GREMLIN Database
Q97V78 - Pyruvate synthase alpha chain (Pyruvic-ferredoxin oxidoreductase alpha chain) (PorA-2)
UniProt: Q97V78 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 400 (351)
Sequences: 5065 (3065)
Seq/√Len: 163.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_D315_K5.6061.00
140_Q144_D3.9711.00
287_K370_N3.5561.00
235_K239_R3.4041.00
258_Y282_D3.3481.00
281_V293_M3.3201.00
265_Y316_A3.0631.00
12_V142_A2.6721.00
134_A152_I2.6411.00
269_L277_A2.6391.00
266_A314_K2.6341.00
366_V370_N2.5721.00
260_L266_A2.3701.00
74_R154_E2.3381.00
368_I371_K2.3101.00
303_S306_E2.3071.00
146_T164_I2.2511.00
79_T84_L2.2481.00
284_L366_V2.2291.00
262_D290_K2.0681.00
18_L143_L2.0611.00
145_L297_R2.0451.00
104_V149_A2.0331.00
354_G364_D2.0271.00
143_L181_P2.0151.00
311_L317_V2.0091.00
283_T366_V2.0061.00
294_L307_I1.9811.00
21_V150_F1.9801.00
91_V131_W1.9751.00
266_A310_T1.9491.00
136_A164_I1.9331.00
12_V146_T1.9191.00
14_L42_M1.9021.00
265_Y289_I1.8981.00
335_V339_S1.8981.00
284_L369_F1.8871.00
267_V277_A1.8441.00
16_V76_F1.8441.00
42_M45_K1.8211.00
132_I152_I1.8061.00
106_G166_M1.8061.00
68_A75_A1.7971.00
267_V369_F1.7851.00
141_E295_R1.7831.00
22_G73_V1.7801.00
269_L293_M1.7731.00
24_T78_A1.7721.00
91_V103_M1.7721.00
266_A311_L1.7561.00
299_L336_E1.7421.00
264_D290_K1.7401.00
259_K282_D1.7351.00
182_D185_Q1.7311.00
155_D251_Y1.7291.00
265_Y318_L1.7291.00
84_L163_M1.7131.00
316_A347_Q1.7061.00
66_F94_V1.7031.00
62_M90_M1.6931.00
65_T101_V1.6371.00
242_N251_Y1.6161.00
148_Q254_L1.6051.00
296_I333_L1.6021.00
38_K41_E1.5881.00
239_R243_K1.5841.00
62_M103_M1.5831.00
12_V166_M1.5811.00
205_V208_G1.5651.00
302_W340_T1.5621.00
338_K342_S1.5561.00
255_N303_S1.5511.00
147_L186_V1.5491.00
66_F90_M1.5421.00
92_W125_S1.5131.00
274_A295_R1.5101.00
269_L274_A1.5061.00
253_T256_V1.5001.00
341_I348_I1.4771.00
305_K309_N1.4611.00
200_D203_D1.4371.00
63_A90_M1.4371.00
91_V163_M1.4361.00
109_A356_G1.4151.00
19_A150_F1.4141.00
204_P208_G1.4141.00
277_A320_L1.4091.00
262_D285_R1.4071.00
17_K78_A1.4011.00
294_L306_E1.3991.00
279_E283_T1.3971.00
21_V76_F1.3941.00
306_E309_N1.3901.00
367_Y371_K1.3871.00
25_G65_T1.3771.00
267_V281_V1.3771.00
25_G64_A1.3601.00
242_N246_N1.3571.00
230_S233_V1.3521.00
289_I370_N1.3481.00
266_A317_V1.3451.00
65_T75_A1.3341.00
266_A294_L1.3331.00
132_I160_L1.3301.00
94_V101_V1.3281.00
277_A365_L1.3231.00
360_V365_L1.3201.00
106_G172_S1.3161.00
274_A278_M1.3081.00
204_P207_M1.3061.00
138_N275_G1.3051.00
137_S274_A1.3011.00
287_K366_V1.2891.00
308_R344_V1.2621.00
41_E45_K1.2611.00
155_D236_E1.2601.00
263_A292_G1.2481.00
361_N364_D1.2441.00
23_V68_A1.2401.00
23_V64_A1.2351.00
85_L126_E1.2321.00
134_A162_M1.2321.00
69_A99_V1.2271.00
62_M101_V1.2201.00
242_N324_T1.2151.00
269_L273_W1.2121.00
294_L310_T1.2091.00
