GREMLIN Database
Q97V88 - Uncharacterized protein
UniProt: Q97V88 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 262 (251)
Sequences: 5995 (4569)
Seq/√Len: 288.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_A69_Q2.9631.00
199_L226_I2.9051.00
75_A106_Y2.9041.00
57_E64_K2.8431.00
88_I98_Q2.6011.00
160_E194_S2.5771.00
136_R248_E2.5351.00
100_I111_D2.5291.00
10_A22_F2.5261.00
236_D240_N2.3691.00
9_E23_K2.3451.00
96_S115_T2.2711.00
100_I109_K2.2431.00
163_I190_C2.1671.00
13_L20_Y2.1651.00
109_K134_N2.1481.00
83_K99_Y2.1281.00
96_S113_V2.1131.00
21_S28_D2.0951.00
98_Q113_V2.0521.00
126_K254_Y2.0511.00
209_T260_R2.0501.00
128_V252_S2.0401.00
94_S117_K1.9941.00
124_R256_A1.9771.00
218_I226_I1.9461.00
126_K256_A1.9231.00
14_T84_E1.8931.00
17_A97_L1.8531.00
113_V128_V1.8441.00
11_E21_S1.8431.00
122_G258_A1.8351.00
248_E251_E1.8221.00
119_F122_G1.8061.00
98_Q111_D1.7801.00
61_E136_R1.7731.00
12_I97_L1.7711.00
91_S94_S1.7671.00
8_T22_F1.7591.00
201_S206_V1.7491.00
10_A19_L1.7441.00
59_V64_K1.7351.00
122_G260_R1.7331.00
198_Q207_R1.7271.00
117_K126_K1.7261.00
166_C176_E1.7191.00
57_E66_T1.7021.00
128_V254_Y1.7021.00
130_R252_S1.6901.00
10_A123_L1.6731.00
138_P246_I1.6691.00
68_P104_E1.6531.00
124_R258_A1.6511.00
54_K236_D1.6191.00
230_P257_F1.5941.00
60_F246_I1.5731.00
110_L139_L1.5631.00
80_V112_C1.5521.00
45_I114_I1.5461.00
17_A45_I1.5441.00
46_L142_G1.5181.00
119_F124_R1.5081.00
51_N217_Q1.5041.00
156_V198_Q1.5041.00
80_V99_Y1.4911.00
5_K120_K1.4881.00
154_R200_H1.4561.00
12_I95_I1.4431.00
61_E135_K1.4351.00
30_I145_P1.4301.00
115_T128_V1.4281.00
71_R74_N1.4241.00
140_T233_G1.4211.00
213_M255_F1.4181.00
73_G170_N1.4151.00
89_G96_S1.3991.00
94_S115_T1.3671.00
89_G94_S1.3671.00
103_H135_K1.3651.00
88_I96_S1.3591.00
49_F238_Y1.3481.00
111_D130_R1.3471.00
212_N255_F1.3431.00
63_V135_K1.3411.00
117_K124_R1.3281.00
213_M233_G1.3151.00
192_L234_A1.3141.00
236_D239_H1.2941.00
15_K84_E1.2931.00
19_L123_L1.2841.00
49_F245_K1.2831.00
8_T24_I1.2691.00
154_R202_S1.2651.00
198_Q209_T1.2541.00
19_L30_I1.2511.00
166_C178_V1.2331.00
131_N249_P1.2241.00
233_G245_K1.2171.00
136_R249_P1.2111.00
86_N98_Q1.1941.00
210_R260_R1.1821.00
8_T118_V1.1621.00
216_V228_I1.1611.00
88_I113_V1.1481.00
129_V139_L1.1431.00
101_L109_K1.1421.00
201_S204_S1.1261.00
167_I171_K1.1211.00
136_R246_I1.1171.00
139_L253_S1.1061.00
161_E179_K1.1021.00
41_G81_M1.0941.00
48_P101_L1.0821.00
55_N73_G1.0711.00
56_A66_T1.0681.00
157_V218_I1.0611.00
7_D25_G1.0611.00
22_F147_F1.0561.00
162_S178_V1.0541.00
190_C217_Q1.0531.00
200_H207_R1.0511.00
55_N74_N1.0501.00
87_V95_I1.0361.00
13_L18_Y1.0361.00
174_T177_L1.0341.00
221_G225_S1.0341.00
