84
33_C	40_C	0.895	0.84
217_F	221_S	0.893	0.84
194_I	198_S	0.891	0.84
163_A	166_E	0.889	0.83
150_L	182_I	0.885	0.83
7_K	59_V	0.876	0.82
232_I	236_C	0.869	0.82
228_L	232_I	0.867	0.82
177_F	206_F	0.864	0.82
143_V	161_L	0.863	0.82
105_K	129_V	0.862	0.81
108_L	133_Y	0.861	0.81
230_N	233_L	0.861	0.81
182_I	232_I	0.855	0.81
116_I	139_V	0.852	0.81
93_I	97_R	0.846	0.80
89_A	120_S	0.837	0.80
181_I	186_N	0.834	0.79
37_C	40_C	0.832	0.79
104_L	129_V	0.832	0.79
87_T	91_Q	0.832	0.79
89_A	117_Q	0.819	0.78
124_L	159_G	0.812	0.77
62_K	90_Y	0.808	0.77
138_D	204_V	0.801	0.76
47_P	215_L	0.798	0.76
99_L	102_E	0.795	0.76
101_R	126_D	0.790	0.75
192_N	196_E	0.783	0.75
84_S	89_A	0.782	0.75
124_L	167_L	0.782	0.75
62_K	126_D	0.780	0.75
107_L	114_V	0.776	0.74
114_V	137_V	0.776	0.74
8_S	61_V	0.776	0.74
44_N	216_K	0.774	0.74
83_I	100_T	0.767	0.73
85_T	117_Q	0.766	0.73
140_G	204_V	0.765	0.73
132_E	165_E	0.764	0.73
96_L	149_K	0.760	0.73
19_G	164_L	0.756	0.72
226_V	232_I	0.754	0.72
123_V	167_L	0.753	0.72
233_L	236_C	0.750	0.72
197_I	202_A	0.750	0.72
229_K	233_L	0.750	0.72
230_N	235_N	0.750	0.72
81_V	225_W	0.748	0.71
106_I	110_N	0.745	0.71
179_G	206_F	0.741	0.71
8_S	64_N	0.740	0.71
236_C	239_Y	0.738	0.70
228_L	236_C	0.734	0.70
146_L	196_E	0.734	0.70
65_L	103_S	0.734	0.70
85_T	177_F	0.733	0.70
25_Y	85_T	0.727	0.69
90_Y	101_R	0.726	0.69
62_K	125_R	0.726	0.69
28_N	87_T	0.726	0.69
193_I	197_I	0.723	0.69
28_N	35_F	0.723	0.69
114_V	133_Y	0.723	0.69
15_L	25_Y	0.719	0.68
41_Y	100_T	0.719	0.68
211_Y	216_K	0.715	0.68
63_E	67_E	0.710	0.67
164_L	176_I	0.708	0.67
237_K	240_S	0.703	0.67
196_E	200_I	0.699	0.66
94_E	126_D	0.698	0.66
25_Y	112_F	0.696	0.66
41_Y	45_F	0.696	0.66
63_E	97_R	0.696	0.66
155_P	219_E	0.695	0.66
90_Y	100_T	0.695	0.66
230_N	237_K	0.692	0.65
10_R	63_E	0.690	0.65
189_E	193_I	0.679	0.64
127_I	131_L	0.671	0.63
130_L	167_L	0.670	0.63
73_V	107_L	0.668	0.63
23_L	82_G	0.667	0.63
29_P	103_S	0.667	0.63
59_V	91_Q	0.665	0.62
83_I	114_V	0.665	0.62
134_K	137_V	0.664	0.62
227_N	234_E	0.663	0.62
143_V	197_I	0.661	0.62
34_V	91_Q	0.660	0.62
161_L	200_I	0.656	0.61
42_A	91_Q	0.655	0.61
16_S	23_L	0.653	0.61
118_T	142_T	0.649	0.61
41_Y	82_G	0.647	0.60
181_I	207_D	0.646	0.60
66_L	99_L	0.645	0.60
117_Q	177_F	0.644	0.60
11_V	14_A	0.641	0.60
225_W	228_L	0.638	0.59
218_K	222_I	0.637	0.59
212_Y	217_F	0.635	0.59
41_Y	107_L	0.632	0.58
127_I	167_L	0.629	0.58
90_Y	123_V	0.628	0.58
39_Y	144_T	0.627	0.58
131_L	135_D	0.627	0.58
94_E	125_R	0.625	0.58
131_L	172_L	0.622	0.57
116_I	130_L	0.621	0.57
125_R	128_D	0.617	0.57
138_D	175_W	0.614	0.56
111_G	133_Y	0.613	0.56