268_V307_I1.2091.00
319_V337_I1.2081.00
228_R233_V1.1951.00
166_M172_S1.1901.00
304_E340_T1.1881.00
240_E243_K1.1871.00
88_H124_T1.1851.00
141_E297_R1.1811.00
134_A298_Y1.1811.00
102_V149_A1.1801.00
137_S141_E1.1791.00
309_N312_K1.1791.00
292_G314_K1.1781.00
206_G209_N1.1771.00
241_Y244_K1.1721.00
7_S10_E1.1701.00
131_W163_M1.1611.00
273_W360_V1.1591.00
266_A292_G1.1531.00
205_V209_N1.1531.00
283_T286_E1.1521.00
260_L263_A1.1511.00
13_A35_I1.1491.00
32_Q78_A1.1451.00
43_R50_T1.1411.00
10_E38_K1.1371.00
237_I240_E1.1371.00
334_Y338_K1.1231.00
24_T36_I1.1191.00
318_L352_V1.1181.00
273_W365_L1.1141.00
38_K42_M1.1001.00
134_A149_A1.0951.00
88_H126_E1.0941.00
270_M323_S1.0871.00
240_E244_K1.0871.00
243_K246_N1.0790.99
239_R242_N1.0740.99
338_K343_N1.0670.99
156_E251_Y1.0650.99
285_R291_I1.0650.99
137_S295_R1.0560.99
13_A38_K1.0510.99
310_T314_K1.0500.99
15_G143_L1.0480.99
231_E234_I1.0460.99
14_L18_L1.0450.99
22_G50_T1.0450.99
260_L285_R1.0410.99
350_G353_S1.0260.99
102_V150_F1.0240.99
15_G146_T1.0230.99
284_L289_I1.0220.99
74_R150_F1.0170.99
101_V153_S1.0110.99
84_L107_T1.0110.99
19_A183_Q1.0100.99
259_K285_R1.0080.99
156_E230_S1.0080.99
26_I36_I1.0070.99
241_Y245_I1.0060.99
281_V285_R1.0000.99
148_Q152_I0.9840.99
242_N245_I0.9840.99
133_M163_M0.9840.99
274_A277_A0.9800.99
234_I238_G0.9780.99
135_F165_G0.9720.99
149_A164_I0.9700.99
9_N34_T0.9690.99
104_V146_T0.9510.99
227_L230_S0.9500.99
256_V297_R0.9480.99
305_K308_R0.9480.99
238_G242_N0.9450.99
55_V64_A0.9450.99
268_V311_L0.9450.99
126_E133_M0.9410.99
232_D236_E0.9390.99
109_A115_N0.9340.99
92_W128_D0.9330.99
239_R355_L0.9320.99
265_Y369_F0.9300.98
285_R288_G0.9300.98
204_P209_N0.9270.98
348_I351_V0.9260.98
134_A145_L0.9260.98
236_E243_K0.9260.98
188_D191_P0.9210.98
255_N294_L0.9190.98
235_K306_E0.9190.98
61_A87_M0.9170.98
237_I241_Y0.9110.98
126_E163_M0.9100.98
306_E310_T0.9100.98
77_T103_M0.9060.98
236_E240_E0.9040.98
304_E308_R0.9030.98
23_V73_V0.9000.98
250_D305_K0.8960.98
296_I299_L0.8950.98
76_F150_F0.8930.98
307_I337_I0.8870.98
12_V164_I0.8840.98
5_I175_K0.8840.98
278_M295_R0.8830.98
109_A114_W0.8830.98
118_N322_R0.8820.98
230_S234_I0.8770.98
147_L151_R0.8760.98
124_T332_P0.8740.98
270_M333_L0.8720.98
267_V365_L0.8720.98
277_A280_A0.8690.98
121_T216_Y0.8670.98
145_L148_Q0.8630.98
76_F104_V0.8590.97
367_Y370_N0.8530.97
6_I178_V0.8530.97
35_I106_G0.8470.97
267_V318_L0.8340.97
268_V294_L0.8290.97
278_M293_M0.8280.97
35_I76_F0.8240.97
260_L290_K0.8220.97
252_S255_N0.8210.97
185_Q188_D0.8210.97
184_D188_D0.8200.97
99_V153_S0.8180.97
19_A147_L0.8180.97
92_W129_S0.8170.97
296_I307_I0.8130.96
29_I82_Q0.8110.96
141_E144_D0.8050.96
265_Y291_I0.8040.96
53_V64_A0.8010.96
18_L147_L0.8010.96
13_A39_L0.8010.96
70_L207_M0.8010.96
233_V236_E0.8000.96
116_I122_D0.8000.96
