GREMLIN Database
Q97V91 - Uncharacterized protein
UniProt: Q97V91 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 261 (235)
Sequences: 1718 (1116)
Seq/√Len: 72.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_E109_K5.1341.00
14_A65_L4.4211.00
165_E169_N3.2991.00
64_N67_E3.2941.00
108_L132_E3.0491.00
111_G136_R2.9581.00
140_G175_W2.7591.00
131_L170_E2.4411.00
8_S97_R2.4121.00
121_P155_P2.3981.00
124_L163_A2.3921.00
164_L174_T2.3501.00
143_V164_L2.3241.00
101_R128_D2.2711.00
121_P159_G2.2501.00
162_R165_E2.2251.00
141_F163_A2.1711.00
66_L102_E2.1481.00
104_L114_V2.0961.00
178_L193_I2.0391.00
102_E105_K2.0381.00
8_S63_E1.9891.00
161_L196_E1.9851.00
124_L166_E1.9711.00
165_E199_N1.9391.00
141_F164_L1.9191.00
159_G162_R1.8921.00
127_I172_L1.8901.00
176_I197_I1.8851.00
6_V61_V1.8811.00
148_N158_K1.8351.00
66_L106_I1.8341.00
162_R166_E1.8131.00
49_R60_A1.8001.00
24_N79_G1.7621.00
164_L202_A1.7331.00
15_L69_L1.7231.00
127_I170_E1.7111.00
178_L181_I1.7101.00
175_W204_V1.6951.00
59_V93_I1.6631.00
181_I190_V1.6431.00
234_E238_R1.6401.00
210_H236_C1.6391.00
196_E199_N1.6331.00
235_N238_R1.6280.99
74_K110_N1.6170.99
85_T89_A1.6000.99
130_L137_V1.5920.99
108_L136_R1.5910.99
158_K196_E1.4730.99
178_L190_V1.4680.99
15_L72_E1.4660.99
69_L107_L1.4570.99
218_K233_L1.4450.99
123_V139_V1.4430.99
179_G208_S1.4400.99
139_V172_L1.4170.99
14_A68_V1.4130.99
168_S174_T1.4110.99
66_L103_S1.4030.98
39_Y119_K1.4020.98
11_V64_N1.3940.98
124_L127_I1.3930.98
90_Y126_D1.3900.98
123_V163_A1.3750.98
25_Y79_G1.3700.98
47_P51_A1.3660.98
166_E170_E1.3650.98
166_E169_N1.3540.98
168_S203_R1.3450.98
143_V193_I1.3290.98
13_S68_V1.3050.98
185_V225_W1.2850.97
222_I230_N1.2600.97
6_V93_I1.2570.97
148_N156_P1.2550.97
27_L103_S1.2410.97
7_K58_V1.2410.97
17_K25_Y1.2360.97
70_E110_N1.2360.97
11_V68_V1.2270.96
121_P163_A1.2140.96
111_G132_E1.2060.96
9_I64_N1.1770.95
140_G177_F1.1760.95
195_R199_N1.1660.95
222_I229_K1.1650.95
68_V71_R1.1610.95
122_L125_R1.1570.95
6_V59_V1.1530.95
45_F86_I1.1500.95
107_L133_Y1.1480.95
219_E223_H1.1420.95
80_V115_S1.1370.94
82_G85_T1.1330.94
105_K109_K1.1300.94
139_V167_L1.1180.94
155_P159_G1.1150.94
228_L231_K1.1140.94
194_I205_I1.1030.94
13_S75_I1.0960.93
221_S226_V1.0960.93
6_V97_R1.0950.93
30_Y94_E1.0920.93
218_K237_K1.0850.93
132_E135_D1.0790.93
222_I233_L1.0530.92
67_E102_E1.0510.92
165_E168_S1.0480.92
148_N157_A1.0400.91
231_K234_E1.0400.91
29_P83_I1.0400.91
182_I217_F1.0380.91
98_K102_E1.0330.91
108_L129_V1.0150.90
81_V107_L1.0100.90
123_V137_V1.0100.90