138_D	177_F	0.611	0.56
146_L	193_I	0.609	0.56
62_K	94_E	0.606	0.55
174_T	203_R	0.606	0.55
34_V	93_I	0.603	0.55
63_E	66_L	0.601	0.55
218_K	232_I	0.599	0.54
34_V	153_N	0.595	0.54
115_S	140_G	0.595	0.54
131_L	166_E	0.593	0.54
191_E	195_R	0.592	0.54
81_V	112_F	0.591	0.53
144_T	151_E	0.590	0.53
8_S	96_L	0.588	0.53
198_S	210_H	0.585	0.53
26_S	85_T	0.583	0.53
35_F	88_D	0.583	0.53
117_Q	138_D	0.582	0.52
37_C	180_P	0.581	0.52
154_A	160_R	0.578	0.52
10_R	67_E	0.571	0.51
192_N	199_N	0.571	0.51
156_P	159_G	0.570	0.51
157_A	197_I	0.569	0.51
64_N	68_V	0.568	0.51
132_E	162_R	0.568	0.51
44_N	47_P	0.566	0.50
30_Y	126_D	0.564	0.50
162_R	199_N	0.564	0.50
172_L	234_E	0.563	0.50
44_N	51_A	0.561	0.50
108_L	111_G	0.558	0.49
16_S	24_N	0.558	0.49
114_V	117_Q	0.556	0.49
9_I	61_V	0.556	0.49
192_N	195_R	0.554	0.49
164_L	200_I	0.552	0.49
101_R	129_V	0.552	0.49
213_R	216_K	0.552	0.49
14_A	64_N	0.551	0.49
27_L	108_L	0.551	0.49
74_K	136_R	0.550	0.48
147_N	189_E	0.549	0.48
18_S	21_K	0.547	0.48
101_R	104_L	0.546	0.48
143_V	163_A	0.545	0.48
120_S	175_W	0.543	0.48
15_L	27_L	0.542	0.47
229_K	238_R	0.537	0.47
144_T	189_E	0.537	0.47
184_G	236_C	0.537	0.47
23_L	117_Q	0.536	0.47
227_N	231_K	0.535	0.47
212_Y	226_V	0.535	0.47
178_L	205_I	0.533	0.46
62_K	65_L	0.532	0.46
101_R	105_K	0.531	0.46
87_T	146_L	0.531	0.46
67_E	70_E	0.529	0.46
176_I	179_G	0.527	0.46
9_I	60_A	0.527	0.46
68_V	72_E	0.526	0.45
161_L	197_I	0.526	0.45
33_C	180_P	0.525	0.45
85_T	107_L	0.524	0.45
99_L	108_L	0.523	0.45
98_K	125_R	0.520	0.45
105_K	169_N	0.519	0.45
70_E	106_I	0.518	0.44
7_K	49_R	0.517	0.44
152_P	160_R	0.516	0.44
84_S	187_D	0.515	0.44
168_S	199_N	0.514	0.44
130_L	141_F	0.513	0.44
28_N	62_K	0.513	0.44
123_V	130_L	0.513	0.44
33_C	39_Y	0.513	0.44
190_V	193_I	0.513	0.44
120_S	140_G	0.512	0.44
42_A	62_K	0.512	0.44
29_P	87_T	0.505	0.43
40_C	180_P	0.504	0.43
178_L	197_I	0.503	0.43
32_G	37_C	0.502	0.43
26_S	189_E	0.502	0.43
156_P	161_L	0.502	0.43
151_E	160_R	0.502	0.43
155_P	163_A	0.502	0.43
122_L	126_D	0.501	0.42
197_I	204_V	0.500	0.42
56_G	59_V	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4fhdA	1	0.9579	100	0.56	Contact Map
3c8fA	1	0.8621	99.4	0.812	Contact Map
2yx0A	1	0.9349	99.4	0.812	Contact Map
3iixA	1	0.9425	99.2	0.827	Contact Map
2z2uA	1	0.8352	99.2	0.829	Contact Map
1tv8A	2	0.908	99.2	0.83	Contact Map
2a5hA	4	0.9004	99.1	0.835	Contact Map
4u0oB	1	0.931	99	0.84	Contact Map
3rfaA	1	0.9157	99	0.84	Contact Map
2qgqA	1	0.7739	99	0.841	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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