85_L110_V0.8000.96
7_S175_K0.7950.96
285_R290_K0.7950.96
238_G241_Y0.7950.96
263_A266_A0.7890.96
9_N32_Q0.7870.96
209_N212_P0.7860.96
114_W122_D0.7850.96
220_R223_I0.7830.96
88_H129_S0.7780.95
363_N366_V0.7780.95
132_I162_M0.7770.95
17_K42_M0.7770.95
283_T287_K0.7760.95
183_Q187_D0.7760.95
151_R240_E0.7760.95
233_V237_I0.7760.95
152_I237_I0.7740.95
277_A293_M0.7730.95
135_F270_M0.7690.95
338_K348_I0.7680.95
36_I40_A0.7670.95
107_T122_D0.7660.95
256_V295_R0.7650.95
302_W307_I0.7640.95
16_V150_F0.7630.95
302_W333_L0.7630.95
229_N234_I0.7610.95
12_V104_V0.7580.95
9_N172_S0.7580.95
236_E239_R0.7570.95
36_I52_I0.7570.95
261_E313_D0.7550.95
120_H123_F0.7550.95
151_R188_D0.7520.95
123_F135_F0.7430.94
162_M230_S0.7400.94
232_D305_K0.7370.94
280_A284_L0.7370.94
335_V340_T0.7360.94
211_F219_L0.7350.94
363_N367_Y0.7320.94
127_R332_P0.7300.94
124_T129_S0.7300.94
214_E218_R0.7280.94
85_L88_H0.7280.94
337_I341_I0.7260.94
62_M65_T0.7240.93
226_A229_N0.7240.93
133_M299_L0.7240.93
258_Y281_V0.7200.93
206_G210_I0.7200.93
113_P122_D0.7160.93
349_K371_K0.7160.93
16_V146_T0.7150.93
258_Y285_R0.7140.93
151_R155_D0.7140.93
96_G112_A0.7130.93
148_Q151_R0.7120.93
215_G218_R0.7110.93
24_T76_F0.7100.93
245_I250_D0.7100.93
354_G360_V0.7090.93
318_L368_I0.7080.93
242_N250_D0.7070.93
125_S129_S0.7070.93
146_T150_F0.7050.92
4_K180_I0.7050.92
15_G19_A0.7050.92
257_S260_L0.7040.92
268_V337_I0.7020.92
318_L349_K0.7010.92
136_A145_L0.6990.92
259_K263_A0.6980.92
257_S292_G0.6970.92
277_A281_V0.6970.92
334_Y351_V0.6920.92
229_N232_D0.6900.92
312_K344_V0.6890.92
234_I237_I0.6860.91
118_N122_D0.6860.91
16_V35_I0.6860.91
310_T313_D0.6830.91
92_W126_E0.6820.91
143_L180_I0.6810.91
4_K14_L0.6790.91
18_L181_P0.6780.91
168_G173_H0.6760.91
14_L143_L0.6710.91
219_L227_L0.6700.90
262_D292_G0.6660.90
113_P116_I0.6650.90
316_A350_G0.6640.90
107_T165_G0.6620.90
255_N306_E0.6610.90
290_K315_K0.6610.90
231_E235_K0.6600.90
113_P118_N0.6590.90
195_Q223_I0.6590.90
167_D272_A0.6560.90
352_V358_V0.6520.89
148_Q253_T0.6520.89
254_L306_E0.6500.89
365_L368_I0.6490.89
68_A73_V0.6490.89
121_T323_S0.6480.89
123_F165_G0.6480.89
260_L292_G0.6440.89
155_D191_P0.6410.88
58_E83_G0.6400.88
10_E14_L0.6400.88
22_G48_I0.6400.88
142_A164_I0.6390.88
93_W97_S0.6380.88
366_V369_F0.6370.88
225_L228_R0.6320.88
24_T39_L0.6310.88
65_T94_V0.6300.88
109_A216_Y0.6280.87
276_D280_A0.6220.87
292_G313_D0.6210.87
34_T38_K0.6200.87
212_P215_G0.6200.87
350_G354_G0.6200.87
227_L232_D0.6190.87
304_E339_S0.6190.87
21_V39_L0.6170.87
153_S162_M0.6170.87
16_V19_A0.6160.86
156_E160_L0.6160.86
250_D256_V0.6160.86
7_S34_T0.6140.86
32_Q36_I0.6110.86
14_L180_I0.6110.86
84_L105_V0.6100.86
59_H87_M0.6090.86
94_V131_W0.6090.86
114_W119_E0.6080.86
81_S113_P0.6080.86
218_R358_V0.6070.86
139_P176_T0.6070.86