98_K105_K1.0010.90
146_L161_L0.9980.90
82_G117_Q0.9940.89
120_S155_P0.9920.89
78_R112_F0.9820.89
83_I103_S0.9810.89
184_G231_K0.9760.89
141_F167_L0.9670.88
234_E237_K0.9660.88
70_E74_K0.9660.88
71_R75_I0.9650.88
33_C37_C0.9570.88
76_Y112_F0.9550.87
61_V97_R0.9420.87
178_L186_N0.9400.87
41_Y85_T0.9370.86
117_Q140_G0.9370.86
121_P124_L0.9350.86
90_Y125_R0.9310.86
65_L68_V0.9230.86
132_E136_R0.9200.85
85_T155_P0.9160.85
95_A122_L0.9140.85
168_S201_K0.9130.85
41_Y86_I0.9130.85
168_S202_A0.9070.85
233_L237_K0.9050.84
179_G207_D0.9030.84
60_A120_S0.9010.84
33_C40_C0.8950.84
217_F221_S0.8930.84
194_I198_S0.8910.84
163_A166_E0.8890.83
150_L182_I0.8850.83
7_K59_V0.8760.82
232_I236_C0.8690.82
228_L232_I0.8670.82
177_F206_F0.8640.82
143_V161_L0.8630.82
105_K129_V0.8620.81
108_L133_Y0.8610.81
230_N233_L0.8610.81
182_I232_I0.8550.81
116_I139_V0.8520.81
93_I97_R0.8460.80
89_A120_S0.8370.80
181_I186_N0.8340.79
37_C40_C0.8320.79
104_L129_V0.8320.79
87_T91_Q0.8320.79
89_A117_Q0.8190.78
124_L159_G0.8120.77
62_K90_Y0.8080.77
138_D204_V0.8010.76
47_P215_L0.7980.76
99_L102_E0.7950.76
101_R126_D0.7900.75
192_N196_E0.7830.75
84_S89_A0.7820.75
124_L167_L0.7820.75
62_K126_D0.7800.75
107_L114_V0.7760.74
114_V137_V0.7760.74
8_S61_V0.7760.74
44_N216_K0.7740.74
83_I100_T0.7670.73
85_T117_Q0.7660.73
140_G204_V0.7650.73
132_E165_E0.7640.73
96_L149_K0.7600.73
19_G164_L0.7560.72
226_V232_I0.7540.72
123_V167_L0.7530.72
233_L236_C0.7500.72
197_I202_A0.7500.72
229_K233_L0.7500.72
230_N235_N0.7500.72
81_V225_W0.7480.71
106_I110_N0.7450.71
179_G206_F0.7410.71
8_S64_N0.7400.71
236_C239_Y0.7380.70
228_L236_C0.7340.70
146_L196_E0.7340.70
65_L103_S0.7340.70
85_T177_F0.7330.70
25_Y85_T0.7270.69
90_Y101_R0.7260.69
62_K125_R0.7260.69
28_N87_T0.7260.69
193_I197_I0.7230.69
28_N35_F0.7230.69
114_V133_Y0.7230.69
15_L25_Y0.7190.68
41_Y100_T0.7190.68
211_Y216_K0.7150.68
63_E67_E0.7100.67
164_L176_I0.7080.67
237_K240_S0.7030.67
196_E200_I0.6990.66
94_E126_D0.6980.66
25_Y112_F0.6960.66
41_Y45_F0.6960.66
63_E97_R0.6960.66
155_P219_E0.6950.66
90_Y100_T0.6950.66
230_N237_K0.6920.65
10_R63_E0.6900.65
189_E193_I0.6790.64
127_I131_L0.6710.63
130_L167_L0.6700.63
73_V107_L0.6680.63
23_L82_G0.6670.63
29_P103_S0.6670.63
59_V91_Q0.6650.62
83_I114_V0.6650.62
134_K137_V0.6640.62
227_N234_E0.6630.62
143_V197_I0.6610.62
34_V91_Q0.6600.62
161_L200_I0.6560.61
42_A91_Q0.6550.61
16_S23_L0.6530.61
118_T142_T0.6490.61
41_Y82_G0.6470.60
181_I207_D0.6460.60
66_L99_L0.6450.60
117_Q177_F0.6440.60
11_V14_A0.6410.60
225_W228_L0.6380.59