155_I199_L1.0181.00
114_I125_I1.0101.00
24_I29_M1.0071.00
139_L247_L1.0071.00
93_D117_K1.0061.00
215_F234_A1.0041.00
190_C215_F1.0021.00
18_Y44_A0.9981.00
151_D223_R0.9931.00
28_D32_R0.9901.00
49_F75_A0.9831.00
54_K168_S0.9821.00
61_E248_E0.9761.00
31_L225_S0.9761.00
69_Q73_G0.9721.00
54_K172_I0.9701.00
66_T69_Q0.9691.00
116_Y125_I0.9641.00
59_V62_G0.9641.00
49_F53_V0.9621.00
40_R82_D0.9571.00
237_A245_K0.9571.00
187_Y191_F0.9551.00
19_L145_P0.9511.00
115_T126_K0.9431.00
247_L252_S0.9231.00
45_I143_A0.9221.00
23_K28_D0.9201.00
112_C141_V0.9091.00
74_N170_N0.9081.00
53_V67_L0.9081.00
48_P110_L0.9001.00
83_K102_E0.8971.00
102_E109_K0.8971.00
54_K239_H0.8951.00
153_W201_S0.8951.00
155_I218_I0.8951.00
125_I143_A0.8861.00
6_G120_K0.8851.00
71_R76_I0.8841.00
87_V90_K0.8811.00
144_H229_E0.8781.00
193_I211_R0.8781.00
99_Y104_E0.8781.00
97_L116_Y0.8721.00
45_I116_Y0.8631.00
22_F30_I0.8591.00
112_C129_V0.8581.00
141_V253_S0.8501.00
5_K118_V0.8481.00
58_Y65_Y0.8471.00
156_V200_H0.8441.00
197_I216_V0.8401.00
77_H229_E0.8401.00
157_V197_I0.8381.00
61_E246_I0.8331.00
230_P255_F0.8291.00
185_T222_V0.8251.00
80_V110_L0.8181.00
22_F29_M0.8181.00
162_S166_C0.8161.00
187_Y218_I0.8050.99
114_I127_I0.8000.99
215_F243_G0.7980.99
138_P238_Y0.7940.99
47_I112_C0.7940.99
77_H144_H0.7930.99
41_G76_I0.7920.99
138_P244_L0.7900.99
45_I127_I0.7850.99
67_L75_A0.7840.99
90_K95_I0.7840.99
85_F112_C0.7820.99
157_V216_V0.7810.99
33_G41_G0.7750.99
75_A78_G0.7700.99
155_I228_I0.7640.99
210_R258_A0.7640.99
131_N247_L0.7640.99
127_I141_V0.7630.99
234_A243_G0.7620.99
161_E177_L0.7580.99
68_P75_A0.7500.99
79_L82_D0.7500.99
85_F114_I0.7480.99
158_E194_S0.7450.99
11_E20_Y0.7440.99
47_I80_V0.7430.99
233_G237_A0.7370.99
32_R148_I0.7360.99
90_K94_S0.7320.99
24_I206_V0.7310.99
110_L137_A0.7290.99
57_E239_H0.7250.99
8_T121_Y0.7200.99
19_L143_A0.7200.99
80_V101_L0.7140.99
149_T153_W0.7130.99
30_I147_F0.7120.99
185_T188_D0.7100.99
21_S32_R0.7070.99
190_C231_M0.7040.99
8_T29_M0.7020.99
127_I142_G0.7000.99
51_N190_C0.6990.99
18_Y38_P0.6970.99
52_R69_Q0.6910.98
218_I228_I0.6890.98
12_I19_L0.6880.98
69_Q75_A0.6880.98
199_L228_I0.6870.98
49_F138_P0.6870.98
19_L22_F0.6860.98
11_E23_K0.6860.98
60_F108_S0.6850.98
152_D203_Y0.6840.98
49_F237_A0.6830.98
54_K240_N0.6800.98
8_T25_G0.6790.98
110_L129_V0.6780.98
186_D220_T0.6760.98
7_D121_Y0.6730.98
212_N256_A0.6600.98
113_V130_R0.6600.98
38_P81_M0.6590.98
127_I255_F0.6580.98
22_F123_L0.6580.98
131_N137_A0.6580.98
48_P78_G0.6570.98
14_T87_V0.6550.98
151_D154_R0.6530.98
55_N69_Q0.6520.98
87_V97_L0.6510.98
46_L50_A0.6500.98
147_F259_F0.6500.98
153_W199_L0.6500.98
127_I257_F0.6500.98
163_I234_A0.6450.98