280_A362_K0.6060.86
26_I78_A0.6000.85
35_I78_A0.5990.85
278_M282_D0.5980.85
215_G219_L0.5980.85
311_L341_I0.5960.85
258_Y278_M0.5960.85
195_Q198_V0.5960.85
142_A166_M0.5930.84
98_R244_K0.5910.84
309_N313_D0.5910.84
11_A15_G0.5900.84
214_E217_M0.5900.84
104_V166_M0.5900.84
39_L52_I0.5890.84
360_V364_D0.5880.84
115_N356_G0.5880.84
35_I166_M0.5870.84
16_V24_T0.5820.83
336_E339_S0.5800.83
316_A349_K0.5800.83
323_S332_P0.5790.83
251_Y256_V0.5770.83
111_G114_W0.5770.83
65_T77_T0.5760.83
268_V296_I0.5750.82
66_F69_A0.5750.82
113_P120_H0.5740.82
4_K10_E0.5720.82
187_D190_L0.5710.82
150_F154_E0.5710.82
61_A65_T0.5680.82
112_A216_Y0.5680.82
351_V354_G0.5670.82
35_I104_V0.5670.82
102_V162_M0.5660.81
308_R312_K0.5660.81
137_S278_M0.5660.81
19_A146_T0.5650.81
104_V164_I0.5610.81
199_I202_E0.5580.81
113_P117_W0.5570.80
33_T37_E0.5560.80
260_L294_L0.5560.80
207_M210_I0.5560.80
102_V153_S0.5550.80
280_A366_V0.5550.80
225_L229_N0.5550.80
14_L38_K0.5540.80
353_S357_G0.5540.80
152_I234_I0.5540.80
364_D367_Y0.5540.80
57_S116_I0.5540.80
20_R150_F0.5530.80
234_I298_Y0.5520.80
284_L291_I0.5510.80
114_W117_W0.5480.79
114_W121_T0.5480.79
70_L99_V0.5470.79
268_V319_V0.5470.79
98_R240_E0.5470.79
342_S347_Q0.5460.79
70_L205_V0.5460.79
274_A293_M0.5430.79
88_H128_D0.5420.79
36_I78_A0.5400.78
286_E289_I0.5390.78
21_V50_T0.5380.78
311_L314_K0.5370.78
107_T272_A0.5360.78
39_L50_T0.5350.78
98_R157_R0.5340.78
350_G368_I0.5330.77
189_F237_I0.5330.77
93_W114_W0.5320.77
34_T173_H0.5300.77
59_H110_V0.5300.77
308_R341_I0.5290.77
234_I241_Y0.5290.77
365_L369_F0.5280.77
98_R160_L0.5230.76
139_P178_V0.5210.76
39_L43_R0.5210.76
25_G61_A0.5200.76
246_N250_D0.5200.76
84_L88_H0.5200.76
268_V317_V0.5200.76
105_V163_M0.5190.76
11_A142_A0.5190.76
30_T34_T0.5190.76
308_R343_N0.5190.76
18_L21_V0.5180.75
16_V186_V0.5170.75
113_P119_E0.5170.75
197_Y203_D0.5170.75
216_Y219_L0.5150.75
6_I11_A0.5140.75
102_V154_E0.5130.75
276_D365_L0.5130.75
122_D163_M0.5120.75
118_N121_T0.5100.74
12_V106_G0.5100.74
123_F126_E0.5090.74
36_I39_L0.5090.74
24_T35_I0.5090.74
153_S160_L0.5080.74
20_R187_D0.5080.74
120_H125_S0.5070.74
6_I10_E0.5070.74
307_I311_L0.5060.74
149_A162_M0.5060.74
80_A106_G0.5050.74
98_R226_A0.5050.74
235_K254_L0.5050.74
310_T317_V0.5020.73
93_W111_G0.5020.73
25_G68_A0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c42A 2 0.985 100 0.266 Contact Map
5c4iA 2 0.95 100 0.371 Contact Map
1yd7A 1 0.405 100 0.44 Contact Map
1qs0B 2 0.7625 100 0.7 Contact Map
1umdB 2 0.725 100 0.709 Contact Map
1w85B 2 0.7225 100 0.724 Contact Map
1ik6A 3 0.6525 100 0.728 Contact Map
2ozlB 2 0.7375 100 0.731 Contact Map
2bfdB 2 0.7275 100 0.739 Contact Map
2o1sA 2 0.705 100 0.74 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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