218_K222_I0.6370.59
212_Y217_F0.6350.59
41_Y107_L0.6320.58
127_I167_L0.6290.58
90_Y123_V0.6280.58
39_Y144_T0.6270.58
131_L135_D0.6270.58
94_E125_R0.6250.58
131_L172_L0.6220.57
116_I130_L0.6210.57
125_R128_D0.6170.57
138_D175_W0.6140.56
111_G133_Y0.6130.56
138_D177_F0.6110.56
146_L193_I0.6090.56
62_K94_E0.6060.55
174_T203_R0.6060.55
34_V93_I0.6030.55
63_E66_L0.6010.55
218_K232_I0.5990.54
34_V153_N0.5950.54
115_S140_G0.5950.54
131_L166_E0.5930.54
191_E195_R0.5920.54
81_V112_F0.5910.53
144_T151_E0.5900.53
8_S96_L0.5880.53
198_S210_H0.5850.53
26_S85_T0.5830.53
35_F88_D0.5830.53
117_Q138_D0.5820.52
37_C180_P0.5810.52
154_A160_R0.5780.52
10_R67_E0.5710.51
192_N199_N0.5710.51
156_P159_G0.5700.51
157_A197_I0.5690.51
64_N68_V0.5680.51
132_E162_R0.5680.51
44_N47_P0.5660.50
30_Y126_D0.5640.50
162_R199_N0.5640.50
172_L234_E0.5630.50
44_N51_A0.5610.50
108_L111_G0.5580.49
16_S24_N0.5580.49
114_V117_Q0.5560.49
9_I61_V0.5560.49
192_N195_R0.5540.49
164_L200_I0.5520.49
101_R129_V0.5520.49
213_R216_K0.5520.49
14_A64_N0.5510.49
27_L108_L0.5510.49
74_K136_R0.5500.48
147_N189_E0.5490.48
18_S21_K0.5470.48
101_R104_L0.5460.48
143_V163_A0.5450.48
120_S175_W0.5430.48
15_L27_L0.5420.47
229_K238_R0.5370.47
144_T189_E0.5370.47
184_G236_C0.5370.47
23_L117_Q0.5360.47
227_N231_K0.5350.47
212_Y226_V0.5350.47
178_L205_I0.5330.46
62_K65_L0.5320.46
101_R105_K0.5310.46
87_T146_L0.5310.46
67_E70_E0.5290.46
176_I179_G0.5270.46
9_I60_A0.5270.46
68_V72_E0.5260.45
161_L197_I0.5260.45
33_C180_P0.5250.45
85_T107_L0.5240.45
99_L108_L0.5230.45
98_K125_R0.5200.45
105_K169_N0.5190.45
70_E106_I0.5180.44
7_K49_R0.5170.44
152_P160_R0.5160.44
84_S187_D0.5150.44
168_S199_N0.5140.44
130_L141_F0.5130.44
28_N62_K0.5130.44
123_V130_L0.5130.44
33_C39_Y0.5130.44
190_V193_I0.5130.44
120_S140_G0.5120.44
42_A62_K0.5120.44
29_P87_T0.5050.43
40_C180_P0.5040.43
178_L197_I0.5030.43
32_G37_C0.5020.43
26_S189_E0.5020.43
156_P161_L0.5020.43
151_E160_R0.5020.43
155_P163_A0.5020.43
122_L126_D0.5010.42
197_I204_V0.5000.42
56_G59_V0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fhdA 1 0.9579 100 0.56 Contact Map
3c8fA 1 0.8621 99.4 0.812 Contact Map
2yx0A 1 0.9349 99.4 0.812 Contact Map
3iixA 1 0.9425 99.2 0.827 Contact Map
2z2uA 1 0.8352 99.2 0.829 Contact Map
1tv8A 2 0.908 99.2 0.83 Contact Map
2a5hA 4 0.9004 99.1 0.835 Contact Map
4u0oB 1 0.931 99 0.84 Contact Map
3rfaA 1 0.9157 99 0.84 Contact Map
2qgqA 1 0.7739 99 0.841 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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