129_V253_S0.6430.97
5_K8_T0.6420.97
26_N206_V0.6400.97
53_V238_Y0.6390.97
112_C127_I0.6380.97
48_P104_E0.6370.97
44_A81_M0.6360.97
166_C174_T0.6330.97
78_G106_Y0.6320.97
55_N170_N0.6290.97
191_F218_I0.6270.97
131_N136_R0.6250.97
50_A231_M0.6240.97
170_N173_P0.6210.97
174_T178_V0.6200.97
54_K170_N0.6150.97
58_Y67_L0.6120.97
201_S205_K0.6110.97
182_L186_D0.6090.97
93_D120_K0.6090.97
208_I259_F0.6080.96
86_N100_I0.6070.96
247_L251_E0.6060.96
45_I112_C0.6060.96
12_I123_L0.6050.96
210_R213_M0.6050.96
46_L81_M0.6030.96
50_A233_G0.6030.96
166_C177_L0.6020.96
76_I81_M0.5980.96
9_E21_S0.5980.96
27_R205_K0.5950.96
217_Q231_M0.5950.96
211_R257_F0.5940.96
190_C193_I0.5940.96
121_Y260_R0.5920.96
129_V141_V0.5900.96
65_Y108_S0.5900.96
14_T86_N0.5850.96
60_F67_L0.5840.96
7_D120_K0.5810.95
15_K18_Y0.5810.95
52_R56_A0.5800.95
52_R77_H0.5800.95
43_M143_A0.5800.95
106_Y137_A0.5770.95
184_H223_R0.5760.95
80_V85_F0.5750.95
52_R229_E0.5740.95
57_E69_Q0.5710.95
33_G40_R0.5690.95
168_S171_K0.5660.95
71_R75_A0.5630.95
59_V65_Y0.5620.95
50_A140_T0.5610.95
50_A217_Q0.5610.95
85_F99_Y0.5600.95
245_K253_S0.5600.95
80_V83_K0.5600.95
15_K36_E0.5550.94
36_E84_E0.5550.94
17_A116_Y0.5530.94
14_T97_L0.5510.94
186_D191_F0.5500.94
146_Y219_Y0.5470.94
53_V58_Y0.5460.94
8_T122_G0.5450.94
18_Y82_D0.5400.93
33_G38_P0.5380.93
127_I213_M0.5380.93
154_R158_E0.5360.93
101_L110_L0.5350.93
148_I153_W0.5350.93
56_A75_A0.5350.93
79_L104_E0.5340.93
108_S137_A0.5310.93
53_V56_A0.5290.93
12_I116_Y0.5290.93
206_V209_T0.5280.93
54_K74_N0.5280.93
145_P230_P0.5270.93
155_I226_I0.5270.93
137_A247_L0.5270.93
162_S191_F0.5270.93
60_F65_Y0.5260.92
219_Y227_A0.5260.92
233_G244_L0.5260.92
56_A68_P0.5260.92
18_Y42_G0.5250.92
142_G227_A0.5250.92
237_A243_G0.5230.92
161_E194_S0.5230.92
90_K96_S0.5220.92
216_V230_P0.5200.92
78_G104_E0.5180.92
33_G42_G0.5160.92
143_A257_F0.5160.92
168_S173_P0.5150.92
99_Y102_E0.5150.92
6_G121_Y0.5150.92
88_I111_D0.5150.92
182_L185_T0.5140.92
87_V98_Q0.5130.92
175_G178_V0.5090.91
59_V239_H0.5080.91
58_Y239_H0.5060.91
20_Y41_G0.5060.91
17_A114_I0.5040.91
159_K180_T0.5030.91
116_Y123_L0.5010.91
70_N74_N0.5000.90
177_L192_L0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z45A 2 0.9885 100 0.194 Contact Map
1ygaA 2 0.9885 100 0.198 Contact Map
1lurA 1 0.9809 100 0.212 Contact Map
1snzA 1 0.9771 100 0.223 Contact Map
4rnlA 1 0.9771 100 0.226 Contact Map
1nsxA 2 0.9771 100 0.241 Contact Map
3imhA 3 0.9695 100 0.246 Contact Map
3mwxA 1 0.9885 100 0.249 Contact Map
3q1nA 1 0.9618 100 0.253 Contact Map
3nreA 1 0.9809 100 0.256 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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